LOCUS AF510501 5250 bp mRNA linear HUM 30-OCT-2002
DEFINITION Homo sapiens Na+/Ca2+ exchanger isoform 3 splice variant 2 (SLC8A3)
mRNA, complete cds; alternatively spliced.
ACCESSION AF510501
VERSION AF510501.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 5250)
AUTHORS Gabellini,N., Bortoluzzi,S., Danieli,G.A. and Carafoli,E.
TITLE The human SLC8A3 gene and the tissue-specific Na(+)/Ca(2+)
exchanger 3 isoforms
JOURNAL Gene 298 (1), 1-7 (2002)
PUBMED 12406570
REFERENCE 2 (bases 1 to 5250)
AUTHORS Gabellini,N., Bortoluzzi,S., Danieli,G.A. and Carafoli,E.
TITLE Direct Submission
JOURNAL Submitted (09-MAY-2002) Department of Biology, Unv. of Padova, via
G. Colombo, Padova, PD 35131, Italy
FEATURES Location/Qualifiers
source 1..5250
/db_xref="H-InvDB:HIT000081046"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="14"
/map="14q24.2"
gene 1..5250
/gene="SLC8A3"
5'UTR 1..754
/gene="SLC8A3"
CDS 755..3520
/gene="SLC8A3"
/note="NCX3.2; expressed in brain and skeletal muscle;
alternatively spliced"
/codon_start=1
/product="Na+/Ca2+ exchanger isoform 3 splice variant 2"
/protein_id="AAN60790.1"
/translation="MAWLRLQPLTSAFLHFGLVTFVLFLNGLRAEAGGSGDVPSTGQN
NESCSGSSDCKEGVILPIWYPENPSLGDKIARVIVYFVALIYMFLGVSIIADRFMASI
EVITSQEREVTIKKPNGETSTTTIRVWNETVSNLTLMALGSSAPEILLSLIEVCGHGF
IAGDLGPSTIVGSAAFNMFIIIGICVYVIPDGETRKIKHLRVFFITAAWSIFAYIWLY
MILAVFSPGVVQVWEGLLTLFFFPVCVLLAWVADKRLLFYKYMHKKYRTDKHRGIIIE
TEGDHPKGIEMDGKMMNSHFLDGNLVPLEGKEVDESRREMIRILKDLKQKHPEKDLDQ
LVEMANYYALSHQQKSRAFYRIQATRMMTGAGNILKKHAAEQAKKASSMSEVHTDEPE
DFISKVFFDPCSYQCLENCGAVLLTVVRKGGDMSKTMYVDYKTEDGSANAGADYEFTE
GTVVLKPGETQKEFSVGIIDDDIFEEDEHFFVRLSNVRIEEEQPEEGMPPAIFNSLPL
PRAVLASPCVATVTILDDDHAGIFTFECDTIHVSESIGVMEVKVLRTSGARGTVIVPF
RTVEGTAKGGGEDFEDTYGELEFKNDETVKTIRVKIVDEEEYERQENFFIALGEPKWM
ERGISDVTDRKLTMEEEEAKRIAEMGKPVLGEHPKLEVIIEESYEFKTTVDKLIKKTN
LALVVGTHSWRDQFMEAITVSAAGDEDEDESGEERLPSCFDYVMHFLTVFWKVLFACV
PPTEYCHGWACFAVSILIIGMLTAIIGDLASHFGCTIGLKDSVTAVVFVAFGTSVPDT
FASKAAALQDVYADASIGNVTGSNAVNVFLGIGLAWSVAAIYWALQGQEFHVSAGTLA
FSVTLFTIFAFVCISVLLYRRRPHLGGELGGPRGCKLATTWLFVSLWLLYILFATLEA
YCYIKGF"
3'UTR 3521..5250
/gene="SLC8A3"
regulatory 5221..5226
/regulatory_class="polyA_signal_sequence"
/gene="SLC8A3"
BASE COUNT 1256 a 1351 c 1359 g 1284 t
ORIGIN
1 cggcgctgtc tcccagctga tagggtgacg ttccgtttgg aggcttggag attggctttt
61 tgatttggct tcttccggca gcttaatggg caaagctctc cgctcgccca gaaaccagcc
121 tctccgcgcg tcccctctgc gcgcggcgag gccgagacgt ctcccgcggt gacagcgtgc
181 aaggcggaga cccggcgcgc tcccagccca gggaaagccc aggcgacgcg accgcaagcc
241 cgagcccagg tccctcggag ccgccagggc gcgccgggct gcttgccttc ctgccccttc
301 ctgcaggaat cccccgccgc ccgcggccgg gactccgggc ctctcccggg cgtagattcc
361 agtcaccgct ctgggtcggg gtttccctct ttctgaaatc cgtgcggaag gacccctccc
421 ggggcccctc gccctggccc cagacaccct ccctcccaga ccccgcgctc cagatgcgct
