LOCUS AF527605 7522 bp mRNA linear HUM 04-SEP-2002
DEFINITION Homo sapiens zizimin1 mRNA, complete cds.
ACCESSION AF527605
VERSION AF527605.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 7522)
AUTHORS Meller,N., Irani-Tehrani,M., Kiosses,W.B., Del Pozo,M.A. and
Schwartz,M.A.
TITLE Zizimin1, a novel Cdc42 activator, reveals a new GEF domain for Rho
proteins
JOURNAL Nat. Cell Biol. 4 (9), 639-647 (2002)
PUBMED 12172552
REFERENCE 2 (bases 1 to 7522)
AUTHORS Meller,N. and Schwartz,M.A.
TITLE Direct Submission
JOURNAL Submitted (05-JUL-2002) Cell Biology, The Scripps Research
Institute, 10550 N. Torrey Pines Rd., La Jolla, CA 92037, USA
FEATURES Location/Qualifiers
source 1..7522
/db_xref="H-InvDB:HIT000081253"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="13"
CDS 56..6265
/note="guanine nucleotide exchange factor; Cdc42
activator"
/codon_start=1
/product="zizimin1"
/protein_id="AAM90306.1"
/translation="MSQPPLLPASAETRKFTRALSKPGTAAELRQSVSEVVRGSVLLA
KPKLIEPLDYENVIVQKKTQILNDCLREMLLFPYDDFQTAILRRQGRYICSTVPAKAE
EEAQSLFVTECIKTYNSDWHLVNYKYEDYSGEFRQLPNKVVKLDKLPVHVYEVDEEVD
KDEDAASLGSQKGGITKHGWLYKGNMNSAISVTMRSFKRRFFHLIQLGDGSYNLNFYK
DEKISKEPKGSIFLDSCMGVVQNNKVRRFAFELKMQDKSSYLLAADSEVEMEEWITIL
NKILQLNFEAAMQEKRNGDSHEDDEQSKLEGSGSGLDSYLPELAKSAREAEIKLKSES
RVKLFYLDPDAQKLDFSSAEPEVKSFEEKFGKRILVKCNDLSFNLQCCVAENEEGPTT
NVEPFFVTLSLFDIKYNRKISADFHVDLNHFSVRQMLATTSPALMNGSGQSPSVLKGI
LHEAAMQYPKQGIFSVTCPHPDIFLVARIEKVLQGSITHCAEPYMKSSDSSKVAQKVL
KNAKQACQRLGQYRMPFAWAARTLFKDASGNLDKNARFSAIYRQDSNKLSNDDMLKLL
ADFRKPEKMAKLPVILGNLDITIDNVSSDFPNYVNSSYIPTKQFETCSKTPITFEVEE
FVPCIPKHTQPYTIYTNHLYVYPKYLKYDSQKSFAKARNIAICIEFKDSDEEDSQPLK
CIYGRPGGPVFTRSAFAAVLHHHQNPEFYDEIKIELPTQLHEKHHLLLTFFHVSCDNS
SKGSTKKRDVVETQVGYSWLPLLKDGRVVTSEQHIPVSANLPSGYLGYQELGMGRHYG
PEIKWVDGGKPLLKISTHLVSTVYTQDQHLHNFFQYCQKTESGAQALGNELVKYLKSL
HAMEGHVMIAFLPTILNQLFRVLTRATQEEVAVNVTRVIIHVVAQCHEEGLESHLRSY
VKYAYKAEPYVASEYKTVHEELTKSMTTILKPSADFLTSNKLLKYSWFFFDVLIKSMA
QHLIENSKVKLLRNQRFPASYHHAVETVVNMLMPHITQKFRDNPEASKNANHSLAVFI
KRCFTFMDRGFVFKQINNYISCFAPGDPKTLFEYKFEFLRVVCNHEHYIPLNLPMPFG
KGRIQRYQDLQLDYSLTDEFCRNHFLVGLLLREVGTALQEFREVRLIAISVLKNLLIK
HSFDDRYASRSHQARIATLYLPLFGLLIENVQRINVRDVSPFPVNAGMTVKDESLALP
AVNPLVTPQKGSTLDNSLHKDLLGAISGIASPYTTSTPNINSVRNADSRGSLISTDSG
NSLPERNSEKSNSLDKHQQSSTLGNSVVRCDKLDQSEIKSLLMCFLYILKSMSDDALF
TYWNKASTSELMDFFTISEVCLHQFQYMGKRYIARTGMMHARLQQLGSLDNSLTFNHS
YGHSDADVLHQSLLEANIATEVCLTALDTLSLFTLAFKNQLLADHGHNPLMKKVFDVY
