LOCUS       AJ132932                2986 bp    mRNA    linear   HUM 07-OCT-2008
DEFINITION  Homo sapiens mRNA for tyrosinase related protein-2, partial, exons
            7, 8, 8b (alternative) and 3'UTR.
ACCESSION   AJ132932
VERSION     AJ132932.1
KEYWORDS    TRP-2 gene; tyrosinase-related protein-2.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2986)
  AUTHORS   Sensi M.
  JOURNAL   Submitted (21-JAN-1999) to the INSDC. Sensi M., Human Tumors
            Immunobiology, Department of Experimental Oncology, Istituto
            Nazionale per lo Studio e la Cura dei Tumori, Via Venezian 1, 20133
            Milano, ITALY.
REFERENCE   2
  AUTHORS   Pisarra P., Lupetti R., Palumbo A., Napolitano A., Prota G.,
            Parmiani G., Anichini A., Sensi M.
  TITLE     Human melanocytes and melanomas express novel mRNA isoforms of the
            tyrosinase-related protein-2/DOPAchrome tautomerase gene: molecular
            and functional characterization
  JOURNAL   J. Invest. Dermatol. 115(1), 48-56(2000).
   PUBMED   10886507
FEATURES             Location/Qualifiers
     source          1..2986
                     /db_xref="H-InvDB:HIT000244757"
                     /organism="Homo sapiens"
                     /map="13q31-q32"
                     /mol_type="mRNA"
                     /sex="male"
                     /haplotype="A*0201 A*6801 B44 B51 C2 C5"
                     /clone="TRP-2-LT"
                     /cell_line="Me18732"
                     /cell_type="metastatic melanoma"
                     /tissue_type="lymphnode melanoma metastases"
                     /db_xref="taxon:9606"
     CDS             <1..381
                     /codon_start=1
                     /gene="TRP-2"
                     /product="tyrosinase-related protein-2"
                     /function="dopachrome-tautomerase"
                     /db_xref="GOA:Q9NQD8"
                     /db_xref="H-InvDB:HIT000244757.15"
                     /db_xref="InterPro:IPR008922"
                     /db_xref="UniProtKB/TrEMBL:Q9NQD8"
                     /protein_id="CAB93530.1"
                     /translation="VLHSFTDAIFDEWMKRFNPPADAWPQELAPIGHNRMYNMVPFFP
                     PVTNEELFLTSDQLGYSYAIDLPVSVEETPGWPTTLLVVMGTLVALVGLFVLLAFLQY
                     RRLRKGYTPLMETHLSSKRYTEEA"
     exon            1..202
                     /gene="TRP-2"
                     /number=7
     mat_peptide     <1..378
                     /gene="TRP-2"
                     /product="tyrosinase-related-protein-2"
     exon            203..381
                     /gene="TRP-2"
                     /number=8
     3'UTR           382..2986
                     /gene="TRP-2"
     polyA_site      604
                     /gene="TRP-2"
     exon            1631..1680
                     /gene="TRP-2"
                     /number=8
                     /note="8b, alternative"
     polyA_site      2951
                     /gene="TRP-2"
BASE COUNT          946 a          550 c          544 g          946 t
ORIGIN      
        1 gttcttcatt cctttactga tgccatcttt gatgagtgga tgaaaagatt taatcctcct
       61 gcagatgcct ggcctcagga gctggcccct attggtcaca atcggatgta caacatggtt
      121 cctttcttcc ctccagtgac taatgaagaa ctctttttaa cctcagacca acttggctac
      181 agctatgcca tcgatctgcc agtttcagtt gaagaaactc caggttggcc cacaactctc
      241 ttagtagtca tgggaacact ggtggctttg gttggtcttt ttgtgctgtt ggcttttctt
