LOCUS AJ003125 3636 bp mRNA linear HUM 21-OCT-2008
DEFINITION Homo sapiens mRNA for procollagen I-N proteinase.
ACCESSION AJ003125
VERSION AJ003125.1
KEYWORDS hPCPNI gene; procollagen I-N proteinase.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 3636)
AUTHORS Colige A.C.
JOURNAL Submitted (24-NOV-1997) to the INSDC. Colige A.C., Laboratory of
Connective Tissues Biology, University of Liege, Tour de
pathologie, B23/3, B-4000, BELGIUM.
REFERENCE 2
AUTHORS Colige A.C., Sieron A.L., Li S.W., Schwarze U., Petty E.,
Wertelecki W., Wilcox W., Krakow D., Cohn D.H., Reardon W.,
Byers P.H., Lapiere C.M., Prockop D.J., Nusgens B.V.
TITLE Human Ehlers-Danlos syndrome type VII C and bovine dermatosparaxis
are caused by mutations in the procollagen I N-proteinase gene
JOURNAL Am. J. Hum. Genet. 65(2), 308-317(1999).
PUBMED 10417273
FEATURES Location/Qualifiers
source 1..3636
/db_xref="H-InvDB:HIT000244001"
/organism="Homo sapiens"
/mol_type="mRNA"
/cell_type="fibroblasts"
/tissue_type="skin"
/db_xref="taxon:9606"
CDS 1..3636
/codon_start=1
/gene="hPCPNI"
/product="procollagen I N-proteinase"
/function="cleavage of the aminopropeptide of procollagens
I, II and V"
/EC_number="3.4.24.14"
/db_xref="GOA:O95450"
/db_xref="H-InvDB:HIT000244001.14"
/db_xref="HGNC:HGNC:218"
/db_xref="InterPro:IPR000884"
/db_xref="InterPro:IPR001590"
/db_xref="InterPro:IPR002870"
/db_xref="InterPro:IPR010294"
/db_xref="InterPro:IPR010909"
/db_xref="InterPro:IPR013273"
/db_xref="InterPro:IPR013275"
/db_xref="InterPro:IPR024079"
/db_xref="InterPro:IPR036383"
/db_xref="InterPro:IPR041645"
/db_xref="UniProtKB/Swiss-Prot:O95450"
/experiment="experimental evidence, no additional details
recorded"
/protein_id="CAA05880.1"
/translation="MDPPAGAARRLLCPALLLLLLLLPPPLLPPPPPPANARLAAAAD
PPGGPLGHGAERILAVPVRTDAQGRLVSHVVSAATSRAGVRARRAAPVRTPSFPGGNE
EEPGSHLFYNVTVFGRDLHLRLRPNARLVAPGATMEWQGEKGTTRVEPLLGSCLYVGD
VAGLAEASSVALSNCDGLAGLIRMEEEEFFIEPLEKGLAAQEAEQGRVHVVYRRPPTS
PPLGGPQALDTGASLDSLDSLSRALGVLEEHANSSRRRARRHAADDDYNIEVLLGVDD
SVVQFHGKEHVQKYLLTLMNIVNEIYHDESLGAHINVVLVRIILLSYGKSMSLIEIGN
PSQSLENVCRWAYLQQKPDTGHDEYHDHAIFLTRQDFGPSGMQGYAPVTGMCHPVRSC
TLNHEDGFSSAFVVAHETGHVLGMEHDGQGNRCGDEVRLGSIMAPLVQAAFHRFHWSR
CSQQELSRYLHSYDCLLDDPFAHDWPALPQLPGLHYSMNEQCRFDFGLGYMMCTAFRT
FDPCKQLWCSHPDNPYFCKTKKGPPLDGTMCAPGKHCFKGHCIWLTPDILKRDGSWGA
WSPFGSCSRTCGTGVKFRTRQCDNPHPANGGRTCSGLAYDFQLCSRQDCPDSLADFRE
EQCRQWDLYFEHGDAQHHWLPHEHRDAKERCHLYCESRETGEVVSMKRMVHDGTRCSY
