LOCUS AJ004832 4391 bp mRNA linear HUM 07-OCT-2008
DEFINITION Homo sapiens mRNA for neuropathy target esterase.
ACCESSION AJ004832
VERSION AJ004832.1
KEYWORDS neuropathy target esterase.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 4391)
AUTHORS Glynn P.
JOURNAL Submitted (19-MAR-1998) to the INSDC. Glynn P., MRC Toxicology
Unit, University of Leicester, Hodgkin Building, Lancaster Road,
Leicester, LE1 9HN, UK.
REFERENCE 2
AUTHORS Lush M.J., Li Y., Read D.J., Willis A.C., Glynn P.
TITLE Neuropathy Target Esterase (NTE) and a homologous Drosophila
neurodegeneration-associated mutant protein contain a novel domain
conserved from bacteria to man.
JOURNAL Biochem. J. 332, 1-4(1998).
PUBMED 9576844
FEATURES Location/Qualifiers
source 1..4391
/db_xref="H-InvDB:HIT000244006"
/organism="Homo sapiens"
/mol_type="mRNA"
/dev_stage="foetal"
/clone="D16"
/tissue_type="brain"
/db_xref="taxon:9606"
CDS 158..4141
/product="neuropathy target esterase"
/note="putative esterase domain is located within residues
900-1150"
/note="active site serine residue is predicted to be at
residue 966"
/db_xref="GOA:Q8IY17"
/db_xref="H-InvDB:HIT000244006.13"
/db_xref="HGNC:HGNC:16268"
/db_xref="InterPro:IPR000595"
/db_xref="InterPro:IPR001423"
/db_xref="InterPro:IPR002641"
/db_xref="InterPro:IPR014710"
/db_xref="InterPro:IPR016035"
/db_xref="InterPro:IPR018490"
/db_xref="UniProtKB/Swiss-Prot:Q8IY17"
/protein_id="CAA06164.1"
/translation="MEAPLQTGMVLGVMIGAGVAVVVTAVLILLVVRRLRVPKTPAPD
GPRYRFRKRDKVLFYGRKIMRKVSQSTSSLVDTSVSATSRPRMRKKLKMLNIAKKILR
IQKETPTLQRKEPPPAVLEADLTEGDLANSHLPSEVLYMLKNVRVLGHFEKPLFLELC
RHMVFQRLGQGDYVFRPGQPDASIYVVQDGLLELCLPGPDGKECVVKEVVPGDSVNSL
LSILDVITGHQHPQRTVSARAARDSTVLRLPVEAFSAVFTKYPESLVRVVQIIMVRLQ
RVTFLALHNYLGLTNELFSHEIQPLRLFPSPGLPTRTSPVRGSKRMVSTSATDEPRET
PGRPPDPTGAPLPGPTGDPVKPTSLETPSAPLLSRCVSMPGDISGLQGGPRSDFDMAY
ERGRISVSLQEEASGGSLAAPARTPTQEPREQPAGACEYSYCEDESATGGCPFGPYQG
RQTSSIFEAAKQELAKLMRIEDPSLLNSRVLLHHAKAGTIIARQGDQDVSLHFVLWGC
LHVYQRMIDKAEDVCLFVAQPGELVGQLAVLTGEPLIFTLRAQRDCTFLRISKSDFYE
IMRAQPSVVLSAAHTVAARMSPFVRQMDFAIDWTAVEAGRALYRQGDRSDCTYIVLNG
RLRSVIQRGSGKKELVGEYGRGDLIGVVEALTRQPRATTVHAVRDTELAKLPEGTLGH
IKRRYPQVVTRLIHLLSQKILGNLQQLQGPFPAGSGLGVPPHSELTNPASNLATVAIL
PVCAEVPMVAFTLELQHALQAIGPTLLLNSDIIRARLGASALDSIQEFRLSGWLAQQE
DAHRIVLYQTDASLTPWTVRCLRQADCILIVGLGDQEPTLGQLEQMLENTAVRALKQL
VLLHREEGAGPTRTVEWLNMRSWCSGHLHLRCPRRLFSRRSPAKLHELYEKVFSRRAD
RHSDFSRLARVLTGNTIALVLGGGGARGCSHIGVLKALEEAGVPVDLVGGTSIGSFIG
ALYAEERSASRTKQRAREWAKSMTSVLEPVLDLTYPVTSMFTGSAFNRSIHRVFQDKQ
IEDLWLPYFNVTTDITASAMRVHKDGSLWRYVRASMTLSGYLPPLCDPKDGHLLMDGG
YINNLPADIARSMGAKTVIAIDVGSQDETDLSTYGDSLSGWWLLWKRLNPWADKVKVP
DMAEIQSRLAYVSCVRQLEVVKSSSYCEYLRPPIDCFKTMDFGKFDQIYDVGYQYGKA
VFGGWSRGNVIEKMLTDRRSTDLNESRRADVLAFPSSGFTDLAEIVSRIEPPTSYVSD
