LOCUS AJ001696 3143 bp mRNA linear HUM 07-OCT-2008
DEFINITION Homo sapiens mRNA for hurpin, clone R7-1.1.
ACCESSION AJ001696
VERSION AJ001696.2
KEYWORDS hurpin; PI13 gene; serine protease inhibitor.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 3143)
AUTHORS Abts H.F.
JOURNAL Submitted (29-SEP-1997) to the INSDC. Abts H.F., Dermatology,
Heinrich-Heine Universitaet, Duesseldorf, Moorenstr. 5,
Cytokinlabor, Geb. 11-80, 40225, GERMANY.
REMARK Revised by author 08-OCT-1999
REFERENCE 2
AUTHORS Abts H.F., Breuhahn K., Michel G., Koehrer K., Esser P., Ruzicka T.
TITLE Analysis of UVB-modulated gene expression in human keratinocytes by
mRNA differential display polymerase chain reaction
JOURNAL Photochem. Photobiol. 66(3), 363-367(1997).
PUBMED 9297979
REFERENCE 3
AUTHORS Abts H.F., Welss T., Mirmohammadsadegh A., Koehrer K., Michel G.,
Ruzicka T.
TITLE Cloning and characterization of hurpin (protease inhibitor 13): A
new skin-specific, UV-repressible serine proteinase inhibitor of
the ovalbumin serpin family
JOURNAL J. Mol. Biol. 293(1), 29-39(1999).
PUBMED 10512713
FEATURES Location/Qualifiers
source 1..3143
/db_xref="H-InvDB:HIT000243890"
/organism="Homo sapiens"
/mol_type="mRNA"
/dev_stage="adult"
/clone_lib="HaCaT lambda II"
/clone="R7-1.1"
/cell_line="HaCaT"
/cell_type="keratinocyte"
/tissue_type="skin"
/db_xref="taxon:9606"
CDS 103..1278
/gene="PI13"
/product="hurpin"
/function="serine protease inhibitor"
/db_xref="GOA:Q9UIV8"
/db_xref="H-InvDB:HIT000243890.14"
/db_xref="HGNC:HGNC:8944"
/db_xref="InterPro:IPR000215"
/db_xref="InterPro:IPR023795"
/db_xref="InterPro:IPR023796"
/db_xref="InterPro:IPR036186"
/db_xref="InterPro:IPR042178"
/db_xref="InterPro:IPR042185"
/db_xref="UniProtKB/Swiss-Prot:Q9UIV8"
/protein_id="CAA04935.2"
/translation="MDSLGAVSTRLGFDLFKELKKTNDGNIFFSPVGILTAIGMVLLG
TRGATASQLEEVFHSEKETKSSRIKAEEKEVIENTEAVHQQFQKFLTEISKLTNDYEL
NITNRLFGEKTYLFLQKYLDYVEKYYHASLEPVDFVNAADESRKKINSWVESKTNEKI
KDLFPDGSISSSTKLVLVNMVYFKGQWDREFKKENTKEEKFWMNKSTSKSVQMMTQSH
SFSFTFLEDLQAKILGIPYKNNDLSMFVLLPNDIDGLEKIIDKISPEKLVEWTSPGHM
EERKVNLHLPRFEVEDGYDLEAVLAAMGMGDAFSEHKADYSGMSSGSGLYAQKFLHSS
FVAVTEEGTEAAAATGIGFTVTSAPGHENVHCNHPFLFFIRHNESNSILFFGRFSSP"
BASE COUNT 928 a 585 c 600 g 1030 t
ORIGIN
1 ctataaatta aggatcccag ctacttaatt gacttatgct tcctagttcg ttgcccagcc
61 accaccgtct ctccaaaaac ccgaggtctc gctaaaatca tcatggattc acttggcgcc
121 gtcagcactc gacttgggtt tgatcttttc aaagagctga agaaaacaaa tgatggcaac
181 atcttctttt cccctgtggg catcttgact gcaattggca tggtcctcct ggggacccga
241 ggagccaccg cttcccagtt ggaggaggtg tttcactctg aaaaagagac gaagagctca
301 agaataaagg ctgaagaaaa agaggtgatt gagaacacag aagcagtaca tcaacaattc
361 caaaagtttt tgactgaaat aagcaaactc actaatgatt atgaactgaa cataaccaac
421 aggctgtttg gagaaaaaac atacctcttc cttcaaaaat acttagatta tgttgaaaaa
481 tattatcatg catctctgga acctgttgat tttgtaaatg cagccgatga aagtcgaaag
541 aagattaatt cctgggttga aagcaaaaca aatgaaaaaa tcaaggactt gttcccagat
601 ggctctatta gtagctctac caagctggtg ctggtgaaca tggtttattt taaagggcaa
