LOCUS AF519459 6543 bp mRNA linear HUM 23-SEP-2002
DEFINITION Homo sapiens MLL5 (MLL5) mRNA, complete cds.
ACCESSION AF519459
VERSION AF519459.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 6543)
AUTHORS Emerling,B.M., Bonifas,J., Kratz,C.P., Donovan,S., Taylor,B.R.,
Green,E.D., Le Beau,M.M. and Shannon,K.M.
TITLE MLL5, a homolog of Drosophila trithorax located within a segment of
chromosome band 7q22 implicated in myeloid leukemia
JOURNAL Oncogene 21 (31), 4849-4854 (2002)
PUBMED 12101424
REFERENCE 2 (bases 1 to 6543)
AUTHORS Emerling,B.M., Bonifas,J.M., Kratz,C.P., Donovan,S., Taylor,B.R.,
Green,E.D., Le Beau,M.M. and Shannon,K.M.
TITLE Direct Submission
JOURNAL Submitted (06-JUN-2002) Pediatrics, UCSF, HSE302, 513 Parnassus,
San Francisco, CA 94143, USA
FEATURES Location/Qualifiers
source 1..6543
/db_xref="H-InvDB:HIT000081138"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="7"
/map="7q22"
gene 1..6543
/gene="MLL5"
CDS 202..5778
/gene="MLL5"
/note="contains PHD and SET domains; similar to Drosophila
trithorax"
/codon_start=1
/product="MLL5"
/protein_id="AAM74947.1"
/translation="MSIVIPLGVDTAETSYLEMAAGSEPESVEASPVVVEKSNSYPHQ
LYTSSSHHSHSYIGLPYADHNYGARPPPTPPASPPPSVLISKNEVGIFTTPNFDETSS
ATTISTSEDGSYGTDVTRCICGFTHDDGYMICCDKCSVWQHIDCMGIDRQHIPDTYLC
ERCQPRNLDKERAVLLQRRKRENMSDGDTSATESGDEVPVELYTAFQHTPTSITLTAS
RVSKVNDKRRKKSGEKEQHISKCKKAFREGSRKSSRVKGSAPEIDPSSDGSNFGWETK
IKAWMDRYEEANNNQYSEGVQREAQRIALRLGNGNDKKEMNKSDLNTNNLLFKPPVES
HIQKNKKILKSAKDLPPDALIIEYRGKFMLREQFEANGYFFKRPYPFVLFYSKFHGLE
MCVDARTFGNEARFIRRSCTPNAEVRHEIQDGTIHLYIYSIHSIPKGTEITIAFDFDY
GNCKYKVDCACLKENPECPVLKRSSESMENINSGYETRRKKGKKDEDISKEKDTQNQN
ITLDCEGATNKMKSPETKQRKLSPLRLSVSNNQEPDFIDDIEEKTPISNEVEMESEEQ
IAERKRKMTREERKMEAILQAFARLEKREKRREQALERISTAKTEVKTECKDTQIVSD
AEVIQEQAKEENASKPTPAKVNRTKQRKSFSRSRTHIGQQRRRHRTVSMCSDIQPSSP
DIEVTSQQNDIENTVLTIEPETETALAEIITETEVPALNKCPTKYPKTKKHLVNEWLS
EKNEKTGKPSDGLSERPLRITTDPEVLATQLNSLPGLTYSPHVYSTPKHYIRFTSPFL
SEKRRRKEPTENISGSCKKRWLKQALEEENSAILHRFNSPCQERSRSPAVNGENKSPL
LLNDSCSLPDLTTPLKKRRFYQLLDSVYSETSTPTPSPYATPTHTDITPMDPSFATPP
RIKSDDETCRNGYKPIYSPVTPVTPGTPGNTMHFENISSPESSPEIKRRTYSQEGYDR
SSTMLTLGPFRNSNLTELGLQEIKTIGYTSPRSRTEVNRQCPGEKEPASDLQLGLDAV
EPTALHKTLETPAHDRAEPNSQLDSTHSGRGTMYSSWVKSPDSTGVNFSVNSNLRDLT
PPHQLEVGGGSRISESKCLMQDDTRGMFMETTVFCTSEDGLVSGFGRTVNDNLIDGNC
TPQNPPQKKKVSLLEYRKRQRKARKSGSKTENFPLISVSPHASGSLSNNGDGCASSND
NGEQVDHTASLPLPTPATVYNATSEETSNNCPVKDATASEKNEPEVQWTASTSVEQVR
ERSYQRALLLSDHRKDKDSGGESPCVSCSPSHVQSSPSSHSNHIPQLQAKGPVPSFSE
LMEDPDPENPEPTTTNECPSPDTSQNTCKSPPKMSKPGSPGSVIPAQAHGKIFTKPDP
QWDSTVSASEAENGVHLKTELQQKQLSNNNQALSKNHPPQTHVRNSSEQLSQKLPSVP
TKLHCPPSPHLENPPKSSTPHTPVQHGYLSPKPPSQQLGSPYRPHHSQSPQVGTPQRE
PQRNFYPAAQNLPANTQQATSGTLFTQTPSGQSSATYSQFNQQSLNSTAPPPPPPPPP
