LOCUS AJ005282 3482 bp mRNA linear HUM 07-OCT-2008
DEFINITION Homo sapiens mRNA for NPR-Bi.
ACCESSION AJ005282
VERSION AJ005282.1
KEYWORDS natriuretic peptide receptor.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 3482)
AUTHORS Kruhoffer M.
JOURNAL Submitted (14-APR-1998) to the INSDC. Kruhoffer M., Department of
Molecular and Structural Biologi, Aarhus University, C.F. Moellers
Alle Bldg. 130, Aarhus C, 8000, DENMARK.
REFERENCE 2
AUTHORS Hirsch J.R., Meyer M., Magert H.J., Forssmann W.G., Mollerup S.,
Herter P., Weber G., Cermak R., Ankorina-Stark I., Schlatter E.,
Kruhoffer M.
TITLE cGMP-dependent and -independent inhibition of a K+ conductance by
natriuretic peptides: molecular and functional studies in human
proximal tubule cells
JOURNAL J. Am. Soc. Nephrol. 10(3), 472-480(1999).
PUBMED 10073597
COMMENT Related sequence: L13436
FEATURES Location/Qualifiers
source 1..3482
/db_xref="H-InvDB:HIT000244033"
/organism="Homo sapiens"
/mol_type="mRNA"
/cell_line="IHKE-1"
/tissue_type="kidney"
/db_xref="taxon:9606"
CDS 1..2988
/product="NPR-Bi"
/note="B-type natriuretic peptide receptor (NPR-B/GC-B)
splice variant. Identical to NPR-B/GC-B (Acc. No L13436)
except an insertion of 71 nucleotides at position 3537 in
NPR-B (nucleotides 2887-2958 in NPR-Bi) containing perfect
5' (GTRAG) and 3' (AG) splicing sites. The C-terminus of
the encoded protein differs."
/db_xref="GOA:P20594"
/db_xref="H-InvDB:HIT000244033.12"
/db_xref="HGNC:HGNC:7944"
/db_xref="InterPro:IPR000719"
/db_xref="InterPro:IPR001054"
/db_xref="InterPro:IPR001170"
/db_xref="InterPro:IPR001245"
/db_xref="InterPro:IPR001828"
/db_xref="InterPro:IPR011009"
/db_xref="InterPro:IPR018297"
/db_xref="InterPro:IPR028082"
/db_xref="InterPro:IPR029787"
/db_xref="UniProtKB/Swiss-Prot:P20594"
/protein_id="CAA06466.1"
/translation="MALPSLLLLVAALAGGVRPPGARNLTLAVVLPEHNLSYAWAWPR
VGPAVALAVEALGRALPVDLRFVSSELEGACSEYLAPLSAVDLKLYHDPDLLLGPGCV
YPAASVARFASHWRLPLLTAGAVASGFSAKNDHYRTLVRTGPSAPKLGEFVVTLHGHF
NWTARAALLYLDARTDDRPHYFTIEGVFEALQGSNLSVQHQVYAREPGGPEQATHFIR
ANGRIVYICGPLEMLHEILLQAQRENLTNGDYVFFYLDVFGESLRAGPTRATGRPWQD
NRTREQAQALREAFQTVLVITYREPPNPEYQEFQNRLLIRAREDFGVELGPSLMNLIA
GCFYDGILLYAEVLNETIQEGGTREDGLRIVEKMQGRRYHGVTGLVVMDKNNDRETDF
VLWAMGDLDSGDFQPAAHYSGAEKQIWWTGRPIPWVKGAPPSDNPPCAFDLDDPSCDK
TPLSTLAIVALGTGITFIMFGVSSFLIFRKLMLEKELASMLWRIRWEELQFGNSERYH
KGAGSRLTLSLRGSSYGSLMTAHGKYQIFANTGHFKGNVVAIKHVNKKRIELTRQVLF
ELKHMRDVQFNHLTRFIGACIDPPNICIVTEYCPRGSLQDILENDSINLDWMFRYSLI
NDLVKGMAFLHNSIISSHGSLKSSNCVVDSRFVLKITDYGLASFRSTAEPDDSHALYA
KKLWTAPELLSGNPLPTTGMQKADVYSFGIILQEIALRSGPFYLEGLDLSPKEIVQKV
RNGQRPYFRPSIDRTQLNEELVLLMERCWAQDPAERPDFGQIKGFIRRFNKEGGTSIL
DNLLLRMEQYANNLEKLVEERTQAYLEEKRKAEALLYQILPHSVAEQLKRGETVQAEA
FDSVTIYFSDIVGFTALSAESTPMQVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMV
VSGLPGRNGQRHAPEIARMALALLDAVSSFRIRHRPHDQLRLRIGVHTGKADSHSSPS
LHLSQTLPTCFFSKGQSVLGLLA"
BASE COUNT 782 a 939 c 929 g 832 t
ORIGIN
1 atggcgctgc catcacttct gctgttggtg gcagccctgg caggtggggt gcgtcctccc
61 ggggcgcgga acctgacgct ggcggtggtg ctgccagaac acaacctgag ctatgcctgg
121 gcctggccac gggtgggacc cgctgtggca ctagctgtgg aggctctggg ccgggcactg
181 cccgtggacc tgcggtttgt cagctccgaa ctggaaggcg cctgctctga gtacctggca
241 ccgctgagcg ctgtggacct caagctgtac catgaccccg acctgctgtt aggtcccggt
301 tgcgtgtacc ctgctgcctc tgtggcccgc tttgcctccc actggcgcct tcccctgctg
361 actgcgggtg ctgtggcctc tggtttttcg gctaagaatg accattatcg taccctggtt
421 cgcactggcc cctctgctcc caagctgggt gagtttgtgg tgacactaca cgggcacttc
481 aattggactg cccgtgctgc cttgctgtac ctggatgctc gcacagatga ccggcctcac
