LOCUS AJ009936 4448 bp mRNA linear HUM 07-OCT-2008
DEFINITION Homo sapiens mRNA for nuclear hormone receptor PRR1.
ACCESSION AJ009936
VERSION AJ009936.1
KEYWORDS nuclear hormone receptor; orphan nuclear receptor; PRR1 gene.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 4448)
AUTHORS Heard D.J.
JOURNAL Submitted (31-JUL-1998) to the INSDC. Heard D.J., Novo Nordisk A/S,
Molecular Genetics, Novo Alle, DK-2880, Bagsvaerd, DENMARK.
REFERENCE 2
AUTHORS Heard D.J., Holloway J., Hansen C., Tommerup N., Aagaard L.,
Vissing H.
TITLE Identification of a novel protein isoform of the human nuclear
hormone receptor PXR/SXR and localization to chromosome 3q12.1 -
13.3
JOURNAL Eur. J. Hum. Genet. 0, 0(0).
FEATURES Location/Qualifiers
source 1..4448
/db_xref="H-InvDB:HIT000244363"
/organism="Homo sapiens"
/chromosome="3"
/map="q12-q13.3"
/mol_type="mRNA"
/tissue_type="liver"
/tissue_type="intestine"
/tissue_type="colon"
/db_xref="taxon:9606"
CDS 1771..3144
/transl_except=(pos:1771..1773,aa:Met)
/gene="PRR1"
/product="nuclear hormone receptor PRR1-C"
/note="isoform with longer A/B domain, translation
initiates at GUG-1771 5 fold less efficiently than at
CUG-1840"
/db_xref="GOA:O75469"
/db_xref="HGNC:HGNC:7968"
/db_xref="InterPro:IPR000536"
/db_xref="InterPro:IPR001628"
/db_xref="InterPro:IPR001723"
/db_xref="InterPro:IPR013088"
/db_xref="InterPro:IPR035500"
/db_xref="PDB:1ILG"
/db_xref="PDB:1ILH"
/db_xref="PDB:1M13"
/db_xref="PDB:1NRL"
/db_xref="PDB:1SKX"
/db_xref="PDB:2O9I"
/db_xref="PDB:2QNV"
/db_xref="PDB:3CTB"
/db_xref="PDB:3HVL"
/db_xref="PDB:3R8D"
/db_xref="PDB:4J5W"
/db_xref="PDB:4J5X"
/db_xref="PDB:4NY9"
/db_xref="PDB:4S0S"
/db_xref="PDB:4S0T"
/db_xref="PDB:4X1F"
/db_xref="PDB:4X1G"
/db_xref="PDB:4XAO"
/db_xref="PDB:4XHD"
/db_xref="PDB:5A86"
/db_xref="PDB:5X0R"
/db_xref="PDB:6BNS"
/db_xref="PDB:6DUP"
/db_xref="UniProtKB/Swiss-Prot:O75469"
/protein_id="CAB55490.1"
/translation="MDPRGEVGAKNLPPNSPRGPEANLEVRPKESWNHTDFVHCEDTE
SVPGKPSVNADEEVGGPQICRVCGDKATGYHFNVMTCEGCKGFFRRAMKRNARLRCPF
RKGACEITRKTRRQCQACRLRKCLESGMKNEMIMSDEAVEERRALIKRKKSERTGTQP
LGVQGLTEEQRMMIRELMDAQMKTFDTTFSHFKNFRLPGVLSSGCELPESLQAPSREE
AAKWSQVRKDLCSLKVSLQLRGEDGSVWNYKPPADSGGKEIFSLLPHMADMSTYMFKG
IISFAKVISYFRDLPIEDQISLLKGAAFELCQLRFNTVFNAETGTWECGRLSYCLEDT
AGGFQQLLLEPMLKFHYMLKKLQLHEEEYVLMQAISLFSPDRPGVLQHRVVDQLQEQF
AITLKSYIECNRPQPAHRFLFLKIMAMLTELRSINAQHTQRLLRIQDIHPFATPLMQE
LFGITGS"
CDS 1840..3144
/gene="PRR1"
/product="nuclear hormone receptor PRR1-A"
/function="transcription factor"
/note="full length receptor"
/db_xref="GOA:O75469"
/db_xref="H-InvDB:HIT000244363.15"
