LOCUS AF536977 2220 bp mRNA linear HUM 24-JUL-2003
DEFINITION Homo sapiens cAMP-specific phosphodiesterase PDE4D8 (PDE4D) mRNA,
complete cds; alternatively spliced.
ACCESSION AF536977
VERSION AF536977.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2220)
AUTHORS Wang,D., Deng,C., Bugaj-Gaweda,B., Kwan,M., Gunwaldsen,C.,
Leonard,C., Xin,X., Hu,Y., Unterbeck,A. and De Vivo,M.
TITLE Cloning and characterization of novel PDE4D isoforms PDE4D6 and
PDE4D7
JOURNAL Cell. Signal. 15 (9), 883-891 (2003)
PUBMED 12834813
REFERENCE 2 (bases 1 to 2220)
AUTHORS Wang,D., Bugaj-Gaweda,B., Kwan,M., Unterbeck,A. and De Vivo,M.
TITLE Direct Submission
JOURNAL Submitted (12-AUG-2002) Discovery Research, Memory Pharmaceuticals
Corp., 100 Philips Parkway, Montvale, NJ 07645, USA
FEATURES Location/Qualifiers
source 1..2220
/db_xref="H-InvDB:HIT000081435"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="5"
gene 1..2220
/gene="PDE4D"
CDS 56..2119
/gene="PDE4D"
/note="alternatively spliced"
/codon_start=1
/product="cAMP-specific phosphodiesterase PDE4D8"
/protein_id="AAN10119.1"
/translation="MAFVWDPLGATVPGPSTRAKSRLRFSKSYSFDVDNGTSAGRSPL
DPMTSPGSGLILQANFVHSQRRESFLYRSDSDYDLSPKSMSRNSSIASDIHGDDLIVT
PFAQVLASLRTVRNNFAALTNLQDRAPSKRSPMCNQPSINKATITEEAYQKLASETLE
ELDWCLDQLETLQTRHSVSEMASNKFKRMLNRELTHLSEMSRSGNQVSEFISNTFLDK
QHEVEIPSPTQKEKEKKKRPMSQISGVKKLMHSSSLTNSSIPRFGVKTEQEDVLAKEL
EDVNKWGLHVFRIAELSGNRPLTVIMHTIFQERDLLKTFKIPVDTLITYLMTLEDHYH
ADVAYHNNIHAADVVQSTHVLLSTPALEAVFTDLEILAAIFASAIHDVDHPGVSNQFL
INTNSELALMYNDSSVLENHHLAVGFKLLQEENCGIFQNLTKKQRQSLRKMVIDIVLA
TDMSKHMNLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLQNMVHCADLSNPTKPLQL
YRQWTDRIMEEFFRQGDRERERGMEISPMCDKHNASVEKSQVGFIDYIVHPLWETWAD
LVHPDAQDILDTLEDNREWYQSTIPQSPSPAPDDPEEGRQGQTEKFQFELTLEEDGES
DTEKDSGSQVEEDTSCSDSKTLCTQDSESTEIPLDEQVEEEAVGEEEESQPEACVIDD
RSPDT"
BASE COUNT 652 a 509 c 500 g 559 t
ORIGIN
1 ccgcaccagc tctgacttct cgtggttcct ggggatctgg catcgtccat taaaaatggc
61 ttttgtttgg gatcctctgg gagccacggt gccaggacca tctacaagag ccaaatcaag
121 attgcgtttc tcaaagtcct acagttttga tgtggacaat ggcacatctg cgggacggag
181 tcccttggat cccatgacca gcccaggatc cgggctaatt ctccaagcaa attttgtcca
241 cagtcaacga cgggagtcct tcctgtatcg atccgacagc gattatgacc tctctccaaa
301 gtctatgtcc cggaactcct ccattgccag tgatatacac ggagatgact tgattgtgac
361 tccatttgct caggtcttgg ccagtctgcg aactgtacga aacaactttg ctgcattaac
421 taatttgcaa gatcgagcac ctagcaaaag atcacccatg tgcaaccaac catccatcaa
481 caaagccacc ataacagagg aggcctacca gaaactggcc agcgagaccc tggaggagct
541 ggactggtgt ctggaccagc tagagaccct acagaccagg cactccgtca gtgagatggc
601 ctccaacaag tttaaaagga tgcttaatcg ggagctcacc catctctctg aaatgagtcg
661 gtctggaaat caagtgtcag agtttatatc aaacacattc ttagataagc aacatgaagt
721 ggaaattcct tctccaactc agaaggaaaa ggagaaaaag aaaagaccaa tgtctcagat
781 cagtggagtc aagaaattga tgcacagctc tagtctgact aattcaagta tcccaaggtt
841 tggagttaaa actgaacaag aagatgtcct tgccaaggaa ctagaagatg tgaacaaatg
901 gggtcttcat gttttcagaa tagcagagtt gtctggtaac cggcccttga ctgttatcat
961 gcacaccatt tttcaggaac gggatttatt aaaaacattt aaaattccag tagatacttt
1021 aattacatat cttatgactc tcgaagacca ttaccatgct gatgtggcct atcacaacaa
1081 tatccatgct gcagatgttg tccagtctac tcatgtgcta ttatctacac ctgctttgga
1141 ggctgtgttt acagatttgg agattcttgc agcaattttt gccagtgcaa tacatgatgt
1201 agatcatcct ggtgtgtcca atcaatttct gatcaataca aactctgaac ttgccttgat
1261 gtacaatgat tcctcagtct tagagaacca tcatttggct gtgggcttta aattgcttca
1321 ggaagaaaac tgtggcattt tccagaattt gaccaaaaaa caaagacaat ctttaaggaa
1381 aatggtcatt gacatcgtac ttgcaacaga tatgtcaaaa cacatgaatc tactggctga
1441 tttgaagact atggttgaaa ctaagaaagt gacaagctct ggagttcttc ttcttgataa
1501 ttattccgat aggattcagg ttcttcagaa tatggtgcac tgtgcagatc tgagcaaccc
1561 aacaaagcct ctccagctgt accgccagtg gacggaccgg ataatggagg agttcttccg
1621 ccaaggagac cgagagaggg aacgtggcat ggagataagc cccatgtgtg acaagcacaa
1681 tgcttccgtg gaaaaatcac aggtgggctt catagactat attgttcatc ccctctggga
1741 gacatgggca gacctcgtcc accctgacgc ccaggatatt ttggacactt tggaggacaa
1801 tcgtgaatgg taccagagca caatccctca gagcccctct cctgcacctg atgacccaga
1861 ggagggccgg cagggtcaaa ctgagaaatt ccagtttgaa ctaactttag aggaagatgg
1921 tgagtcagac acggaaaagg acagtggcag tcaagtggaa gaagacacta gctgcagtga
1981 ctccaagact ctttgtactc aagactcaga gtctactgaa attccccttg atgaacaggt
2041 tgaagaggag gcagtagggg aagaagagga aagccagcct gaagcctgtg tcatagatga
2101 tcgttctcct gacacgtaac agtgcaaaaa ctttcatgcc tttttttttt ttaagtagaa
2161 aaattgtttc caaagtgcat gtcacatgcc acaaccacgg tcacacctca ctgtcatctg
//