LOCUS AJ000008 4880 bp mRNA linear HUM 07-OCT-2008
DEFINITION Homo sapiens mRNA for C2 domain containing PI3-kinase.
ACCESSION AJ000008
VERSION AJ000008.1
KEYWORDS C2 domain; PI3-kinase.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 4880)
AUTHORS Rozycka M.
JOURNAL Submitted (01-JUL-1997) to the INSDC. Rozycka M., Cell Biology and
Experimental Pathology, Haddow Labs, Institute of Cancer Research,
15 Cotswold Rd, Sutton, Surrey, SM5 5NG, ENGLAND.
REFERENCE 2
AUTHORS Rozycka M., Lu Y.J., Brown R.A., Lau M.R., Shipley J.M., Fry M.J.
TITLE cDNA cloning of a third human C2-domain-containing class II
phosphoinositide 3-kinase, PI3K-C2gamma, and chromosomal assignment
of this gene (PIK3C2G) to 12p12
JOURNAL Genomics 54(3), 569-574(1998).
PUBMED 9878262
FEATURES Location/Qualifiers
source 1..4880
/db_xref="H-InvDB:HIT000243789"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
CDS 142..4488
/codon_start=1
/product="PI3-kinase"
/note="C2 domain"
/db_xref="GOA:O75747"
/db_xref="H-InvDB:HIT000243789.14"
/db_xref="HGNC:HGNC:8973"
/db_xref="InterPro:IPR000008"
/db_xref="InterPro:IPR000341"
/db_xref="InterPro:IPR000403"
/db_xref="InterPro:IPR001263"
/db_xref="InterPro:IPR001683"
/db_xref="InterPro:IPR002420"
/db_xref="InterPro:IPR011009"
/db_xref="InterPro:IPR015433"
/db_xref="InterPro:IPR016024"
/db_xref="InterPro:IPR018936"
/db_xref="InterPro:IPR029071"
/db_xref="InterPro:IPR035892"
/db_xref="InterPro:IPR036871"
/db_xref="InterPro:IPR036940"
/db_xref="InterPro:IPR037707"
/db_xref="InterPro:IPR042236"
/db_xref="PDB:2WWE"
/db_xref="UniProtKB/Swiss-Prot:O75747"
/protein_id="CAA03853.1"
/translation="MAYSWQTDPNPNESHEKQYEHQEFLFVNQPHSSSQVSLGFDQIV
DEISGKIPHYESEIDENTFFVPTAPKWDSTGHSLNEAHQISLNEFTSKSRELSWHQVS
KAPAIGFSPSVLPKPQNTNKECSWGSPIGKHHGADDSRFSILAPSFTSLDKINLEKEL
ENENHNYHIGFESSIPPTNSSFSSDFMPKEENKRSGHVNIVEPSLMLLKGSLQPGMWE
STWQKNIESIGCSIQLVEVPQSSNTSLASFCNKVKKIRERYHAADVNFNSGKIWSTTT
AFPYQLFSKTKFNIHIFIDNSTQPLHFMPCANYLVKDLIAEILHFCTNDQLLPKDHIL
SVCGSEEFLQNDHCLGSHKMFQKDKSVIQLHLQKSREAPGKLSRKHEEDHSQFYLNQL
LEFMHIWKVSRQCLLTLIRKYDFHLKYLLKTQENVYNIIEEVKKICSVLGCVETKQIT
DAVNELSLILQRKGENFYQSSETSAKGLIEKVTTELSTSIYQLINVYCNSFYADFQPV
NVPRCTSYLNPGLPSHLSFTVYAAHNIPETWVHRINFPLEIKSLPRESMLTVKLFGIA
CATNNANLLAWTCLPLFPKEKSILGSMLFSMTLQSEPPVEMITPGVWDVSQPSPVTLQ
IDFPATGWEYMKPDSEENRSNLEEPLKECIKHIARLSQKQTPLLLSEEKKRYLWFYRF
YCNNENCSLPLVLGSAPGWDERTVSEMHTILRRWTFSQPLEALGLLTSSFPDQEIRKV
AVQQLDNLLNDELLEYLPQLVQAVKFEWNLESPLVQLLLHRSLQSIQVAHRLYWLLKN
AENEAYFKSWYQKLLAALQFCAGKALNDEFSKEQKLIKILGDIGERVKSASDHQRQEV
LKKEIGRLEEFFQDVNTCHLPLNPALCIKGIDHDACSYFTSNALPLKITFINANLMGK
NISIIFKAGDDLRQDMLVLQLIQVMDNIWLQEGLDMQMIIYRCLSTGKDQRLVQMVPD
AVTLAKIHRHSGLIGPLKENTIKKWFSQHNHLKADYEKALRNFFYSCAGWCVVTFILG
VCDRHNDNIMLTKSGHMFHIDFGKFLGHAQTFGGIKRDRAPFIFTSEMEYFITEGGKN
PQHFQDFVELCCRAYNIIRKHSQLLLNLLEMMLYAGLPELSGIQDLKYVYNNLRPQDT
DLEATSHFTKKIKESLECFPVKLNNLIHTLAQMSAISPAKSTSQTFPQESCLLSTTRS
IERAILGFSKKSSNLYLIQVTHSNNETSLTEKSFEQFSKLHSQLQKQFASLTLPEFPH
WWHLPFTNSDHRRFRDLNHYMEQILNVSHEVTNSDCVLSFFLSEAVQQTVESSPVYLG