KDAFSLCVRGDCRKVGCDGVIGSSKQEDKCGVCGGDNSHCKVVKGTFTRSPKKHGYIK
MFEIPAGARHLLIQEVDATSHHLAVKNLETGKFILNEENDVDASSKTFIAMGVEWEYR
DEDGRETLQTMGPLHGTITVLVIPVGDTRVSLTYKYMIHEDSLNVDDNNVLEEDSVVY
EWALKKWSPCSKPCGGGSQFTKYGCRRRLDHKMVHRGFCAALSKPKAIRRACNPQECS
QPVWVTGEWEPCSQTCGRTGMQVRSVRCIQPLHDNTTRSVHAKHCNDARPESRRACSR
ELCPGRWRAGPWSQCSVTCGNGTQERPVPCRTADDSFGICQEERPETARTCRLGPCPR
NISDPSKKSYVVQWLSRPDPDSPIRKISSKGHCQGDKSIFCRMEVLSRYCSIPGYNKL
SCKSCNLYNNLTNVEGRIEPPPGKHNDIDVFMPTLPVPTVAMEVRPSPSTPLEVPLNA
SSTNATEDHPETNAVDEPYKIHGLEDEVQPPNLIPRRPSPYEKTRNQRIQELIDEMRK
KEMLGKF"
BASE COUNT 738 a 1192 c 1101 g 605 t
ORIGIN
1 atggatccgc cggcgggagc cgctcgccgc ctgctctgcc ccgcgctgct gctgctgctg
61 ctgctgctgc cgccgccgct cctgccgccg ccgccgccgc ccgcgaacgc caggctcgcc
121 gccgccgccg accccccagg cgggcccctg gggcacggag cggagcgcat cctggcggtg
181 cccgtgcgca ctgacgccca gggccgcttg gtgtcccacg tggtgtcggc agctacgtcc
241 agagcagggg tacgagcccg cagggccgcc ccggtccgga ccccgagctt ccccggaggc
301 aacgaggagg agcctggcag tcacctcttc tacaatgtca cggtctttgg ccgagacctg
361 cacctgcggc tgcggcccaa cgcccgcctc gtggcgcccg gggccactat ggagtggcag
421 ggcgagaagg gcaccacccg cgtggagccc ctgctcggga gctgtctcta cgtcggagac
481 gtggccggcc tagccgaagc ctcctctgtg gcgctcagca actgcgatgg gctggctggt
541 ctgatccgga tggaggagga ggagttcttc atcgaaccct tggagaaggg gctggcggcg
601 caggaggctg agcaaggccg tgtgcatgtg gtgtatcgcc ggccacccac gtcccctcct
661 ctcggggggc cacaggccct ggacacaggg gcctccctgg acagcctgga cagcctcagc
721 cgcgccctgg gcgtcctaga ggagcacgcc aacagctcga ggcggagggc acgcaggcat
781 gctgcagacg atgactacaa catcgaggtc ctgctgggcg tggatgactc tgtggtgcag
841 ttccacggga aggagcacgt acagaagtac ctgctgacac tcatgaacat tgtcaatgaa
901 atctaccatg acgagtcctt gggtgcccac atcaacgtgg tcctggtgcg gatcatcctc
961 ctgagctatg gaaagtccat gagcctcatc gagatcggga acccctctca gagcctggag
1021 aatgtctgcc gctgggccta cctccagcag aagccagaca cgggccacga tgaataccac
1081 gatcacgcca tcttcctcac acggcaggac tttgggcctt ccggcatgca aggctatgct
1141 cctgtcaccg gcatgtgcca tccggtccgc agctgcaccc tgaaccatga ggacggcttc
1201 tcctcagcgt ttgtggtggc ccatgagact ggccacgtgc tgggcatgga gcacgacggg
1261 cagggcaacc gctgtggcga cgaggtgcgg ctgggcagca tcatggcgcc cctggtgcag
1321 gccgccttcc accgcttcca ctggtcccgc tgcagccagc aggagctgag ccgctacctg
1381 cactcctatg actgcctgct ggatgacccc ttcgcccacg actggccggc gctgccccag
1441 ctcccgggac tgcactactc catgaacgag caatgccgct ttgacttcgg cctgggctac
1501 atgatgtgca cggcgttccg gacctttgac ccctgcaagc agctgtggtg cagccatcct
