LOCUS AH012204 4365 bp DNA linear HUM 10-JUN-2016
DEFINITION Homo sapiens cob(I)alamin adenosyltransferase (MMAB) gene, complete
cds.
ACCESSION AH012204 AF550396 AF550397 AF550398 AF550399 AF550400 AF550401
AF550402 AF550403 AF550404
VERSION AH012204.2
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 4365)
AUTHORS Dobson,C.M., Wai,T., Leclerc,D., Kadir,H., Narang,M.,
Lerner-Ellis,J.P., Hudson,T.J., Rosenblatt,D.S. and Gravel,R.A.
TITLE Identification of the gene responsible for the cblB complementation
group of vitamin B12-dependent methylmalonic aciduria
JOURNAL Hum. Mol. Genet. 11 (26), 3361-3369 (2002)
PUBMED 12471062
REFERENCE 2 (bases 1 to 4365)
AUTHORS Dobson,C.M., Wai,T., Leclerc,D., Kadir,H., Narang,M.A.,
Lernerr-Ellis,J.P., Hudson,T.J., Rosenblatt,D.S. and Gravel,R.A.
TITLE Direct Submission
JOURNAL Submitted (09-OCT-2002) Biochemistry and Molecular Biology,
University of Calgary, Rm 250 Alberta Heritage Medical Research
Building, 3330 Hospital Drive NW, Calgary, Alberta T2N4N1, Canada
COMMENT On or before Jun 10, 2016 this sequence version replaced
AF550396.1, AF550397.1, AF550398.1, AF550399.1, AF550400.1,
AF550401.1, AF550402.1, AF550403.1, AF550404.1, AH012204.1.
FEATURES Location/Qualifiers
source 1..4365
/organism="Homo sapiens"
/mol_type="genomic DNA"
/db_xref="taxon:9606"
gene <110..>4071
/gene="MMAB"
/note="responsible for methylmalonic aciduria linked to
complementation group cblB"
mRNA join(<110..243,600..661,999..1092,1527..1584,1953..2025,
2374..2471,2931..2995,3514..3573,3963..>4071)
/gene="MMAB"
/product="cob(I)alamin adenosyltransferase"
CDS join(110..243,600..661,999..1092,1527..1584,1953..2025,
2374..2471,2931..2995,3514..3573,3963..4071)
/gene="MMAB"
/codon_start=1
/product="cob(I)alamin adenosyltransferase"
/protein_id="AAN85091.1"
/translation="MAVCGLGSRLGLGSRLGLRGCFGAARLLYPRFQSRGPQGVEDGD
RPQPSSKTPRIPKIYTKTGDKGFSSTFTGERRPKDDQVFEAVGTTDELSSAIGFALEL
VTEKGHTFAEELQKIQCTLQDVGSALATPCSSAREAHLKYTTFKAGPILELEQWIDKY
TSQLPPLTAFILPSGGKISSALHFCRAVCRRAERRVVPLVQMGETDANVAKFLNRLSD
YLFTLARYAAMKEGNQEKIYMKNDPSAESEGL"
exon <110..243
/gene="MMAB"
/number=1
gap 366..465
/estimated_length=unknown
exon 600..661
/gene="MMAB"
/number=2
gap 770..869
/estimated_length=unknown
exon 999..1092
/gene="MMAB"
/number=3
gap 1208..1307
/estimated_length=unknown
exon 1527..1584
/gene="MMAB"
/number=4
gap 1665..1764
/estimated_length=unknown
exon 1953..2025
/gene="MMAB"
/number=5
gap 2104..2203
/estimated_length=unknown
exon 2374..2471
/gene="MMAB"
/number=6
gap 2590..2689
/estimated_length=unknown
exon 2931..2995
/gene="MMAB"
/number=7
gap 3174..3273
/estimated_length=unknown
exon 3514..3573
/gene="MMAB"
/number=8
gap 3704..3803
/estimated_length=unknown
exon 3963..>4071
/gene="MMAB"
/number=9
BASE COUNT 817 a 945 c 1017 g 786 t
ORIGIN
1 accaataaaa attgaaacct gagcggtggc gcggccagct gtgggtggag tcaccccgcg
61 gactggacgg gaacctggcg gggtcaggtc ccgtcaagca gcctggctca tggctgtgtg
121 cggcctgggg agccgtcttg gcctggggag ccgtcttggc ctgcgcgggt gcttcggcgc
181 cgccaggctc ctgtatcccc gtttccagag ccgcggccct cagggcgtgg aagacgggga
241 caggtgagtg gctggcggga agggcaactc gaacacctgc cgtgaatcgt ggtgtcgtcg
301 ccatgggtac gtcacaccgc cgtgaggtca ccgcggcaac cgtcaggtga cgtctccacg
361 ctgttnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
421 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnagatg accatctaag
481 cagtaagggg taagtgctgc ctctgaggtt acaagcagca agctgggacc ctctgaagga
541 gctgaccctc tgtgtaagcc atccccactc accagatact gatgtttatt tctcattagg
601 ccacagcctt cctcgaagac acccaggatc cccaagattt acaccaaaac gggagacaaa
661 ggtagggtgg ggacaggtga aaaatgcaaa gaaatactca tggcatacac cattttaaag
721 ttcttccaaa ttctttgcag ccactttaaa gtataatata ccaggcgcgn nnnnnnnnnn
781 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
841 nnnnnnnnnn nnnnnnnnnn nnnnnnnnng cctggatgac agagtgactg ttcaaaaaag
901 agaaagttct ttaaaatctt tgaaagttta aaaaaaaaaa aacagcatat caggaaaaca
961 gaatcttaat ttgggtggct aaacattttt ttccacaggg ttttctagta ccttcacagg