/db_xref="HGNC:HGNC:7968"
/db_xref="InterPro:IPR000536"
/db_xref="InterPro:IPR001628"
/db_xref="InterPro:IPR001723"
/db_xref="InterPro:IPR013088"
/db_xref="InterPro:IPR035500"
/db_xref="PDB:1ILG"
/db_xref="PDB:1ILH"
/db_xref="PDB:1M13"
/db_xref="PDB:1NRL"
/db_xref="PDB:1SKX"
/db_xref="PDB:2O9I"
/db_xref="PDB:2QNV"
/db_xref="PDB:3CTB"
/db_xref="PDB:3HVL"
/db_xref="PDB:3R8D"
/db_xref="PDB:4J5W"
/db_xref="PDB:4J5X"
/db_xref="PDB:4NY9"
/db_xref="PDB:4S0S"
/db_xref="PDB:4S0T"
/db_xref="PDB:4X1F"
/db_xref="PDB:4X1G"
/db_xref="PDB:4XAO"
/db_xref="PDB:4XHD"
/db_xref="PDB:5A86"
/db_xref="PDB:5X0R"
/db_xref="PDB:6BNS"
/db_xref="PDB:6DUP"
/db_xref="UniProtKB/Swiss-Prot:O75469"
/protein_id="CAB55489.1"
/translation="MEVRPKESWNHTDFVHCEDTESVPGKPSVNADEEVGGPQICRVC
GDKATGYHFNVMTCEGCKGFFRRAMKRNARLRCPFRKGACEITRKTRRQCQACRLRKC
LESGMKNEMIMSDEAVEERRALIKRKKSERTGTQPLGVQGLTEEQRMMIRELMDAQMK
TFDTTFSHFKNFRLPGVLSSGCELPESLQAPSREEAAKWSQVRKDLCSLKVSLQLRGE
DGSVWNYKPPADSGGKEIFSLLPHMADMSTYMFKGIISFAKVISYFRDLPIEDQISLL
KGAAFELCQLRFNTVFNAETGTWECGRLSYCLEDTAGGFQQLLLEPMLKFHYMLKKLQ
LHEEEYVLMQAISLFSPDRPGVLQHRVVDQLQEQFAITLKSYIECNRPQPAHRFLFLK
IMAMLTELRSINAQHTQRLLRIQDIHPFATPLMQELFGITGS"
CDS 2005..3144
/gene="PRR1"
/product="nuclear hormone receptor PRR1-B"
/note="truncated receptor"
/db_xref="GOA:O75469"
/db_xref="HGNC:HGNC:7968"
/db_xref="InterPro:IPR000536"
/db_xref="InterPro:IPR001628"
/db_xref="InterPro:IPR001723"
/db_xref="InterPro:IPR013088"
/db_xref="InterPro:IPR035500"
/db_xref="PDB:1ILG"
/db_xref="PDB:1ILH"
/db_xref="PDB:1M13"
/db_xref="PDB:1NRL"
/db_xref="PDB:1SKX"
/db_xref="PDB:2O9I"
/db_xref="PDB:2QNV"
/db_xref="PDB:3CTB"
/db_xref="PDB:3HVL"
/db_xref="PDB:3R8D"
/db_xref="PDB:4J5W"
/db_xref="PDB:4J5X"
/db_xref="PDB:4NY9"
/db_xref="PDB:4S0S"
/db_xref="PDB:4S0T"
/db_xref="PDB:4X1F"
/db_xref="PDB:4X1G"
/db_xref="PDB:4XAO"
/db_xref="PDB:4XHD"
/db_xref="PDB:5A86"
/db_xref="PDB:5X0R"
/db_xref="PDB:6BNS"
/db_xref="PDB:6DUP"
/db_xref="UniProtKB/Swiss-Prot:O75469"
/protein_id="CAB55491.1"
/translation="MTCEGCKGFFRRAMKRNARLRCPFRKGACEITRKTRRQCQACRL
RKCLESGMKNEMIMSDEAVEERRALIKRKKSERTGTQPLGVQGLTEEQRMMIRELMDA
QMKTFDTTFSHFKNFRLPGVLSSGCELPESLQAPSREEAAKWSQVRKDLCSLKVSLQL
RGEDGSVWNYKPPADSGGKEIFSLLPHMADMSTYMFKGIISFAKVISYFRDLPIEDQI
SLLKGAAFELCQLRFNTVFNAETGTWECGRLSYCLEDTAGGFQQLLLEPMLKFHYMLK
KLQLHEEEYVLMQAISLFSPDRPGVLQHRVVDQLQEQFAITLKSYIECNRPQPAHRFL
FLKIMAMLTELRSINAQHTQRLLRIQDIHPFATPLMQELFGITGS"
BASE COUNT 1157 a 1132 c 1095 g 1064 t
ORIGIN
1 ttcttaaccc tttccagctt tcccaccctc tttggcttta gccatggcct tctgatctgt
61 gtttctcagg ggacctgcag gccccagata tagccccatg ctgtcctcct accccagagc
