LOCUS AF525689 2992 bp mRNA linear HUM 02-DEC-2002
DEFINITION Homo sapiens signal peptide-CUB-EGF-like domain containing protein
1 (SCUBE1) mRNA, complete cds.
ACCESSION AF525689
VERSION AF525689.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2992)
AUTHORS Yang,R.B., Ng,C.K., Wasserman,S.M., Colman,S.D., Shenoy,S.,
Mehraban,F., Komuves,L.G., Tomlinson,J.E. and Topper,J.N.
TITLE Identification of a novel family of cell-surface proteins expressed
in human vascular endothelium
JOURNAL J. Biol. Chem. 277 (48), 46364-46373 (2002)
PUBMED 12270931
REFERENCE 2 (bases 1 to 2992)
AUTHORS Yang,R.-B., Ng,C.K.D., Wasserman,S.M., Colman,S.D., Shenoy,S.,
Mehraban,F., Komuves,L., Tomlinson,J.E. and Topper,J.N.
TITLE Direct Submission
JOURNAL Submitted (28-JUN-2002) Vascular Biology, Millennium
Pharmaceuticals, Inc., 256 E. Grand Ave., South San Francisco, CA
94080, USA
FEATURES Location/Qualifiers
source 1..2992
/db_xref="H-InvDB:HIT000081238"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
gene 1..2992
/gene="SCUBE1"
CDS 21..2987
/gene="SCUBE1"
/note="endothelial secreted and cell-surface protein;
contains signal peptide at the N-terminus followed by ten
EGF-like domains and one CUB domain at the C-terminus"
/codon_start=1
/product="signal peptide-CUB-EGF-like domain containing
protein 1"
/protein_id="AAN77133.1"
/translation="MGAAAVRWHLCVLLALGTRGRLAGGSGLPGSVDVDECSEGTDDC
HIDAICQNAPKSYKCLCKPGYKGEGKQCGDIDECENDYYNGGCVHECINIPGNYRCTC
FDGFMLAHDGHNCLDVDECQDNNGGCQQICVNAMGSYECQCHSGFFLSDNQHTCIHRS
NEGMNCMNKDHGCAHICRETPKGGVACDCRPGFDLAQNQKDCTLTCNYGNGGCQHSCE
DTDTGPTCGCHQKYAPHSDGRTCIETCAVNNGGCDRTCKDTATGVRCSCPVGFTLQPD
GKTCKDINECLVNNGGCDHFCRNTVGSFECGCRKGYKLLTDERTCQDIDECSFERTCD
HICINSPGSFQCLCHRGYILYGTTHCGDVDECSMSNGSCDQGCVNTKGSYECVCPPGR
RLHWNRKDCVETGKCLSRAKTSPRAQLSCSKAGGVESCFLSCPAHTLFVPDSENSYVL
SCGVPGPQGKALQKRNGTSSGLGPSCSDAPTTPIKQKARFKIRDAKCHLRPHSQARAK
ETARQPLLDHCHVTFVTLKCDSSKKRRRGRKSPSKEVSHITAEFEIETKMEEASDTCE
ADCLRKRAEQSLQAAIKTLRKSIGRQQFYVQVSGTEYEVAQRPAKALEGQGACGAGQV
LQDSKCVACGPGTHFGGELGQCVPCMPGTYQDMEGQLSCTPCPSSDGLGLPGARNVSE
CGGQCSPGFFSADGFKPCQACPVGTYQPEPGRTGCFPCGGGLLTKHEGTTSFQDCEAK
VHCSPGHHYNTTTHRCIRCPVGTYQPEFGQNHCITCPGNTSTDFDGSTNVTHCKNQHC
GGELGDYTGYIESPNYPGDYPANAECVWHIAPPPKRRILIVVPEIFLPIEDECGDVLV
MRKSASPTSITTYETCQTYERPIAFTSRSRKLWIQFKSNEGNSGKGFQVPYVTYDEDY
QQLIEDIVRDGRLYASENHQEILKDKKLIKALFDVLAHPQNYFKYTAQESKEMFPRSF
IKLLRSKVSRFLRPYK"
BASE COUNT 672 a 961 c 864 g 495 t
ORIGIN
1 cagcggggcc cgcattgagc atgggcgcgg cggccgtgcg ctggcacttg tgcgtgctgc
61 tggccctggg cacacgcggg cggctggccg ggggcagcgg gctcccaggg tcagtcgacg
121 tggatgagtg ctcagagggc acagatgact gccacatcga tgccatctgt cagaacgcgc
181 ccaagtccta caaatgcctc tgcaagccag gctacaaggg ggaaggcaag cagtgtggag
241 acattgacga gtgtgagaat gactactaca atgggggctg tgtccacgag tgcatcaaca
301 tcccggggaa ctacaggtgt acctgctttg atggcttcat gctggcacac gatggacaca
361 actgcctgga tgtggacgag tgtcaggaca ataatggtgg ctgccagcag atctgcgtca
421 atgccatggg cagctacgag tgtcagtgcc acagtggctt cttccttagt gacaaccagc