      301 caatatagaa gacttcgaaa aggatataca cccctaatgg agacacattt aagcagcaag
      361 agatacacag aagaagccta gggtgctcat gccttaccta agagaagagg ctggccaagc
      421 cacagttctg acgctgacaa taaaggaact aatcctcact gttccttctt gagttgaaga
      481 tctttgacat aggttcttct atagtgatga tgatctcatt cagaagatgc ttagctgtag
      541 tttccgcttt gcttgcttgt ttaacaaacc caactaaagt gcttgaggct acctctacct
      601 tcaaataaag atagacctga caatttgtga tatctaataa taaccccccc cccaatattg
      661 attaagcctc ctccttttct gaaagcattt aaaaaaaaca aaaaaaatcc caaaacattg
      721 atccagggga gtcatttaaa tttgcaggtc agtgcaatgt gagacctggc caagaccata
      781 catcaatctt tcttagcccc agtgtcttta ttggtaatgc catggaggtg ggagttggta
      841 ggtgctagat gagtctccaa gatccctttt agctataaac atctctgctt ctaggcaccc
      901 tcctgattat cttccttggg cttctttttc ttcttttctc tatatttttc ctctccagct
      961 tagaagatga gaataagcct tgttttcttt acaggatgga aaatgactaa atgaaggatc
     1021 aattccactc tattgtgtaa actagatttt acggatttta cttaaaatct gcagttttaa
     1081 acagtagacc tatattacag gattcaatag ctggatacac attgattcta tagtgataaa
     1141 tagagaagat aataaaatta tagagtttcc tggttagttg atatgctact gtaaacctat
     1201 taacaaatac agaattactc tttccaagga aggctgactg aaggctggtg aggctgtaaa
     1261 cctgaacatg agacaatttg acttgagtcc cattactctg aggtctcttt ggctgatcct
     1321 ctaccaattt ctttactagg tagcctcaga tgaaaaatta ttcccacata atgcactggg
     1381 cttattttta agcattgatg ttagattgat taatgttgcc gaatactcac agttacttat
     1441 gaatgctgat caattaagtc ttatcatttg aaagcaaacc atctgtacaa aacatgacaa
     1501 ttcagaatta agtggttata ttctgctatg caatcatcag atcatgagga ataagaatga
     1561 gacaatcttt actacgatgt tcagacttat catgatggac cccacttcag agaagttaat
     1621 ggctcttgag atttccaggc aaatttcatc tgctcatatc tggtttctgt gcatcaggag
     1681 tgagactgaa gttctagggc gtggcttgtc tgtcgaggcc cctctctact ggaatgaatg
     1741 aatgtaaaga atgggtgtta agaggtccct ggagctgcct tcaacataag ggtcctagag
     1801 ggtgcaagac tcatcaagaa ccagtttacc ccatgcaaaa ggactgctaa agccagagaa
     1861 atggacaaag cccagttgga actgaatttg aatctcataa agctacaggt gcatctgaga
     1921 gcaggctcag tggtgaagat caagatagcc cggtaaagcc ctgcttgggc tttttagcct
     1981 cagccacatg gatacctctc agttcctgcc attaacaata ttcatggaaa atacagcact
     2041 gtgtctttca catgctccac tctggaaggt ttatgctctg agctcaggat agttggggaa
     2101 cacattttta aatcttggtt ttaaacaaaa agagaaattt attaaaatgg agatataatt
     2161 gtgcatggta catatatttc tgaaaagtta tgtataaatc aattatgtta aaagcgccag
     2221 aagttacttt ttataagtga actattacga ataatttcat aaagcaaata accacctcta
     2281 gcttatctgt caggtatatc agaattctca tatatcatag tctcataaga cttggttaaa
     2341 gcagatctat cttaggtagg aaaaaatagt aatcgattat acttagctgc ttttatctgt
     2401 agtgtgggtg actttttata actattatgt tttataatgt cttcctgaga gaatttccta
     2461 attttgtagt tcatataaga gaaatacaat tttctagcat tttctgacct tacaataaat
     2521 caattatgaa tgcattttaa caaatattaa ggtaggataa accaacagaa taaaaagttg
     2581 gtatttactt acattgaata tcatgcaaat aaactcagaa aatgtcacca aatactgtgg
     2641 gctatatttc tcaatgatag ggggaagaat tcaaccttgg agaaaatgac cagatcactt
     2701 tactgcttat atcttcagta ttagaaaaac tgcatgtatg attttaatag aaatgctttt
     2761 tataaagcta acattcagaa atgggataaa atgcaataac atctttcctt tgtgcattaa
     2821 attcccttct aattctaaaa ttgacatttg tatcttgctt aggatttaac attgttaatt
     2881 ataatacttt taatgactag ttttaatctc attattaaga agtagaaaac ttactaaaaa
     2941 ggaaactaaa aataaatgtt gttttgcaga ttaaaaaaaa aaaaaa
//