LOCUS AJ012376 6880 bp mRNA linear HUM 07-OCT-2008 DEFINITION Homo sapiens mRNA for ATP-binding cassette transporter-1 (ABC-1). ACCESSION AJ012376 VERSION AJ012376.1 KEYWORDS ABC-1 gene; ATP-binding cassette transporter-1. SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 6880) AUTHORS Langmann T. JOURNAL Submitted (11-NOV-1998) to the INSDC. Langmann T., Institute for Clinical Chemistry and Laboratory Medicine, University of Regensburg, Franz-Josef-Strauss-Allee 11, 93053, GERMANY. REFERENCE 2 AUTHORS Langmann T., Klucken J., Reil M., Liebisch G., Luciani M.F., Chimini G., Kaminski W., Schmitz G. TITLE Molecular cloning of the human ATP-binding cassette transporter 1 (hABC1): evidence for sterol-dependent regulation in macrophages JOURNAL Biochem. Biophys. Res. Commun. 257(1), 29-33(1999). PUBMED 10092505 REFERENCE 3 AUTHORS Langmann T., Klucken J., Reil M., Liebisch G., Luciani M.F., Chimini G., Kaminski W., Schmitz G. TITLE Molecular Cloning of the Human ATP-Binding Cassette Transporter 1 (hABC1): Evidence for Dterol-Dependent Regulation in Macrophages JOURNAL Proc. Natl. Acad. Sci. U.S.A. 97, 7987-7992(2000). PUBMED 10884428 FEATURES Location/Qualifiers source 1..6880 /db_xref="H-InvDB:HIT000244566" /organism="Homo sapiens" /chromosome="9" /map="9q22-31" /mol_type="mRNA" /cell_type="monocytes/macrophages" /db_xref="taxon:9606" 5'UTR 1..120 /gene="ABC-1" CDS 121..6726 /gene="ABC-1" /product="ATP-binding cassette transporter-1 (ABC-1)" /db_xref="GOA:O95477" /db_xref="H-InvDB:HIT000244566.13" /db_xref="HGNC:HGNC:29" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR026082" /db_xref="InterPro:IPR027417" /db_xref="PDB:5XJY" /db_xref="UniProtKB/Swiss-Prot:O95477" /protein_id="CAA10005.1" /translation="MPSAGTLPWVQGIICNANNPCFRYPTPGEAPGVVGNFNKSIVAR LFSDARRLLLYSQKDTSMKDMRKVLRTLQQIKKSSSNLKLQDFLVDNETFSGFLYHNL SLPKSTVDKMLRADVILHKVFLQGYQLHLTSLCNGSKSEEMIQLGDQEVSELCGLPRE KLAAAERVLRSNMDILKPILRTLNSTSPFPSKELAEATKTLLHSLGTLAQELFSMRSW SDMRQEVMFLTNVNSSSSSTQIYQAVSRIVCGHPEGGGLKIKSLNWYEDNNYKALFGG NGTEEDAETFYDNSTTPYCNDLMKNLESSPLSRIIWKALKPLLVGKILYTPDTPATRQ VMAEVNKTFQELAVFHDLEGMWEELSPKIWTFMENSQEMDLVRMLLDSRDNDHFWEQQ LDGLDWTAQDIVAFLAKHPEDVQSSNGSVYTWREAFNETNQAIRTISRFMECVNLNKL EPIATEVWLINKSMELLDERKFWAGIVFTGITPGSIELPHHVKYKIRMDIDNVERTNK IKDGYWDPGPRADPFEDMRYVWGGFAYLQDVVEQAIIRVLTGTEKKTGVYMQQMPYPC YVDDIFLRVMSRSMPLFMTLAWIYSVAVIIKGIVYEKEARLKETMRIMGLDNSILWFS WFISSLIPLLVSAGLLVVILKLGNLLPYSDPSVVFVFLSVFAVVTILQCFLISTLFSR