LOCUS AF513978 6978 bp mRNA linear HUM 24-MAY-2003
DEFINITION Homo sapiens CENTRIOLIN mRNA, complete cds.
ACCESSION AF513978
VERSION AF513978.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 6978)
AUTHORS Gromley,A., Jurczyk,A., Sillibourne,J., Halilovic,E., Mogensen,M.,
Groisman,I., Blomberg,M. and Doxsey,S.
TITLE A novel human protein of the maternal centriole is required for the
final stages of cytokinesis and entry into S phase
JOURNAL J. Cell Biol. 161 (3), 535-545 (2003)
PUBMED 12732615
REFERENCE 2 (bases 1 to 6978)
AUTHORS Gromley,A.S., Jurczyk,A., Sillibourne,J.E., Halilovic,E. and
Doxsey,S.J.
TITLE Direct Submission
JOURNAL Submitted (21-MAY-2002) Molecular Medicine, University of
Massachusetts Medical School, 373 Plantation St., Biotech II,
Worcester, MA 01605, USA
FEATURES Location/Qualifiers
source 1..6978
/db_xref="H-InvDB:HIT000081092"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="9"
CDS 1..6978
/note="centriolar protein"
/codon_start=1
/product="CENTRIOLIN"
/protein_id="AAP43846.1"
/translation="MKKGSQQKIFSKAKIPSSSHSPIPSSMSNMRSRSLSPLIGSETL
PFHSGGQWCEQIEIADENNMLLDYQDHKGADSHAGVRYITEALIKKLTKQDNLALIKS
LNLSLSKDGGKKFKYIENLEKCVKLEVLNLSYNLIGKIEKLDKLLKLRELNLSYNKIS
KIEGIENMCNLQKLNLAGNEIEHIPVWLGKKLKSLRVLNLKGNKISSLQDISKLKPLQ
DLISLILVENPVVTLPHYLQFTIFHLRSLESLEGQPVTTQDRQEAFERFSLEEVERLE
RDLEKKMIETEELKSKQTRFLEEIKNQDKLNKSLKEEAMLQKQSCEELKSDLNTKNEL
LKQKTIELTRACQKQYELEQELAFYKIDAKFEPLNYYPSEYAEIDKAPDESPYIGKSR
YKRNMFATESYIIDSAQAVQIKKMEPDEQLRNDHMNLRGHTPLDTQLEDKEKKISAAQ
TRLSELHDEIEKAEQQILRATEEFKQLEEAIQLKKISEAGKDLLYKQLSGRLQLVNKL
RQEALDLELQMEKQKQEIAGKQKEIKDLQIAIDSLDSKDPKHSHMKAQKSGKEQQLDI
MNKQYQQLESRLDEILSRIAKETEEIKDLEEQLTEGQIAANEALKKDLEGVISGLQEY
LGTIKGQATQAQNECRKLRDEKETLLQRLTEVEQERDQLEIVAMDAENMRKELAELES
ALQEQHEVNASLQQTQGDLSAYEAELEARLNLRDAEANQLKEELEKVTRLTQLEQSAL
QAELEKERQALKNALGKAQFSEEKEQENSELHAKLKHLQDDNNLLKQQLKDFQNHLNH
VVDGLVRPEEVAARVDELRRKLKLGTGEMNIHSPSDVLGKSLADLQKQFSEILARSKW
ERDEAQVRERKLQEEMALQQEKLATGQEEFRQACERALEARMNFDKRQHEARIQQMEN
EIHYLQENLKSMEEIQGLTDLQLQEADEEKERILAQLRELEKKKKLEDAKSQEQVFGL
DKELKKLKKAVATSDKLATAELTIAKDQLKSLHGTVMKINQERAEELQEAERFSRKAA
QAARDLTRAEAEIELLQNLLRQKGEQFRLEMEKTGVGTGANSQVLEIEKLNETMERQR
TEIARLQNVLDLTGSDNKGGFENVLEEIAELRREVSYQNDYISSMADPFKRRGYWYFM
PPPPSSKVSSHSSQATKDSGVGLKYSASTPVRKPRPGQQDGKEGSQPPPASGYWVYSP
IRSGLHKLFPSRDADSGGDSQEESELDDQEEPPFVPPPGYMMYTVLPDGSPVPQGMAL