LCFLQKHQSETALKNVFTALRSLIYKFPSTFYEGRADMCAALCYEILKCCNSKLSSIR
TEASQLLYFLMRNNFDYTGKKSFVRTHLQVIISVSQLIADVVGIGGTRFQQSLSIINN
CANSDRLIKHTSFSSDVKDLTKRIRTVLMATAQMKEHENDPEMLVDLQYSLAKSYAST
PELRKTWLDSMARIHVKNGDLSEAAMCYVHVTALVAEYLTRKEAVQWEPPLLPHSHSA
CLRRSRGGVFRQGCTAFRVITPNIDEEASMMEDVGMQDVHFNEDVLMELLEQCADGLW
KAERYELIADIYKLIIPIYEKRRDFERLAHLYDTLHRAYSKVTEVMHSGRRLLGTYFR
VAFFGQAAQYQFTDSETDVEGFFEDEDGKEYIYKEPKLTPLSEISQRLLKLYSDKFGS
ENVKMIQDSGKVNPKDLDSKYAYIQVTHVIPFFDEKELQERKTEFERSHNIRRFMFEM
PFTQTGKRQGGVEEQCKRRTILTAIHCFPYVKKRIPVMYQHHTDLNPIEVAIDEMSKK
VAELRQLCSSAEVDMIKLQLKLQGSVSVQVNAGPLAYARAFLDDTNTKRYPDNKVKLL
KEVFRQFVEACGQALAVNERLIKEDQLEYQEEMKANYREMAKELSEIMHEQLG"
BASE COUNT 2146 a 1694 c 1774 g 1908 t
ORIGIN
1 gcggccgggc cgggccgcgg gagcaggcgg aggcggaggc ggcgggggca ggaggatgtc
61 gcagccgccg ctgctccccg cctcggcgga gactcggaag ttcacccggg cgctgagtaa
121 gccgggcacg gcggccgagc tgcggcagag cgtgtctgag gtggtgcgcg gctccgtgct
181 cctggcaaag ccaaagctaa ttgagccact cgactatgaa aatgtcatcg tccagaagaa
241 gactcagatc ctgaacgact gtttacggga gatgctgctc ttcccttacg atgactttca
301 gacggccatc ctgagacgac agggtcgata catatgctca acagtgcctg cgaaggcgga
361 agaggaagca cagagcttgt ttgttacaga gtgcatcaaa acctataact ctgactggca
421 tcttgtgaac tataaatatg aagattactc aggagagttt cgacagcttc cgaacaaagt
481 ggtcaagttg gataaacttc cagttcatgt ctatgaagtt gacgaggagg tcgacaaaga
541 tgaggatgct gcctcccttg gttcccagaa gggtgggatc accaagcatg gctggctgta
601 caaaggcaac atgaacagtg ccatcagcgt gaccatgagg tcatttaaga gacgattttt
661 ccacctgatt caacttggcg atggatccta taatttgaat ttttataaag atgaaaagat
721 ctccaaagaa ccaaaaggat caatatttct ggattcctgt atgggtgtcg ttcagaacaa
781 caaagtcagg cgttttgctt ttgagctcaa gatgcaggac aaaagtagtt atctcttggc
841 agcagacagt gaagtggaaa tggaagaatg gatcacaatt ctaaataaga tcctccagct
901 caactttgaa gctgcaatgc aagaaaagcg aaatggcgac tctcacgaag atgatgaaca
961 aagcaaattg gaaggttctg gttccggttt agatagctac ctgccggaac ttgccaagag
1021 tgcaagagaa gcagaaatca aactgaaaag tgaaagcaga gtcaaacttt tttatttgga
1081 cccagatgcc cagaagcttg acttctcatc agctgagcca gaagtgaagt catttgaaga
1141 gaagtttgga aaaaggatcc ttgtcaagtg caatgattta tctttcaatt tgcaatgctg
1201 tgttgccgaa aatgaagaag gacccactac aaatgttgaa cctttctttg ttactctatc
1261 cctgtttgac ataaaataca accggaagat ttctgccgat ttccacgtag acctgaacca
1321 tttctcagtg aggcaaatgc tcgccaccac gtccccggcg ctgatgaatg gcagtgggca
1381 gagcccatct gtcctcaagg gcatccttca tgaagccgcc atgcagtatc cgaagcaggg