481 atacctgcat ccaccgctcc aatgagggta tgaactgcat gaacaaagac catggctgtg
541 cccacatctg ccgggagacg cccaaaggtg gggtggcctg cgactgcagg cccggctttg
601 accttgccca aaaccagaag gactgcacac taacctgtaa ttatggaaac ggaggctgcc
661 agcacagctg tgaggacaca gacacaggcc ccacgtgtgg ttgccaccag aagtacgccc
721 cccactcaga cggtcgcacg tgcatcgaga cgtgcgcagt caataacgga ggctgcgacc
781 ggacatgcaa ggacacagcc actggcgtgc gatgcagctg ccccgttgga ttcacactgc
841 agccggacgg gaagacatgc aaagacatca acgagtgcct ggtcaacaac ggaggctgcg
901 accacttctg ccgcaacacc gtaggcagct tcgagtgcgg ctgccggaag ggctacaagc
961 tgctcaccga cgagcgcacc tgccaggaca tcgacgagtg ctccttcgag cggacctgtg
1021 accacatctg catcaactcc ccgggcagct tccagtgcct gtgtcaccgc ggctacatcc
1081 tctacgggac aacccactgc ggagatgtgg acgagtgcag catgagcaac gggagctgtg
1141 accagggctg cgtcaacacc aagggcagct acgagtgcgt ctgtcccccg gggaggcggc
1201 tccactggaa ccggaaggat tgcgtggaga caggcaagtg tctttctcgc gccaagacct
1261 ccccccgggc ccagctgtcc tgcagcaagg caggcggtgt ggagagctgc ttcctttcct
1321 gcccggctca cacactcttc gtgccagact cggaaaatag ctacgtcctg agctgcggag
1381 ttccagggcc gcagggcaag gcgctgcaga aacgcaacgg caccagctct ggcctcgggc
1441 ccagctgctc agatgccccc accaccccca tcaaacagaa ggcccgcttc aagatccgag
1501 atgccaagtg ccacctccgg ccccacagcc aggcacgagc aaaggagacc gccaggcagc
1561 cgctgctgga ccactgccat gtgactttcg tgaccctcaa gtgtgactcc tccaagaaga
1621 ggcgccgtgg ccgcaagtcc ccatccaagg aggtgtccca cattacagca gagtttgaga
1681 tcgagacaaa gatggaagag gcctcagaca catgcgaagc ggactgcttg cggaagcgag
1741 cagaacagag cctgcaggcc gccatcaaga ccctgcgcaa gtccatcggc cggcagcagt
1801 tctatgtcca ggtctcaggc actgagtacg aggtagccca gaggccagcc aaggcgctgg
1861 aggggcaggg ggcatgtggc gcaggccagg tgctacagga cagcaaatgc gttgcctgtg
1921 ggcctggcac ccacttcggt ggtgagctcg gccagtgtgt gccatgtatg ccaggaacat
1981 accaggacat ggaaggccag ctcagttgca caccgtgccc cagcagcgac gggcttggtc
2041 tgcctggtgc ccgcaacgtg tcggaatgtg gaggccagtg ttctccaggc ttcttctcgg
2101 ccgatggctt caagccctgc caggcctgcc ccgtgggcac gtaccagcct gagcccgggc
2161 gcaccggctg cttcccctgt ggagggggtt tgctcaccaa acacgaaggc accacctcct
2221 tccaggactg cgaggctaaa gtgcactgct cccccggcca ccactacaac accaccaccc
2281 accgctgcat ccgctgcccc gtcggcacct accagcccga gtttggccag aaccactgca
2341 tcacctgtcc gggcaacacc agcacagact tcgatggctc caccaacgtc acacactgca
2401 aaaaccagca ctgcggcggc gagcttggtg actacaccgg ctacatcgag tcccccaact
2461 accctggcga ctacccagcc aacgctgaat gcgtctggca catcgcacct cccccaaagc
2521 gcaggatcct catcgtggtc cctgagatct tcctgcccat cgaggatgag tgcggcgatg
2581 ttctggtcat gaggaagagt gcctctccca cgtccatcac cacctatgag acctgccaga
2641 cctacgagag gcccatcgcc ttcacctccc gctcccgcaa gctctggatc cagttcaaat
2701 ccaatgaagg caacagcggc aaaggcttcc aagtgcccta tgtcacctac gatgaggact
2761 accagcaact catagaggac atcgtgcgcg atgggcgcct gtacgcctcg gagaaccacc
2821 aggaaatttt gaaagacaag aagctgatca aggccctctt cgacgtgctg gcgcatcccc
2881 agaactactt caagtacaca gcccaggaat ccaaggagat gttcccacgg tccttcatca
2941 aactgctgcg ctccaaagtg tctcggttcc tgcggcccta caaataaccg gg
//