LOCUS AF509504 4889 bp mRNA linear HUM 29-JUL-2002
DEFINITION Homo sapiens DOT1-like protein (DOT1L) mRNA, complete cds.
ACCESSION AF509504
VERSION AF509504.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 4889)
AUTHORS Feng,Q., Wang,H., Ng,H.H., Erdjument-Bromage,H., Tempst,P.,
Struhl,K. and Zhang,Y.
TITLE Methylation of H3-lysine 79 is mediated by a new family of HMTases
without a SET domain
JOURNAL Curr. Biol. 12 (12), 1052-1058 (2002)
PUBMED 12123582
REFERENCE 2 (bases 1 to 4889)
AUTHORS Zhang,Y. and Feng,Q.
TITLE Direct Submission
JOURNAL Submitted (05-MAY-2002) Lineberger Comprehensive Cancer Center,
University of North Carolina at Chapel Hill, CB 7295, Mason Farm
Road, Chapel Hill, NC 27599-7295, USA
FEATURES Location/Qualifiers
source 1..4889
/db_xref="H-InvDB:HIT000081035"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="19"
/map="19p13.3"
gene 1..4889
/gene="DOT1L"
/note="hDOT1L"
CDS 37..4650
/gene="DOT1L"
/function="methylates lysine 79 of histone H3"
/note="histone methyltransferase"
/codon_start=1
/product="DOT1-like protein"
/protein_id="AAM88322.1"
/translation="MGEKLELRLKSPVGAEPAVYPWPLPVYDKHHDAAHEIIETIRWV
CEEIPDLKLAMENYVLIDYDTKSFESMQRLCDKYNRAIDSIHQLWKGTTQPMKLNTRP
STGLLRHILQQVYNHSVTDPEKLNNYEPFSPEVYGETSFDLVAQMIDEIKMTDDDLFV
DLGSGVGQVVLQVAAATNCKHHYGVEKADIPAKYAETMDREFRKWMKWYGKKHAEYTL
ERGDFLSEEWRERIANTSVIFVNNFAFGPEVDHQLKERFANMKEGGRIVSSKPFAPLN
FRINSRNLSDIGTIMRVVELSPLKGSVSWTGKPVSYYLHTIDRTILENYFSSLKNPKL
REEQEAARRRQQRESKSNAATPTKGPEGKVAGPADAPMDSGAEEEKAGAATVKKPSPS
KARKKKLNKKGRKMAGRKRGRPKKMNTANPERKPKKNQTALDALHAQTVSQTAASSPQ
DAYRSPHSPFYQLPPSVQRHSPNPLLVAPTPPALQKLLESFKIQYLQFLAYTKTPQYK
ASLQELLGQEKEKNAQLLGAAQQLLSHCQAQKEEIRRLFQQKLDELGVKALTYNDLIQ
AQKEISAHNQQLREQSEQLEQDNRALRGQSLQLLKARCEELQLDWATLSLEKLLKEKQ
ALKSQISEKQRHCLELQISIVELEKSQRQQELLQLKSCVPPDDALSLHLRGKGALGRE
LEPDASRLHLELDCTKFSLPHLSSMSPELSMNGQAAGYELCGVLSRPSSKQNTPQYLA
SPLDQEVVPCTPSHVGRPRLEKLSGLAAPDYTRLSPAKIVLRRHLSQDHTVPGRPAAS
ELHSRAEHTKENGLPYQSPSVPGSMKLSPQDPRPLSPGALQLAGEKSSEKGLRERAYG
SSGELITSLPISIPLSTVQPNKLPVSIPLASVVLPSRAERARSTPSPVLQPRDPSSTL
EKQIGANAHGAGSRSLALAPAGFSYAGSVAISGALAGSPASLTPGAEPATLDESSSSG
SLFATVGSRSSTPQHPLLLAQPRNSLPASPAHQLSSSPRLGGAAQGPLPEASKGDLPS
DSGFSDPESEAKRRIVFTITTGAGSAKQSPSSKHSPLTASARGDCVPSHGQDSRRRGR
RKRASAGTPSLSAGVSPKRRALPSVAGLFTQPSGSPLNLNSMVSNINQPLEITAISSP
ETSLKSSPVPYQDHDQPPVLKKERPLSQTNGAHYSPLTSDEEPGSEDEPSSARIERKI
ATISLESKSPPKTLENGGGLAGRKPAPAGEPVNSSKWKSTFSPISDIGLAKSADSPLQ
ASSALSQNSLFTFRPALEEPSADAKLAAHPRKGFPGSLSGADGLSPGTNPANGCTFGG
GLAADLSLHSFSDGASLPHKGPEAAGLSSPLSFPSQRGKEGSDANPFLSKRQLDGLAG
LKGEGSRGKEAGEGGLPLCGPTDKTPLLSGKAAKARDREVDLKNGHNLFISAAAVPPG
SLLSGPGLAPAASSAGGAASSAQTHRSFLGPFPPGPQFALGPMSLQANLGSVAGSSVL
QSLFSSVPAAAGLVHVSSAATRLTNSHAMGSFSGVAGGTVGGN"
BASE COUNT 1014 a 1631 c 1477 g 767 t
ORIGIN
1 cccgcctagc atggtgcggc ggccgcgcgc gcggacatgg gggagaagct ggagctgaga
61 ctgaagtcgc ccgtgggggc tgagcccgcc gtctacccgt ggccgctgcc ggtctacgat
