LOCUS AJ132429 5065 bp mRNA linear HUM 07-OCT-2008
DEFINITION Homo sapiens mRNA for hyperpolarization-activated cyclic nucleotide
gated cation channel hHCN4.
ACCESSION AJ132429
VERSION AJ132429.1
KEYWORDS HCN4 gene; hyperpolarization-activated cyclic nucleotide gated
cation channel.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 5065)
AUTHORS Ludwig A.
JOURNAL Submitted (21-JAN-1999) to the INSDC. Ludwig A., Institut fuer
Pharmakologie und Toxikologie, Technische Universitaet Muenchen,
Medizinische Fakultaet, Biedersteinerstr. 29, D-80802 Muenchen,
GERMANY.
REFERENCE 3
AUTHORS Ludwig A., Zong X., Stieber J., Hullin R., Hofmann F., Biel M.
TITLE Two pacemaker channels from human heart with profoundly different
activation kinetics
JOURNAL EMBO J. 18(9), 2323-2329(1999).
PUBMED 10228147
FEATURES Location/Qualifiers
source 1..5065
/db_xref="H-InvDB:HIT000244699"
/organism="Homo sapiens"
/mol_type="mRNA"
/tissue_type="heart (atrioventricular node region)"
/db_xref="taxon:9606"
CDS 567..4178
/gene="HCN4"
/product="hyperpolarization-activated cyclic nucleotide
gated cation channel hHCN4"
/function="pacemaker channel of human heart"
/db_xref="GOA:Q9Y3Q4"
/db_xref="H-InvDB:HIT000244699.15"
/db_xref="HGNC:HGNC:16882"
/db_xref="InterPro:IPR000595"
/db_xref="InterPro:IPR003938"
/db_xref="InterPro:IPR005821"
/db_xref="InterPro:IPR013621"
/db_xref="InterPro:IPR014710"
/db_xref="InterPro:IPR018488"
/db_xref="InterPro:IPR018490"
/db_xref="InterPro:IPR027359"
/db_xref="InterPro:IPR030173"
/db_xref="PDB:2MNG"
/db_xref="PDB:3OTF"
/db_xref="PDB:3U11"
/db_xref="PDB:4HBN"
/db_xref="PDB:4KL1"
/db_xref="PDB:4NVP"
/db_xref="PDB:6GYN"
/db_xref="PDB:6GYO"
/db_xref="UniProtKB/Swiss-Prot:Q9Y3Q4"
/experiment="experimental evidence, no additional details
recorded"
/protein_id="CAB42604.1"
/translation="MDKLPPSMRKRLYSLPQQVGAKAWIMDEEEDAEEEGAGGRQDPS
RRSIRLRPLPSPSPSAAAGGTESRSSALGAADSEGPARGAGKSSTNGDCRRFRGSLAS
LGSRGGGSGGTGSGSSHGHLHDSAEERRLIAEGDASPGEDRTPPGLAAEPERPGASAQ
PAASPPPPQQPPQPASASCEQPSVDTAIKVEGGAAAGDQILPEAEVRLGQAGFMQRQF
GAMLQPGVNKFSLRMFGSQKAVEREQERVKSAGFWIIHPYSDFRFYWDLTMLLLMVGN
LIIIPVGITFFKDENTTPWIVFNVVSDTFFLIDLVLNFRTGIVVEDNTEIILDPQRIK
MKYLKSWFMVDFISSIPVDYIFLIVETRIDSEVYKTARALRIVRFTKILSLLRLLRLS
RLIRYIHQWEEIFHMTYDLASAVVRIVNLIGMMLLLCHWDGCLQFLVPMLQDFPDDCW
VSINNMVNNSWGKQYSYALFKAMSHMLCIGYGRQAPVGMSDVWLTMLSMIVGATCYAM
FIGHATALIQSLDSSRRQYQEKYKQVEQYMSFHKLPPDTRQRIHDYYEHRYQGKMFDE
ESILGELSEPLREEIINFNCRKLVASMPLFANADPNFVTSMLTKLRFEVFQPGDYIIR
EGTIGKKMYFIQHGVVSVLTKGNKETKLADGSYFGEICLLTRGRRTASVRADTYCRLY
SLSVDNFNEVLEEYPMMRRAFETVALDRLDRIGKKNSILLHKVQHDLNSGVFNYQENE
IIQQIVQHDREMAHCAHRVQAAASATPTPTPVIWTPLIQAPLQAAAATTSVAIALTHH
PRLPAAIFRPPPGSGLGNLGAGQTPRHLKRLQSLIPSALGSASPASSPSQVDTPSSSS
FHIQQLAGFSAPAGLSPLLPSSSSSPPPGACGSPSAPTPSAGVAATTIAGFGHFHKAL
GGSLSSSDSPLLTPLQPGARSPQAAQPSPAPPGARGGLGLPEHFLPPPPSSRSPSSSP
GQLGQPPGELSLGLATGPLSTPETPPRQPEPPSLVAGASGGASPVGFTPRGGLSPPGH
SPGPPRTFPSAPPRASGSHGSLLLPPASSPPPPQVPQRRGTPPLTPGRLTQDLKLISA
SQPALPQDGAQTLRRASPHSSGESMAAFPLFPRAGGGSGGSGSSGGLGPPGRPYGAIP
GQHVTLPRKTSSGSLPPPLSLFGARATSSGGPPLTAGPQREPGARPEPVRSKLPSNL"