481 gccccgcagc tccctgacag ctgcgagccc acgaaccccg gcgggagggc ggcggcggcg
541 gactgacatg ccccggacgc ggctgcggcc ggcgggcagc ccgcgggggc gatgagccgc
601 tgcgaccggt gaggcgccgg gcggcggggg catcgcgtac cttcctcacc cccctccctt
661 gcccactccg ctcgggaggc cgagaggaaa cggtctctgg cctatcagga ggacaactgg
721 tgctgcaata gaagccagtg gctaagtctc gtgtatggcg tggttaaggt tgcagcctct
781 cacctctgcc ttcctccatt ttgggctggt tacctttgtg ctcttcctga atggtcttcg
841 agcagaggct ggtggctcag gggacgtgcc aagcacaggg cagaacaatg agtcctgttc
901 agggtcatcg gactgcaagg agggtgtcat cctgccaatc tggtacccgg agaacccttc
961 ccttggggac aagattgcca gggtcattgt ctattttgtg gccctgatat acatgttcct
1021 tggggtgtcc atcattgctg accgcttcat ggcatctatt gaagtcatca cctctcaaga
1081 gagggaggtg acaattaaga aacccaatgg agaaaccagc acaaccacta ttcgggtctg
1141 gaatgaaact gtctccaacc tgacccttat ggccctgggt tcctctgctc ctgagatact
1201 cctctcttta attgaggtgt gtggtcatgg gttcattgct ggtgatctgg gaccttctac
1261 cattgtaggg agtgcagcct tcaacatgtt catcatcatt ggcatctgtg tctacgtgat
1321 cccagacgga gagactcgca agatcaagca tctacgagtc ttcttcatca ccgctgcttg
1381 gagtatcttt gcctacatct ggctctatat gattctggca gtcttctccc ctggtgtggt
1441 ccaggtttgg gaaggcctcc tcactctctt cttctttcca gtgtgtgtcc ttctggcctg
1501 ggtggcagat aaacgactgc tcttctacaa atacatgcac aaaaagtacc gcacagacaa
1561 acaccgagga attatcatag agacagaggg tgaccaccct aagggcattg agatggatgg
1621 gaaaatgatg aattcccatt ttctagatgg gaacctggtg cccctggaag ggaaggaagt
1681 ggatgagtcc cgcagagaga tgatccggat tctcaaggat ctgaagcaaa aacacccaga
1741 gaaggactta gatcagctgg tggagatggc caattactat gctctttccc accaacagaa
1801 gagccgtgcc ttctaccgta tccaagccac tcgtatgatg actggtgcag gcaatatcct
1861 gaagaaacat gcagcagaac aagccaagaa ggcctccagc atgagcgagg tgcacaccga
1921 tgagcctgag gactttattt ccaaggtctt ctttgaccca tgttcttacc agtgcctgga
1981 gaactgtggg gctgtactcc tgacagtggt gaggaaaggg ggagacatgt caaagaccat
2041 gtatgtggac tacaaaacag aggatggttc tgccaatgca ggggctgact atgagttcac
2101 agagggcacg gtggttctga agccaggaga gacccagaag gagttctccg tgggcataat
2161 tgatgacgac atttttgagg aggatgaaca cttctttgta aggttgagca atgtccgcat
2221 agaggaggag cagccagagg aggggatgcc tccagcaata ttcaacagtc ttcccttgcc
2281 tcgggctgtc ctagcctccc cttgtgtggc cacagttacc atcttggatg atgaccatgc
2341 aggcatcttc acttttgaat gtgatactat tcatgtcagt gagagtattg gtgttatgga
2401 ggtcaaggtt ctgcggacat caggtgcccg gggtacagtc atcgtcccct ttaggacagt
2461 agaagggaca gccaagggtg gcggtgagga ctttgaagac acatatgggg agttggaatt
2521 caagaatgat gaaactgtga aaaccataag ggttaaaata gtagatgagg aggaatacga
2581 aaggcaagag aatttcttca ttgcccttgg tgaaccgaaa tggatggaac gtggaatatc
2641 agatgtgaca gacaggaagc tgactatgga agaagaggag gccaagagga tagcagagat
2701 gggaaagcca gtattgggtg aacaccccaa actagaagtc atcattgaag agtcctatga
2761 gttcaagact acggtggaca aactgatcaa gaagacaaac ctggccttgg ttgtggggac
2821 ccattcctgg agggaccagt tcatggaggc catcaccgtc agtgcagcag gggatgagga