1021 agaaaggaga cccaaagatg accaagtgtt tgaagccgtg ggaactacag atgaattaag
1081 ttcagctatt gggtaagggg gacaggattg gccttgaggt tgcgtttgag tcgagtatga
1141 gtaaacgtaa tgaatgtgaa gctctcacgc atgctgggca gcagcctcgg aggttgtcag
1201 cccttatnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
1261 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnngac tggaaataat
1321 gagcatccga aaaggcattt caagaaacaa ataccaccgc ccccaaatgg aaggctataa
1381 tgttcttatt gttagcaaga aaaataacat ggctattata gctaaattaa ctaaatggcc
1441 tgccacctga gaatctattg tttatggcaa gacagggcct agggacatta cattacaggc
1501 aaattctttt tcctttttct tcataggttt gctctggaat tagtcacaga aaagggccat
1561 acatttgccg aagagcttca gaaagtgagt aacaccatct cacccaagct gggaatcttc
1621 agccccggtg gccatcacgg gactcagcat ccagccacca gttannnnnn nnnnnnnnnn
1681 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
1741 nnnnnnnnnn nnnnnnnnnn nnnncacctc caactctggg gatcacaatt taacatgaga
1801 tttggatggg gacacattgc caaaccatat cacagccctt catgagctag ctggcacagg
1861 ctttgccggc gtattaggtg gcgcctctgc acattgtctc tgtccagccc atctcacata
1921 gatcttgact gtcactttct gtcgcccccc agatccagtg cacattgcag gacgtcggct
1981 cggccctggc gacaccatgc tcctcggccc gggaggctca cttaagtaat tctcaaactc
2041 ctgtgggtgt tcagagggcc ctagggtcag gggactctcc tagggtcacc atctgggatc
2101 ccannnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
2161 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnncacgggt gggtcagtta
2221 gccttgctcg tagctcctgg gagggaaggt accttctgag ccagtggaag cagtctgcgg
2281 gacacccagg tggaagggcg gcgggggtgg ttcccgccat ggtctggtgg gtgatggcct
2341 catggcagtt ccctctgctc cttggctcct cagagtatac cacgttcaag gcggggccca
2401 tcctggagct ggagcagtgg atcgacaagt acaccagcca gctcccacca ctcacggcct
2461 tcatcctgcc tgtaggtact gggcaggctt aaccgggggc ggctgcaggc aggttcagtg
2521 acagacacac atgggctctg aataaatccc tcttttcaca gtgacagacg ctgtcctcca
2581 gttccccaan nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
2641 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnna tccctctttt
2701 cacagtgaca gacgctgtcc tccagttccc caagtccctc caggtcctca ccggtccctc
2761 ccagccctgc ccactctgga gcagcgtgcc cggtgggtgt gccgtggcag ggctcctgga
2821 ggcagaacac tgcccggttt ggggggcagg gctggacttc agaggagctc ctgtccgcag
2881 tgggcacacc tttcccaccc tgctcaggca atgtcccttt ctcctttcag tcgggaggca
2941 agatcagctc ggcgctgcat ttctgccggg ccgtgtgccg ccgggccgag agacggtaag
3001 agggctggag agagggagag ggcccaaggg agagggagag gaacaagggg gaggggggag
3061 ggagagggag aggaggacgg tagatgggga gagggagagg ggcctctgca cagcgggcag
3121 gaggcaggta cagcagggcc atctctgagc catccagcca cacatcaaca gacnnnnnnn
3181 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
3241 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnctcacca gccatccttg atccctcctt
3301 ggccaggccg tcctgcgatg tgctggtgga aagggggccg atggcctgtt taaacccacc
3361 tgtgatggat ttgtcatctc cactgccggc cgagcctgtg caggttcagg ttgagcggtg
3421 gcaggatgtg aaatgctgct caaggtttag gcccaggtca gagcctgttg agccccataa
3481 tgtcacgtga ctcagtgtct cctccctttc tagtgtggtg cctcttgtcc agatgggaga
3541 gaccgatgcg aacgtggcca agttcttaaa caggtactcg cgtggaacct gggggttcct
3601 ctctgaaagc cgaggctcat ctgtgggaag tagcagcggt gcagcggtcc gggaagcagt
3661 gtggggcagc attcccgcac cccctccttc attcccttag tgtnnnnnnn nnnnnnnnnn
3721 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
3781 nnnnnnnnnn nnnnnnnnnn nnncattaag tgcaagatgg ctgggccccc gccctccctg
3841 cacaatgtgc ccagagtgcg tcatttatat ctcctccttg taggcggata tgggaagacc
3901 cagttagcgt tgatctctca tttcaaacca ttctgtttgc ttctctctct ctgcccctcc
3961 agactcagtg actatctctt cacgctagcc agatatgcag ccatgaagga ggggaatcaa
4021 gagaaaatat acatgaaaaa tgacccatcg gccgagtctg agggactctg aaatcacaga
4081 aagtgggagc ttggaggatc cctccatggc gatggccgtg gagagaggag cttgcccttc
4141 tggggtcctg gttcctgaag agctcaccca gagaggctca aagcagcctt ttgtcccagc
4201 tcagctttga tctacacctc ttgccacctt cctcaaggga ctgtgaccct ttggggattc
4261 tgtccctgac cctgcttccc caagctctcc tgggtcttgg agggatgtgg gaatgaattg
4321 gcattgcagg aaagacaggt aaagtgattg ctgcaatgag aagga
//