LOCUS AF508787 1927 bp mRNA linear HUM 06-NOV-2002
DEFINITION Homo sapiens presenilin stabilization factor (PSF) mRNA, complete
cds.
ACCESSION AF508787
VERSION AF508787.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 1927)
AUTHORS Lee,H.-J. and Kim,T.-W.
TITLE PSF is essential for gamma-secretase activity and stabilization of
presenilin and nicastrin
JOURNAL Unpublished
REFERENCE 2 (bases 1 to 1927)
AUTHORS Lee,H.-J. and Kim,T.-W.
TITLE Direct Submission
JOURNAL Submitted (01-MAY-2002) Pathology, Columbia University, 630 West
168th Street P&S 14-511, New York, NY 10032, USA
FEATURES Location/Qualifiers
source 1..1927
/db_xref="H-InvDB:HIT000081018"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="1"
/map="1p36.13-q31.3"
gene 1..1927
/gene="PSF"
CDS 58..813
/gene="PSF"
/note="polytopic transmembrane protein; CGI-78 protein"
/codon_start=1
/product="presenilin stabilization factor"
/protein_id="AAN63816.1"
/translation="MGAAVFFGCTFVAFGPAFALFLITVAGDPLRVIILVAGAFFWLV
SLLLASVVWFILVHVTDRSDARLQYGLLIFGAAVSVLLQEVFRFAYYKLLKKADEGLA
SLSEDGRSPISIRQMAYVSGLSFGIISGVFSVINILADALGPGVVGIHGDSPYYFLTS
AFLTAAIILLHTFWGVVFFDACERRRYWALGLVVGSHLLTSGLTFLNPWYEASLLPIY
AVTVSMGLWAFITAGGSLRSIQRSSCVRTDYLD"
BASE COUNT 338 a 526 c 513 g 550 t
ORIGIN
1 cccctcccat ttgcctgtcc tggtcaggcc cccacccccc ttcccacctg accagccatg
61 ggggctgcgg tgtttttcgg ctgcactttc gtcgcgttcg gcccggcctt cgcgcttttc
121 ttgatcactg tggctgggga cccgcttcgc gttatcatcc tggtcgcagg ggcatttttc
181 tggctggtct ccctgctcct ggcctctgtg gtctggttca tcttggtcca tgtgaccgac
241 cggtcagatg cccggctcca gtacggcctc ctgatttttg gtgctgctgt ctctgtcctt
301 ctacaggagg tgttccgctt tgcctactac aagctgctta agaaggcaga tgaggggtta
361 gcatcgctga gtgaggacgg aagatcaccc atctccatcc gccagatggc ctatgtttct
421 ggtctctcct tcggtatcat cagtggtgtc ttctctgtta tcaatatttt ggctgatgca
481 cttgggccag gtgtggttgg gatccatgga gactcaccct attacttcct gacttcagcc
541 tttctgacag cagccattat cctgctccat accttttggg gagttgtgtt ctttgatgcc
601 tgtgagagga gacggtactg ggctttgggc ctggtggttg ggagtcacct actgacatcg
661 ggactgacat tcctgaaccc ctggtatgag gccagcctgc tgcccatcta tgcagtcact
721 gtttccatgg ggctctgggc cttcatcaca gctggagggt ccctccgaag tattcagcgc
781 agctcttgtg taaggactga ctacctggac tgatcgcctg acagatccca cctgcctgtc
841 cactgcccat gactgagccc agccccagcc cggggtccat tgcccacatt ctctgtctcc
901 ttctcgtcgg tctaccccac tacctccagg gttttgcttt gtccttttgt gaccgttagt
961 ctctaagctt taccaggagc agcctgggtt cagccagtca gtgactggtg ggtttgaatc
1021 tgcacttatc cccaccacct ggggaccccc ttgttgtgtc caggactccc cctgtgtcag
1081 tgctctgctc tcaccctgcc caagactcac ctcccttccc ctctgcaggc cgacggcagg
1141 aggacagtcg ggtgatggtg tattctgccc tgcgcatccc acccgaggac tgagggaacc
1201 taggggggac ccctgggcct ggggtgccct cctgatgtcc tcgccctgta tttctccatc
1261 tccagttctg gacagtgcag gttgccaaga aaagggacct agtttagcca ttgccctgga
1321 gatgaaatta atggaggctc aaggatagat gagctctgag tttctcagta ctccctcaag
1381 actggacatc ttggtctttt tctcaggcct gagggggaac catttttggt gtgataaata
1441 ccctaaactg cctttttttc ttttttgagg tggggggagg gaggaggtat attggaactc
1501 ttctaacctc cttgggctat attttctctc ctcgagttgc tcctcatggc tgggctcatt
1561 tcggtccctt tctccttggt cccagacctt gggggaaagg aaggaagtgc atgtttggga
1621 actggcatta ctggaactaa tggttttaac ctccttaacc accagcatcc ctcctctccc
1681 caaggtgaag tggagggtgc tgtggtgagc tggccactcc agagctgcag tgccactgga
1741 ggagtcagac taccatgaca tcgtagggaa ggaggggaga tttttttgta gtttttaatt
1801 ggggtgtggg aggggcgggg aggttttcta taaactgtat cattttctgc tgagggtgga
1861 gtgtcccatc cttttaatca aggtgattgt gattttgact aataaaaaag aatttgtaaa
1921 aaaaaaa
//