LOCUS AJ010046 2493 bp mRNA linear HUM 07-OCT-2008
DEFINITION Homo sapiens mRNA for Rho guanine nucleotide-exchange factor,
splice variant NET1A.
ACCESSION AJ010046
VERSION AJ010046.1
KEYWORDS guanine nucleotide-exchange factor; net1a gene; rho.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2493)
AUTHORS Wempe F.
JOURNAL Submitted (03-AUG-1998) to the INSDC. Wempe F., Laboratory for
Molecular Hematology, Dept. of Hematology, University of Frankfurt
Medical School, Theodor-Stern-Kai 7, 60596 Frankfurt a. M., 60596
Frankfurt a. M., GERMANY.
REFERENCE 2
AUTHORS Chan A.M., Takai S., Yamada K., Miki T.
TITLE Isolation of a novel oncogene, NET1, from neuroepithelioma cells by
expression cDNA cloning
JOURNAL Oncogene 12(6), 1259-1266(1996).
PUBMED 8649828
REFERENCE 3
AUTHORS Wempe F., Nigro S., Melchner H.
TITLE NET1A: A new transforming splice-varriant of the Rho guanine
nucleotide-exchange factor NET1
JOURNAL Unpublished.
COMMENT Related sequence: U02081
FEATURES Location/Qualifiers
source 1..2493
/db_xref="H-InvDB:HIT000244376"
/organism="Homo sapiens"
/mol_type="mRNA"
/cell_line="K562"
/db_xref="taxon:9606"
exon 1..239
/number=1
/note="net1a-specific alternative exon"
CDS 149..1795
/gene="net1a"
/standard_name="neuro epithelioma transforming gene"
/product="guanine nucleotide-exchange factor"
/note="residues 1 to 30 differ from NET1 (U02081)"
/db_xref="GOA:Q7Z628"
/db_xref="H-InvDB:HIT000244376.13"
/db_xref="HGNC:HGNC:14592"
/db_xref="InterPro:IPR000219"
/db_xref="InterPro:IPR001331"
/db_xref="InterPro:IPR001849"
/db_xref="InterPro:IPR011993"
/db_xref="InterPro:IPR035899"
/db_xref="InterPro:IPR037853"
/db_xref="PDB:3EO2"
/db_xref="PDB:4XH9"
/db_xref="UniProtKB/Swiss-Prot:Q7Z628"
/protein_id="CAA08974.1"
/translation="MVAHDETGGLLPIKRTIRVLDVNNQSFREQEEPSNKRVRPLARV
TSLANLISPVRNGAVRRFGQTIQSFTLRGDHRSPASAQKFSSRSTVPTPAKRRSSALW
SEMLDITMKESLTTREIRRQEAIYEMSRGEQDLIEDLKLARKAYHDPMLKLSIMSEEE
LTHIFGDLDSYIPLHEDLLTRIGEATKPDGTVEQIGHILVSWLPRLNAYRGYCSNQLA
AKALLDQKKQDPRVQDFLQRCLESPFSRKLDLWSFLDIPRSRLVKYPLLLKEILKHTP
KEHPDVQLLEDAILIIQGVLSDINLKKGESECQYYIDKLEYLDEKQRDPRIEASKVLL
CHGELRSKSGHKLYIFLFQDILVLTRPVTRNERHSYQVYRQPIPVQELVLEDLQDGDV
RMGGSFRGAFSNSEKAKNIFRIRFHDPSPAQSHTLQANDVFHKQQWFNCIRAAIAPFQ
SAGSPPELQGLPELHEECEGNHPSARKLTAQRRASTVSSVTQVEVDENAYRCGSGMQM
AEDSKSLKTHQTQPGIRRARDKALLVANGKRLWCREGSVC"
BASE COUNT 700 a 535 c 571 g 687 t
ORIGIN
1 tgctccaccg cggcgagagg catgggcacg tggctgccga gggtggccga gctctgggaa
61 gaaaagcccg tgtgcctctg catagcgtcg ctacagcgct gactcggtgt ggattgattg
121 gaaaggtttg agggagtact tgggaagcat ggtggcacat gatgagactg gaggtctcct
181 acctattaaa aggaccatac gagtcctaga tgtcaataac cagtccttca gagaacaaga
