LOCUS AJ228139 3528 bp mRNA linear HUM 27-APR-2010 DEFINITION Homo sapiens mRNA for LETKI precursor. ACCESSION AJ228139 VERSION AJ228139.2 KEYWORDS LETKI precursor; serine proteinase inhibitor. SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 AUTHORS Maegert H.J., Standker L., Kreutzmann P., Zucht HD., Reinecke M., Sommerhoff C.P., Fritz H., Forssmann W.G. TITLE LETKI - A novel fifteen-domain type of Human serine proteinase inhibitor. JOURNAL J Biol Chem 274(31), 21499-21502(1999). PUBMED 10419450 REFERENCE 2 AUTHORS Maegert H.J. JOURNAL Submitted (10-MAR-1998) to the INSDC. Magert H.J., Molecular Biology, Lower Saxony Institute for, Peptide Research, Feodor-Lynen-Strasse 31, Hannover, Lower Saxony, D-30625, Germany REMARK revised by [3] REFERENCE 3 (bases 1 to 3528) AUTHORS Maegert H.J. JOURNAL Submitted (06-APR-1999) to the INSDC. gert, Molecular Biology, Lower Saxony Institute for, Peptide Research, Feodor-Lynen-Strasse 31, Hannover, Lower Saxony, D-30625, Germany FEATURES Location/Qualifiers source 1..3528 /db_xref="H-InvDB:HIT000245068" /organism="Homo sapiens" /mol_type="mRNA" /sex="female" /dev_stage="adult" /clone_lib="RT-PCR fragments in pGEM" /tissue_type="vaginal epithelium" /db_xref="taxon:9606" 5'UTR 1..43 CDS 44..3238 /product="LEKTI precursor" /function="Serine proteinase inhibitor" /db_xref="GOA:Q9NQ38" /db_xref="H-InvDB:HIT000245068.12" /db_xref="HGNC:HGNC:15464" /db_xref="InterPro:IPR002350" /db_xref="InterPro:IPR036058" /db_xref="PDB:1H0Z" /db_xref="PDB:1HDL" /db_xref="PDB:1UUC" /db_xref="PDB:1UVF" /db_xref="PDB:1UVG" /db_xref="PDB:5YHN" /db_xref="UniProtKB/Swiss-Prot:Q9NQ38" /experiment="experimental evidence, no additional details recorded" /protein_id="CAB40839.1" /translation="MKIATVSVLLPLALCLIQDAASKNEDQEMCHEFQAFMKNGKLFC PQDKKFFQSLDGIMFINKCATCKMILEKEAKSQKRARHLARAPKATAPTELNCDDFKK GERDGDFICPDYYEAVCGTDGKTYDNRCALCAENAKTGSQIGVKSEGECKSSNPEQDV CSAFRPFVRDGRLGCTRENDPVLGPDGKTHGNKCAMCAELFLKEAENAKREGETRIRR NAEKDFCKEYEKQVRNGRLFCTRESDPVRGPDGRMHGNKCALCAEIFKRRFSEENSKT DQNLGKAEEKTKVKREIVKLCSQYQNQAKNGILFCTRENDPIRGPDGKMHGNLCSMCQ VYFQAENEEKKKAEARARNKRESGKATSYAELCNEYRKLVRNGKLACTRENDPIQGPD GKVHGNTCSMCEVFFQAEEEEKKKKEGESRNKRQSKSTASFEELCSEYRKSRKNGRLF CTRENDPIQGPDGKMHGNTCSMCEAFFQQEERARAKAKREAAKEICSEFRDQVRNGTL ICTREHNPVRGPDGKMHGNKCAMCASVFKLEEEEKKNDKEEKGKVEAEKVKREAVQEL CSEYRHYVRNGRLPCTRENDPIEGLDGKIHGNTCSMCEAFFQQEAKEKERAEPRAKVK REAEKETCDEFRRLLQNGKLFCTRENDPVRGPDGKTHGNKCAMCKAVFQKENEERKRK EEEDQRNAAGHGSSGGGGGNTQDECAEYQEQMKNGRLSCTRESDPVRDADGKSYNNQC TMCKAKLEREAERKNEYSRSRSNGTGSESGKDTCDEFRSQMKNGKLICTRESDPVRGP