1441 aatattttca gtcacttgtc ctcatccaga tatatttctt gtggccagaa ttgaaaaagt
1501 ccttcagggg agcatcacac attgcgctga gccatatatg aaaagttcag actcttctaa
1561 ggtggcccag aaggtgctga agaatgccaa gcaggcatgc caaagactag gacagtatag
1621 aatgccattt gcttgggcag caaggacatt gtttaaggat gcatctggaa atcttgacaa
1681 aaatgccaga ttttctgcca tctacaggca agacagcaat aagctatcca atgatgacat
1741 gctcaagtta cttgcagact ttcggaaacc tgagaagatg gctaagctcc cagtgatttt
1801 aggcaatcta gacattacaa ttgataatgt ttcctcagac ttccctaatt atgttaattc
1861 atcatacatt cccacaaaac aatttgaaac ctgcagtaaa actcccatca cgtttgaagt
1921 ggaggaattt gtgccctgca taccaaaaca cactcagcct tacaccatct acaccaatca
1981 cctttacgtt tatcctaagt acttgaaata cgacagtcag aagtcttttg ccaaggctag
2041 aaatattgcg atttgcattg aattcaaaga ttcagatgag gaagactctc agccccttaa
2101 gtgcatttat ggcagacctg gtgggccagt tttcacaaga agcgcctttg ctgcagtttt
2161 acaccatcac caaaacccag aattttatga tgagattaaa atagagttgc ccactcagct
2221 gcatgaaaag caccacctgt tgctcacatt cttccatgtc agctgtgaca actcaagtaa
2281 aggaagcacg aagaagaggg atgtcgttga aacccaagtt ggctactcct ggcttcccct
2341 cctgaaagac ggaagggtgg tgacaagcga gcagcacatc ccggtctcgg cgaaccttcc
2401 ttcgggctat cttggctacc aggagcttgg gatgggcagg cattatggtc cggaaattaa
2461 atgggtagat ggaggcaagc cactgctgaa aatttccact catctggttt ctacagtgta
2521 tactcaggat cagcatttac ataatttttt ccagtactgt cagaaaaccg aatctggagc
2581 ccaagcctta ggaaacgaac ttgtaaagta ccttaagagt ctgcatgcga tggaaggcca
2641 cgtgatgatc gccttcttgc ccactatcct aaaccagctg ttccgagtcc tcaccagagc
2701 cacacaggaa gaagtcgcgg ttaacgtgac tcgggtcatt attcatgtgg ttgcccagtg
2761 ccatgaggaa ggattggaga gccacttgag gtcatatgtt aagtacgcgt ataaggctga
2821 gccatatgtt gcctctgaat acaagacagt gcatgaagaa ctgaccaaat ccatgaccac
2881 gattctcaag ccttctgccg atttcctcac cagcaacaaa ctactgaagt actcatggtt
2941 tttctttgat gtactgatca aatctatggc tcagcatttg atagagaact ccaaagttaa
3001 gttgctgcga aaccagagat ttcctgcatc ctatcatcat gcagtggaaa ccgttgtaaa
3061 tatgctgatg ccacacatca ctcagaagtt tcgagataat ccagaggcat ctaagaacgc
3121 gaatcatagc cttgctgtct tcatcaagag atgtttcacc ttcatggaca ggggctttgt
3181 cttcaagcag atcaacaact acattagctg ttttgctcct ggagacccaa agaccctctt
3241 tgaatacaag tttgaatttc tccgtgtagt gtgcaaccat gaacattata ttccgttgaa
3301 cttaccaatg ccatttggaa aaggcaggat tcaaagatac caagacctcc agcttgacta
3361 ctcattaaca gatgagttct gcagaaacca cttcttggtg ggactgttac tgagggaggt
3421 ggggacagcc ctccaggagt tccgggaggt ccgtctgatc gccatcagtg tgctcaagaa
