LOCUS AJ001698 2831 bp mRNA linear HUM 07-OCT-2008
DEFINITION Homo sapiens mRNA for hurpin, clone R7-16.1.
ACCESSION AJ001698
VERSION AJ001698.1
KEYWORDS hurpin; PI13 gene; serine protease inhibitor.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2831)
AUTHORS Abts H.F.
JOURNAL Submitted (29-SEP-1997) to the INSDC. Abts H.F., Dermatology,
Heinrich-Heine Universitaet, Duesseldorf, Moorenstr. 5,
Cytokinlabor, Geb. 11-80, 40225, GERMANY.
REFERENCE 2
AUTHORS Abts H.F., Breuhahn K., Michel G., Koehrer K., Esser P., Ruzicka T.
TITLE Analysis of UVB-modulated gene expression in human keratinocytes by
mRNA differential display polymerase chain reaction
JOURNAL Photochem. Photobiol. 66(3), 363-367(1997).
PUBMED 9297979
REFERENCE 3
AUTHORS Abts H.F., Welss T., Mirmohammadsadegh A., Koehrer K., Michel G.,
Ruzicka T.
TITLE Cloning and characterization of hurpin (protease inhibitor 13): A
new skin-specific, UV-repressible serine proteinase inhibitor of
the ovalbumin serpin family
JOURNAL J. Mol. Biol. 293(1), 29-39(1999).
PUBMED 10512713
FEATURES Location/Qualifiers
source 1..2831
/db_xref="H-InvDB:HIT000243892"
/organism="Homo sapiens"
/mol_type="mRNA"
/dev_stage="adult"
/clone_lib="HaCaT lambda II"
/clone="R7-16.1"
/cell_line="HaCaT"
/cell_type="keratinocyte"
/tissue_type="skin"
/db_xref="taxon:9606"
CDS join(40..507,721..1425)
/gene="PI13"
/product="hurpin"
/function="serine protease inhibitor"
/db_xref="GOA:Q9UIV8"
/db_xref="H-InvDB:HIT000243892.12"
/db_xref="HGNC:HGNC:8944"
/db_xref="InterPro:IPR000215"
/db_xref="InterPro:IPR023795"
/db_xref="InterPro:IPR023796"
/db_xref="InterPro:IPR036186"
/db_xref="InterPro:IPR042178"
/db_xref="InterPro:IPR042185"
/db_xref="UniProtKB/Swiss-Prot:Q9UIV8"
/protein_id="CAA04937.1"
/translation="MDSLGAVSTRLGFDLFKELKKTNDGNIFFSPVGILTAIGMVLLG
TRGATASQLEEVFHSEKETKSSRIKAEEKEIENTEAVHQQFQKFLTEISKLTNDYELN
ITNRLFGEKTYLFLQKYLDYVEKYYHASLEPVDFVNAADESRKKINSWVESKTNEKIK
DLFPDGSISSSTKLVLVNMVYFKGQWDREFKKENTKEEKFWMNKSTSKSVQMMTQSHS
FSFTFLEDLQAKILGIPYKNNDLSMFVLLPNDIDGLEKIIDKISPEKLVEWTSPGHME
ERKVNLHLPRFEVEDGYDLQAVLAAMGMGDAFSEHKADYSGMSSGSGLYAQKFLHSSF
VAVTEEGTEAAAATGIGFTVTSAPGHENVHCNHPFLFFIRHNESNSILFFGRFSSP"
BASE COUNT 858 a 547 c 558 g 868 t
ORIGIN
1 accgtctctc caaaaacccg aggtctcgct aaaatcatca tggattcact tggcgccgtc
61 agcactcgac ttgggtttga tcttttcaaa gagctgaaga aaacaaatga tggcaacatc
121 ttcttttccc ctgtgggcat cttgactgca attggcatgg tcctcctggg gacccgagga
181 gccaccgctt cccagttgga ggaggtgttt cactctgaaa aagagacgaa gagctcaaga
241 ataaaggctg aagaaaaaga gattgagaac acagaagcag tacatcaaca attccaaaag
301 tttttgactg aaataagcaa actcactaat gattatgaac tgaacataac caacaggctg
361 tttggagaaa aaacatacct cttccttcaa aaatacttag attatgttga aaaatattat
421 catgcatctc tggaacctgt tgattttgta aatgcagccg atgaaagtcg aaagaagatt
481 aattcctggg ttgaaagcaa aacaaatgat gtggaaactg aggcacagag agtttaaata