ANLAAACGGIIYFTLYLPYVLCVAWQDYVGFTLKIFASLLSPVAFGFGCEYFALFEEQ GIGVQWDNLFESPVEEDGFNLTTSVSMMLFDTFLYGVMTWYIEAVFPGQYGIPRPWYF PCTKSYWFGEESDEKSHPGSNQKRISEICMEEEPTHLKLGVSIQNLVKVYRDGMKVAV DGLALNFYEGQITSFLGHNGAGKTTTMSILTGLFPPTSGTAYILGKDIRSEMSTIRQN LGVCPQHNVLFDMLTVEEHIWFYARLKGLSEKHVKAEMEQMALDVGLPSSKLKSKTSQ LSGGMQRKLSVALAFVGGSKVVILDEPTAGVDPYSRRGIWELLLKYRQGRTIILSTHH MDEADVLGDRIAIISHGKLCCVGSSLFLKNQLGTGYYLTLVKKDVESSLSSCRNSSST VSYLKKEDSVSQSSSDAGLGSDHESDTLTIDVSAISNLIRKHVSEARLVEDIGHELTY VLPYEAAKEGAFVELFHEIDDRLSDLGISSYGISETTLEEIFLKVAEESGVDAETSDG TLPARRNRRAFGDKQSCLRPFTEDDAADPNDSDIDPESRETDLLSGMDGKGSYQVKGW KLTQQQFVALLWKRLLIARRSRKGFFAQIVLPAVFVCIALVFSLIVPPFGKYPSLELQ PWMYNEQYTFVSNDAPEDTGTLELLNALTKDPGFGTRCMEGNPIPDTPCQAGEEEWTT APVPQTIMDLFQNGNWTMQNPSPACQCSSDKIKKMLPVCPPGAGGLPPPQRKQNTADI LQDLTGRNISDYLVKTYVQIIAKSLKNKIWVNEFRYGGFSLGVSNTQALPPSQEVNDA TKQMKKHLKLAKDSSADRFLNSLGRFMTGLDTRNNVKVWFNNKGWHAISSFLNVINNA ILRANLQKGENPSHYGITAFNHPLNLTKQQLSEVAPMTTSVDVLVSICVIFAMSFVPA SFVVFLIQERVSKAKHLQFISGVKPVIYWLSNFVWDMCNYVVPATLVIIIFICFQQKS YVSSTNLPVLALLLLLYGWSITPLMYPASFVFKIPSTAYVVLTSVNLFIGINGSVATF VLELFTDNKLNNINDILKSVFLIFPHFCLGRGLIDMVKNQAMADALERFGENRFVSPL SWDLVGRNLFAMAVEGVVFFLITVLIQYRFFIRPRPVNAKLSPLNDEDEDVRRERQRI LDGGGQNDILEIKELTKIYRRKRKPAVDRICVGIPPGECFGLLGVNGAGKSSTFKMLT GDTTVTRGDAFLNRNSILSNIHEVHQNMGYCPQFDAITELLTGREHVEFFALLRGVPE KEVGKVGEWAIRKLGLVKYGEKYAGNYSGGNKRKLSTAMALIGGPPVVFLDEPTTGMD PKARRFLWNCALSVVKEGRSVVLTSHSMEECEALCTRMAIMVNGRFRCLGSVQHLKNR FGDGYTIVVRIAGSNPDLKPVQDFFGLAFPGSVPKEKHRNMLQYQLPSSLSSLARIFS ILSQSKKRLHIEDYSVSQTTLDQVFVNFAKDQSDDDHLKDLSLHKNQTVVDVAVLTSF LQDEKVKESYV" 3'UTR 6727..6880 /gene="ABC-1" BASE COUNT 1760 a 1656 c 1783 g 1681 t ORIGIN 1 caaacatgtc agctgttact ggaagtggcc tggcctctat ttatcttcct gatcctgatc 61 tctgttcggc tgagctaccc accctatgaa caacatgaat gccattttcc aaataaagcc 121 atgccctctg caggaacact tccttgggtt caggggatta tctgtaatgc caacaacccc 181 tgtttccgtt acccgactcc tggggaggct cccggagttg ttggaaactt taacaaatcc 241 attgtggctc gcctgttctc agatgctcgg aggcttcttt tatacagcca gaaagacacc 301 agcatgaagg acatgcgcaa agttctgaga acattacagc agatcaagaa atccagctca 361 aacttgaagc ttcaagattt cctggtggac aatgaaacct tctctgggtt cctgtatcac 421 aacctctctc tcccaaagtc tactgtggac aagatgctga gggctgatgt cattctccac 481 aaggtatttt tgcaaggcta ccagttacat ttgacaagtc tgtgcaatgg atcaaaatca 541 gaagagatga ttcaacttgg tgaccaagaa gtttctgagc tttgtggcct accaagggag 601 aaactggctg cagcagagcg agtacttcgt tccaacatgg acatcctgaa gccaatcctg 661 agaacactaa actctacatc tcccttcccg agcaaggagc