LOCUS AF536216 3983 bp mRNA linear HUM 09-JUL-2003
DEFINITION Homo sapiens sodium solute symporter family 5 member 8 protein
(SLC5A8) mRNA, complete cds.
ACCESSION AF536216
VERSION AF536216.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 3983)
AUTHORS Li,H., Myeroff,L., Smiraglia,D., Romero,M.F., Pretlow,T.P.,
Kasturi,L., Lutterbaugh,J., Rerko,R.M., Casey,G., Issa,J.P.,
Willis,J., Willson,J.K., Plass,C. and Markowitz,S.D.
TITLE SLC5A8, a sodium transporter, is a tumor suppressor gene silenced
by methylation in human colon aberrant crypt foci and cancers
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 100 (14), 8412-8417 (2003)
PUBMED 12829793
REFERENCE 2 (bases 1 to 3983)
AUTHORS Li,H., Myeroff,L., Kasturi,L., Lutterbaugh,J., Smiraglia,D.,
Plass,C., Issa,J.-P., Willson,J., Romero,M. and Markowitz,S.
TITLE Direct Submission
JOURNAL Submitted (07-AUG-2002) Molecular Biology and Microbiology, Case
Western Reserve University, 11001 Cedar Ave., Cleveland, OH 44106,
USA
FEATURES Location/Qualifiers
source 1..3983
/db_xref="H-InvDB:HIT000243748"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="12"
/map="12q22-q23"
gene 1..3983
/gene="SLC5A8"
CDS 364..2196
/gene="SLC5A8"
/note="colon cancer methylation target"
/codon_start=1
/product="sodium solute symporter family 5 member 8
protein"
/protein_id="AAP46193.1"
/translation="MDTPRGIGTFVVWDYVVFAGMLVISAAIGIYYAFAGGGQQTSKD
FLMGGRRMTAVPVALSLTASFMSAVTVLGTPSEVYRFGAIFSIFAFTYFFVVVISAEV
FLPVFYKLGITSTYEYLELRFNKCVRLCGTVLFIVQTILYTGIVIYAPALALNQVTGF
DLWGAVVATGVVCTFYCTLGGLKAVIWTDVFQIGIMVAGFASVIIQAVVMQGGISTIL
NDAYDGGRLNFWNFNPNPLQRHTFWTIIIGGTFTWTSIYGVNQSQVQRYISCKSRFQA
KLSLYINLVGLWAILTCSVFCGLALYSRYHDCDPWTAKKVSAPDQLMPYLVLDILQDY
PGLPGLFVACAYSGTLSTVSSSINALAAVTVEDLIKPYFRSLSERSLSWISQGMSVVY
GALCIGMAALASLMGALLQAALSVFGMVGGPLMGLFALGILVPFANSIGALVGLMAGF
AISLWVGIGAQIYPPLPERTLPLHLDIQGCNSTYNETNLITTTEMPFTTSVFQIYNVQ
RTPLMDNWYSLSYLYFSTVGTLVTLLVGILVSLSTGGRKQNLDPRYILTKEDFLSNFD
IFKKKKHVLSYKSHPVEDGGTDNPAFNHIELNSDQSGKSNGTRL"
BASE COUNT 1014 a 833 c 900 g 1236 t
ORIGIN
1 gtgtagattc gctggaagca gctggaggct ccagttctca tctgctcagg tgtccccggc
61 gccttggcga actcggccac tccagttcct cacgtggtga gcactcaggg cagcgggtcg
121 attttccgag gtcccatacc tgggtttgag gggcgcggct cgcagcggcg ggtgcagggg
181 cgactgccag ccctcacccc gcctcggggt gcgttcggag gccgacacct ggaggacgcc
241 tccagtcccc gcgggacgcc acgcctgcgc gccagggatc cgggataaga agtgcgcgcc
301 gggctccggc tgcgcgccgc ggggccacca gtttgcgcgc agggctcagg cgaccgtgcg
361 gccatggaca cgccacgggg catcggcacc ttcgtggtgt gggactacgt ggtgttcgcg
421 ggcatgctgg tcatctcggc cgccatcggc atctactacg ccttcgctgg gggcggccag
481 cagacctcca aggacttcct gatgggcggc cgcagaatga ccgcagtgcc cgtggcgctg
541 tccctcaccg ctagcttcat gtcagccgtc actgtcctgg gcaccccctc cgaggtctac
601 cgttttgggg ccatttttag catctttgcc ttcacctact tctttgtggt ggtcatcagc
661 gcggaggtct tcctcccggt gttctacaaa ctgggaatta ccagcaccta cgagtattta
721 gaacttcgat ttaacaaatg tgttcgtctc tgtggaacag tcctcttcat tgttcaaaca
781 attctgtata ctggaattgt tatttatgcc cctgccctgg ctttgaatca agtcacagga
841 tttgatctgt ggggcgcggt agtggcaacg ggggtggtct gcacattcta ctgcacactg
901 ggtggtctta aagcagttat ctggacagat gtttttcaaa ttgggatcat ggtggctgga
961 tttgcatccg tgattataca ggctgtggtg atgcaaggtg gaatcagcac tattttaaat
1021 gatgcctatg atggtggaag attaaatttc tggaatttta atcctaaccc tttgcaaaga
1081 cacaccttct ggacaattat tataggaggg accttcacat ggaccagcat ctacggtgtc