SSSYYQNQQPSANFQNYNQLKGSLSQQTVFTSGPNQALPGTTSQQTVPGHHVTPGHFL
PSQNPTIHHQTAAAVVPPPPPPPPAPGPHLVQQPNSHQQHSVAHVVGPVHAVTPGSHI
HSQTAGHHLPPPPPPPGPAPHHHPPPHPSTGLQGLQAQHQHVVNSAPPPPPPPPPSSV
LASGHHTTSAQALHHPPHQGPPLFPSSAHPTVPPYPSQATHHTTLGPGPQHQPSGTGP
HCPLPVTGPHLQPQGPNSIPTPTASGFCPHPGSVALPHGVQGPQQASPVPGQIPIHRA
QVPPTFQNNYHGSGWH"
BASE COUNT 2082 a 1506 c 1270 g 1685 t
ORIGIN
1 aagaggctgc gcgctgctgt ttggggaggg ggtgtgtgga gccgggtcct gtgtccgcag
61 tggctgctgt cggggggtcg cctgttcgcg gaggtgcgga gagactcctt gggggtcgag
121 cactgtggct ggcatgcccc agtgttttgg ataccaatgc ataggactcc atagtaatcg
181 aatttaccag aggcgaacgt catgagcata gtgatcccat tgggggttga tacagcagag
241 acgtcatact tggaaatggc tgcaggttca gaaccagaat ccgtagaagc tagccctgtg
301 gtagttgaga aatccaacag ttatccccac cagttatata ccagcagctc acatcattca
361 cacagttaca ttggtttgcc ctatgcggac cataattatg gtgctcgtcc tcctccgaca
421 cctccggctt cccctcctcc atcagtcctt attagcaaaa atgaagtagg catatttacc
481 actcctaatt ttgatgaaac ttccagtgct actacaatca gcacatctga ggatggaagt
541 tatggtactg atgtaaccag gtgcatatgt ggttttacac atgatgatgg atacatgatc
601 tgttgtgaca aatgcagcgt ttggcaacat attgactgca tggggattga taggcagcat
661 attcctgata catatctatg tgaacgttgt cagcctagga atttggataa agagagggca
721 gtgctactac aacgccggaa aagggaaaat atgtcagatg gtgataccag tgcaactgag
781 agtggtgatg aggttcctgt ggaattatat actgcatttc agcatactcc aacatcaatt
841 actttaactg cttcaagagt ttccaaagtt aatgataaaa gaaggaaaaa aagcggggag
901 aaagaacaac acatttcaaa atgtaaaaag gcatttcgtg aaggatctag gaagtcatca
961 agagttaagg gttcagctcc agagattgat ccttcatctg atggttcaaa ttttggatgg
1021 gagacaaaga tcaaagcatg gatggatcga tatgaagaag caaataacaa ccagtatagt
1081 gagggtgttc agagggaggc acaaagaata gctctgagat taggcaatgg aaatgacaaa
1141 aaagagatga ataaatccga tttgaatacc aacaatttgc tcttcaaacc tcctgtagag
1201 agccatatac aaaagaataa gaaaattctt aaatctgcaa aagatttgcc tcctgatgca
1261 cttatcattg aatacagagg gaagtttatg ctgagagaac agtttgaagc aaatgggtat
1321 ttctttaaaa gaccataccc ttttgtgtta ttctactcta aatttcatgg gctagaaatg
1381 tgtgttgatg caaggacttt tgggaatgag gctcgattca tcaggcggtc ttgtacaccc
1441 aatgcagagg tgaggcatga aattcaagat ggaaccatac atctttatat ttattctata
1501 cacagtattc caaagggaac tgaaattact attgcctttg attttgacta tggaaattgt
1561 aagtacaagg tggactgtgc atgcctcaaa gaaaacccag agtgccctgt tctaaaacgt
1621 agttctgaat ccatggaaaa tatcaatagt ggttatgaga ccagacggaa aaaaggaaaa
1681 aaagacgaag atatttcaaa agaaaaagat acacaaaatc agaatattac tttggattgt
1741 gaaggagcga ccaacaaaat gaagagccca gaaactaaac aaagaaagct ttctccactg
1801 agactatcag tatcaaataa tcaggaacca gattttattg atgatataga agaaaaaact
1861 cctattagta atgaagtaga aatggaatca gaggagcaga ttgcagaaag gaaaaggaag
1921 atgacaagag aagaaagaaa aatggaagca attttgcaag cttttgccag acttgaaaag
