LOCUS AH006514 7597 bp DNA linear HUM 10-JUN-2016
DEFINITION Homo sapiens chromosome 22 aconitate hydratase (ACO2) gene,
complete cds.
ACCESSION AH006514 U87926 U87927 U87928 U87929 U87930 U87931 U87932 U87933
U87934 U87935 U87936 U87937 U87938 U87939
VERSION AH006514.2
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 7597)
AUTHORS Mirel,D.B., Marder,K., Graziano,J., Freyer,G., Zhao,Q., Mayeux,R.
and Wilhelmsen,K.C.
TITLE Characterization of the human mitochondrial aconitase gene (ACO2)
JOURNAL Gene 213 (1-2), 205-218 (1998)
PUBMED 9630632
REFERENCE 2 (bases 1 to 7597)
AUTHORS Mirel,D.B. and Wilhelmsen,K.C.
TITLE Direct Submission
JOURNAL Submitted (30-JAN-1997) Ernest Gallo Clinic and Research Center,
University of California, San Francisco, SFGH Bldg1, Room 101; 1001
Potrero Avenue, San Francisco, CA 94110, USA
COMMENT On or before Jun 10, 2016 this sequence version replaced U87926.1,
U87927.1, U87928.1, U87929.1, U87930.1, U87931.1, U87932.1,
U87933.1, U87934.1, U87935.1, U87936.1, U87937.1, U87938.1,
U87939.1, AH006514.1.
FEATURES Location/Qualifiers
source 1..7597
/organism="Homo sapiens"
/mol_type="genomic DNA"
/db_xref="taxon:9606"
/chromosome="22"
/map="22q13"
gene 197..7597
/gene="ACO2"
mRNA join(197..252,655..791,1182..1440,1674..1766,2057..2215,
2446..2596,2870..2974,3283..3374,3704..3809,4042..4199,
4415..4488,4726..4837,5142..5264,5486..5641,5865..6056,
6324..6456,6789..6910,7359..>7597)
/gene="ACO2"
/product="aconitate hydratase"
exon 197..252
/gene="ACO2"
/number=1
CDS join(217..252,655..791,1182..1440,1674..1766,2057..2215,
2446..2596,2870..2974,3283..3374,3704..3809,4042..4199,
4415..4488,4726..4837,5142..5264,5486..5641,5865..6056,
6324..6456,6789..6910,7359..7493)
/gene="ACO2"
/codon_start=1
/product="aconitate hydratase"
/protein_id="AAC39921.1"
/translation="MAPYSLLVTRLQKALGVRQYHVASVLCQRAKVAMSHFEPNEYIH
YDLLEKNINIVRKRLNRPLTLSEKIVYGHLDDPASQEIERGKSYLRLRPDRVAMQDAT
AQMAMLQFISSGLSKVAVPSTIHCDHLIEAQVGGEKDLRRAKDINQEVYNFLATAGAK
YGVGFWKPGSGIIHQIILENYAYPGVLLIGTDSHTPNGGGLGGICIGVGGADAVDVMA
GIPWELKCPKVIGVKLTGSLSGWSSPKDVILKVAGILTVKGGTGAIVEYHGPGVDSIS
CTGMATICNMGAEIGATTSVFPYNHRMKKYLSKTGREDIANLADEFKDHLVPDPGCHY
DQLIEINLSELKPHINGPFTPDLAHPVAEVGKVAEKEGWPLDIRVGLIGSCTNSSYED
MGRSAAVAKQALAHGLKCKSQFTITPGSEQIRATIERDGYAQILRDLGGIVLANACGP
CIGQWDRKDIKKGEKNTIVTSYNRNFTGRNDANPETHAFVTSPEIVTALAIAGTLKFN
PETDYLTGTDGKKFRLEAPDADELPKGEFDPGQDTYQHPPKDSSGQHVDVSPTSQRLQ
LLEPFDKWDGKDLEDLQILIKVKGKCTTDHISAAGPWLKFRGHLDNISNNLLIGAINI
ENGKANSVRNAVTQEFGPVPDTARYYKKHGIRWVVIGDENYGEGSSREHAALEPRHLG
GRAIITKSFARIHETNLKKQGLLPLTFADPADYNKIHPVDKLTIQGLKDFTPGKPLKC
IIKHPNGTQETILLNHTFNETQIEWFRAGSALNRMKELQQ"
intron 253..>374
/gene="ACO2"
/number=1
gap 375..474
/estimated_length=unknown
intron <475..654
/gene="ACO2"
/number=1
exon 655..791
/gene="ACO2"
/number=2
intron 792..>897
/gene="ACO2"
/number=2
gap 898..997