121 acactgttca ggctacttcc actggtactg aaatccagta tttcactcac tcttttcctt
181 tccaatatcc tcatgacatt caatatttca cttactctag gtcctccctg cctaaggccc
241 aagtcaactt tctgtccagt gggatttgta atccaatgcc tcctagccct agcagaatcc
301 catgtggata atcagaaatg tgactggaaa aaggacagag ctctatggct gtgggtccca
361 gtccccactg ctggcagtaa gtccccagca gtgagctgtg taagcacctt acattctgtg
421 cttggttgaa aacagcaagg caagcatcca cttgagaaat gtcaacccct aggaaatccc
481 agcctcaagt ctttctcatc ccttgggaag tgcaaattgg atagagaaga aaccaattaa
541 aaacaaaaca aacaaatcat acttagatat tctggctttt ctcaccaggg ctggattaaa
601 gcatgtactt caaaataata acaacttaag tcaataaata aatgtaagga agtccaaatg
661 ttcacctgaa gacaactgtg gtcatttttt ggcaatccca ggttctcttt tctacctgtt
721 tgctcaatcg tggtctccct ctccctctct tgttggggcc catgcccctg ctttactgtt
781 gccagaggct tgtacttgtt tgccttttag gtaggagcag ttacttccac tcccctcacc
841 tgccataaag catctttata aacaaagcaa gtagaagaaa cacatcctgg tatccaccac
901 attcggcttt tgttgattct gttcacttgg gagcacctgc tgctagggaa taagaaggtt
961 gaggctgaag agtgaggact cttcagctcc cctctggcag gacccgggag aggaaagagc
1021 cctcagctgg tccatcctcc ccactcctgg tcagccttct gttctgagat caaagtggtg
1081 gggtcacatt ctcgagaact gtgctcagcc ccctcatctc acaccctttc cctctccctg
1141 tgtgcctgcc cccctcttac ataaccatgc tggtgattgg caccgtcata aatcaatact
1201 ttgctcactt tcacatcaag taacactatc cagggaggtg gtttcaacaa aggaggaagt
1261 ataaggagat ctaggttcaa attaatgttg cccctagtgg taaaggacag agaccctcag
1321 actgatgaaa tgcactcaga attacttaga caaagcggat atttgccact ctcttcccct
1381 tttcctgtgt ttttgtagtg aagagacctg aaagaaaaaa gtagggagaa cataatgaga
1441 acaaatacgg taatctcttc atttgctagt tcaagtgctg gacttgggac ttaggagggg
1501 caatggagcc gcttagtgcc tacatctgac ttggactgaa atataggtga gagacaagat
1561 tgtctcatat ccggggaaat cataacctat gactaggacg ggaagaggaa gcactgcctt
1621 tacttcagtg ggaatctcgg cctcagcctg caagccaagt gttcacagtg agaaaagcaa
1681 gagaataagc taatactcct gtcctgaaca aggcagcggc tccttggtaa agctactcct
1741 tgatcgatcc tttgcaccgg attgttcaaa gtggacccca ggggagaagt cggagcaaag
1801 aacttaccac caaacagtcc aagaggccca gaagcaaacc tggaggtgag acccaaagaa
1861 agctggaacc atactgactt tgtacactgt gaggacacag agtctgttcc tggaaagccc
1921 agtgtcaacg cagatgagga agtcggaggt ccccaaatct gccgtgtatg tggggacaag
1981 gccactggct atcacttcaa tgtcatgaca tgtgaaggat gcaagggctt tttcaggagg
2041 gccatgaaac gcaacgcccg gctgaggtgc cccttccgga agggcgcctg cgagatcacc
2101 cggaagaccc ggcgacagtg ccaggcctgc cgcctgcgca agtgcctgga gagcggcatg
2161 aagaatgaga tgatcatgtc cgacgaggcc gtggaggaga ggcgggcctt gatcaagcgg
2221 aagaaaagtg aacggacagg gactcagcca ctgggagtgc aggggctgac agaggagcag