1981 agagagaaaa gaagagaaca agctttggaa aggatcagca cagccaaaac tgaagttaaa
2041 actgaatgta aagatacaca gattgtcagt gatgctgaag ttattcagga acaagcaaaa
2101 gaagaaaatg ctagcaagcc aacccctgcc aaagtaaata gaactaaaca gagaaaaagt
2161 ttttctcgga gtaggactca cattggacag cagcgtcgga gacacagaac tgtcagcatg
2221 tgttcagata tccagccatc ttctcctgat atagaagtta cttcacaaca aaatgatatt
2281 gaaaatactg tacttacaat agaaccagaa actgaaactg cactagcaga aataattact
2341 gaaactgaag ttccagcact taataaatgt cctaccaagt accccaaaac aaagaagcac
2401 ttggttaatg aatggttaag tgagaagaat gagaagacag gaaaaccttc agatggcctt
2461 tcagaaaggc ctctacgcat aactacagat cctgaagtgt tagctacaca actcaattct
2521 ttaccaggtc tcacttacag cccccatgta tactccactc ctaagcatta tattagattt
2581 acttcaccat tcctttcaga aaaaaggaga agaaaagaac ctactgaaaa catttctggt
2641 tcatgcaaga agcgatggtt gaaacaagct ctggaagaag aaaattcagc aattttacat
2701 agatttaatt caccctgtca agaaagatcc agaagtcctg cagtcaatgg tgaaaataaa
2761 agtccactac tattaaatga cagctgttcc cttccagatt taactacacc actaaaaaaa
2821 cgaagatttt atcagttgct agattcggtt tactcagaaa cctccacacc tactccttcc
2881 ccgtatgcta caccaactca caccgatatt actcctatgg acccatcttt tgccacgcct
2941 ccacggataa aatcggatga tgaaacttgt agaaatggtt ataaacccat atattcacca
3001 gttaccccag taactcctgg tacaccagga aataccatgc actttgagaa tatttcttcc
3061 ccagaaagtt ctccagaaat aaagagacgc acttatagtc aagagggata tgacagatct
3121 tcaaccatgt taacattggg gccttttaga aattctaatt taactgaact gggtctgcaa
3181 gaaataaaga ctattggtta tacgagccct aggagtagga ctgaagtcaa caggcagtgt
3241 cctggagaaa aggaacctgc gtcagacctt cagctaggac tcgatgcagt tgagccaact
3301 gccctacata aaaccctgga aacgcctgca catgacaggg ctgagcccaa cagccaactg
3361 gactcgactc actctggacg gggcacaatg tattcttcct gggtaaagag ccctgacagt
3421 acaggagtta acttctcagt gaactccaac ttgagggacc tgacaccccc gcatcagttg
3481 gaggttggag gaggctcccg aataagtgag tcaaagtgcc tgatgcagga tgacaccaga
3541 ggcatgttta tggaaacaac tgtgttttgt acttccgaag atgggcttgt atctggtttc
3601 ggacggactg ttaatgacaa tttgatcgac gggaattgca caccccagaa tccaccacaa
3661 aagaaaaagg tttctctatt agaataccgt aagagacaac gtaaagctag gaaaagtggc
3721 tctaagacag agaactttcc actcattagt gtatcacccc atgcaagtgg aagcttgagc
3781 aacaatggtg atggctgtgc cagcagtaat gacaatgggg agcaggtgga ccacactgct
3841 agcctacctt taccaacacc agctacagtt tataatgcca cttctgaaga aactagcaat
3901 aactgccctg ttaaggatgc tactgctagt gagaagaatg aaccagaagt tcaatggact
3961 gcctcaactt cagtggaaca agtcagagaa aggagttatc agagagcttt acttctcagt
4021 gatcaccgaa aagataaaga tagtggggga gaatcaccat gtgtctcatg ttcaccgagt
4081 catgttcagt cttcaccttc atctcattca aatcacatac cccagttgca agctaagggc
4141 ccagtccctt ctttcagtga acttatggaa gaccctgatc ctgaaaatcc agaacccaca
4201 actacgaatg aatgtccatc cccagatact tctcaaaata cttgtaaaag tcctccaaaa