/estimated_length=unknown
intron <998..1181
/gene="ACO2"
/number=2
exon 1182..1440
/gene="ACO2"
/number=3
intron 1441..>1497
/gene="ACO2"
/number=3
gap 1498..1597
/estimated_length=unknown
intron <1598..1673
/gene="ACO2"
/number=3
exon 1674..1766
/gene="ACO2"
/number=4
intron 1767..>1898
/gene="ACO2"
/number=4
gap 1899..1998
/estimated_length=unknown
intron <1999..2056
/gene="ACO2"
/number=4
exon 2057..2215
/gene="ACO2"
/number=5
intron 2216..2445
/gene="ACO2"
/number=5
exon 2446..2596
/gene="ACO2"
/number=6
intron 2597..>2684
/gene="ACO2"
/number=6
gap 2685..2784
/estimated_length=unknown
intron <2785..2869
/gene="ACO2"
/number=6
exon 2870..2974
/gene="ACO2"
/number=7
intron 2975..>3110
/gene="ACO2"
/number=7
gap 3111..3210
/estimated_length=unknown
intron <3211..3282
/gene="ACO2"
/number=7
exon 3283..3374
/gene="ACO2"
/number=8
intron 3375..>3534
/gene="ACO2"
/number=8
repeat_region 3456..3527
/gene="ACO2"
/rpt_family="ALU"
gap 3535..3634
/estimated_length=unknown
intron <3635..3703
/gene="ACO2"
/number=8
exon 3704..3809
/gene="ACO2"
/number=9
intron 3810..>3891
/gene="ACO2"
/number=9
gap 3892..3991
/estimated_length=unknown
intron <3992..4041
/gene="ACO2"
/number=9
exon 4042..4199
/gene="ACO2"
/number=10
intron 4200..4414
/gene="ACO2"
/number=10
exon 4415..4488
/gene="ACO2"
/number=11
intron 4489..>4545
/gene="ACO2"
/number=11
gap 4546..4645
/estimated_length=unknown
intron <4646..4725
/gene="ACO2"
/number=11
exon 4726..4837
/gene="ACO2"
/number=12
intron 4838..>4967
/gene="ACO2"
/number=13
gap 4968..5067
/estimated_length=unknown
intron <5068..5141
/gene="ACO2"
/number=12
exon 5142..5264
/gene="ACO2"
/number=13
intron 5265..5485
/gene="ACO2"
/number=13
exon 5486..5641
/gene="ACO2"
/number=14
intron 5642..>5726
/gene="ACO2"
/number=14
gap 5727..5826
/estimated_length=unknown
intron <5827..5864
/gene="ACO2"
/number=14
exon 5865..6056
/gene="ACO2"
/number=15
intron 6057..>6157
/gene="ACO2"
/number=15
gap 6158..6257
/estimated_length=unknown
intron <6258..6323
/gene="ACO2"
/number=15
exon 6324..6456
/gene="ACO2"
/number=16
intron 6457..>6535
/gene="ACO2"
/number=16
gap 6536..6635
/estimated_length=unknown
intron <6636..6788
/gene="ACO2"
/number=16
exon 6789..6910
/gene="ACO2"
/number=17
intron 6911..7358
/gene="ACO2"
/number=17
exon 7359..>7597
/gene="ACO2"
/number=18
BASE COUNT 1315 a 1826 c 1859 g 1297 t
ORIGIN
1 ctatttctgc aagtgtcttt gggcagtccg atttcctctt gcgtgtctgt tcgttgcacg
61 tgcgtccgcc cattgcgttc acagggttct ggcgcctcta gggagcctcg ccttcaccgt
121 gacgccccac tcttccggca cgcccctgcc caaaggcttt aaaggcgccg tgtgggacgt
181 cactttaatg cgacctcatc tttgtcagtg cacaaaatgg cgccctacag cctactggtg
241 actcggctgc aggtgagcga gctcagggac ctctgggttc acgggggcgg ggtgctccta
301 ctgtgccggc ggtgtgggcg aggcagggcg aggcgggccc aacctggggc caacttctcg
361 tgtacctgtc ccggnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