BASE COUNT 919 a 1783 c 1497 g 866 t
ORIGIN
1 ggtcgctggg ctccgctcgg ttgcggcggg agccccggga cgggccggac gggccggggc
61 agaggaggcg aggcgagctc gcgggtggcc agccacaaag cccgggcggc gagacagacg
121 gacagccagc cctcccgcgg gacgcacgcc cgggacccgc gcgggccgtg cgctctgcac
181 tccggagcgg ttccctgagc gccgcggccg cagagcctct ccggccggcg cccattgttc
241 cccgcggggg cggggcgcct ggagccgggc ggcgcgccgc gcccctgaac gccagaggga
301 gggagggagg caagaaggga gcgcggggtc cccgcgccca gccgggcccg ggaggaggtg
361 tagcgcggcg agcccgggga ctcggagcgg gactaggatc ctccccgcgg cgcgcagcct
421 gcccaagcat gggcgcctga ggctgccccc acgccggcgg caaaggacgc gtccccacgg
481 gcggactgac cggcgggcgg acctggagcc cgtccgcggc gccgcgctcc tgcccccggc
541 ccggtccgac cccggcccct ggcgccatgg acaagctgcc gccgtccatg cgcaagcggc
601 tctacagcct cccgcagcag gtgggggcca aggcgtggat catggacgag gaagaggacg
661 ccgaggagga gggggccggg ggccgccaag accccagccg caggagcatc cggctgcggc
721 cactgccctc gccctccccc tcggcggccg cgggtggcac ggagtcccgg agctcggccc
781 tcggggcagc ggacagcgaa gggccggccc gcggcgcggg caagtccagc acgaacggcg
841 actgcaggcg cttccgcggg agcctggcct cgctgggcag ccggggcggc ggcagcggcg
901 gcacggggag cggcagcagt cacggacacc tgcatgactc cgcggaggag cggcggctca
961 tcgccgaggg cgacgcgtcc cccggcgagg acaggacgcc cccaggcctg gcggccgagc
1021 ccgagcgccc cggcgcctcg gcgcagcccg cagcctcgcc gccgccgccc cagcagccac
1081 cgcagccggc ctccgcctcc tgcgagcagc cctcggtgga caccgctatc aaagtggagg
1141 gaggcgcggc tgccggcgac cagatcctcc cggaggccga ggtgcgcctg ggccaggccg
1201 gcttcatgca gcgccagttc ggggccatgc tccaacccgg ggtcaacaaa ttctccctaa
1261 ggatgttcgg cagccagaaa gccgtggagc gcgaacagga gagggtcaag tcggccggat
1321 tttggattat ccacccctac agtgacttca gattttactg ggacctgacc atgctgctgc
1381 tgatggtggg aaacctgatt atcattcctg tgggcatcac cttcttcaag gatgagaaca
1441 ccacaccctg gattgtcttc aatgtggtgt cagacacatt cttcctcatc gacttggtcc
1501 tcaacttccg cacagggatc gtggtggagg acaacacaga gatcatcctg gacccgcagc
1561 ggattaaaat gaagtacctg aaaagctggt tcatggtaga tttcatttcc tccatccccg
1621 tggactacat cttcctcatt gtggagacac gcatcgactc ggaggtctac aagactgccc
1681 gggccctgcg cattgtccgc ttcacgaaga tcctcagcct cttacgcctg ttacgcctct
1741 cccgcctcat tcgatatatt caccagtggg aagagatctt ccacatgacc tacgacctgg
1801 ccagcgccgt ggtgcgcatc gtgaacctca tcggcatgat gctcctgctc tgccactggg
1861 acggctgcct gcagttcctg gtacccatgc tacaggactt ccctgacgac tgctgggtgt
1921 ccatcaacaa catggtgaac aactcctggg ggaagcagta ctcctacgcg ctcttcaagg
1981 ccatgagcca catgctgtgc atcggctacg ggcggcaggc gcccgtgggc atgtccgacg
2041 tctggctcac catgctcagc atgatcgtgg gtgccacctg ctacgccatg ttcattggcc
2101 acgccactgc cctcatccag tccctggact cctcccggcg ccagtaccag gaaaagtaca
2161 agcaggtgga gcagtacatg tcctttcaca agctcccgcc cgacacccgg cagcgcatcc
2221 acgactacta cgagcaccgc taccagggca agatgttcga cgaggagagc atcctgggcg
2281 agctaagcga gcccctgcgg gaggagatca tcaactttaa ctgtcggaag ctggtggcct
2341 ccatgccact gtttgccaat gcggacccca acttcgtgac gtccatgctg accaagctgc
2401 gtttcgaggt cttccagcct ggggactaca tcatccggga aggcaccatt ggcaagaaga
2461 tgtacttcat ccagcatggc gtggtcagcg tgctcaccaa gggcaacaag gagaccaagc