YAPPPPLPNNSRPLTPGTVVYGPPPAGAPMVYGPPPPNFSIPFIPMGVLHCNVPEHHN
LENEVSRLEDIMQHLKSKKREERWMRASKRQSEKEMEELHHNIDDLLQEKKSLECEVE
ELHRTVQKRQQQKDFIDGNVESLMTELEIEKSLKHHEDIVDEIECIEKTLLKRRSELR
EADRLLAEAESELSCTKEKTKNAVEKFTDAKRSLLQTESDAEELERRAQETAVNLVKA
DQQLRSLQADAKDLEQHKIKQEEILKEINKIVAAKDSDFQCLSKKKEKLTEELQKLQK
DIEMAERNEDHHLQVLKESEVLLQAKRAELEKLKSQVTSQQQEMAVLDRQLGHKKEEL
HLLQGSMVQAKADLQEALRLGETEVTEKCNHIREVKSLLEELSFQKGELNVQISERKT
QLTLIKQEIEKEEENLQVVLRQMSKHKTELKNILDMLQLENHELQGLKLQHDQRVSEL
EKTQVAVLEEKLELENLQQISQQQKGEIEWQKQLLERDKREIERMTAESRALQSCVEC
LSKEKEDLQEKCDIWEKKLAQTKRVLAAAEENSKMEQSNLEKLELNVRKLQQELDQLN
RDKLSLHNDISAMQQQLQEKREAVNSLQEELANVQDHLNLAKQDLLHTTKHQDVLLSE
QTRLQKDISEWANRFEDCQKEEETKQQQLQVLQNEIEENKLKLVQQEMMFQRLQKERE
SEESKLETSKVTLKEQQHQLEKELTDQKSKLDQVLSKVLAAEERVRTLQEEERWCESL
EKTLSQTKRQLSEREQQLVEKSGELLALQKEADSMRADFSLLRNQFLTERKKAEKQVA
SLKEALKIQRSQLEKNLLEQKQENSCIQKEMATIELVAQDNHERARRLMKELNQMQYE
YTELKKQMANQKDLERRQMEISDAMRTLKSEVKDEIRTSLKNLNQFLPELPADLEAIL
ERNENLEGELESLKENLPFTMNEGPFEEKLNFSQVHIMDEHWRGEALREKLRHREDRL
KAQLRHCMSKQAEVLIKGKRQTEGTLHSLRRQVDALGELVTSTSADSASSPSLSQLES
SLTEDSQLGQNQEKNASAR"
BASE COUNT 2552 a 1330 c 1672 g 1424 t
ORIGIN
1 atgaagaaag gttctcaaca aaaaatattc tccaaagcaa agataccatc atcatctcac
61 tctcctatcc catcatctat gtccaatatg agatctaggt cactttcacc tttgattgga
121 tcagagactc taccttttca ttctggagga cagtggtgtg agcaaattga gattgcagat
181 gaaaacaata tgcttttgga ctatcaagac cataaaggag ctgattcaca tgcaggagtt
241 agatatatta cagaggccct cattaaaaaa cttactaaac aggataattt ggctttgata
301 aaatctctga acctttcact ttctaaagac ggtggcaaga aatttaagta tattgagaat
361 ttggaaaaat gtgttaaact tgaagtactg aatctcagct ataatctaat agggaagatt
421 gaaaagttgg acaagctgtt aaaattacgt gaactcaact tatcatataa caaaatcagc
481 aaaattgaag gcatagaaaa tatgtgtaat ctgcaaaagc ttaaccttgc aggaaatgaa
541 attgagcata ttccagtatg gttagggaag aagttaaaat ctttgcgagt cctcaatttg
601 aaaggcaaca agatatcatc gctccaagat ataagcaagt tgaaaccgct tcaagatttg
661 atttctctga tcctagttga aaatccagtt gtgacccttc ctcattacct ccagtttacc
721 attttccacc tccgttcatt ggaaagtttg gaaggtcagc cagtaaccac tcaggataga
781 caggaggctt ttgagagatt cagtttagaa gaggtagaaa gactggaaag agacctagaa
841 aaaaagatga tagaaactga agagcttaag agcaaacaaa caaggttcct tgaggaaatt
901 aaaaatcaag ataaattgaa taaatcatta aaagaggagg ccatgttaca gaaacagagc
961 tgtgaggaac tcaagagtga cttaaacaca aaaaatgaat tgctaaaaca gaagaccata
1021 gaattaacac gagcatgtca gaagcaatat gagctggaac aggaattggc cttttataaa