GCADGEESDCLTEYEEDAGPDCSRDEGGSPEGASPSTASEMEEEKSILRQRRCLPQEP
PGSATDA"
regulatory 4323..4328
/regulatory_class="polyA_signal_sequence"
BASE COUNT 857 a 1407 c 1362 g 765 t
ORIGIN
1 ccccacgcca ccccaagcat cccaggactc ttctgaaaca gggcagtgac ccgggaggaa
61 gtcaccaggt gcagaggacc gtgccctgtg gggacctgcc tgcaggctgc tgacagactc
121 cgggctacca gatcggccgt ccagctggaa tcaaccgatg gaggctccgc tgcaaactgg
181 aatggtgctt ggcgtgatga tcggggccgg agtggcggtg gtggtcacgg ccgtgctcat
241 cctcctggtg gtgcggaggc tgcgagtgcc aaaaacccca gccccggatg gcccccggta
301 tcggttccgg aagagggaca aagtgctctt ctatggccgg aagattatgc ggaaggtgtc
361 acaatccacc tcctccctcg tggatacctc tgtctccgcc acctcccggc cacgcatgag
421 gaagaaactg aagatgctca acattgccaa gaagatcctg cgcatccaga aagagacgcc
481 cacgctgcag cggaaggagc ccccgcccgc agtgctagaa gctgacctga ccgagggcga
541 cctggctaac tcccatctgc cctctgaagt gctttatatg ctcaagaacg tccgggtgct
601 gggccacttc gagaagccac tcttcctgga gctctgccgc cacatggtct tccagcggct
661 gggccagggt gactacgtct tccggccggg ccagccagat gccagcatct acgtggtgca
721 ggacgggctg ctggagctct gtctgccagg gcctgacggg aaggagtgtg tggtgaagga
781 agtggttcct ggggacagcg tcaacagcct tctcagcatc ctggatgtca tcaccggtca
841 ccagcatccc cagcggaccg tgtctgcccg ggcggcccgg gactccacgg tgctgcgcct
901 gccggtggaa gcattctccg cggtcttcac caagtacccg gagagcttgg tgcgggtcgt
961 gcagatcatc atggtgcggc tgcagcgagt caccttcctg gcactgcaca actacctggg
1021 tctgaccaat gagctcttca gccacgagat ccagcccctg cgtctgttcc ccagccccgg
1081 cctcccaact cgcaccagcc ctgtgcgggg ctccaagaga atggtcagca cctcagctac
1141 agacgagccc agggagaccc cagggcggcc acccgatccc accggggccc cgctgcctgg
1201 acctacaggg gaccctgtga agcccacatc cctggaaacc ccctcggccc ctctgctgag
1261 ccgctgcgtc tccatgccag gggacatctc aggcttgcag ggtggccccc gctccgactt
1321 cgacatggcc tatgagcgtg gccggatctc cgtgtccctg caggaagagg cctccggggg
1381 gtccctggca gcccccgctc ggacccccac tcaggagcct cgtgagcagc cggcaggcgc
1441 ctgtgaatac agctactgtg aggatgagtc ggccactggt ggctgccctt tcgggcccta
1501 ccagggccgc cagaccagca gcatcttcga ggcagcaaag caggagctgg ccaagctgat
1561 gcggattgag gacccctccc tcctgaacag cagagtcttg ctgcaccacg ccaaagctgg
1621 caccatcatt gcccgccagg gagaccagga cgtgagcctg cacttcgtgc tctggggctg
1681 cctgcacgtg taccagcgca tgatcgacaa ggcggaggac gtgtgcctgt tcgtagcgca
1741 gcccggggaa ctggtggggc agctggcggt gctcactggc gaacctctca tcttcacact
1801 gcgagcccaa cgcgactgca ccttcctgcg gatctccaag tccgacttct atgagatcat
1861 gcgcgcacag cccagtgtgg tgctgagtgc ggcgcacacg gtggcagcca ggatgtcgcc
1921 cttcgtgcgc cagatggact tcgccatcga ctggactgca gtggaggcgg gacgcgcgct
1981 gtacaggcag ggcgaccgct ccgactgcac ttacatcgtg ctcaatgggc ggctgcgtag
2041 cgtgatccag cgaggcagtg gcaagaagga gctggtgggc gagtacggcc gcggcgacct