tggccgaagc cacaaaaaca 721 ttgctgcata gtcttgggac tctggcccag gagctgttca gcatgagaag ctggagtgac 781 atgcgacagg aggtgatgtt tctgaccaat gtgaacagct ccagctcctc cacccaaatc 841 taccaggctg tgtctcgtat tgtctgcggg catcccgagg gaggggggct gaagatcaag 901 tctctcaact ggtatgagga caacaactac aaagccctct ttggaggcaa tggcactgag 961 gaagatgctg aaaccttcta tgacaactct acaactcctt actgcaatga tttgatgaag 1021 aatttggagt ctagtcctct ttcccgcatt atctggaaag ctctgaagcc gctgctcgtt 1081 gggaagatcc tgtatacacc tgacactcca gccacaaggc aggtcatggc tgaggtgaac 1141 aagaccttcc aggaactggc tgtgttccat gatctggaag gcatgtggga ggaactcagc 1201 cccaagatct ggaccttcat ggagaacagc caagaaatgg accttgtccg gatgctgttg 1261 gacagcaggg acaatgacca cttttgggaa cagcagttgg atggcttaga ttggacagcc 1321 caagacatcg tggcgttttt ggccaagcac ccagaggatg tccagtccag taatggttct 1381 gtgtacacct ggagagaagc tttcaacgag actaaccagg caatccggac catatctcgc 1441 ttcatggagt gtgtcaacct gaacaagcta gaacccatag caacagaagt ctggctcatc 1501 aacaagtcca tggagctgct ggatgagagg aagttctggg ctggtattgt gttcactgga 1561 attactccag gcagcattga gctgccccat catgtcaagt acaagatccg aatggacatt 1621 gacaatgtgg agaggacaaa taaaatcaag gatgggtact gggaccctgg tcctcgagct 1681 gacccctttg aggacatgcg gtacgtctgg gggggcttcg cctacttgca ggatgtggtg 1741 gagcaggcaa tcatcagggt gctgacgggc accgagaaga aaactggtgt ctatatgcaa 1801 cagatgccct atccctgtta cgttgatgac atctttctgc gggtgatgag ccggtcaatg 1861 cccctcttca tgacgctggc ctggatttac tcagtggctg tgatcatcaa gggcatcgtg 1921 tatgagaagg aggcacggct gaaagagacc atgcggatca tgggcctgga caacagcatc 1981 ctctggttta gctggttcat tagtagcctc attcctcttc ttgtgagcgc tggcctgcta 2041 gtggtcatcc tgaagttagg aaacctgctg ccctacagtg atcccagcgt ggtgtttgtc 2101 ttcctgtccg tgtttgctgt ggtgacaatc ctgcagtgct tcctgattag cacactcttc 2161 tccagagcca acctggcagc agcctgtggg ggcatcatct acttcacgct gtacctgccc 2221 tacgtcctgt gtgtggcatg gcaggactac gtgggcttca cactcaagat cttcgctagc 2281 ctgctgtctc ctgtggcttt tgggtttggc tgtgagtact ttgccctttt tgaggagcag 2341 ggcattggag tgcagtggga caacctgttt gagagtcctg tggaggaaga tggcttcaat 2401 ctcaccactt cggtctccat gatgctgttt gacaccttcc tctatggggt gatgacctgg 2461 tacattgagg ctgtctttcc aggccagtac ggaattccca ggccctggta ttttccttgc 2521 accaagtcct actggtttgg cgaggaaagt gatgagaaga gccaccctgg ttccaaccag 2581 aagagaatat cagaaatctg catggaggag gaacccaccc acttgaagct gggcgtgtcc 2641 attcagaacc tggtaaaagt ctaccgagat gggatgaagg tggctgtcga tggcctggca 2701 ctgaattttt atgagggcca gatcacctcc ttcctgggcc acaatggagc ggggaagacg 2761 