3481 cctgctgata aagcattctt ttgatgacag atatgcttca aggagccatc aggcaaggat
3541 agccaccctc tacctgcctc tgtttggtct gctgattgaa aacgtccagc ggatcaatgt
3601 gagggatgtg tcacccttcc ctgtgaacgc gggcatgact gtgaaggatg aatccctggc
3661 tctaccagct gtgaatccgc tggtgacgcc gcagaaggga agcaccctgg acaacagcct
3721 gcacaaggac ctgctgggcg ccatctccgg cattgcttct ccatatacaa cctcaactcc
3781 aaacatcaac agtgtgagaa atgctgattc gagaggatct ctcataagca cagattcggg
3841 taacagcctt ccagaaagga atagtgagaa gagcaattcc ctggataagc accaacaaag
3901 tagcacattg ggaaattccg tggttcgctg tgataaactt gaccagtctg agattaagag
3961 cctactgatg tgtttcctct acatcttaaa gagcatgtct gatgatgctt tgtttacata
4021 ttggaacaag gcttcaacat ctgaacttat ggattttttt acaatatctg aagtctgcct
4081 gcaccagttc cagtacatgg ggaagcgata catagccaga acaggaatga tgcatgccag
4141 attgcagcag ctgggcagcc tggataactc tctcactttt aaccacagct atggccactc
4201 ggacgcagat gttctgcacc agtcattact tgaagccaac attgctactg aggtttgcct
4261 gacagctctg gacacgcttt ctctatttac attggcgttt aagaaccagc tcctggccga
4321 ccatggacat aatcctctca tgaaaaaagt ttttgatgtc tacctgtgtt ttcttcaaaa
4381 acatcagtct gaaacggctt taaaaaatgt cttcactgcc ttaaggtcct taatttataa
4441 gtttccctca acattctatg aagggagagc ggacatgtgt gcggctctgt gttacgagat
4501 tctcaagtgc tgtaactcca agctgagctc catcaggacg gaggcctccc agctgctcta
4561 cttcctgatg aggaacaact ttgattacac tggaaagaag tcctttgtcc ggacacattt
4621 gcaagtcatc atatctgtca gccagctgat agcagacgtt gttggcattg ggggaaccag
4681 attccagcag tccctgtcca tcatcaacaa ctgtgccaac agtgaccggc ttattaagca
4741 caccagcttc tcctctgatg tgaaggactt aaccaaaagg atacgcacgg tgctaatggc
4801 caccgcccag atgaaggagc atgagaacga cccagagatg ctggtggacc tccagtacag
4861 cctggccaaa tcctatgcca gcacgcccga gctcaggaag acgtggctcg acagcatggc
4921 caggatccat gtcaaaaatg gcgatctctc agaggcagca atgtgctatg tccacgtaac
4981 agccctagtg gcagaatatc tcacacggaa agaagcagtc cagtgggagc cgccccttct
5041 cccccacagc catagcgcct gcctgaggag gagccgggga ggcgtgttta gacaaggatg
5101 caccgccttc agggtcatta ccccaaacat cgacgaggag gcctccatga tggaagacgt
5161 ggggatgcag gatgtccatt tcaacgagga tgtgctgatg gagctccttg agcagtgcgc
5221 agatggactc tggaaagccg agcgctacga gctcattgcc gacatctaca aacttatcat
5281 ccccatttat gagaagcgga gggattttga gaggctggcc catctgtatg acacgctgca
5341 ccgggcctac agcaaagtga ccgaggtcat gcactcgggc cgcaggcttc tggggaccta
5401 cttccgggta gccttcttcg ggcaggcagc gcaataccag tttacagaca gtgaaacaga
5461 tgtggaggga ttctttgaag atgaagatgg aaaggagtat atttacaagg aacccaaact