2281 cggatgatga tcagggagct gatggacgct cagatgaaaa cctttgacac taccttctcc
2341 catttcaaga atttccggct gccaggggtg cttagcagtg gctgcgagtt gccagagtct
2401 ctgcaggccc catcgaggga agaagctgcc aagtggagcc aggtccggaa agatctgtgc
2461 tctttgaagg tctctctgca gctgcggggg gaggatggca gtgtctggaa ctacaaaccc
2521 ccagccgaca gtggcgggaa agagatcttc tccctgctgc cccacatggc tgacatgtca
2581 acctacatgt tcaaaggcat catcagcttt gccaaagtca tctcctactt cagggacttg
2641 cctatcgagg accagatctc cctgctgaag ggggccgctt tcgagctgtg tcaactgaga
2701 ttcaacacag tgttcaacgc ggagactgga acctgggagt gtggccggct gtcctactgc
2761 ttggaagaca ctgcaggtgg cttccagcaa cttctactgg agcccatgct gaaattccac
2821 tacatgctga agaagctgca gctgcatgag gaggagtatg tgctgatgca ggccatctcc
2881 ctcttctccc cagaccgccc aggtgtgctg cagcaccgcg tggtggacca gctgcaggag
2941 caattcgcca ttactctgaa gtcctacatt gaatgcaatc ggccccagcc tgctcatagg
3001 ttcttgttcc tgaagatcat ggctatgctc accgagctcc gcagcatcaa tgctcagcac
3061 acccagcggc tgctgcgcat ccaggacata cacccctttg ctacgcccct catgcaggag
3121 ttgttcggca tcacaggtag ctgagcggct gcccttgggg tgacacctcc gagaggcagc
3181 cagacccaga gccctctgag ccgccactcc cgggccaaga cagatggaca ctgccaagag
3241 ccgacaatgc cctgctggcc tgtctcccta gggaattcct gctatgacag ctggctagca
3301 ttcctcagga aggacatggg tgccccccac ccccagttca gtctgtaggg agtgaagcca
3361 cagactctta cgtggagagt gcactgacct gtaggtcagg accatcagag aggcaaggtt
3421 gccctttcct tttaaaaggc cctgtggtct ggggagaaat ccctcagatc ccactaaagt
3481 gtcaaggtgt ggaagggacc aagcgaccaa ggataggcca tctggggtct atgcccacat
3541 acccacgttt gttcgcttcc tgagtctttt cattgctacc tctaatagtc ctgtctccca
3601 cttcccactc gttcccctcc tcttccgagc tgctttgtgg gctccaggcc tgtactcatc
3661 ggcaggtgca tgagtatctg tgggagtcct ctagagagat gagaagccag gaggcctgca
3721 ccaaatgtca gaagcttggc atgacctcat tccggccaca tcattctgtg tctctgcatc
3781 catttgaaca cattattaag caccgataat aggtagcctg ctgtggggta tacagcattg
3841 actcagatat agatcctgag ctcacagagt ttatagttaa aaaaaacaaa cagaaacaca
3901 aacaatttgg atcaaaagga gaaatgataa gtgacaaaag cagcacaagg aatttccctg
3961 tgtggatgct gagctgtgat ggcgggcact gggtacccaa gtgaaggttc ccgaggacat
4021 gagtctgtag gagcaagggc acaaactgca gctgtgagtg cgtgtgtgtg atttggtgta
4081 ggtaggtctg tttgccactt gatggggcct gggtttgttc ctggggctgg aatgctgggt
4141 atgctctgtg acaaggctac gctgacaatc agttaaacac accggagaag aaccatttac
4201 atgcacctta tatttctgtg tacacatcta ttctcaaagc taaagggtat gaaagtgcct
4261 gccttgttta tagccacttg tgagtaaaaa tttttttgca ttttcacaaa ttatacttta
4321 tataaggcat tccacaccta agaactagtt ttgggaaatg tagccctggg tttaatgtca
4381 aatcaaggca aaaggaatta aataatgtac ttttggctaa aaaaaaaaaa aaaaaaaaaa
4441 aaaaaaaa
//