LOCUS AJ001381 2538 bp mRNA linear HUM 07-OCT-2008
DEFINITION Homo sapiens incomplete cDNA for a mutated allele of a myosin class
I, myh-1c.
ACCESSION AJ001381
VERSION AJ001381.1
KEYWORDS myosin class I.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2538)
AUTHORS Zorn E.
JOURNAL Submitted (05-DEC-1997) to the INSDC. Zorn E., U267, INSERM,
Hopital Paul Brousse, 12-14 Av. Paul Vaillant-Couturier, Villejuif,
94807, FRANCE.
REFERENCE 2
AUTHORS Zorn E., Hercend T.
TITLE A mutated non conventional class I myosin peptide elicits a
dominant CTL response in a regressive human primary melanoma lesion
JOURNAL Unpublished.
REFERENCE 3
AUTHORS Ruppert C., Kroschewski R., Bahler M.
TITLE Identification, characterization and cloning of myr 1, a mammalian
myosin-I
JOURNAL J. Cell Biol. 120(6), 1393-1403(1993).
PUBMED 8449985
COMMENT A g to a somatic mutation (position 804 of the cDNA) results in a
Glu to
Lys replacement in the amino acid sequence. This mutation
generates a T
cell neoepitope recognized by an amplified Tumor-infiltrating
lymphocyte in
a melanoma patient in the context of a spontaneous tumor
regression.
Except for the mutation, myh-1c is 98% identical in amino acids to
the rat
myosin class I myr-1c.
FEATURES Location/Qualifiers
source 1..2538
/db_xref="H-InvDB:HIT000243858"
/organism="Homo sapiens"
/mol_type="mRNA"
/sex="female"
/cell_line="M10"
/cell_type="melanoma"
/db_xref="taxon:9606"
CDS <1..1310
/codon_start=3
/gene="myh-1"
/product="myh-1c"
/db_xref="GOA:O43795"
/db_xref="H-InvDB:HIT000243858.13"
/db_xref="HGNC:HGNC:7596"
/db_xref="InterPro:IPR000048"
/db_xref="InterPro:IPR001609"
/db_xref="InterPro:IPR010926"
/db_xref="InterPro:IPR027417"
/db_xref="InterPro:IPR036072"
/db_xref="InterPro:IPR036961"
/db_xref="UniProtKB/Swiss-Prot:O43795"
/protein_id="CAA04712.1"
/translation="RYKMLCKQTWPHWKGPARSGVEVLFNELEIPVEEYSFGRSKIFI
RNPRTLFKLEDLRKQRLEDLATLIQKIYRGWKCRTHFLLMKKSQIVIAAWYRRYAQQK
RYQQTKSSALVIQSYIRGWKARKILRELKHQKRCKEAVTTIAAYWHGTQVRREYRKFF
RANAGKKIYEFTLQRIVQKYFLEMKNKMPSLSPIDKNWPSRPYLFLDSTHKELKRIFH
LWRCKKYRDQFTDQQKLIYEEKLEASELFKDKKALYPSSVGQPFQGAYLKINKNPKYK
KLKDAIEEKIIIAEVVNKINRANGKSTSRIFLLTNNNLLLADQKSGQIKSEVPLVDVT
KVSMSSQNDGFFAVHLKEGSEAASKGDFLFSSDHLIEMATKLYRTTLSQTKQKLNIEI
SDEFLVQFRQDKVCVKFIQGNQKNGSVPTCKRKNNRLLEVAVP"
BASE COUNT 847 a 446 c 499 g 746 t
ORIGIN
1 aaagatacaa aatgctttgt aaacaaacat ggcctcattg gaaaggacca gccaggtctg
61 gtgtggaggt cctatttaat gaattagaaa ttcccgtgga agaatactcc tttggtagat
121 caaagatatt catccgaaac ccaagaacat tattcaaatt agaagacctg aggaagcaac
181 gcctggagga cttggccact ctcattcaga agatatatcg ggggtggaaa tgccgcacac
241 acttcctgct aatgaaaaaa agccaaattg tgattgccgc ctggtacagg agatatgcgc