2881 tgaggatgaa tccggggagg agaggctgcc ctcctgcttt gactacgtca tgcacttcct
2941 gactgtcttc tggaaggtgc tgtttgcctg tgtgcccccc acagagtact gccacggctg
3001 ggcctgcttc gccgtctcca tcctcatcat tggcatgctc accgccatca ttggggacct
3061 ggcctcgcac ttcggctgca ccattggtct caaagattca gtcacagctg ttgttttcgt
3121 ggcatttggc acctctgtcc cagatacgtt tgccagcaaa gctgctgccc tccaggatgt
3181 atatgcagac gcctccattg gcaacgtgac gggcagcaac gccgtcaatg tcttcctggg
3241 catcggcctg gcctggtccg tggccgccat ctactgggct ctgcagggac aggagttcca
3301 cgtgtcggcc ggcacactgg ccttctccgt caccctcttc accatctttg catttgtctg
3361 catcagcgtg ctcttgtacc gaaggcggcc gcacctggga ggggagcttg gtggcccccg
3421 tggctgcaag ctcgccacaa catggctctt tgtgagcctg tggctcctct acatactctt
3481 tgccacacta gaggcctatt gctacatcaa ggggttctaa gccacacaac agagcctcca
3541 gcagggcagg cctaggactt ctcctaagag aagggcactt ccccaccagt gatctctccc
3601 gactgcactg ccctggagag gcagcatcag gacctaagcc ccaggaactt cacccaactt
3661 aggccctggc aattaactga aagggcaaag tcttaatcaa tcaaacaatg gaggaatcac
3721 cgactttaca cagtatttaa ttgaatacaa acaagcaaca gcaacaaatc cacctccacc
3781 ccatctcccc ctcatatccc tgacccaaag caaaggtcag agcctttcgc ctccttctat
3841 tccatctttt gattattcct ttgcctctca tttctttgga agcagggttt ctcctctctg
3901 cccaattcca tatgtcccta ttatctcact cagctgacaa gacgtgaaaa tgagtcacat
3961 tcatgtggct ggggtggggt tcttttttca ttgtaatcat tattgtggtt gctttcgttt
4021 tgccattagg ttttgcttat tattttgttt tgtctttttt ttctgaagtg agtgaaaaag
4081 gtgccacaaa ggaattccag gtccgagcca acagagagaa acatgaattt ttagacacat
4141 gctctcctgc cacctcttgg ctccatcaag atccagttcc ccatctcact gttttctctg
4201 agttcttggg aggagtgatg gtgttggggt agaaataagc tcactcaccc acgcagggta
4261 ctaaagatct tacaggagct tcaactggag caggaggagc tttttatgct tatgttgaat
4321 caagtcagat acaaaaagca attgtccctc tttgcccaag cctttccaat tctgtgtgtc
4381 ttgttgtgtc agtgtccact tgtgtatcct tctgcaggaa gacccgccaa atagaagaga
4441 tgggacaaaa ataggaatgg tgtgtgacga caaagggcta ctggaagaac aaaagggata
4501 caggccttct tgattatctt tggctttgta cctgaggcag gagagaagag atgtccaacc
4561 agtgagatct ttaagagaaa agtttgtatt ttaaatgtca atgtgcctga gaaatgtcag
4621 cttcaccacg ctcttgcttc ctaatgctct atacaaagag ggctgactat atttcttgaa
4681 gtggtgtaaa aacttagaga ttttataaga gaaccagggg ctcccttcac ctctcctggt
4741 ccctcaggtc acatatgaaa gcatttttac aagataggaa ctggaattcc tcatttctcc
4801 catgttcctg cttgttctta aacttcatga agctattttt ccagcctatg gggtagttct
4861 tgctccagta agaggaatct tagttgtcat aatcccttgg agcctgggtt tttggagaaa
4921 gagatctccg tgccctacag accttttctc aacgaatgtg ggaaggacct ggctttaaaa
4981 cacgcacaca aacacacaaa taaacagaca taagatgtca tcacgaaact gcccacggat
5041 ctttaggctt tctgcattga cataaataca ttttctaagg ggggggggga agaaattaaa
5101 aaacacctgt taattttaaa cacatttttt aagaaaaaaa taattaaaaa agaaacagtg
5161 ctcatgtcat aagctatgtt gacagttgcc agtggaaatg ttgggttggt tcaaaaaaaa
5221 aataaaagct atactatatc tctctacata
//