421 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnngctgtg
481 ttccttgtgg ctgctttgtc atccctgtcc tgcagatgag gaagctgagg ctgcagttac
541 tgaacagctc ttgacacttt aattcctgga tttttttcac catactgagc tgccctcggg
601 gatggactct cctaagtgct ccattgacag tggctgtcat gtttcttctt gcagaaagct
661 ctgggtgtgc ggcagtacca tgtggcctca gtcctgtgcc aacgggccaa ggtggcgatg
721 agccactttg agcccaacga gtacatccat tatgacctgc tagagaagaa cattaacatt
781 gttcgcaaac ggtaaggctg cagatgggag gctgtgactg tcaagggcat tgcgtctgct
841 gcctgcccgt cagcagagaa ggaggtgttt tgtgaaggat gcttggtgat agtggcannn
901 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
961 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnagg tgaggaggtg gtgcagtgaa
1021 caggacccag cagtcccacc aagtggaacg ttgaggtcct gagttcagac tccctgtccc
1081 tggccactgt tgaggttgcc acatggactg agagggagag gcagggcggg aggaggccgt
1141 gcagctagca ccaggccacc cttctgctct tctccccaca gactgaaccg gccgctgaca
1201 ctctcggaga agattgtgta tggacacctg gatgaccccg ccagccagga aattgagcga
1261 ggcaagtcgt acctgcggct gcggccggac cgtgtggcca tgcaggatgc gacggcccag
1321 atggccatgc tccagttcat cagcagcggg ctgtccaagg tggctgtgcc atccaccatc
1381 cactgtgacc atctgattga agcccaggtt gggggcgaga aagacctgcg ccgggccaag
1441 gtgagcagaa ggtggctttg ggggtgggca agtgggcaag actgggcgag aggctcannn
1501 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
1561 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnggt ggggagggct tggtgagggt
1621 cacctggaca caaaccatgt tgctaacgcc caattattga tttgtctcaa taggacatca
1681 accaggaagt ttataatttc ctggcaactg caggtgccaa atatggcgtg ggcttctgga
1741 agcctggatc tggaatcatt caccaggtaa agctgggctc agtctgccgt cccaagggcc
1801 caagcagaga agtatgttcc aggcctatgg ggggaggggg tttgaggccc aggggcgtga
1861 ggggaactgg atgacatatc catcagctct tatgctctnn nnnnnnnnnn nnnnnnnnnn
1921 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
1981 nnnnnnnnnn nnnnnnnnat tttttggtat tctcggctga gggcttctaa atataacatc
2041 ttggattatt tttcagatta ttctggaaaa ctatgcgtac cctggtgttc ttctgattgg
2101 cactgactcc cacaccccca atggtggcgg ccttgggggc atctgcattg gagttggggg
2161 tgccgatgct gtggatgtca tggctgggat cccctgggag ctgaagtgcc ccaaggtgag
2221 ggtggggagg gactcattct gggctggctg tggggtggtg gttggtgggg atgaacggga
2281 gacggtggga cccaggagga aaagggaaca agttagactc gaatcttctg ggagggaggt
2341 agagaccaat aagcagcaat gtgaatggca gcagggccat cctgacttcg tggctggcac
2401 aggcacacac ggcctctcac agccgcctcg ccccctcctg tccaggtgat tggcgtgaag
2461 ctgacgggct ctctctccgg ttggtcctca cccaaagatg tgatcctgaa ggtggcaggc
2521 atcctcacgg tgaaaggtgg cacaggtgca atcgtggaat accacgggcc tggtgtagac
2581 tccatctcct gcactggtga ggaaggcggc caggcgacgt ggcccctacc ctgtgctggg
2641 cctgatgggt ctccagttgg gagtagaagc ggtgaagtgg ccttnnnnnn nnnnnnnnnn
2701 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
2761 nnnnnnnnnn nnnnnnnnnn nnnntgtgaa gatgcaggtg gccgcgtagc aggtgtgtgg