4261 atgagcaagc ctggttcacc tggatctgta attcctgctc aagcacacgg gaaaatattc
4321 acaaaaccag atccccaatg ggactccaca gttagtgcat ccgaagctga aaatggtgtt
4381 cacctaaaaa cagagctcca acaaaaacag ctatcaaata acaaccaagc actttcaaag
4441 aatcatcctc ctcagacaca cgttcgtaat tcatctgagc aactttcaca aaagctgcct
4501 tctgtgccaa caaagttgca ctgtcctcca tcacctcacc tagaaaatcc tccaaagtca
4561 tccacgcctc acacacctgt acagcatggt tatctttcac caaagcctcc ttcacagcag
4621 ttaggatctc cctacaggcc tcatcattca cagtcacctc aagttggaac acctcagcga
4681 gagcctcaaa gaaactttta tccagcagca cagaaccttc cagccaatac tcagcaggca
4741 acttctggaa cattatttac acagacaccc tcaggacaat cttcagcaac atacagtcag
4801 tttaaccaac aaagtctgaa cagcacggca ccaccccctc cacctcctcc acctccttct
4861 tcgtcttact atcaaaacca gcagccctct gcaaactttc agaattataa tcagctcaaa
4921 ggtagtcttt ctcaacaaac tgtgtttaca tcaggaccaa atcaagcact tcctggcacc
4981 acaagccagc aaacagttcc aggacaccac gtgactccag ggcatttttt gccctctcag
5041 aaccctacca ttcaccatca aactgctgct gccgtagtcc cccctcctcc tccaccacca
5101 cctgctccag gaccgcacct tgtacaacag ccgaattccc atcagcaaca ctctgtagca
5161 catgtagtag ggcctgttca tgcggtcacc cctgggtcgc atattcattc tcaaactgct
5221 ggacaccact tacccccacc cccaccccct cctggtcctg cccctcatca ccatccacca
5281 ccccatccat ccacaggact ccaaggtcta caagcacaac accagcatgt tgtaaattca
5341 gcacccccac caccccctcc gccgccacct tccagtgttt tggcttctgg gcatcatacc
5401 acatcagctc aagccttaca ccacccacct catcaaggac ctccactttt tccttcgagt
5461 gctcatccaa ctgtaccacc gtatccctca caagctacac atcataccac tttgggaccg
5521 ggaccccagc accagccttc tggaacaggg ccacattgtc cattacctgt cacaggtcct
5581 catctccagc cccaaggacc aaacagtatt ccaacaccta ctgcttcagg gttctgtcct
5641 catcctggct ctgtggccct gccacatggg gttcaaggac ctcagcaggc atctccagtg
5701 cctggacaga ttccaattca cagagcacag gtgccaccaa catttcaaaa caattaccat
5761 gggtcagggt ggcattaaaa tggactccaa aaacattttt ttaaatgttc tgtaagataa
5821 actgtatatt tcatatgtac ctgttaaggt actttttaaa gcttgtacat gaacctttgt
5881 ataaaaaaca ccagtgctct ttcgttgtat ttttctcatt tttgcttttt aaaattcctt
5941 taaaaaatgt gctgttaagc cagtattagg tatctttatt ttgtaagtga acattccagc
6001 tgtttttttc tggcagatct gatgctgatt tgatgctgta tgatcttttt ttttttttta
6061 gttaaattca tttagtgaat gttctattat tttatacata cacattaagt actcagctaa
6121 gtaatggcac tatgaggatt ttttttttct ttcctgtcag cagcagttct gtgaatgcat
6181 cttaggtata aaaatgcaat acagattttt atattttggt gtggacatgg ctcattttgt
6241 tttaccagtt atttgcaagc aaaatgtaat ttaatgtata gatgatttct aatgtctcct
6301 gacaaactgt aaatactgca tttcttttgc gtatataatt gcttacagct tttctcattt
6361 gatatatagc attgtacata tgacaagtct tttgcaaaac tgtgtgatct ttgtgaaagt
6421 agtacagtat atgaccttta atttcttttt tattttaaat atactgtcac actgaagcac
6481 tggttgggca ttttaattca tgttaataaa tcccaattat gtcagattta aaaaaaaaaa
6541 aaa
//