EKKFPDKKPKVQLVISYEDVKLTILVKHMKNIHLPDGSAPSAHVEFYLLPYPSEVLRR
KTKSVPKCTDPTYNEIVVYDEVTELQGHVLMLIVKSKTVFVGAINIRLCSVPLDKEKW
YPLGNSIISPLL"
BASE COUNT 1600 a 959 c 929 g 1392 t
ORIGIN
1 ggctcgagcg gccgcccggg caggttgaga tcgtgtttca tttcaggaag atatatgcgt
61 caggaaaatt tctatcttct tttgtattat caaggagata tttggagcag agtcaaccct
121 ctcagttaca taaaataaaa aatggcatat tcttggcaaa cggatccaaa tcctaatgaa
181 tcacacgaaa agcagtatga acaccaagaa tttctctttg taaatcaacc ccattcttct
241 agccaagtca gtctgggttt tgatcagata gtagatgaga tcagtggcaa aattccacac
301 tacgagagtg aaattgatga aaacaccttt tttgtgccca ctgcaccaaa atgggactca
361 acagggcatt cattaaatga agcacaccaa atatccttga atgaattcac ttctaaaagc
421 cgtgaactct cctggcatca agttagcaaa gcaccagcaa ttggttttag tccttctgtg
481 ttaccaaaac ctcaaaatac gaataaagaa tgctcctggg gaagccccat aggaaaacat
541 catggtgctg atgattccag attcagtatt ttagctccat cattcacaag tttggataaa
601 attaatctag agaaagaatt agaaaatgaa aatcataact accatatagg atttgaaagt
661 agcattcctc caacaaattc atccttctca agtgacttca tgccgaaaga agagaataaa
721 aggagtggac atgtgaacat tgtggaacca tctttgatgc ttttgaaagg ctctcttcaa
781 cccggaatgt gggaaagtac atggcagaag aatatagagt caataggttg ttccattcag
841 ctagtggaag tacctcaaag cagcaatacg agtctggcct ctttttgcaa caaagtaaaa
901 aaaatcagag aaagatatca tgcagctgat gttaatttca attctgggaa gatctggagc
961 actactacag catttccgta tcagctcttt tctaagacca agtttaatat acatattttt
1021 attgataact caacacaacc tcttcatttt atgccatgtg ctaattatct tgtcaaagat
1081 ctaattgcag aaattctgca tttttgcaca aatgaccagc tactccccaa agatcatatt
1141 ctaagtgtat gtggctctga agaattttta caaaacgacc actgtttggg gagccacaaa
1201 atgtttcaaa aagataaatc tgttattcag ctccacctgc agaaaagtag ggaagctcca
1261 ggaaagctat ctcgaaagca tgaagaggac cacagtcagt tttatctgaa tcaacttcta
1321 gaatttatgc atatttggaa agtatccaga caatgtctct taacactcat cagaaaatat
1381 gacttccacc tgaaatacct attgaaaacc caggaaaacg tgtataatat tattgaagaa
1441 gttaaaaaaa tatgcagtgt tctagggtgt gtggaaacca aacaaattac agatgcagta
1501 aatgaactaa gtctaattct tcagagaaaa ggagagaatt tttatcaaag ttcagagact
1561 tcagcaaaag gcttgataga gaaggtaaca actgaactat ccacatccat ctaccagcta
1621 atcaatgtct actgtaacag cttttatgca gattttcagc ctgtaaatgt acctagatgc
1681 acttcctatc taaatcccgg gcttccttcc cacctcagct tcacagtgta tgcagcacac
1741 aacattccag aaacctgggt gcacaggatc aattttcccc ttgaaataaa gtcacttcca
1801 agggaatcca tgctcactgt aaaactgttt gggattgcct gtgcaaccaa caatgcaaat
1861 ttactggcgt ggacttgtct tccactgttt ccaaaagaaa aatccattct cgggtctatg
1921 ctgttcagca tgacattaca gagtgagcct cccgtagaaa tgataactcc aggagtgtgg
1981 gatgtaagtc agccatcccc ggtgaccctg cagattgatt ttccagctac tgggtgggag
2041 tatatgaaac ctgattctga agagaataga agtaatcttg aagagccact aaaggagtgt
2101 ataaaacata ttgccagact ttcacagaaa cagactcccc tactactctc tgaagaaaag
2161 aaaagatatt tatggtttta tcgcttctac tgcaataatg aaaactgctc ccttccttta
2221 gtcctgggta gtgcccctgg atgggatgaa aggactgttt cagaaatgca taccattttg
2281 agaagatgga cattttctca acctttagag gctcttgggc ttttgacttc cagttttcca
2341 gatcaagaaa ttcgtaaagt ggcagttcaa caattagaca acctcttgaa tgatgaacta