541 acttgcccaa gattcctcag ctgataagag gcaaactgga tgctaacaga ggcatctgac
601 cccagagtct ggactcttaa ccatgaacct taatttatcc actgggataa ataggcgatg
661 ggcaaaatga gaacctcccc gtcgattctg ccagcaaacc ctttgtcagc aaggccctca
721 gaaaaaatca aggacttgtt cccagatggc tctattagta gctctaccaa gctggtgctg
781 gtgaacatgg tttattttaa agggcaatgg gacagggagt ttaagaaaga aaatactaag
841 gaagagaaat tttggatgaa taagagcaca agtaaatctg tacagatgat gacacagagc
901 cattccttta gcttcacttt cctggaggac ttgcaggcca aaattctagg gattccatat
961 aaaaacaacg acctaagcat gtttgtgctt ctgcccaacg acatcgatgg cctggagaag
1021 ataatagata aaataagtcc tgagaaattg gtagagtgga ctagtccagg gcatatggaa
1081 gaaagaaagg tgaatctgca cttgccccgg tttgaggtgg aggacggtta cgatctacag
1141 gcggtcctgg ctgccatggg gatgggcgat gccttcagtg agcacaaagc cgactactcg
1201 ggaatgtcgt caggctccgg gttgtacgcc cagaagttcc tgcacagttc ctttgtggca
1261 gtaactgagg aaggcaccga ggctgcagct gccaccggca taggctttac tgtcacatcc
1321 gccccaggtc atgaaaatgt tcactgcaat catcccttcc tgttcttcat caggcacaat
1381 gaatccaaca gcatcctctt cttcggcaga ttttcttctc cttaagatga tcgttgccat
1441 ggcattgctg cttttagcaa aaaacaacta ccagtgttac tcatatgatt atgaaaatcg
1501 tccattcttt taaatgttgt ctcacttgca tttccagtct tggccatcaa atcaatgatt
1561 taatgactcc aataatgtgt gtgtttataa ccatcctcga aagtgaaatg tccttttttt
1621 tgtgccatgc gtaaggtgag tcaaaccaaa cctcattgat aatctcccct ttggtttcct
1681 ttgaaagtaa attggtatct tgtagttttg tgcacacgaa aggagagaaa gtttctccag
1741 taaagagtac gaactagtaa ttttgggggg tctctctaat tctggtattt tgacatgtta
1801 taatacgcaa gtaaaataaa acaatagttt actcagctca tgttactatt ccccaacaga
1861 tattgtggca aatcacacat aggaaagagg atttgggaat acagtagcaa aacataaatt
1921 aaaactcaaa tgcccaggac aaaataaaac aatataccag atggagagga tgcccgtatt
1981 ttcatcttcc attctaacat tatccattgt tagatgcata agcattttga tattgtgtaa
2041 taaatgtggt atttgagaag ataaatgatg tagttgatca gtaatcctcc tctatcacct
2101 ttttagactt tgtaaggtaa atatttggac taacttttag aaaagtttcc ctttttttct
2161 ccatttacat ttttctggtt tttttttttt tttttgagtg aggtacgagt attaccaaat
2221 gatattttct gaagatgctt tttggaaagc tctgaatcta tacctaatgc tcttaattat
2281 tggcttgttt catttttttc ctccagtttt taacaagatc acataactgg cttattttta
2341 acagctttgt caaactacaa tttacatgcc gtaaaatgta cacactgtaa ttttataatt
2401 cattgacttt tagtaaattt tctagcgtta tgcatcgcca caatccagtt ttagaatatt
2461 tccatgaccc taagaagttt cctcatgtct attaatattc ccaatcctag gcaccactga
2521 gttgttttct gtctttataa gtttttcttt ctacatctta tataaatgga atcataatac
2581 atgtagtatt ttgtgtctgg cgtcttgcac ttagcatggt gttcttgagg ttcatctgtt
2641 gtagtatgta ttgatactta ggattttttt attgccgaat actattccat tgcatggaaa
2701 agacctattt tatttctagg ttcaccagtt gagggacatt tggattgttc ccacttcttg
2761 ggctgttagg aataatgttg ctctgaacat gtaaataaag atctttgtgt tcaaaaaaaa
2821 aaaaaaaaaa a
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