1081 attgatgcta aatttgagcc actaaattat tatccatcag agtatgctga aattgataaa
1141 gccccagatg aaagccctta cattggcaaa tccagataca agagaaatat gtttgccaca
1201 gagagttata ttattgacag tgctcaggca gtacagatca agaagatgga gccagatgaa
1261 caacttagaa atgatcacat gaacttgaga ggccacacac cactggacac gcaactggaa
1321 gacaaagaaa aaaaaataag tgcagcacaa actcgactat cagaactgca tgatgaaata
1381 gaaaaggcag aacaacaaat tttgagagct actgaagaat ttaaacaact ggaagaagct
1441 atacaactaa aaaagatttc agaagcaggg aaagaccttc tttacaagca gttgagtggt
1501 agactacaac ttgtaaataa attacgccag gaagctctgg atctagaact gcagatggaa
1561 aagcaaaagc aggaaattgc cggaaagcag aaggagatta aggacctgca aatagccata
1621 gatagcctgg attccaaaga cccaaaacat tcccatatga aggctcaaaa gagcggtaaa
1681 gaacaacagc ttgacattat gaacaagcag taccaacaac ttgaaagtcg tttggatgag
1741 atactttcta gaattgctaa ggaaacggaa gagattaagg accttgaaga acagcttact
1801 gaaggccaga tagcagcaaa tgaagccctg aagaaggatt tagaaggtgt tatcagtggg
1861 ttgcaagaat acctggggac cattaaaggc caggcaactc aggcccagaa tgagtgcagg
1921 aagctgcggg atgagaaaga gacattgttg cagagattga cagaagtcga gcaggagaga
1981 gaccagctgg aaatagttgc catggatgca gaaaatatga ggaaggagct tgcagagcta
2041 gaaagtgccc tccaagagca gcatgaggtg aatgcatctt tgcagcagac ccagggagat
2101 ctcagtgcct atgaagctga gctagaggct cggctaaacc taagggatgc tgaagccaac
2161 cagctcaagg aagagttgga aaaagtaaca agacttaccc agttagaaca atcagccctt
2221 caagcagaac ttgagaagga aaggcaagcc ctcaagaatg cccttggaaa agcccagttc
2281 tcagaagaaa aggagcaaga gaacagtgag ctccatgcaa aacttaaaca cttgcaggat
2341 gacaataatc tgttaaaaca gcaacttaaa gatttccaga atcaccttaa ccatgtggtt
2401 gatggtttgg ttcgtccaga agaagtggca gctcgtgtgg atgagctaag aagaaaactg
2461 aaattaggaa ctggggaaat gaacatccat agtccttcag atgtcttagg gaaaagtctt
2521 gctgatttac agaaacaatt cagtgaaatt cttgcacgct ccaagtggga aagagatgaa
2581 gcacaagtta gagagagaaa actccaagaa gaaatggctc tgcagcaaga gaaactggca
2641 actggacaag aagagttcag gcaggcctgt gagagagccc tggaagcaag aatgaatttt
2701 gataagaggc aacatgaagc aagaatccag caaatggaga atgaaattca ctatttgcaa
2761 gaaaatctaa aaagtatgga ggaaatccaa ggccttacag atctccaact tcaggaagct
2821 gatgaagaga aggagagaat tctggcccaa ctccgagagt tagagaaaaa gaagaaactt
2881 gaagatgcca aatctcagga gcaagttttt ggtttagata aagaactgaa gaaactaaag
2941 aaagccgtgg ccacctctga taagctagcc acagctgagc tcaccattgc caaagaccag