1141 aaccaatccc aggtgcagag atatatttct tgtaaaagca gattccaggc aaaactgtct
1201 ctctacatca atcttgtggg actctgggca atcctcacat gctcagtgtt ttgtgggctc
1261 gccctatatt ccaggtacca tgactgtgat ccttggacag ccaagaaagt gtctgcacca
1321 gaccagctca tgccttattt ggtactggac attctgcaag attatccagg acttcctgga
1381 ctttttgtgg cctgtgctta cagtgggaca ttaagcacag tgtcctccag tattaatgcc
1441 ttagcagcag taactgtgga agatctaatc aaaccttact tcagatcgct ctcagaaagg
1501 tctctgtctt ggatttccca aggaatgagt gtggtgtatg gagccctgtg tattggaatg
1561 gctgcgctgg cgtcacttat gggagctttg ttgcaggcag cactcagcgt atttggtatg
1621 gttggtggac cacttatggg cctgttcgct ttgggcattt tggttccctt tgccaactca
1681 attggagcac ttgttggtct gatggctgga tttgccattt ctctatgggt tggaattgga
1741 gctcaaatat atcctccact tcctgagaga acattgccat tgcaccttga tatccaaggc
1801 tgtaacagca cctacaatga gacaaatttg attacaacca cagaaatgcc atttactact
1861 agtgtttttc aaatatacaa tgttcaaagg actccactga tggataactg gtattcttta
1921 tcatatctgt acttcagcac tgttggaact ttggtaacat tattagtggg gatacttgtc
1981 agtttatcaa caggaggaag aaaacagaac ttagacccca gatatatact aaccaaagag
2041 gactttttat ccaattttga tatttttaag aaaaagaagc atgttttgag ctataaatca
2101 catccagtgg aagatggtgg aactgataat cctgctttca accacattga attgaactca
2161 gatcagagtg gcaagagcaa tgggactcgt ttgtgaagct gctctgatac tagatatcct
2221 taaatgatgt ttcaatttta tatgttttct aagataattg gatcaggttt tctttgtgtg
2281 tgtgtgtgtg tgttgtatca tgagtgtttg ggggataagt ttttgttaaa acaaagtctg
2341 gactatcttc atttactaca tcattaattg atgttactct ggagtttaga attctggcat
2401 tgacatttcc ctctctttcc tttatttcga tgaagctata attgtgaaaa ttgtaactac
2461 atagatgctg aaaggctaat acacacatat gcacatgtat ttgattgtca aaggtatatt
2521 cttaaatttg ggtattattg aaaatatttt ccatgccttg gtgctagcat ataagtttgg
2581 aagtttgcca acatcacaat tcatcttgaa aagagctttt ttccctccta ccacatacac
2641 cattcttagg gagcaatgag gtaacaggtc tgtgttgtct agatctttgc tttttatccc
2701 cctatcagtc cagggcatat actaacctgc aaactgattc tgaatcagga aggtggtaat
2761 caataagtat tctggctggg aaagaccgtg ggcccaatga tcaaagtctt cttggtgctg
2821 ttcattaatt cttgtgcctt ttggcttgtt ttctagagtt tctgggcttt ggctgctgat
2881 actgcctttc ttagactgta atttttatct gcatgcccag tttctgacct atcaacttgg
2941 gttttattgt gcactctaac tgagcttgtc ttcataattt tctgtttatt gccctgggct
3001 tggatatgtc tcaagacact catgtgaatc atgccacccc aaatcctggc ttatcaagtc
3061 ccagactata aattatgaac tcccattagc ttggtactaa catatacttg atgtaggtat
3121 ttatggactt gatgatccaa gaatattata ttcttcaaaa tggttaagct ccatggagtt
3181 agatgactac acttaatgct attaagttga acttttgaat gtcaactaat ttgcaatcaa
3241 ttaaagatac atatgcctag aaattttgaa atttcggtat atttatccag ttaaagggct
3301 aaattatata agcaaacact acttttttta aaacgtctgg actcaaaaaa tgctttgttc
3361 catgttttaa aatttttaag tagcagtctc aaagttgctt agctgtttat tttgctatgt
3421 tcctagctaa gagtttggtt ataggagttc atcaataact tattttttgt acagttccca
3481 cattagatac tgtttaaaag ttctttttta aactcaattt tttttagaaa cataagagaa
3541 atatttagat acatacaaat gtttttatga ttaaataatt ttatgcttat tttctgatac
3601 gtgttattta ggtaatcatg ccctgtacat ttagaggttg ctaactgaca atgttaagaa
3661 atttaaaaaa aaaaaaagcc tgggcatgat ggctcatgct tgtaatctga acatttggga
3721 ggctgaggca ggaagatcgc ttgaggtcca gagtttaagt ccagcctgga aacatagtta
3781 gacctcatct ctacaaaaat aaaaaataaa aataaaaaaa acttagctag gcatgttgcc
3841 acatacttgt agtcccagtt attagggaag ctgaggtggg aggatagctt aagcccagga
3901 tttcaaggct gcattgagct atgattacac cactgcactc cagcctgggt aacagagtga
3961 aatcttgtct ctgggaaaaa aaa
//