301 aacaaaagag gtaccagcag acaaagagtt ccgccttagt aattcagtct tatatccggg
361 gttggaaggc tcgaaaaatt ctgcgggaac tgaagcatca aaagcgctgt aaggaagcag
421 tcacgaccat tgctgcatat tggcatggga cccaggtacg tagagaatac aggaaattct
481 tcagagccaa tgctggaaag aaaatctatg agtttacgct tcagagaatt gtgcaaaaat
541 acttcttgga aatgaaaaat aagatgcctt ccttatctcc aatagacaag aattggccct
601 caagacctta cttattcttg gattctactc acaaggagct aaaaaggatt ttccacttgt
661 ggaggtgtaa aaaatacagg gaccaattca cagaccagca gaaacttatt tatgaagaga
721 aactagaagc cagtgaactc ttcaaagaca agaaggcttt atacccatct agtgttgggc
781 aaccattcca aggggcttac ctgaaaatca acaagaaccc caagtataag aaactcaaag
841 atgccattga agaaaagatc atcattgctg aagtcgtgaa caaaattaac cgtgctaatg
901 ggaagagtac atctcggatt ttcctcttaa caaacaataa tctccttctt gctgaccaaa
961 agtctggaca aatcaagtca gaggttccat tggtggatgt gaccaaggta tcaatgagct
1021 cacaaaatga tggcttcttc gccgtccacc tcaaagaggg ctcagaagca gctagtaaag
1081 gagactttct cttcagcagt gatcacctga ttgaaatggc caccaagctc tatcgcacaa
1141 ctctcagcca aaccaaacag aagctcaata ttgagatttc cgatgagttc ctggtacagt
1201 tcagacagga caaagtatgt gtgaagttta ttcagggaaa ccagaaaaat gggagtgtcc
1261 caacatgtaa acgaaaaaac aaccgtctcc ttgaagttgc tgtcccttaa ctggcgcctc
1321 ctctctactt tcatggactt gttcctttgt aatagtgcaa tttggttttg ttttatttgg
1381 ggttcattgt atgtttggga atcaccaaag gcttttagag ttctttggca aaataaaaat
1441 atttgactaa tcaattttta ttattggaat agttttaacc tttcaaatac atgttctgtc
1501 ctggagcagg attgtagaaa ctaacagtgt ctattttcat gtctgatgtg ttcttccttt
1561 agtcatcatg ttaggtctgt gtaccctaaa tcagcatatt actcataaat cattaattaa
1621 tataagcata ggaaatggtc ttaaaagata ctgcattcat tcatcagata tttattccat
1681 gcctactcta tgctaggcac tgtgctagat ggtatgaaaa cttattagga acctttttgt
1741 ttttgagacc attgcattct ggctggtttg tgctggttta acgacatcta agaaggttta
1801 gaaatggtga gaccaaaaca ataactgtta atgatggaca gcattattag gaaccctgta
1861 gtatgatatt taacaatata ggcttcaaga agggctggtc ctaagagggg gcagaaatga
1921 atgaccaggt taaatccctc tacatgtggt ttctgtttga aaaaaagaaa actgacattt
1981 gaacaggact tttaatttgt ttaaaactct ggtaattact tgtaacagta gaaaatagaa
2041 gtcattctta ttttagaaaa agtgacagaa gcagtccagt aagattatat gtttctgttt
2101 ctggtaaata ccatatatga tcctcgaaat gataatatct ccagaatatt gttttcaccc
2161 aaatttgagt agatatttta aacacctaac aaagtaaagg gctaaaagcc attcagatag
2221 cagtaaaaca ttctgtatga tgtgcaataa aacatccaag atcttttttg aaagttttat
2281 ttataatata catttttgta tgagaaaggt gattggtaca gggtgcctat tttagtcatg
2341 gatcaaaatt tgtgtaactt gcagggcttt ctttcttttt cttcaaattt acaagggttc
2401 attttggaaa ctacatttta aactttggaa tcaaattgtt tcttatttgg gaggataatg
2461 tatatacatt ggtattatgt taaataataa aattgttcta atttggtgcc atttcctgaa
2521 aaaaaaaaaa aaaaaaaa
//