241 ggagccaagc aataaaagag ttcgacctct ggctcgtgtc acgtccttgg caaatttaat
301 ctctcctgta agaaatggag ctgtcagacg ttttggtcaa acaatacagt catttaccct
361 tcgtggtgac cacagatccc cagcctctgc ccagaagttt tctagcaggt caacagtccc
421 aacacccgcc aagagaagga gcagtgcact gtggtcagag atgctggaca tcaccatgaa
481 ggagtctctc accaccaggg agatcagacg gcaggaggca atatatgaaa tgtcccgagg
541 tgaacaggat ttaattgagg atctcaaact tgcaagaaag gcctaccatg accccatgtt
601 aaagttgtcc atcatgtcag aagaggaact cacacatata tttggtgatc tggactctta
661 catacctctg catgaagatt tgttgacaag aataggagaa gcaaccaagc ctgatggaac
721 agtggagcag attggtcaca ttctcgtgag ctggttaccg cgcttgaatg cctacagagg
781 ttactgtagt aaccagctgg cagccaaagc tcttcttgat caaaagaaac aggatccaag
841 agtccaagac ttcctccagc gatgtctcga gtctcccttc agtcgaaaac tagatctttg
901 gagtttccta gatatccctc gaagtcgcct agtcaaatac cctttactgt taaaagaaat
961 tcttaaacac actccaaaag agcaccctga tgttcagctt ctggaggatg ctatattgat
1021 aatacaggga gtcctctctg atatcaactt gaagaaaggt gaatccgagt gccagtatta
1081 catcgacaag ctggagtacc tggatgaaaa gcagagggac cccagaatcg aagcgagcaa
1141 agtgctgctg tgccatgggg agctgcggag caagagtgga cataaacttt acattttcct
1201 gtttcaagac atcttggttc tgactcggcc cgtcacacgg aacgaacggc actcttacca
1261 ggtttaccgg cagccaatcc cagtccaaga gctagtccta gaagacctgc aggatggaga
1321 tgtgagaatg ggaggctcct ttcgaggagc tttcagtaac tcagagaaag ctaaaaatat
1381 ctttagaatt cgcttccatg acccctctcc agcccagtct cacactctgc aagccaatga
1441 cgtgttccac aagcagcagt ggttcaactg tattcgagcg gccattgccc ccttccagtc
1501 ggcaggcagt ccacctgagc tgcagggcct gccggagctg cacgaagagt gtgaggggaa
1561 ccacccctct gcgaggaaac tcacagccca gaggagggca tccacagttt ccagtgttac
1621 tcaggtagaa gttgatgaaa acgcttacag atgtggctct ggcatgcaga tggcagagga
1681 cagcaagagc ttaaagacac accagacaca gcccggcatc cgaagagcga gggacaaagc
1741 ccttctggtg gcaaacggaa agagactttg gtgtagagaa ggctctgtgt gttaactgat
1801 gggagagact gtttgtttat aaatgtgtac agttttgttt tctcgtaagg ggagcatcat
1861 agggttactt tataccagtt gtaacatttt cattgttttt ggttgttctt ttttcttttt
1921 ttaatggcag ctaaagatat acagattact gttaaattgc agtccttttt tttttaaaga
1981 tattttcttg agttatttag aacatggtaa gcctggtatt ttttaatcaa acaaaatatt
2041 tatgaaatgg gttttctctt aattctggat tcatcatggc tttctaatac caattgtaat
2101 atttacaata ttcaccaaaa cttagaattt tgcaaatgca ggaattctgc cagtgtttct
2161 ttgctaagcc ttgcatgcaa aatttgaaat tttaacattg gcacccaaaa cctacatgga
2221 atgtatgtct ggagtatttc aaactttaca ttgaaacata atttccttgg aaaacaaacc
2281 ataagcctga ggaggttttt atcaactgga atgctttata ttagtttgtt tttcactgta
2341 cattcctcat tttacattca tttaacctgc cgattattta atttttttat tgtaaagtag
2401 tttttagcat ttgcttttat ttttttactt tgatgcctta acaaattggc acgtctttaa
2461 agtatttttc ttcctgatta aaaatgtgtg tgt
//