5521 cacaccgctg tcggaaattt ctcagagact ccttaaactg tactcggata aatttggttc
5581 tgaaaatgtc aaaatgatac aggattctgg caaggtcaac cctaaggatc tggattctaa
5641 gtatgcctac atccaggtga ctcacgtcat ccccttcttt gacgaaaaag agttgcaaga
5701 aaggaaaaca gagtttgaga gatcccacaa catccgccgc ttcatgtttg agatgccatt
5761 tacgcagacc gggaagaggc agggcggggt ggaagagcag tgcaaacggc gcaccatcct
5821 gacagccata cactgcttcc cttatgtgaa gaagcgcatc cctgtcatgt accagcacca
5881 cactgacctg aaccccatcg aggtggccat tgacgagatg agtaagaagg tggcggagct
5941 ccggcagctg tgctcctcgg ccgaggtgga catgatcaaa ctgcagctca aactccaggg
6001 cagcgtgagt gttcaggtca atgctggccc actagcatat gcgcgagctt tcttagatga
6061 tacaaacaca aagcgatatc ctgacaataa agtgaagctg cttaaggaag ttttcaggca
6121 atttgtggaa gcttgcggtc aagccttagc ggtaaacgaa cgtctgatta aagaagacca
6181 gctcgagtat caggaagaaa tgaaagccaa ctacagggaa atggcgaagg agctttctga
6241 aatcatgcat gagcagctgg gatgatctgc cccctggagg agaagacgag cgtcttaccg
6301 aattcccttc acatcttcaa cgccatcagt gggactccaa caagcacaat ggttcacggg
6361 atgaccagct cgtcttcggt cgtgtgatta catctcatgg cccgtgtgtg gggacttgct
6421 ttgtcatttg caaactcagg atgctttcca aagccaatca ctggggagac cgagcacagg
6481 gaggaccagg ggaaggggag agaaaggaaa taaagaacaa cgttatttct taacagactt
6541 tctataggag ttgtaagaag gtgcacatat ttttttaaat ctcactggca atattcaaag
6601 ttttcattgt gtcttaacaa aggtgtggta gacactcttg agctggactt agattttatt
6661 cttccttgca gagtagtgtt agaatagatg gcctacagaa aaaaaaggtt ctgggatcta
6721 catggcaggg agggctgcac tgacattgat gcctggggga ccttttgcct cgaggctgag
6781 ctggaaaatc ttgaaaatat tttttttttc ctgtggcaca ttcaggttga atacaagaac
6841 tatttttgtg actagttttt gatgacctaa gggaactgac cattgtaatt tttgtaccag
6901 tgaaccagga gatttagtgc ttttatattc atttccttgc atttaagaaa atatgaaagc
6961 ttaaggaatt atgtgagctt aaaactagtc aagcagttta gaaccaaagg cctatattaa
7021 taaccgcaac tatgctgaaa agtacaaagt agtacagtat attgttatgt acatatcatt
7081 gttaatacag tcctggcatt ctgtacatat atgtattaca tttctacatt tttaatactc
7141 acatgggctt atgcattaag tttaattgtg ataaatttgt gctgttccag tatatgcaat
7201 acactttaat gttttattct tgtacataaa aatgtgcaat atggagatgt atacagtctt
7261 tactatatta ggtttataaa cagttttaag aatttcatcc ttttgccaaa atggtggagt
7321 atgtaattgg taaatcataa atcctgtggt gaatggtggt gtactttaaa gctgtcacca
7381 tgttatattt tcttttaaga cattaattta gtaattttat atttgggaaa ataaaggttt
7441 ttaattttat ttaactggaa tcactgccct gctgtaatta aacattctgt accacatctg
7501 tattaaaaag acattgctga cc
//