DGKTHGNKCTMCKEKLEREAAEKKKKEDEDRSNTGERSNTGERSNDKEDLCREFRSMQ RNGKLICTRENNPVRGPYGKMHINKCAMCQSIFDREANERKKKDEEKSSSKPSNNAKD ECSEFRNYIRNNELICPRENDPVHGADGKFYTNKCYMCRAVFLTEALERAKLQEKPSH VRASQEEDSPDSFSSLDSEMCKDYRVLPRIGYLCPKDLKPVCGDDGQTYNNPCMLCHE NLIRQTNTHIRSTGKCEESSTPGTTAASMPPSDE" misc_feature 110..274 /product="human blood filtrate-derived peptide HF6479" /experiment="experimental evidence, no additional details recorded" misc_feature 332..496 /note="Kazal type serine proteinase inhibitor domain" misc_feature 1109..1312 /product="human blood filtrate-derived peptide HF7665" /function="trypsin inhibitor" /experiment="experimental evidence, no additional details recorded" misc_feature 3020..3181 /product="typical Kazal type serine proteinase inhibitor domain" 3'UTR 3139..3528 regulatory 3509..3514 /regulatory_class="polyA_signal_sequence" BASE COUNT 1252 a 634 c 888 g 754 t ORIGIN 1 tatgcatgga gtggacctgt aggcgacttg catcgtcttc aacatgaaga tagccacagt 61 gtcagtgctt ctgcccttgg ctctttgcct catacaagat gctgccagta agaatgaaga 121 tcaggaaatg tgccatgaat ttcaggcatt tatgaaaaat ggaaaactgt tctgtcccca 181 ggataagaaa ttttttcaaa gtcttgatgg aataatgttc atcaataaat gtgccacgtg 241 caaaatgata ctggaaaaag aagcaaaatc acagaagagg gccaggcatt tagcaagagc 301 tcccaaggct actgccccaa cagagctgaa ttgtgatgat tttaaaaaag gagaaagaga 361 tggggatttt atctgtcctg attattatga agctgtttgt ggcacagatg ggaaaacata 421 tgacaacaga tgtgcactgt gtgctgagaa tgcgaaaacc gggtcccaaa ttggtgtaaa 481 aagtgaaggg gaatgtaaga gcagtaatcc agagcaggat gtatgcagtg cttttcggcc 541 ctttgttaga gatggaagac ttggatgcac aagggaaaat gatcctgttc ttggtcctga 601 tgggaagacg catggcaata agtgtgcaat gtgtgctgag ctgtttttaa aagaagctga 661 aaatgccaag cgagagggtg aaactagaat tcgacgaaat gctgaaaagg atttttgcaa 721 ggaatatgaa aaacaagtga gaaatggaag gcttttttgt acacgggaga gtgatccagt 781 ccgtggccct gacggcagga tgcatggcaa caaatgtgcc ctgtgtgctg aaattttcaa 841 gcggcgtttt tcagaggaaa acagtaaaac agatcaaaat ttgggaaaag ctgaagaaaa 901 aactaaagtt aaaagagaaa ttgtgaaact ctgcagtcaa tatcaaaatc aggcaaagaa 961 tggaatactt ttctgtacca gagaaaatga ccctattcgt ggtccagatg ggaaaatgca 1021 tggcaacttg tgttccatgt gtcaagtcta cttccaagca gaaaatgaag aaaagaaaaa 1081 ggctgaagca cgagctagaa acaaaagaga atctggaaaa gcaacctcat atgcagagct 1141 ttgcaatgaa tatcgaaagc ttgtgaggaa cggaaaactt gcttgcacca gagagaacga 1201 tcctatccag ggcccagatg ggaaagtgca cggcaacacc tgctccatgt gtgaggtctt 1261 cttccaagca gaagaagaag aaaagaaaaa gaaggaaggc gaatcaagaa acaaaagaca 1321 atctaagagt acagcttcct ttgaggagtt gtgtagtgaa taccgcaaat ccaggaaaaa 1381 cggacggctt