LOCUS AJ005197 1340 bp mRNA linear HUM 07-OCT-2008
DEFINITION Homo sapiens mRNA for guanine nucleotide exchange factor GRP1,
complete cds.
ACCESSION AJ005197
VERSION AJ005197.1
KEYWORDS GRP1 protein; guanine nucleotide exchange factor.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 1340)
AUTHORS Cullen P.J.
JOURNAL Submitted (04-JUN-1998) to the INSDC. Cullen P.J., Biochemistry,
The University of Bristol, School of Medical Sciences, University
Walk, Bristol, BS8 1TD, UK.
REFERENCE 2
AUTHORS Venkateswarlu K., Gunn-Moore F., Oatey P.B., Tavare J.M.,
Cullen P.J.
TITLE Nerve growth factor- and epidermal growth factor-simulated
translocation of the ADP-ribosylation factor-exchange factor GRP1
to the plasma membrane of PC12 cells requires activation of
phosphatidylinositol 3-kinase and the GRP1 pleckstrin homology
domain
JOURNAL J. Biochem. 335, 139-146(1998).
COMMENT Related entries: AF001871 & U83897
Submitted as circular mRNA
FEATURES Location/Qualifiers
source 1..1340
/db_xref="H-InvDB:HIT000244026"
/organism="Homo sapiens"
/mol_type="mRNA"
/tissue_lib="circulating blood"
/db_xref="taxon:9606"
CDS 76..1275
/product="GRP1 protein"
/function="guanine nucleotide exchange factor"
/db_xref="GOA:O43739"
/db_xref="H-InvDB:HIT000244026.13"
/db_xref="HGNC:HGNC:9504"
/db_xref="InterPro:IPR000904"
/db_xref="InterPro:IPR001849"
/db_xref="InterPro:IPR011993"
/db_xref="InterPro:IPR023394"
/db_xref="InterPro:IPR035999"
/db_xref="PDB:4KAX"
/db_xref="UniProtKB/Swiss-Prot:O43739"
/protein_id="CAA06434.1"
/translation="MDEDGGGEGGGVPEDLSLEEREELLDIRRRKKELIDDIERLKYE
IAEVMTEIDNLTSVEESKTTQRNKQIAMGRKKFNMDPKKGIQFLIENDLLQSSPEDVA
QFLYKGEGLNKTVIGDYLGERDEFNIKVLQAFVELHEFADLNLVQALRQFLWSFRLPG
EAQKIDRMMEAFASRYCLCNPGVFQSTDTCYVLSFAIIMLNTSLHNHNVRDKPTAERF
IAMNRGINEGGDLPEELLRNLYESIKNEPFKIPEDDGNDLTHTFFNPDREGWLLKLGG
RVKTWKRRWFILTDNCLYYFEYTTDKEPRGIIPLENLSIREVEDPRKPNCFELYNPSH
KGQVIKACKTEADGRVVEGNHVVYRISAPSPEEKEEWMKSIKASISRDPFYDMLATRK
RRIANKK"
BASE COUNT 378 a 343 c 372 g 247 t
ORIGIN
1 ggcacgaggg cgtccccagc ccgcggcccc tctgctgccg gcccccggct cgccggctgc
61 gggagtggcc tcaagatgga tgaagacggc ggcggcgagg gtggtggcgt gcctgaagac
121 ctctcattag aagagagaga agaacttcta gacattcgtc gaagaaaaaa ggaacttatt
181 gatgacattg agaggctgaa atatgaaatt gcagaggtga tgacagagat cgacaatcta
241 acttccgtag aggagagcaa aacgactcag aggaacaaac agatagccat gggaagaaag
301 aaattcaaca tggatcccaa aaagggaatt cagtttctaa tagaaaatga cctgctacag
361 agttccccag aagacgtcgc ccagttcctt tataaaggag aaggcctaaa taagaccgtc
421 attggggact acctgggtga aagggatgaa tttaatatta aagttcttca agcctttgtt
481 gaactccatg agtttgctga tctcaacctt gtacaagcct taaggcagtt cttatggagc
541 ttcaggctgc ccggggaggc gcagaagatt gatcgcatga tggaggcttt cgcttctcgc
601 tactgcctgt gcaaccccgg ggtcttccag tccacagaca cgtgctacgt gctgtcattc
661 gccatcatca tgctcaacac cagcctccac aaccacaacg tgcgtgacaa gcccacggca
721 gaacggttca tcgccatgaa ccgcggcatc aacgagggcg gggacctccc tgaggagctg
781 ctgaggaatt tgtatgagag cattaagaac gagccattta agatcccgga ggacgacggg
841 aacgacctga cccacacctt cttcaacccc gaccgcgagg gctggctcct gaagctggga
901 gggcgtgtga agacctggaa gcgccggtgg ttcatcctga ccgataactg cctctattac
961 tttgaataca caacagataa ggagcccagg ggaatcatcc cgttggaaaa cctcagcatc
1021 agggaggtgg aggacccccg gaaacccaac tgttttgagc tctacaatcc cagccacaaa
1081 gggcaggtca tcaaggcctg taagacggag gccgacggcc gcgtggtaga ggggaaccat
1141 gtggtgtacc ggatctcagc cccgagcccg gaggagaagg aggagtggat gaaatccatc
1201 aaagccagta tcagcagaga tcccttctat gacatgttgg caacgaggaa acgaaggatt
1261 gccaataaaa aatagctttc ctggctaaaa gacccaggta aaagacccaa ccccagcaga
1321 aagacaccgc gggcggcccc
//