3001 ctgaagtccc ttcatggaac tgttatgaaa attaaccagg agcgagcaga ggagttgcag
3061 gaagcagaga ggttcagcag aaaggcagca caagcagcca gagatctcac ccgagcagaa
3121 gctgagatcg aactcctgca gaatctcctc aggcagaagg gggagcagtt tcgacttgag
3181 atggagaaaa caggtgtagg tactggagca aactcacagg tcctagaaat tgagaaactg
3241 aatgagacaa tggaacgaca aaggacagag attgcaaggc tgcagaatgt actagacctc
3301 actggaagtg acaacaaagg aggctttgaa aatgttttag aagaaattgc tgaacttcga
3361 cgtgaagttt cttatcagaa tgattacata agcagcatgg cagatccttt caaaagacga
3421 ggctattggt actttatgcc accaccacca tcatcaaaag tttccagcca tagttcccag
3481 gccaccaagg actctggtgt tggccttaag tactcagcct caactcctgt tagaaaacca
3541 cgccctgggc agcaggatgg gaaggaaggc agtcaacctc cccctgcctc aggatactgg
3601 gtttattctc ccatcaggag tgggttacat aaactgtttc caagtagaga tgcagacagt
3661 ggaggagata gtcaggaaga gagtgagctg gatgaccaag aagaaccccc atttgtgcct
3721 cctcctggat acatgatgta tactgtgctt cctgatggtt ctcctgtacc ccagggcatg
3781 gccctgtatg caccacctcc tcccttgcca aacaatagcc gacctctcac ccctggcact
3841 gttgtttatg gcccacctcc tgctggggcc cccatggtgt atgggcctcc accccccaac
3901 ttctccatcc ccttcatccc tatgggtgtg ctgcattgca acgtccctga acaccataac
3961 ttagagaatg aagtttctag attagaagac ataatgcagc atttaaaatc aaagaagcgg
4021 gaagaaaggt ggatgagagc atccaagcgg cagtcggaga aagaaatgga agaactgcat
4081 cataatattg atgatctttt gcaagagaag aaaagcttag agtgtgaagt agaagaatta
4141 catagaactg tccagaaacg tcaacagcaa aaggacttca ttgatggaaa tgttgagagt
4201 cttatgactg aactagaaat agaaaaatca ctcaaacatc atgaagatat tgtagatgaa
4261 attgagtgca ttgagaagac tcttctgaaa cgtcgctcag agctcaggga agctgaccga
4321 ctcctggcag aggctgagag tgaactttca tgcactaaag aaaagacaaa aaatgctgtt
4381 gaaaagttca ctgatgccaa gagaagttta ttgcaaactg agtcagatgc tgaggaatta
4441 gaaaggagag ctcaggaaac tgctgttaac ctcgtcaaag ctgatcagca gctaagatcg
4501 ctccaggctg atgcaaagga tttggagcag cacaaaatca agcaagaaga aatcttgaaa
4561 gaaataaaca aaattgtagc agcaaaagac tcagacttcc aatgtttaag caagaagaag
4621 gaaaaactga cagaagagct tcagaaacta cagaaagaca tagagatggc agaacgcaat
4681 gaggatcacc acctgcaggt ccttaaagaa tctgaggtgc ttcttcaggc caaaagagcc
4741 gagctggaaa agctgaaaag ccaggtgaca agtcagcagc aggagatggc tgtcttggac
4801 aggcagttag ggcataaaaa ggaggagctg catctactcc aaggaagcat ggtccaggca
4861 aaagctgacc tccaggaagc tctgagactg ggagagactg aagtaactga gaagtgcaat
4921 cacattaggg aagtaaaatc tcttctggaa gaactgagtt ttcagaaagg agaactaaat