661 tgggacaggg agtttaagaa agaaaatact aaggaagaga aattttggat gaataagagc
721 acaagtaaat ctgtacagat gatgacacag agccattcct ttagcttcac tttcctggag
781 gacttgcagg ccaaaattct agggattcca tataaaaaca acgacctaag catgtttgtg
841 cttctgccca acgacatcga tggcctggag aagataatag ataaaataag tcctgagaaa
901 ttggtagagt ggactagtcc agggcatatg gaagaaagaa aggtgaatct gcacttgccc
961 cggtttgagg tggaggacgg ttacgatcta gaggcggtcc tggctgccat ggggatgggc
1021 gatgccttca gtgagcacaa agccgactac tcgggaatgt cgtcaggctc cgggttgtac
1081 gcccagaagt tcctgcacag ttcctttgtg gcagtaactg aggaaggcac cgaggctgca
1141 gctgccaccg gcataggctt tactgtcaca tccgccccag gtcatgaaaa tgttcactgc
1201 aatcatccct tcctgttctt catcaggcac aatgaatcca acagcatcct cttcttcggc
1261 agattttctt ctccttaaga tgatcgttgc catggcattg ctgcttttag caaaaaacaa
1321 ctaccagtgt tactcatatg attatgaaaa tcgtccattc ttttaaatgt tgtctcactt
1381 gcatttccag tcttggccat caaatcaatg atttaatgac tccaataatg tgtgtgttta
1441 taaccatcct cgaaagtgaa atgtcctttt ttttgtgcca tgcgtaaggt gagtcaaacc
1501 aaacctcatt gataatctcc cctttggttt cctttgaaag taaattggta tcttgtagtt
1561 ttgtgcacac gaaaggagag aaagtttctc cagtaaagag tacgaactag taattttggg
1621 gggtctctct aattctggta ttttgacatg ttataatacg caagtaaaat aaaacaatag
1681 tttactcagc tcatgttact attccccaac agatattgtg gcaaatcaca cataggaaag
1741 aggatttggg aatacagtag caaaacataa attaaaactc aaatgcccag gacaaaataa
1801 aacaatatac cagatggaga ggatgcccgt attttcatct tccattctaa cattatccat
1861 tgttagatgc ataagcattt tgatattgtg taataaatgt ggtatttgag aagataaatg
1921 atgtagttga tcagtaatcc tcctctatca cctttttaga ctttgtaagg taaatatttg
1981 gactaacttt tagaaaagtt tccctttttt tctccattta catttttctg gttttttttt
2041 ttttttttga gtgaggtacg agtattacca aatgatattt tctgaagatg ctttttggaa
2101 agctctgaat ctatacctaa tgctcttaat tattggcttg tttcattttt ttcctccagt
2161 ttttaacaag atcacataac tggcttattt ttaacagctt tgtcaaacta caatttacat
2221 gccgtaaaat gtacacactg taattttata attcattgac ttttagtaaa ttttctagcg
2281 ttatgcatcg ccacaatcca gttttagaat atttccatga ccctaagaag tttcctcatg
2341 tctattaata ttcccaatcc taggcaccac tgagttgttt tctgtcttta taagtttttc
2401 tttctacatc ttatataaat ggaatcataa tacatgtagt attttgtgtc tggcgtcttg
2461 cacttagcat ggtgttcttg aggttcatct gttgtagtat gtattgatac ttaggatttt
2521 tttattgccg aatactattc cattgcatgg aaaagaccta ttttatttct aggttcacca
2581 gttgagggac atttggattg ttcccacttc ttgggctgtt aggaataatg ttgctctgaa
2641 catgtaaata aagatctttg tgttcacata tgtttttcat tttctgttgg ggagattccc
2701 taggctagaa attgctgggc catatgaaaa atcaatagtt agctttgtaa gaaacagtca
2761 aactgttttc ccaacgtgac attttatatt cccaccagga atgtttaaaa ctagtgtctt
2821 caaatcctca ccaacatcca ggattgtgtc tttatgatta tagccatttt tgtaggtaca
2881 aagtggcatc tcatggtggt tttaatttgc atttccataa tatctaatta ggttgagctt
2941 tttttatgtg cttattggcc atttgtttga ctttgtttgg tgaaatgtat acaaatcatt
3001 tgctcatttt taatttgggt tgtctgtctt gtcttctcat tttattgagt taaatgagtt
3061 cttaataatc tctggcttac aagtccttaa tttatcaaat atatgatacg tggacatttc
3121 ctcataaaaa aaaaaaaaaa aaa
//