2101 catcggcgtg gtggaggcac tgacccggca gccgcgagcc acgacggtgc acgcggtgcg
2161 cgacacggag ctagccaagc ttcccgaggg caccttgggt cacatcaaac gccggtaccc
2221 gcaggtcgtg acccgcctta tccacctact gagccagaaa attctaggga atttgcagca
2281 gctgcaagga cccttcccag caggctctgg gttgggtgtg cccccacact cggaactcac
2341 caacccagcc agcaacctgg caactgtggc aatcctgcct gtgtgtgctg aggtccccat
2401 ggtggccttc acgctggagc tgcagcacgc cctgcaggcc atcggtccga cgctactcct
2461 taacagtgac atcatccggg cacgcctggg ggcctccgca ctggatagca tccaagagtt
2521 ccggctgtca gggtggctgg cccagcagga ggatgcacac cgtatcgtac tctaccagac
2581 ggacgcctcg ctgacgccct ggaccgtgcg ctgcctgcga caggccgact gcatcctcat
2641 tgtgggcctg ggggaccagg agcctaccct cggccagctg gagcagatgc tggagaacac
2701 ggctgtgcgc gcccttaagc agctagtcct gctccaccga gaggagggtg cgggccccac
2761 gcgcaccgtg gagtggctaa atatgcgcag ctggtgctcg gggcacctgc acctgcgctg
2821 tccgcgccgc ctcttttcgc gccgcagccc tgccaagctg catgagctct acgagaaggt
2881 tttctccagg cgcgcggacc ggcacagcga cttctcccgc ttggcgaggg tgctcacggg
2941 gaacaccatt gcccttgtgc taggcggggg cggggccagg ggctgctcgc acatcggagt
3001 actaaaggca ttagaggagg cgggggtccc cgtggacctg gtgggcggca cgtccattgg
3061 ctctttcatc ggagcgttgt acgcggagga gcgcagcgcc agccgcacga agcagcgggc
3121 ccgggagtgg gccaagagca tgacttcggt gctggaacct gtgttggacc tcacgtaccc
3181 agtcacctcc atgttcactg ggtctgcctt taaccgcagc atccatcggg tcttccagga
3241 taagcagatt gaggacctgt ggctgcctta cttcaacgtg accacagata tcaccgcctc
3301 agccatgcga gtccacaaag atggctccct gtggcggtac gtgcgcgcca gcatgacgct
3361 gtcgggctac ctgcccccgc tgtgcgaccc caaggacggg cacctactca tggatggcgg
3421 ctacatcaac aatctgccag cggacatcgc ccgcagcatg ggtgccaaaa cggtcatcgc
3481 cattgacgtg gggagccagg atgagacgga cctcagcacc tacggggaca gcctgtccgg
3541 ctggtggctg ctgtggaagc ggctgaatcc ctgggctgac aaggtaaagg ttccagacat
3601 ggctgaaatc cagtcccgcc tggcctacgt gtcctgtgtg cggcagctag aggttgtcaa
3661 gtccagctcc tactgcgagt acctgcgccc gcccatcgac tgcttcaaga ccatggactt
3721 tgggaagttc gaccagatct atgatgtggg ctaccagtac gggaaggcgg tgtttggagg
3781 ctggagccgt ggcaacgtca ttgagaaaat gctcacagac cggcggtcta cagaccttaa
3841 tgagagccgc cgtgcagacg tgcttgcctt cccaagctct ggcttcactg acttggcaga
3901 gattgtgtcc cggattgagc cccccacgag ctatgtctct gatggctgtg ctgacggaga
3961 ggagtcagat tgtctgacag agtatgagga ggacgccgga cccgactgct cgagggatga
4021 aggggggtcc cccgagggcg caagtcccag cactgcctcc gagatggagg aggagaagtc
4081 gattctccgg caacgacgct gtctgcccca ggagccgccc ggctcagcca cagatgcctg
4141 aggacctcga caggggtcac cccctccctc ccacccctgg actgggctgg gggtggcccc
4201 gtgggggtag ctcactcccc ctcctgctgc tatgcctgtg acccccgcgg cccacacact
4261 ggactgacct gccctgagcg gggatgcagt gttgcactga tgacttgacc agcccctccc
4321 ccaataaact cgcctcttgg aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
4381 aaaaaaaaaa a
//