541 tacttcacca tcgagggcgt ctttgaggcc ctgcagggca gcaacctcag tgtgcagcac
601 caggtgtatg cccgagagcc agggggcccc gagcaggcca cccacttcat ccgggccaac
661 gggcgcattg tgtatatctg cggccctctg gagatgctgc atgagatcct gcttcaggcc
721 cagagggaga atctgaccaa tggggattat gtcttctttt acctggatgt ctttggggag
781 agtctccgtg caggccccac acgtgctaca ggccggccct ggcaggacaa tcgcacccgg
841 gaacaggccc aggccctcag agaggccttt cagactgtat tggtgatcac gtaccgagaa
901 cccccaaatc ctgagtatca ggaattccag aatcgtctgc tgataagagc ccgggaagac
961 tttggtgtgg agctgggccc ttccctgatg aacctcatcg ctggctgctt ctatgatggg
1021 atcctgctat atgctgaagt cctgaatgag acaatacagg aaggaggcac ccgggaggat
1081 ggacttcgaa ttgtggaaaa gatgcaggga cgaagatatc acggtgtaac tgggctggtt
1141 gtcatggaca agaacaatga ccgagagact gactttgtcc tctgggccat gggagacctg
1201 gattctgggg actttcagcc tgcagcccac tactcgggag ctgagaagca gatttggtgg
1261 acgggacggc ctattccctg ggtgaagggg gctcctccct cggacaatcc cccctgtgcc
1321 tttgacttgg acgacccatc ctgtgataaa actccacttt caaccctggc aattgtggct
1381 ctgggcacag gaatcacctt catcatgttt ggtgtttcca gcttcctaat tttccgaaag
1441 ctgatgctgg agaaggagct ggctagcatg ttgtggcgta ttcgctggga agaactgcag
1501 tttggcaact cagagcgtta tcacaaaggt gcaggcagtc gcctcacact gtcgctgcgg
1561 ggatccagtt acggctcgct catgacagcc catgggaaat accagatctt tgccaacacc
1621 ggtcacttca agggaaatgt tgtcgccatc aaacatgtga ataagaagcg cattgagctg
1681 acccggcagg ttctgtttga actcaaacat atgagagatg ttcagttcaa ccatctcact
1741 cgcttcattg gcgcctgcat agaccctccc aacatttgca ttgtcactga atactgtcct
1801 cgtgggagtt tacaggatat tctagaaaat gacagcatca acttggactg gatgtttcgt
1861 tattcactca ttaatgacct tgttaagggc atggcctttc tccacaacag cattatttca
1921 tcgcatggga gtctcaagtc ctccaactgt gtggtggata gtcgttttgt gctcaaaatc
1981 acagactatg gcctggccag cttccgatca actgctgaac ctgatgacag ccatgccctc
2041 tatgccaaga agctgtggac tgccccagaa ctgctcagtg ggaacccctt gccaaccaca
2101 ggcatgcaga aggctgacgt ctatagcttt gggatcatcc tgcaggagat agcacttcgc
2161 agtggtcctt tctacttgga gggcctggac ctcagcccca aagagattgt ccagaaggta
2221 cgaaatggtc agcggccata tttccggcca agcattgacc ggacccaact gaatgaagag
2281 ctagttttgc tgatggagcg atgttgggct caggacccag ctgagcggcc agactttgga
2341 cagattaagg gcttcattcg gcgctttaac aaggagggtg gcaccagcat attggacaac
2401 ctcctgctgc gcatggaaca gtatgccaat aacttggaga agctggtgga ggaacgcaca
2461 caggcctatc tggaggaaaa acgcaaggct gaagctctgc tctaccaaat cctaccccat
2521 tcagtggcag agcagttaaa acggggagag actgtacagg ctgaggcctt tgacagtgtt
2581 accatctact tcagtgacat tgttggcttc acagcattgt cagcagagag cacccccatg
2641 caggtagtga cacttcttaa tgacctgtat acctgctttg atgccataat tgacaacttt
2701 gatgtctaca aggtggagac gattggggat gcttacatgg tggtatctgg cctcccaggc
2761 cgaaatggtc aacgccatgc accagaaatt gctcgtatgg ccctagcatt actagatgca
2821 gtttcttcct ttcgcatccg ccaccgaccc catgaccagc tgaggctacg cataggggtc
2881 catactggta aggctgactc tcactccagc cctagtctcc acctttccca gactctccca
2941 acctgtttct tctcaaaggg ccagtctgtg ctggggttgt tggcctgaag atgccccgtt
3001 attgtctttt tggagacaca gtgaacactg cttctcgaat ggagtctaat ggtcaagcgc
3061 tgaagatcca tgtctcctct accaccaagg atgccctaga tgagctagga tgcttccagc
3121 tagagcttcg gggggatgtg gaaatgaagg gaaaaggaaa gatgcgaaca tactggctct
3181 taggagagcg gaaaggacct cctggactcc tgtaaacccc cattctttcc aagtcagata
3241 gtcttctgct gctggtacct gggtgggcaa tggccaccat gtctgcacac accagaaatg
3301 gacattttca tatgcaatgg aaaacagcca caaaaagacc taccttatat ggaagttgta
3361 gccctctgca gctcagccct gtacatatac ctgtccctct ctggcttggt ccccttcctc
3421 cctactttct gtaaatatct gtatctaaac cagaatattt tggtcaaata taaaacaata
3481 at
//