2821 gaccctggcc cggccaccag ccaatgcccg gggctctgtt gctccacagg catggcgaca
2881 atctgcaaca tgggtgcaga aattggggcc accacttccg tgttccctta caaccacagg
2941 atgaagaagt acctgagcaa gaccggccgg gaaggtgagc tggcaggggc aggccgtgtg
3001 ggtggaacag tcacatgccc gctcctcccc aagacagagc tatgcctttc cctgtaggca
3061 ggggttctta acccattgtc tccagacagg cgtccgaggc tctgagaaag nnnnnnnnnn
3121 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
3181 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn tgatggtgtg atgaatctct caagaacagt
3241 ttatgtttca cgtgctccat ccccgtccct tgttgatttc agacattgcc aatctagctg
3301 atgaattcaa ggatcacttg gtgcctgacc ctggctgcca ttatgaccaa ctaattgaaa
3361 ttaacctcag tgaggtgagg agacaattaa ctgggttcaa gaagtttctg agagtagtgg
3421 ggagcagggc gggtcctgcc taaatactca ctgagggccg ggtggtggct cacagctgta
3481 atcccagcac tttgggaggc caaggcaggt gggtcagttg aggtcagcag ttcannnnnn
3541 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
3601 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnaagagg ctgtccccgc ttcaaggttt
3661 cttccctcct ctctttcttc tccttgcatg tttgtttctt cagctgaagc cacacatcaa
3721 tgggcccttc acccctgacc tggctcaccc tgtggcagaa gtgggcaagg tggcagagaa
3781 ggaaggatgg cctctggaca tccgagtggg tgagcacctt ccaccccatc tgtttagcag
3841 gtctcagggc cagtggctct gccagggctg tagacaatca cctatgccta cnnnnnnnnn
3901 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
3961 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn ntgctcactg tctcctcctg acccttaacc
4021 ccaccaccca caatgcacca ggtctaattg gtagctgcac caattcaagc tatgaagata
4081 tggggcgctc agcagctgtg gccaagcagg cactggccca tggcctcaag tgcaagtccc
4141 agttcaccat cactccaggt tccgagcaga tccgcgccac cattgagcgg gacggctatg
4201 tgagtgccca tatcccccct gcccatctcc cccaccccat gctgagtaat cctccaggcg
4261 cacaagccag aggcctgttg ggccggggct ggggcaggtc ccagtggctg ccctggggtt
4321 ccagtacagc acttcgtcct gcagccacca catcacccct tcccatcaga ctctcaccca
4381 cccttgacat tctgtcttcc tctctccctg gcaggcacag atcttgaggg atctgggtgg
4441 cattgtcctg gccaatgctt gtggcccctg cattggccag tgggacaggt aagagcatat
4501 ctttttaaga cagcccttgt gcacagggta cagagcccca gaagtnnnnn nnnnnnnnnn
4561 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
4621 nnnnnnnnnn nnnnnnnnnn nnnnnggaac ccagcttatc tgtcctcggg acaggccagg
4681 tgacaaggcc agatatccct aaccctgatc cctctgacct ggcaggaagg acatcaagaa
4741 gggggagaag aacacaatcg tcacctccta caacaggaac ttcacgggcc gcaacgacgc
4801 aaaccccgag acccatgcct ttgtcacgtc cccagaggtg agactgccca gctgcgcaca
4861 agcctgggat ggcctctggg ggtccctggc gggtcagagg aggaggcaga aggagatggg
4921 gactggggtc atccaagtgg tagccaggag ctacaggcct tcccagcnnn nnnnnnnnnn
4981 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
5041 nnnnnnnnnn nnnnnnnnnn nnnnnnncta ggcttttggt aggtgcagga gacaggagtg
5101 gcaattggtg ctgaccaaca aactggccac ctccatttca gattgtcaca gccctggcca
5161 ttgcgggaac cctcaagttc aacccagaga ccgactacct gacgggcacg gatggcaaga