2521 tggccgacgg ctcctacttt ggagagatct gcctgctgac ccggggccgg cgcacagcca
2581 gcgtgagggc cgacacctac tgccgcctct actcgctgag cgtggacaac ttcaatgagg
2641 tgctggagga gtaccccatg atgcgaaggg ccttcgagac cgtggcgctg gaccgcctgg
2701 accgcattgg caagaagaac tccatcctcc tccacaaagt ccagcacgac ctcaactccg
2761 gcgtcttcaa ctaccaggag aatgagatca tccagcagat tgtgcagcat gaccgggaga
2821 tggcccactg cgcgcaccgc gtccaggctg ctgcctctgc caccccaacc cccacgcccg
2881 tcatctggac cccgctgatc caggcaccac tgcaggctgc cgctgccacc acttctgtgg
2941 ccatagccct cacccaccac cctcgcctgc ctgctgccat cttccgccct cccccaggat
3001 ctgggctggg caacctcggt gccgggcaga cgccaaggca cctgaaacgg ctgcagtccc
3061 tgatcccttc tgcgctgggc tccgcctcgc ccgccagcag cccgtcccag gtggacacac
3121 cgtcttcatc ctccttccac atccaacagc tggctggatt ctctgccccc gctggactga
3181 gcccactcct gccctcatcc agctcctccc caccccccgg ggcctgtggc tccccctcgg
3241 ctcccacacc atcagctggc gtagccgcca ccaccatagc cgggtttggc cacttccaca
3301 aggcgctggg tggctccctg tcctcctccg actctcccct gctcaccccg ctgcagccag
3361 gcgcccgctc cccgcaggct gcccagccat ctcccgcgcc acccggggcc cggggaggcc
3421 tgggactccc ggagcacttc ctgccacccc caccctcatc cagatccccg tcatctagcc
3481 ccgggcagct gggccagcct cccggggagt tgtccctagg tctggccact ggcccactga
3541 gcacgccaga gacaccccca cggcagcctg agccgccgtc ccttgtggca ggggcctctg
3601 ggggggcttc ccctgtaggc tttactcccc gaggaggtct cagcccccct ggccacagcc
3661 caggcccccc aagaaccttc ccgagtgccc cgccccgggc ctctggctcc cacggatcct
3721 tgctcctgcc acctgcatcc agccccccac caccccaggt cccccagcgc cggggcacac
3781 ccccgctcac ccccggccgc ctcacccagg acctcaagct catctccgcg tctcagccag
3841 ccctgcctca ggacggggcg cagactctcc gcagagcctc cccgcactcc tcaggggagt
3901 ccatggctgc cttcccgctc ttccccaggg ctgggggtgg cagcgggggc agtgggagca
3961 gcgggggcct cggtccccct gggaggccct atggtgccat ccccggccag cacgtcactc
4021 tgcctcggaa gacatcctca ggttctttgc caccccctct gtctttgttt ggggcaagag
4081 ccacctcttc tggggggccc cctctgactg ctggacccca gagggaacct ggggccaggc
4141 ctgagccagt gcgctccaaa ctgccatcca atctatgagc tgggcccttc cttccctctt
4201 ctttcttctt ttctctccct tccttcttcc ttcaggttta actgtgatta ggagatatac
4261 caataacagt aataattatt taaaaaacca cacacaccag aaaaacaaaa gacagcagaa
4321 aataaccagg tattcttaga gctatagatt tttggtcact tgcttttata gactatttta
4381 atactcagca ctagagggag ggagggggag ggaggaggga gcaggcaggt cccaaatgca
4441 aaagccagag aaaggcagat ggggtctccg gggctgggca ggggtgggag tggccagtgt
4501 tggcggttct tagagcagat gtgtcattgt gttcatttag agaaacagct gccatcagcc
4561 cgttagctgt aacttggagc tccactctgc ccccagaaag gggctgccct ggggtgtgcc
4621 ctggggagcc tcagaagcct gcgaccttgg gagaaaaggg ccagggccct gagggcctag
4681 cattttttct actgtaaacg tagcaagatc tgtatatgaa tatgtatatg tatatgtatg
4741 taagatgtgt atatgtatag ctatgtagcg ctctgtagag ccatgtagat agccactcac
4801 atgtgcgcac acgtgtgcgg tctagtttaa tcccatgttg acaggatgcc caggtcacct
4861 tacacccagc aacccgcctt ggcccgcagg ctgtgcactg catggtctag ggacgttctc
4921 tctccagtcc tcagggaaga ggacgccagg acttcgcagc aggccccctc tctccccatc
4981 tctggtctca aagccagtcc cagcctgacc tctcaccaca cggaagtgga agactcccct
5041 ttcctagggc ctcaagcaca caccg
//