accaccatgt caatcctgac cgggttgttc cccccgacct cgggcaccgc ctacatcctg 2821 ggaaaagaca ttcgctctga gatgagcacc atccggcaga acctgggggt ctgtccccag 2881 cataacgtgc tgtttgacat gctgactgtc gaagaacaca tctggttcta tgcccgcttg 2941 aaagggctct ctgagaagca cgtgaaggcg gagatggagc agatggccct ggatgttggt 3001 ttgccatcaa gcaagctgaa aagcaaaaca agccagctgt caggtggaat gcagagaaag 3061 ctatctgtgg ccttggcctt tgtcggggga tctaaggttg tcattctgga tgaacccaca 3121 gctggtgtgg acccttactc ccgcagggga atatgggagc tgctgctgaa ataccgacaa 3181 ggccgcacca ttattctctc tacacaccac atggatgaag cggacgtcct gggggacagg 3241 attgccatca tctcccatgg gaagctgtgc tgtgtgggct cctccctgtt tctgaagaac 3301 cagctgggaa caggctacta cctgaccttg gtcaagaaag atgtggaatc ctccctcagt 3361 tcctgcagaa acagtagtag cactgtgtca tacctgaaaa aggaggacag tgtttctcag 3421 agcagttctg atgctggcct gggcagcgac catgagagtg acacgctgac catcgatgtc 3481 tctgctatct ccaacctcat caggaagcat gtgtctgaag cccggctggt ggaagacata 3541 gggcatgagc tgacctatgt gctgccatat gaagctgcta aggagggagc ctttgtggaa 3601 ctctttcatg agattgatga ccggctctca gacctgggca tttctagtta tggcatctca 3661 gagacgaccc tggaagaaat attcctcaag gtggccgaag agagtggggt ggatgctgag 3721 acctcagatg gtaccttgcc agcaagacga aacaggcggg ccttcgggga caagcagagc 3781 tgtcttcgcc cgttcactga agatgatgct gctgatccaa atgattctga catagaccca 3841 gaatccagag agacagactt gctcagtggg atggatggca aagggtccta ccaggtgaaa 3901 ggctggaaac ttacacagca acagtttgtg gcccttttgt ggaagagact gctaattgcc 3961 agacggagtc ggaaaggatt ttttgctcag attgtcttgc cagctgtgtt tgtctgcatt 4021 gcccttgtgt tcagcctgat cgtgccaccc tttggcaagt accccagcct ggaacttcag 4081 ccctggatgt acaacgaaca gtacacattt gtcagcaatg atgctcctga ggacacggga 4141 accctggaac tcttaaacgc cctcaccaaa gaccctggct tcgggacccg ctgtatggaa 4201 ggaaacccaa tcccagacac gccctgccag gcaggggagg aagagtggac cactgcccca 4261 gttccccaga ccatcatgga cctcttccag aatgggaact ggacaatgca gaacccttca 4321 cctgcatgcc agtgtagcag cgacaaaatc aagaagatgc tgcctgtgtg tcccccaggg 4381 gcaggggggc tgcctcctcc acaaagaaaa caaaacactg cagatatcct tcaggacctg 4441 acaggaagaa acatttcgga ttatctggtg aagacgtatg tgcagatcat agccaaaagc 4501 ttaaagaaca agatctgggt gaatgagttt aggtatggcg gcttttccct gggtgtcagt 4561 aatactcaag cacttcctcc gagtcaagaa gttaatgatg ccaccaaaca aatgaagaaa 4621 cacctaaagc tggccaagga cagttctgca gatcgatttc tcaacagctt gggaagattt 4681 atgacaggac tggacaccag aaataatgtc aaggtgtggt tcaataacaa gggctggcat 4741 gcaatcagct ctttcctgaa tgtcatcaac aatgccattc tccgggccaa cctgcaaaag 4801 ggagagaacc ctagccatta