LOCUS       AJ228139                3528 bp    mRNA    linear   HUM 27-APR-2010
DEFINITION  Homo sapiens mRNA for LETKI precursor.
ACCESSION   AJ228139
VERSION     AJ228139.2
KEYWORDS    LETKI precursor; serine proteinase inhibitor.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1
  AUTHORS   Maegert H.J., Standker L., Kreutzmann P., Zucht HD., Reinecke M.,
            Sommerhoff C.P., Fritz H., Forssmann W.G.
  TITLE     LETKI - A novel fifteen-domain type of Human serine proteinase
            inhibitor.
  JOURNAL   J Biol Chem 274(31), 21499-21502(1999).
   PUBMED   10419450
REFERENCE   2
  AUTHORS   Maegert H.J.
  JOURNAL   Submitted (10-MAR-1998) to the INSDC. Magert H.J., Molecular
            Biology, Lower Saxony Institute for, Peptide Research,
            Feodor-Lynen-Strasse 31, Hannover, Lower Saxony, D-30625, Germany
  REMARK    revised by [3]
REFERENCE   3  (bases 1 to 3528)
  AUTHORS   Maegert H.J.
  JOURNAL   Submitted (06-APR-1999) to the INSDC. gert, Molecular Biology,
            Lower Saxony Institute for, Peptide Research, Feodor-Lynen-Strasse
            31, Hannover, Lower Saxony, D-30625, Germany
FEATURES             Location/Qualifiers
     source          1..3528
                     /db_xref="H-InvDB:HIT000245068"
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /sex="female"
                     /dev_stage="adult"
                     /clone_lib="RT-PCR fragments in pGEM"
                     /tissue_type="vaginal epithelium"
                     /db_xref="taxon:9606"
     5'UTR           1..43
     CDS             44..3238
                     /product="LEKTI precursor"
                     /function="Serine proteinase inhibitor"
                     /db_xref="GOA:Q9NQ38"
                     /db_xref="H-InvDB:HIT000245068.12"
                     /db_xref="HGNC:HGNC:15464"
                     /db_xref="InterPro:IPR002350"
                     /db_xref="InterPro:IPR036058"
                     /db_xref="PDB:1H0Z"
                     /db_xref="PDB:1HDL"
                     /db_xref="PDB:1UUC"
                     /db_xref="PDB:1UVF"
                     /db_xref="PDB:1UVG"
                     /db_xref="PDB:5YHN"
                     /db_xref="UniProtKB/Swiss-Prot:Q9NQ38"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /protein_id="CAB40839.1"
                     /translation="MKIATVSVLLPLALCLIQDAASKNEDQEMCHEFQAFMKNGKLFC
                     PQDKKFFQSLDGIMFINKCATCKMILEKEAKSQKRARHLARAPKATAPTELNCDDFKK
                     GERDGDFICPDYYEAVCGTDGKTYDNRCALCAENAKTGSQIGVKSEGECKSSNPEQDV
                     CSAFRPFVRDGRLGCTRENDPVLGPDGKTHGNKCAMCAELFLKEAENAKREGETRIRR
                     NAEKDFCKEYEKQVRNGRLFCTRESDPVRGPDGRMHGNKCALCAEIFKRRFSEENSKT
                     DQNLGKAEEKTKVKREIVKLCSQYQNQAKNGILFCTRENDPIRGPDGKMHGNLCSMCQ
                     VYFQAENEEKKKAEARARNKRESGKATSYAELCNEYRKLVRNGKLACTRENDPIQGPD
                     GKVHGNTCSMCEVFFQAEEEEKKKKEGESRNKRQSKSTASFEELCSEYRKSRKNGRLF
                     CTRENDPIQGPDGKMHGNTCSMCEAFFQQEERARAKAKREAAKEICSEFRDQVRNGTL