4981 gttcagatta gtgaaagaaa aactcaactt acacttataa agcaggaaat tgaaaaagag
5041 gaagaaaatc ttcaggttgt tttaaggcag atgtctaaac ataaaaccga actaaagaat
5101 attctggaca tgttgcaact tgaaaaccat gagctacaag gtttgaagct acaacatgac
5161 caaagggtat ctgaattaga gaagactcag gtggcagtgc tagaggagaa actggagtta
5221 gagaatttgc agcagatatc ccagcagcag aaaggggaaa tagagtggca gaagcagctc
5281 cttgagaggg ataaacgaga aatagaacga atgactgctg agtcccgagc tttacaatcg
5341 tgtgttgagt gtttgagcaa agaaaaggaa gatctccaag agaaatgtga catttgggaa
5401 aaaaagttgg cacaaaccaa aagggtttta gcagcagcag aagaaaatag caaaatggag
5461 caatcaaact tagaaaagtt ggaattgaat gtcagaaaac tgcagcagga actagaccaa
5521 ctaaacagag acaagttgtc actgcataac gacatttcag caatgcaaca gcagctccaa
5581 gaaaaacgag aagcagtaaa ctcactgcag gaggaactag ctaatgtcca agaccatttg
5641 aacctagcaa aacaggacct gcttcacacc accaagcatc aggatgtgtt gctcagtgag
5701 cagacccgac tccagaagga catcagtgaa tgggcaaata ggtttgaaga ctgtcagaaa
5761 gaagaggaga caaaacaaca acaacttcaa gtgcttcaga atgagattga agaaaacaag
5821 ctcaaactag tccaacaaga aatgatgttt cagagactcc agaaagagag agaaagtgaa
5881 gaaagcaaat tagaaaccag taaagtgaca ctgaaggagc aacagcacca gctggaaaag
5941 gaattaacag accagaaaag caaactggac caagtgctct caaaggtgct ggcagctgaa
6001 gagcgtgtta ggactctgca ggaagaggag aggtggtgtg agagcctgga gaagacactc
6061 tcccaaacta aacggcagct ttcagaaagg gagcagcaat tggtggagaa atcaggtgag
6121 ctgttggccc tccagaaaga ggcagattct atgagggcag acttcagcct tctgcggaac
6181 cagttcttga cagaaagaaa gaaagctgag aagcaggtgg ccagcctgaa ggaagcactt
6241 aagatccagc ggagccagct ggagaaaaac cttcttgagc aaaaacagga gaacagctgc
6301 atacaaaagg aaatggcaac aattgaactg gtagcccagg acaaccatga gcgggccagg
6361 cgcctgatga aggagctcaa ccagatgcag tatgagtaca cggagctcaa gaaacagatg
6421 gcaaaccaaa aagatttgga gagaagacaa atggaaatca gtgatgcaat gaggacactt
6481 aaatctgagg tgaaggatga aatcagaacc agcttgaaga atcttaatca gtttcttcca
6541 gaactaccag cagatctaga agctattttg gaaagaaacg aaaacctaga aggagaattg
6601 gaaagcttga aagagaacct tccatttacc atgaatgagg gaccttttga agaaaaactg
6661 aacttttccc aagttcacat aatggatgaa cactggcgtg gagaagcact ccgggagaaa
6721 ctgcgtcacc gggaagaccg actcaaggcc caactccgac actgtatgtc caagcaagca
6781 gaagtattaa ttaaaggaaa gcggcagaca gagggcactt tacacagttt gaggagacaa
6841 gtagatgctt taggggaatt ggtcaccagc acctctgcag attcagcgtc atcacccagt
6901 ctgtctcagc tggagtcttc cctcacagag gactctcaac ttggacaaaa tcaggaaaag
6961 aatgcctcag ccagatga
//