5221 agttcaggct ggaggctccg gatgcagatg agcttcccaa aggggtgagc gcccacgccc
5281 cctgcttgct ggttgctgtg tggccacgtc acttccttct caacctcaca gcacctcctg
5341 tgcaggaagg gaggcgctgc tagtgagaag gaagcagctc tgttcctggg aggggaggtg
5401 ggcccgagga aacttgcctt ctgagagtct gtccttgtgg gaactgagga ctcagcaccc
5461 cacgcatccc cattccctgc tgcaggagtt tgacccaggg caggacacct accagcaccc
5521 acccaaggac agcagcgggc agcatgtgga cgtgagcccc accagccagc gcctgcagct
5581 cctggagcct tttgacaagt gggatggcaa ggacctggag gacctgcaga tcctcatcaa
5641 ggtcagcagc atggggacgg caggacagcc ccaccctgcc aggccccccg tccccctgag
5701 catcgggaag ggccatgaac ctggagnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
5761 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
5821 nnnnnncatg ccctgacctc tgtcctctct acttaccacc caaggtcaaa gggaagtgta
5881 ccactgacca catctcagct gctggcccct ggctcaagtt ccgtgggcac ttggataaca
5941 tctccaacaa cctgctcatt ggtgccatca acattgaaaa cggcaaggcc aactccgtgc
6001 gcaatgccgt cactcaggag tttggccccg tccctgacac tgcccgctac tacaaggtgg
6061 gtcagagttg ataggggcaa tgcagtgggt cactcctaag gggcctgcaa cgagtgcagg
6121 gaggacatta ggggagtgga aactggaagg aggccgannn nnnnnnnnnn nnnnnnnnnn
6181 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
6241 nnnnnnnnnn nnnnnnntag ggccagacag gtgaggacgg tgccctcctc tgccttataa
6301 ccttaccccc gcttgcctga cagaaacatg gcatcaggtg ggtggtgatc ggagacgaga
6361 actacggcga gggctcgagc cgggagcatg cagctctgga gcctcgccac cttgggggcc
6421 gggccatcat caccaagagc tttgccagga tccacggtga gctggagtct gtacccaggc
6481 catcctcatc ccatccctag tgatcaaggt cactctccct gcccgtggct gagttnnnnn
6541 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
6601 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnncctag tgaaagggag cagaccaggg
6661 ccccatagtc actgcccggg cattgtccca ggcacaggat tagggcatct cccagagccc
6721 agatgggttc agaaaataac tctccaggct agtcaggccc ccgatgaccg aatgccgcct
6781 gctttcagag accaacctga agaaacaggg cctgctgcct ctgaccttcg ctgacccggc
6841 tgactacaac aagattcacc ctgtggacaa gctgaccatt cagggcctga aggacttcac
6901 ccctggcaag gttaggccgg tccccctgag gtgggtgggg tgaggggcag ccaccttgtt
6961 tcccctcctg cactggcccc agggtagctt ctcccaggag gcttcattcc agctggaaag
7021 gcccccagtt ctccaggtgg ccccacagag aaagcaaagt ggcttctcag agttgggggt
7081 tggagtcaac ccggggccct cacacctccc caacctccct ttactcacca ggacctggca
7141 ctcaggggac agcccaccca ctgcacggac cctctgggcc ccaggaatcc cctgtaggtg
7201 ccacctgggt ctgacctggc catcaggcac agactggcct aggatttggt ttgcctgctg
7261 acctcttagg tccccagcag tgccctgtct ccctgacctg cggggcaacg ggcacacagt
7321 acccaccact tccacccaca cccaccttct ccttgaagcc cctgaagtgc atcatcaagc
7381 accccaacgg gacccaggag accatcctcc tgaaccacac cttcaacgag acgcagattg
7441 agtggttccg cgctggcagt gccctcaaca gaatgaagga actgcaacag tgagggcagt
7501 gcctccccgc cgcgctggcg tcaagttcag ctccacgtgt gccatcagtg gatccgatcc
7561 gtccagccat ggcttcctat tccaagtagt gtaaccc
//