                     ICTREHNPVRGPDGKMHGNKCAMCASVFKLEEEEKKNDKEEKGKVEAEKVKREAVQEL
                     CSEYRHYVRNGRLPCTRENDPIEGLDGKIHGNTCSMCEAFFQQEAKEKERAEPRAKVK
                     REAEKETCDEFRRLLQNGKLFCTRENDPVRGPDGKTHGNKCAMCKAVFQKENEERKRK
                     EEEDQRNAAGHGSSGGGGGNTQDECAEYQEQMKNGRLSCTRESDPVRDADGKSYNNQC
                     TMCKAKLEREAERKNEYSRSRSNGTGSESGKDTCDEFRSQMKNGKLICTRESDPVRGP
                     DGKTHGNKCTMCKEKLEREAAEKKKKEDEDRSNTGERSNTGERSNDKEDLCREFRSMQ
                     RNGKLICTRENNPVRGPYGKMHINKCAMCQSIFDREANERKKKDEEKSSSKPSNNAKD
                     ECSEFRNYIRNNELICPRENDPVHGADGKFYTNKCYMCRAVFLTEALERAKLQEKPSH
                     VRASQEEDSPDSFSSLDSEMCKDYRVLPRIGYLCPKDLKPVCGDDGQTYNNPCMLCHE
                     NLIRQTNTHIRSTGKCEESSTPGTTAASMPPSDE"
     misc_feature    110..274
                     /product="human blood filtrate-derived peptide HF6479"
                     /experiment="experimental evidence, no additional details
                     recorded"
     misc_feature    332..496
                     /note="Kazal type serine proteinase inhibitor domain"
     misc_feature    1109..1312
                     /product="human blood filtrate-derived peptide HF7665"
                     /function="trypsin inhibitor"
                     /experiment="experimental evidence, no additional details
                     recorded"
     misc_feature    3020..3181
                     /product="typical Kazal type serine proteinase inhibitor
                     domain"
     3'UTR           3139..3528
     regulatory      3509..3514
                     /regulatory_class="polyA_signal_sequence"
BASE COUNT         1252 a          634 c          888 g          754 t
ORIGIN      
        1 tatgcatgga gtggacctgt aggcgacttg catcgtcttc aacatgaaga tagccacagt
       61 gtcagtgctt ctgcccttgg ctctttgcct catacaagat gctgccagta agaatgaaga
      121 tcaggaaatg tgccatgaat ttcaggcatt tatgaaaaat ggaaaactgt tctgtcccca
      181 ggataagaaa ttttttcaaa gtcttgatgg aataatgttc atcaataaat gtgccacgtg
      241 caaaatgata ctggaaaaag aagcaaaatc acagaagagg gccaggcatt tagcaagagc
      301 tcccaaggct actgccccaa cagagctgaa ttgtgatgat tttaaaaaag gagaaagaga
      361 tggggatttt atctgtcctg attattatga agctgtttgt ggcacagatg ggaaaacata
      421 tgacaacaga tgtgcactgt gtgctgagaa tgcgaaaacc gggtcccaaa ttggtgtaaa
      481 aagtgaaggg gaatgtaaga gcagtaatcc agagcaggat gtatgcagtg cttttcggcc
      541 ctttgttaga gatggaagac ttggatgcac aagggaaaat gatcctgttc ttggtcctga
      601 tgggaagacg catggcaata agtgtgcaat gtgtgctgag ctgtttttaa aagaagctga
      661 aaatgccaag cgagagggtg aaactagaat tcgacgaaat gctgaaaagg atttttgcaa
      721 ggaatatgaa aaacaagtga gaaatggaag gcttttttgt acacgggaga gtgatccagt
      781 ccgtggccct gacggcagga tgcatggcaa caaatgtgcc ctgtgtgctg aaattttcaa
      841 gcggcgtttt tcagaggaaa acagtaaaac agatcaaaat ttgggaaaag ctgaagaaaa
      901 aactaaagtt aaaagagaaa ttgtgaaact ctgcagtcaa tatcaaaatc aggcaaagaa
      961 tggaatactt ttctgtacca gagaaaatga ccctattcgt ggtccagatg ggaaaatgca
     1021 tggcaacttg tgttccatgt gtcaagtcta cttccaagca gaaaatgaag aaaagaaaaa