121 aaacatcacg atgctgctca tgaaatcatc gagaccatcc gatgggtctg tgaagaaatc
181 ccggatctca agctcgctat ggagaattac gttttaattg actatgacac caaaagcttc
241 gagagcatgc agaggctctg cgacaagtac aaccgtgcca tcgacagcat ccaccagctg
301 tggaagggca ccacgcagcc catgaagctg aacacgcggc cgtccactgg actcctgcgc
361 catatcctgc agcaggtcta caaccactcg gtgaccgacc ccgagaagct caacaactac
421 gagcccttct cccccgaggt gtacggggag acctccttcg acctggtggc ccagatgatt
481 gatgagatca agatgaccga cgacgacctg tttgtggact tggggagcgg tgtgggccag
541 gtcgtgctcc aggttgctgc tgccaccaac tgcaaacatc actatggcgt cgagaaagca
601 gacatcccgg ccaagtatgc ggagaccatg gaccgcgagt tcaggaagtg gatgaaatgg
661 tatggaaaaa agcatgcaga atacacattg gagagaggcg atttcctctc agaagagtgg
721 agggagcgaa tcgccaacac gagtgttata tttgtgaata attttgcctt tggtcctgag
781 gtggatcacc agctgaagga gcggtttgca aacatgaagg aaggtggcag aatcgtgtcc
841 tcgaaaccct ttgcacctct gaacttcaga ataaacagta gaaacttgag tgacatcggc
901 accatcatgc gcgtggtgga gctctcgccc ctgaagggct cggtgtcgtg gacggggaag
961 ccagtctcct actacctgca cactatcgac cgcaccatac ttgaaaacta tttttctagt
1021 ctgaaaaacc caaaactcag ggaggaacag gaggcagccc ggcgccgcca gcagcgcgag
1081 agcaagagca acgcggccac gcccactaag ggcccagagg gcaaggtggc cggccccgcc
1141 gacgccccca tggactctgg tgctgaggaa gagaaggcgg gagcagccac cgtgaagaag
1201 ccgtctccct ccaaagcccg caagaagaag ctaaacaaga aggggaggaa gatggctggc
1261 cgcaagcgcg ggcgccccaa gaagatgaac actgcgaacc ccgagcggaa gcccaagaag
1321 aaccaaactg cactggatgc cctgcacgct cagaccgtgt ctcagacggc ggcctcctca
1381 ccccaggatg cctacagatc ccctcacagc ccgttctacc agctacctcc gagcgtgcag
1441 cggcactccc ccaacccgct gctggtggcg cccaccccgc ccgcgctgca gaagcttcta
1501 gagtccttca agatccagta cctgcagttc ctggcataca caaagacccc ccagtacaag
1561 gccagcctgc aggagctgct gggccaggag aaggagaaga acgcccagct cctgggtgcg
1621 gctcagcagc tcctcagcca ctgccaggcc cagaaggagg agatcaggag gctgtttcag
1681 caaaaattgg atgagctggg tgtgaaggcg ctgacctaca acgacctgat tcaagcgcag
1741 aaggagatct ccgcccataa ccagcagctg cgggagcagt cggagcagct ggagcaggac
1801 aaccgcgcgc tccgcggcca gagcttgcag ctgctcaagg ctcgctgcga ggagctgcag
1861 ctggactggg ccacgctgtc gctggagaag ctgttgaagg agaagcaggc cctgaagagc
1921 cagatctcgg agaagcagag gcactgcctg gagctgcaga tcagcattgt ggagctagag
1981 aagagccagc ggcagcagga gctcctgcag ctcaagtcct gtgtgccgcc tgacgacgcc
2041 ctgtccctgc acctgcgtgg gaagggcgcc ctgggccgcg agctggagcc tgacgccagc
2101 cggctgcacc tggagctgga ctgcaccaag ttctcgctgc ctcacttgag cagcatgagc
2161 ccggagctct ccatgaacgg ccaggctgct ggctatgagc tctgcggtgt gctgagccgg
2221 ccttcgtcga agcagaacac gccccagtac ctggcctcac ccctggacca ggaggtggtg
2281 ccctgtaccc ctagccacgt cggccggccg cgcctggaga agctgtctgg cctagccgca
2341 cccgactaca ctaggctgtc cccggccaag attgtgctga ggcggcacct gagccaggac
2401 cacacggtgc ccggcaggcc ggctgccagt gagctgcatt cgagagctga gcacaccaag
2461 gagaacggcc ttccctacca gagccccagc gtgcctggca gcatgaagct gagccctcag