2401 ctggaatatc tcccacagct agttcaggct gtcaagtttg aatggaacct tgagagtcct
2461 ttagtgcaac ttctactcca ccgctccttg cagagcatcc aggttgccca tcgtctttac
2521 tggctgctaa aaaatgcaga aaatgaagct tattttaaaa gctggtatca gaagctacta
2581 gctgctctcc aattctgtgc aggtaaagcc ttgaatgatg agttttccaa ggagcagaaa
2641 cttatcaaaa ttctgggaga tattggggaa agagtcaagt ctgccagtga ccatcaaaga
2701 caggaggtac tgaagaaaga aattggcaga ctagaagagt tctttcaaga tgtaaatact
2761 tgtcatcttc ctctgaaccc tgccctatgt ataaaaggga ttgatcacga tgcatgttca
2821 tattttacat ctaatgcttt gccattgaag attactttca tcaatgctaa tctgatgggc
2881 aaaaacatca gcattatttt taaggctgga gatgatcttc gtcaggatat gcttgttctg
2941 cagcttattc aagtgatgga caatatttgg ctgcaggaag gcttggatat gcaaatgatc
3001 atttatagat gtctatccac aggaaaagac caacgattgg tgcagatggt acctgatgct
3061 gtgaccctag caaagattca tcgccattct ggactgatag gaccattgaa agaaaatacc
3121 attaaaaagt ggttcagtca gcacaaccac ttaaaggcag attatgaaaa ggccttgagg
3181 aactttttct actcctgtgc tggctggtgt gtggtaacat tcatcctggg agtatgtgac
3241 cgtcacaatg ataatatcat gctgacaaag tcgggccaca tgtttcatat tgactttgga
3301 aaattcttag gtcatgcaca aacatttgga gggataaaaa gggaccgagc tcctttcatt
3361 tttacttcag agatggaata ctttattaca gagggtggga aaaacccaca gcattttcaa
3421 gattttgtgg aactttgctg tcgtgcttat aatattatca gaaagcacag ccaactgctc
3481 ttgaacctgc tggaaatgat gctgtatgca ggactgcctg agctaagtgg aattcaagac
3541 ctgaaatatg tgtataataa tcttcgtcca caagacacag acctggaagc aacaagtcat
3601 tttaccaaga aaataaagga aagtctggag tgtttccctg ttaaattgaa taacttgatc
3661 cacacacttg cacaaatgtc agccataagc cctgccaaat ctacttcaca gacttttcct
3721 caggaatcct gtttgctgag tacaactagg tcgattgaaa gagcaatttt agggttcagc
3781 aagaaatcca gtaatctgta tctgatccag gtgacacaca gcaacaacga aacaagcctg
3841 acagaaaaat catttgagca gttttcaaaa cttcacagcc aacttcagaa gcagtttgca
3901 tcactgactc tcccagagtt tcctcattgg tggcacctac cttttacaaa ttcagatcac
3961 agaagattca gagatctaaa tcattacatg gaacagatat taaatgtatc acatgaagtt
4021 acaaacagtg attgtgtact tagctttttc ctctctgagg ctgtgcaaca aacagttgaa
4081 tcatcacctg tgtacctagg tgagaagaag tttccagaca agaagcctaa ggtgcagtta
4141 gtcatatcct acgaggatgt gaagctgacc atactagtga aacacatgaa aaacattcat
4201 ctcccagatg gctctgcgcc cagtgcacat gttgaatttt atcttttacc atatcccagt
4261 gaagttctga ggaggaaaac aaaatctgtt ccaaaatgta cggaccccac ttacaatgaa
4321 attgtagtat atgatgaagt cacagagctc caaggacatg tcttaatgct tattgtgaag
4381 agtaaaactg tatttgtggg agcaattaac atccgactct gtagtgtccc actcgataaa
4441 gaaaaatggt atccattagg aaacagtata atttcaccat tgctatgaac atatgcatta
4501 ttcattaact acttgtattt tttcacttcc gggcctctga atcacataag taaggcatct
4561 ttgttgtcaa agacagcaca gggtattaag gacacagaaa aaaaatcaga attagtcttt
4621 tgtgttgttt attttctacc tgtgctttca ttgttttttc ataatctttt ctccttcagt
4681 ggagtactga ttgcatgaaa tttgatgtgt aaaataataa aagaccttta attaatcatt
4741 ttaatatatt ttaaattaaa cataggttta catttgtttt aattgtgtgc ctacagttaa
4801 aagcagtatt tttaatgtat tttataagaa agacaatcaa ataaacctca tcaattaatt
4861 caaaaaaaaa aaaaaaaaaa
//