1561 gacaacccct acttttgcaa gaccaagaag gggcccccct tggacgggac tatgtgtgca
1621 cctggcaagc attgttttaa aggacactgc atctggctga cacctgacat cctcaaacgg
1681 gacggcagct ggggcgcttg gagtccgttt ggctcctgct cacgtacctg tggcacgggc
1741 gtgaagttca ggacccgcca gtgtgacaac ccacacccgg ccaacggggg ccgcacctgc
1801 tcgggccttg cctacgactt ccagctctgc agccgccagg actgccccga ctccctggct
1861 gacttccgcg aggagcagtg ccgccagtgg gacctgtact tcgagcacgg cgacgcccag
1921 caccactggc tgccccacga gcaccgggat gccaaggaga gatgccacct gtactgcgag
1981 tccagggaga ccggggaggt ggtgtccatg aagcgcatgg tgcatgatgg gacgcgctgc
2041 tcctacaagg acgccttcag cctctgtgtg cgcggggact gcaggaaggt gggctgtgac
2101 ggtgtgatcg gctccagcaa gcaggaagac aagtgtggcg tgtgcggagg ggacaacagc
2161 cactgcaaag tggtcaaggg cacgttcaca cggtcaccca agaagcatgg ttacatcaag
2221 atgtttgaga tccctgcagg agccagacac ctgctcattc aggaggtaga cgccaccagc
2281 caccatctgg ccgtcaagaa cctggagaca ggcaagttca tcttaaatga agagaatgac
2341 gtggatgcca gttccaaaac cttcattgcc atgggcgtgg agtgggagta cagagacgag
2401 gacggccggg agacgctgca gaccatgggc cccctccacg gcaccatcac cgttctggtc
2461 atcccggtgg gagacacccg ggtctcactg acgtacaaat acatgatcca tgaggactca
2521 ctgaatgtcg atgacaacaa cgtcctggaa gaggactctg tggtctacga gtgggccctg
2581 aagaagtggt ctccgtgctc caagccctgt ggcggagggt cccagttcac caagtatggc
2641 tgccgccgga ggctggacca caagatggta caccgtggct tctgtgccgc cctctcgaag
2701 cccaaagcca tccgcagagc gtgcaaccca caggaatgct cccagccagt gtgggtcaca
2761 ggcgaatggg agccatgtag ccagacctgt gggcggacag gcatgcaggt gcgctccgtg
2821 cgctgcattc agccgctaca cgacaacacc acccgctccg tgcacgccaa gcactgcaat
2881 gacgcccggc ccgagagccg ccgggcctgc agccgcgagc tctgccctgg tcgttggcga
2941 gccgggccct ggtcccagtg ctcagtaacc tgtggcaacg gcacccagga gcggccagtg
3001 ccctgccgca ccgcggacga cagcttcggc atctgccagg aggagcgtcc tgagacagcg
3061 aggacctgca ggcttggccc ctgtccccga aacatctcag atccctccaa gaagagctac
3121 gtagttcagt ggctgtcccg cccggacccc gactcgccca tccggaagat ctcgtcaaag
3181 ggccactgcc aaggcgacaa gtcaatattc tgtaggatgg aagtcttgtc ccgctattgc
3241 tccatcccag gctacaacaa gctgtcctgc aagtcctgta acctgtacaa caacctcacc
3301 aacgtggagg gcaggataga gccaccgcct gggaagcaca acgacattga cgtgttcatg
3361 cctaccctcc cagtgcccac tgtagccatg gaggtgcggc catcaccaag cacccccctg
3421 gaggtccctc tcaatgcctc cagcaccaat gccacagagg atcacccaga aaccaatgcc
3481 gtagatgaac cctacaaaat ccatggcctg gaagatgaag tccagccacc caacctaatc
3541 cctcgacgac cgagccccta tgaaaagacc agaaaccaaa gaatccaaga gctcattgat
3601 gagatgcgga agaaagagat gctcggaaag ttctaa
//