2521 gacccgcggc ccctgtcccc tggggccttg cagcttgctg gagagaagag cagtgagaag
2581 ggcctgagag agcgcgccta cggcagcagc ggggagctca tcaccagcct gcccatcagc
2641 atcccgctca gcaccgtgca gcccaacaag ctcccggtca gcattcccct ggccagcgtg
2701 gtgctgccca gccgcgccga gagggcgagg agcaccccca gtcccgtgct gcagccccgt
2761 gacccctcgt ccacacttga aaagcagatt ggtgctaatg cccacggtgc tgggagcaga
2821 agccttgccc tggcccccgc aggcttctcc tacgctggct cggtggccat cagcggggcc
2881 ttggcgggca gcccggcctc tctcacacct ggagccgagc cggccacctt ggatgagtcc
2941 tccagctctg ggagcctttt tgccaccgtg gggtcccgca gctccacgcc acagcacccc
3001 ctgctgctgg cacagccccg gaactcgctt cctgcctctc ccgcccacca gctctcctcc
3061 agtccccggc ttggtggggc cgcccagggc ccgttgcccg aggccagcaa gggagacctg
3121 ccctccgatt ccggcttctc agatcctgag agtgaagcca agaggaggat tgtgttcacc
3181 atcaccactg gtgcgggcag tgccaagcag tcgccctcca gcaagcacag ccccctgacc
3241 gccagcgccc gtggggactg tgtgccgagc cacgggcagg acagtcgcag gcgcggccgg
3301 cggaagcgag catctgcggg gacgcccagc ttgagcgcag gcgtgtcccc caagcgccga
3361 gccctgccgt ccgtcgctgg ccttttcaca cagccttcgg ggtctcccct caacctcaac
3421 tccatggtca gtaacatcaa ccagcccctg gagattacag ccatctcgtc cccggagacc
3481 tccctgaaga gctcccctgt gccctaccag gaccacgacc agccccccgt gctcaagaag
3541 gagcggcctc tgagccagac caatggggca cactactccc cactcacctc agacgaggag
3601 ccaggctctg aggacgagcc cagcagtgct cgaattgaga gaaaaattgc aacaatctcc
3661 ttagaaagca aatctccccc gaaaaccttg gaaaatggtg gtggcttggc gggaaggaag
3721 cccgcgcccg ccggcgagcc agtcaatagc agcaagtgga agtccacctt ctcgcccatc
3781 tccgacatcg gcctggccaa gtcggcggac agcccgctgc aggccagctc cgccctcagc
3841 cagaactccc tgttcacgtt ccggcccgcc ctggaggagc cctctgccga tgccaagctg
3901 gccgctcacc ccaggaaagg ctttcccggc tccctgtcgg gggctgacgg actcagcccg
3961 ggcaccaacc ctgccaacgg ctgcaccttc ggcgggggcc tggccgcgga cctgagttta
4021 cacagcttca gtgatggtgc ttctcttccc cacaagggcc ccgaggcggc cggcctgagc
4081 tccccgctga gcttcccctc gcagcgcggc aaggagggct cggacgccaa ccctttcctg
4141 agcaagaggc agctggacgg cctggctggg ctgaagggcg agggcagccg cggcaaggag
4201 gcaggggagg gcggcctacc gctgtgcggg cccacggaca agaccccact gctgagcggc
4261 aaggccgcca aggcccggga ccgcgaggtc gacctcaaga atggccacaa cctcttcatc
4321 tctgcggcgg ccgtgcctcc cggaagcctc ctcagcggcc ccggcctggc cccggcggcg
4381 tcctccgcag gcggcgcggc gtcctccgcc cagacgcacc ggtccttcct gggccccttc
4441 ccgccgggac cgcagttcgc gctcggcccc atgtccctgc aggccaacct cggctccgtg
4501 gccggctcct ccgtgctgca gtcgctgttc agctctgtgc cggccgccgc aggcctggtg
4561 cacgtgtcgt ccgctgccac cagactgacc aactcgcacg ccatgggcag cttttccggg
4621 gtggcaggcg gcacagttgg aggtaactag gatttctacc tcaaccgcga gacctatgca
4681 aggacggtgt ggaccaactc gcgcccgcgg catggtgccc gccggcctgc cgggctccca
4741 cccctggacg gcagaggcaa ggacggacgg gagctccact gtgaatcggc ggcacgcgcc
4801 gcaggaggct gggactggtc cagtttgtac tgtcgatagt tttagataaa gtatttatca
4861 ttttttaaaa agtaaaaaaa aaaaaaaaa
//