     1081 ggctgaagca cgagctagaa acaaaagaga atctggaaaa gcaacctcat atgcagagct
     1141 ttgcaatgaa tatcgaaagc ttgtgaggaa cggaaaactt gcttgcacca gagagaacga
     1201 tcctatccag ggcccagatg ggaaagtgca cggcaacacc tgctccatgt gtgaggtctt
     1261 cttccaagca gaagaagaag aaaagaaaaa gaaggaaggc gaatcaagaa acaaaagaca
     1321 atctaagagt acagcttcct ttgaggagtt gtgtagtgaa taccgcaaat ccaggaaaaa
     1381 cggacggctt ttttgcacca gagagaatga ccccatccag ggcccagatg ggaaaatgca
     1441 tggcaacacc tgctccatgt gtgaggcctt ctttcaacaa gaagaaagag caagagcaaa
     1501 ggctaaaaga gaagctgcaa aggaaatctg cagtgaattt cgggaccaag tgaggaatgg
     1561 aacacttata tgcaccaggg agcataatcc tgtccgtgga ccagatggca aaatgcatgg
     1621 aaacaagtgt gccatgtgtg ccagtgtgtt caaacttgaa gaagaagaga agaaaaatga
     1681 taaagaagaa aaagggaaag ttgaggctga aaaagttaag agagaagcag ttcaggagct
     1741 gtgcagtgaa tatcgtcatt atgtgaggaa tggacgactc ccctgtacca gagagaatga
     1801 tcctattgag ggtctagatg ggaaaatcca cggcaacacc tgctccatgt gtgaagcctt
     1861 cttccagcaa gaagcaaaag aaaaagaaag agctgaaccc agagcaaaag tcaaaagaga
     1921 agctgaaaag gagacatgcg atgaatttcg gagacttttg caaaatggaa aacttttctg
     1981 cacaagagaa aatgatcctg tgcgtggccc agatggcaag acccatggca acaagtgtgc
     2041 catgtgtaag gcagtcttcc agaaagaaaa tgaggaaaga aagaggaaag aagaggaaga
     2101 tcagagaaat gctgcaggac atggttccag tggtggtgga ggaggaaaca ctcaggacga
     2161 atgtgctgag tatcaggaac aaatgaaaaa tggaagactc agctgtactc gggagagtga
     2221 tcctgtacgt gatgctgatg gcaaatcgta caacaatcag tgtaccatgt gtaaagcaaa
     2281 attggaaaga gaagcagaga gaaaaaatga gtattctcgc tccagatcaa atgggactgg
     2341 atcagaatca gggaaggata catgtgatga gtttagaagc caaatgaaaa atggaaaact
     2401 tatctgcact cgagaaagtg accctgtccg gggtccagat ggcaagacac atggtaataa
     2461 gtgtactatg tgtaaggaaa aactggaaag ggaagcagct gaaaaaaaaa agaaagagga
     2521 tgaagacagg agcaatacag gagaaaggag caatacagga gaaaggagca atgacaaaga
     2581 ggatctgtgt cgtgaatttc gaagcatgca gagaaatgga aagcttatct gcaccagaga
     2641 aaataaccct gttcgaggcc catatggcaa gatgcacatc aataaatgtg ctatgtgtca
     2701 gagcatcttt gatcgagaag ctaatgaaag aaaaaagaaa gatgaagaga aatcaagtag
     2761 caagccctca aataatgcaa aggatgagtg cagtgaattt cgaaactata taaggaacaa
     2821 tgaactcatc tgccctagag agaatgaccc agtgcacggt gctgatggaa agttctatac
     2881 aaacaagtgc tacatgtgca gagctgtctt tctaacagaa gctttggaaa gggcaaagct
     2941 tcaagaaaag ccatcccatg ttagagcttc tcaagaggaa gacagcccag actctttcag
     3001 ttctctggat tctgagatgt gcaaagacta ccgagtattg cccaggatag gctatctttg
     3061 tccaaaggat ttaaagcctg tctgtggtga cgatggccaa acctacaaca atccttgcat
     3121 gctctgtcat gaaaacctga tacgccaaac aaatacacac atccgcagta cagggaagtg
     3181 tgaggagagc agcaccccag gaaccaccgc agccagcatg cccccgtctg acgaatgaca
     3241 ggaagattgt tgaaagccat gagggaaaaa ataaacccca gttctgaatc acctaccttc
     3301 accatctgta tatacaaaga attcttcgga gcttgtctta tttgctatag aaaacaatac
     3361 agagcttttg ggaatggaat cactgatttt cagtcttttc catttctttc ctcctagaat
     3421 ctgtgatctg agggtataaa gacatttcca ccaagtttga gccctcaaaa tgtcctgatt
     3481 acaatgctgt ctgtccaact gcctgttcaa taaaagtaaa ctcagcag
//