tggaattact gctttcaatc atcccctgaa tctcaccaag 4861 cagcagctct cagaggtggc tccgatgacc acatcagtgg atgtccttgt gtccatctgt 4921 gtcatctttg caatgtcctt cgtcccagcc agctttgtcg tattcctgat ccaggagcgg 4981 gtcagcaaag caaaacacct gcagttcatc agtggagtga agcctgtcat ctactggctc 5041 tctaattttg tctgggatat gtgcaattac gttgtccctg ccacactggt cattatcatc 5101 ttcatctgct tccagcagaa gtcctatgtg tcctccacca atctgcctgt gctagccctt 5161 ctacttttgc tgtatgggtg gtcaatcaca cctctcatgt acccagcctc ctttgtgttc 5221 aagatcccca gcacagccta tgtggtgctc accagcgtga acctcttcat tggcattaat 5281 ggcagcgtgg ccacctttgt gctggagctg ttcaccgaca ataagctgaa taatatcaat 5341 gatatcctga agtccgtgtt cttgatcttc ccacattttt gcctgggacg agggctcatc 5401 gacatggtga aaaaccaggc aatggctgat gccctggaaa ggtttgggga gaatcgcttt 5461 gtgtcaccat tatcttggga cttggtggga cgaaacctct tcgccatggc cgtggaaggg 5521 gtggtgttct tcctcattac tgttctgatc cagtacagat tcttcatcag gcccagacct 5581 gtaaatgcaa agctatctcc tctgaatgat gaagatgaag atgtgaggcg ggaaagacag 5641 agaattcttg atggtggagg ccagaatgac atcttagaaa tcaaggagtt gacgaagata 5701 tatagaagga agcggaagcc tgctgttgac aggatttgcg tgggcattcc tcctggtgag 5761 tgctttgggc tcctgggagt taatggggct ggaaaatcat caactttcaa gatgttaaca 5821 ggagatacca ctgttaccag aggagatgct ttccttaaca gaaatagtat cttatcaaac 5881 atccatgaag tacatcagaa catgggctac tgccctcagt ttgatgccat cacagagctg 5941 ttgactggga gagaacacgt ggagttcttt gcccttttga gaggagtccc agagaaagaa 6001 gttggcaagg ttggtgagtg ggcgattcgg aaactgggcc tcgtgaagta tggagaaaaa 6061 tatgctggta actatagtgg aggcaacaaa cgcaagctct ctacagccat ggctttgatc 6121 ggcgggcctc ctgtggtgtt tctggatgaa cccaccacag gcatggatcc caaagcccgg 6181 cggttcttgt ggaattgtgc cctaagtgtt gtcaaggagg ggagatcagt agtgcttaca 6241 tctcatagta tggaagaatg tgaagctctt tgcactagga tggcaatcat ggtcaatgga 6301 aggttcaggt gccttggcag tgtccagcat ctaaaaaata ggtttggaga tggttataca 6361 atagttgtac gaatagcagg gtccaacccg gacctgaagc ctgtccagga tttctttgga 6421 cttgcatttc ctggaagtgt tccaaaagag aaacaccgga acatgctaca ataccagctt 6481 ccatcttcat tatcttctct ggccaggata ttcagcatcc tctcccagag caaaaagcga 6541 ctccacatag aagactactc tgtttctcag acaacacttg accaagtatt tgtgaacttt 6601 gccaaggacc aaagtgatga tgaccactta aaagacctct cattacacaa aaaccagaca 6661 gtagtggacg ttgcagttct cacatctttt ctacaggatg agaaagtgaa agaaagctat 6721 gtatgaagaa tcctgttcat acggggtggc tgaaagtaaa gagggactag actttccttt 6781 gcaccatgtg aagtgttgtg gagaaaagag ccagaagttg atgtgggaag aagtaaactg 6841 gatactgtac tgatactatt caatgcaatg caattcaatg //