ttttgcacca gagagaatga ccccatccag ggcccagatg ggaaaatgca 1441 tggcaacacc tgctccatgt gtgaggcctt ctttcaacaa gaagaaagag caagagcaaa 1501 ggctaaaaga gaagctgcaa aggaaatctg cagtgaattt cgggaccaag tgaggaatgg 1561 aacacttata tgcaccaggg agcataatcc tgtccgtgga ccagatggca aaatgcatgg 1621 aaacaagtgt gccatgtgtg ccagtgtgtt caaacttgaa gaagaagaga agaaaaatga 1681 taaagaagaa aaagggaaag ttgaggctga aaaagttaag agagaagcag ttcaggagct 1741 gtgcagtgaa tatcgtcatt atgtgaggaa tggacgactc ccctgtacca gagagaatga 1801 tcctattgag ggtctagatg ggaaaatcca cggcaacacc tgctccatgt gtgaagcctt 1861 cttccagcaa gaagcaaaag aaaaagaaag agctgaaccc agagcaaaag tcaaaagaga 1921 agctgaaaag gagacatgcg atgaatttcg gagacttttg caaaatggaa aacttttctg 1981 cacaagagaa aatgatcctg tgcgtggccc agatggcaag acccatggca acaagtgtgc 2041 catgtgtaag gcagtcttcc agaaagaaaa tgaggaaaga aagaggaaag aagaggaaga 2101 tcagagaaat gctgcaggac atggttccag tggtggtgga ggaggaaaca ctcaggacga 2161 atgtgctgag tatcaggaac aaatgaaaaa tggaagactc agctgtactc gggagagtga 2221 tcctgtacgt gatgctgatg gcaaatcgta caacaatcag tgtaccatgt gtaaagcaaa 2281 attggaaaga gaagcagaga gaaaaaatga gtattctcgc tccagatcaa atgggactgg 2341 atcagaatca gggaaggata catgtgatga gtttagaagc caaatgaaaa atggaaaact 2401 tatctgcact cgagaaagtg accctgtccg gggtccagat ggcaagacac atggtaataa 2461 gtgtactatg tgtaaggaaa aactggaaag ggaagcagct gaaaaaaaaa agaaagagga 2521 tgaagacagg agcaatacag gagaaaggag caatacagga gaaaggagca atgacaaaga 2581 ggatctgtgt cgtgaatttc gaagcatgca gagaaatgga aagcttatct gcaccagaga 2641 aaataaccct gttcgaggcc catatggcaa gatgcacatc aataaatgtg ctatgtgtca 2701 gagcatcttt gatcgagaag ctaatgaaag aaaaaagaaa gatgaagaga aatcaagtag 2761 caagccctca aataatgcaa aggatgagtg cagtgaattt cgaaactata taaggaacaa 2821 tgaactcatc tgccctagag agaatgaccc agtgcacggt gctgatggaa agttctatac 2881 aaacaagtgc tacatgtgca gagctgtctt tctaacagaa gctttggaaa gggcaaagct 2941 tcaagaaaag ccatcccatg ttagagcttc tcaagaggaa gacagcccag actctttcag 3001 ttctctggat tctgagatgt gcaaagacta ccgagtattg cccaggatag gctatctttg 3061 tccaaaggat ttaaagcctg tctgtggtga cgatggccaa acctacaaca atccttgcat 3121 gctctgtcat gaaaacctga tacgccaaac aaatacacac atccgcagta cagggaagtg 3181 tgaggagagc agcaccccag gaaccaccgc agccagcatg cccccgtctg acgaatgaca 3241 ggaagattgt tgaaagccat gagggaaaaa ataaacccca gttctgaatc acctaccttc 3301 accatctgta tatacaaaga attcttcgga gcttgtctta tttgctatag aaaacaatac 3361 agagcttttg ggaatggaat cactgatttt cagtcttttc catttctttc ctcctagaat 3421 ctgtgatctg agggtataaa gacatttcca ccaagtttga gccctcaaaa tgtcctgatt 3481 acaatgctgt ctgtccaact gcctgttcaa taaaagtaaa ctcagcag //