LOCUS AF508978 2144 bp mRNA linear HUM 30-AUG-2002
DEFINITION Homo sapiens MTA1S mRNA, complete cds; alternatively spliced.
ACCESSION AF508978
VERSION AF508978.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2144)
AUTHORS Kumar,R., Wang,R.A., Mazumdar,A., Talukder,A.H., Mandal,M.,
Yang,Z., Bagheri-Yarmand,R., Sahin,A., Hortobagyi,G., Adam,L.,
Barnes,C.J. and Vadlamudi,R.K.
TITLE A naturally occurring MTA1 variant sequesters oestrogen
receptor-alpha in the cytoplasm
JOURNAL Nature 418 (6898), 654-657 (2002)
PUBMED 12167865
REFERENCE 2 (bases 1 to 2144)
AUTHORS Kumar,R., Wang,R.-A., Mazumdar,A. and Vadlamudi,R.K.
TITLE Direct Submission
JOURNAL Submitted (02-MAY-2002) Molecular and Cellular Oncology, UT MDACC,
1515 Holcomb Blvd, Houston, TX 77030, USA
FEATURES Location/Qualifiers
source 1..2144
/db_xref="H-InvDB:HIT000081032"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="14"
/map="14Q32"
CDS 21..1313
/note="MTA1 splice variant; interacts with ER and enhances
non-genomic responses of ER; expression elevated in human
breast tumors with low levels of nuclear ER; alternatively
spliced"
/codon_start=1
/product="MTA1S"
/protein_id="AAN01613.1"
/translation="MAANMYRVGDYVYFENSSSNPYLIRRIEELNKTANGNVEAKVVC
FYRRRDISSTLIALADKHATLSVCYKAGPGADNGEEGEIEEEMENPEMVDLPEKLKHQ
LRHRELFLSRQLESLPATHIRGKCSVTLLNETESLKSYLEREDFFFYSLVYDPQQKTL
LADKGEIRVGNRYQADITDLLKEGEEDGRDQSRLETQVWEAHNPLTDKQIDQFLVVAR
SVGTFARALDCSSSVRQPSLHMSAAAASRDITLFHAMDTLHKNIYDISKAISALVPQG
GPVLCRDEMEEWSASEANLFEEALEKYGKDFTDIQQDFLPWKSLTSIIEYYYMWKTTD
RYVQQKRLKAAEAESKLKQVYIPNYNKPNPNQISVNNVKAGVVNGTGAPGQSPGAGRA
CESCYMSSLRILLDILEEIWWLENANPVRWREARTKPQ"
misc_feature 1218..1232
/note="Region: nuclear receptor binding motif"
BASE COUNT 502 a 691 c 627 g 324 t
ORIGIN
1 ccgccgccgc cggcccggac atggccgcca acatgtacag ggtcggagac tacgtctact
61 ttgagaactc ctccagcaac ccatacctga tccggagaat cgaggagctc aacaagacgg
121 ccaatgggaa cgtggaggcc aaagtggtgt gcttctaccg gaggcgggac atctccagca
181 ccctcatcgc cctggccgac aagcacgcaa ccctgtcagt ctgctataag gccggaccgg
241 gggcggacaa cggcgaggaa ggggaaatag aagaggaaat ggagaatccg gaaatggtgg
301 acctgcccga gaaactaaag caccagctgc ggcatcggga gctgttcctc tcccggcagc
361 tggagtctct gcccgccacg cacatcaggg gcaagtgcag cgtcaccctg ctcaacgaga
421 ccgagtcgct caagtcctac ctggagcggg aggatttctt cttctattct ctagtctacg
481 acccacagca gaagaccctg ctggcagata aaggagagat tcgagtagga aaccggtacc
541 aggcagacat caccgacttg ttaaaagaag gcgaggagga tggccgagac cagtccaggt
601 tggagaccca ggtgtgggag gcgcacaacc cactcacaga caagcagatc gaccagttcc
661 tggtggtggc ccgctctgtg ggcaccttcg cacgggccct ggactgcagc agctccgtcc
721 gacagcccag cctgcacatg agcgccgcag ctgcctcccg agacatcacc ctgttccacg
781 ccatggatac tctccacaag aacatctacg acatctccaa ggccatctcg gcgctggtgc
841 cgcagggcgg gcccgtgctc tgcagggacg agatggagga gtggtctgca tcagaggcca
901 accttttcga ggaagccctg gaaaaatatg ggaaggattt cacggacatt cagcaagatt
961 ttctcccgtg gaagtcgctg accagcatca ttgagtacta ctacatgtgg aagaccaccg
1021 acagatacgt gcagcagaaa cgcttgaaag cagctgaagc tgagagcaag ttaaagcaag
1081 tttatattcc caactataac aagccaaatc cgaaccaaat cagcgtcaac aacgtcaagg
1141 ccggtgtggt gaacggcacg ggggcgccgg gccagagccc tggggctggc cgggcctgcg
1201 agagctgtta catgtcgtct ctgcgcatct tgttggacat attggaagaa atatggtggc
1261 ttgaaaatgc caacccggtt agatggagag aggccaggac caaaccgcag taacatgagt
1321 ccccacggcc tcccagcccg gagcagcggg agccccaagt ttgccatgaa gaccaggcag
1381 gctttctatc tgcacacgac gaagctgacg cggatcgccc ggcgcctgtg ccgtgagatc
1441 ctgcgcccgt ggcacgctgc gcggaacccc tacctgccca tcaacagcgc ggccatcaag
1501 gccgagtgca cggcgcggct gcccgaagcc tcccagagcc cgctggtgct gaagcaggcg
1561 gtacgcaagc cgctggaagc cgtgcttcgg tatcttgaga cccacccccg cccccccaag
1621 cctgaccccg tgaaaagcgt gtccagcgtg ctcagcagcc tgacgcccgc caaggtggcc
1681 cccgtcatca acaacggctc ccccaccatc ctgggcaagc gcagctacga gcagcacaac
1741 ggggtggacg gcaacatgaa gaagcgcctc ttgatgccca gtaggggtct ggcaaaccac
1801 ggacagacca ggcacatggg accaagccgg aacctcctgc tcaacgggaa gtcctacccc
1861 accaaagtgc gcctgatccg ggggggctcc ctgcccccag tcaagcggcg gcggatgaac
1921 tggatcgacg ccccgggtga cgtgttctac atgcccaaag aggagaccag gaagatccgc
1981 aagctgctct catcctcgga aaccaagcgt gctgcccgcc ggccctacaa gcccatcgcc
2041 ctgcgccaga gccaggccct gccgccgcgg ccaccgccac ctgcgcccgt caacgacgag
2101 cccatcgtca tcgaggacta ggggccgccc ccacctgcgg ccgc
//