LOCUS AF480462 7195 bp mRNA linear HUM 15-APR-2002
DEFINITION Homo sapiens mixed lineage kinase-related kinase MRK-beta mRNA,
complete cds.
ACCESSION AF480462
VERSION AF480462.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 7195)
AUTHORS Gross,E.A., Callow,M.G., Waldbaum,L., Thomas,S. and Ruggieri,R.
TITLE MRK, a mixed lineage kinase-related molecule that plays a role in
gamma-radiation-induced cell cycle arrest
JOURNAL J. Biol. Chem. 277 (16), 13873-13882 (2002)
PUBMED 11836244
REFERENCE 2 (bases 1 to 7195)
AUTHORS Gross,E.A., Callow,M.G. and Ruggieri,R.
TITLE Direct Submission
JOURNAL Submitted (04-FEB-2002) North Shore-Long Island Jewish Research
Institute, 350 Community Drive, Manhasset, NY 11030, USA
FEATURES Location/Qualifiers
source 1..7195
/db_xref="H-InvDB:HIT000080455"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="2"
/map="2q31"
CDS 196..1563
/codon_start=1
/product="mixed lineage kinase-related kinase MRK-beta"
/protein_id="AAL85892.1"
/translation="MSSLGASFVQIKFDDLQFFENCGGGSFGSVYRAKWISQDKEVAV
KKLLKIEKEAEILSVLSHRNIIQFYGVILEPPNYGIVTEYASLGSLYDYINSNRSEEM
DMDHIMTWATDVAKGMHYLHMEAPVKVIHRDLKSRNVVIAADGVLKICDFGASRFHNH
TTHMSLVGTFPWMAPEVIQSLPVSETCDTYSYGVVLWEMLTREVPFKGLEGLQVAWLV
VEKNERLTIPSSCPRSFAELLHQCWEADAKKRPSFKQIISILESMSNDTSLPDKCNSF
LHNKAEWRCEIEATLERLKKLERDLSFKEQELKERERRLKMWEQKLTEQSNTPLLLPL
AARMSEESYFESKTEESNSAEMSCQITATSNGEGHGMNPSLQAMMLMGFGDIFSMNKA
GAVMHSGMQINMQAKQNSSKTTSKRRGKKVNMALGFSDFDLSEGDDDDDDDGEEEDND
MDNSE"
BASE COUNT 2257 a 1324 c 1506 g 2108 t
ORIGIN
1 cttcctcatt ggcgccgtgc agagaggcgg aatgttcaac tcctaactgc ggcggaaacg
61 tgggagccgc gcgggccgct gtcgtcccaa cccccgccgc cctcgtcgcg cgcggggcct
121 ccgcgccccc ggctgctgct cacgccccgc ccgggagcca gattttgtgg aagtataata
181 ctttgtcatt atgagatgtc gtctctcggt gcctcctttg tgcaaattaa atttgatgac
241 ttgcagtttt ttgaaaactg cggtggagga agttttggga gtgtttatcg agccaaatgg
301 atatcacagg acaaggaggt ggctgtaaag aagctcctca aaatagagaa agaggcagaa
361 atactcagtg tcctcagtca cagaaacatc atccagtttt atggagtaat tcttgaacct
421 cccaactatg gcattgtcac agaatatgct tctctgggat cactctatga ttacattaac
481 agtaacagaa gtgaggagat ggatatggat cacattatga cctgggccac tgatgtagcc
541 aaaggaatgc attatttaca tatggaggct cctgtcaagg tgattcacag agacctcaag
601 tcaagaaacg ttgttatagc tgctgatgga gtattgaaga tctgtgactt tggtgcctct
661 cggttccata accatacaac acacatgtcc ttggttggaa ctttcccatg gatggctcca
721 gaagttatcc agagtctccc tgtgtcagaa acttgtgaca catattccta tggtgtggtt
781 ctctgggaga tgctaacaag ggaggtcccc tttaaaggtt tggaaggatt acaagtagct
841 tggcttgtag tggaaaaaaa cgagagatta accattccaa gcagttgccc cagaagtttt
901 gctgaactgt tacatcagtg ttgggaagct gatgccaaga aacggccatc attcaagcaa
961 atcatttcaa tcctggagtc catgtcaaat gacacgagcc ttcctgacaa gtgtaactca
1021 ttcctacaca acaaggcgga gtggaggtgc gaaattgagg caactcttga gaggctaaag
1081 aaactagagc gtgatctcag ctttaaggag caggagctta aagaacgaga aagacgttta
1141 aagatgtggg agcaaaagct gacagagcag tccaacaccc cgcttctctt gcctcttgct
1201 gcaagaatgt ctgaggagtc ttactttgaa tctaaaacag aggagtcaaa cagtgcagag
1261 atgtcatgtc agatcacagc aacaagtaac ggggagggcc atggcatgaa cccaagtctg
1321 caggccatga tgctgatggg ctttggggat atcttctcaa tgaacaaagc aggagctgtg
1381 atgcattctg ggatgcagat aaacatgcaa gccaagcaga attcttccaa aaccacatct
1441 aagagaaggg ggaagaaagt caacatggct ctggggttca gtgattttga cttgtcagaa
1501 ggtgacgatg atgatgatga tgacggtgag gaggaggata atgacatgga taatagtgaa
1561 tgaaagcaga aagcaaagta ataaaatcac aaatgtttgg aaaacacaaa agtaacttgt
1621 ttatctcagt ctgtacaaaa acagtaagga ggcagaaagc caagcactgc atttttaggc
1681 caatcacatt tacatgaccg taatttctta tcaattctac ttttattttt gcttacagaa
1741 aaacgggggg agaattaagc caaagaagta tatttatgaa tcagcaaatg tggtgcctga
1801 ttatagaaat ttgtgatccc tatatacaat ataggatttt taaagttgag acattctggc
1861 tttttctttt aatgaatact ttttagtttg tattggactt tatttccttt attcaaatca
1921 tttttaaaaa ctaacatttt gaacaaacat tcttaactcc taattgttct tagacacgta
1981 gtaattctgt gacatacttt ttttttctta tagcaataca ctgtaatatc agaaatggtt
2041 ggcctgagca acctagtaag acttcgtctc tactaataat taaaaaacta gctggcatgg
2101 tagcacacac ctgtagtccc agatacttgg gaggccaagg caggaggatt gcttgagacc
2161 tagcaatcag tcagggctgc agtgagccat gaggcaccac tgcactctag cctgggcaag
2221 agaacaagat cctgtctcaa aaaacaaaaa aaagaaagaa ttgatagtac aaaatccaac
2281 aacaatactg agatgatcta agaaggttat aacaaaatgc tcttcagaaa tacctaagtg
2341 ctgagaattt ttagtactaa agagcacagc tgctcaaagt aaagcctgag cagtgttctc
2401 agtaatgtat ttgaaggaaa aataccctga tttgaaacca acagcagatg ttgcaaactt
2461 tcataccact gctggccatg gaagcctctt aacaacacac tgtcatttaa ggctgtgctt
2521 gtgctttata caaagagaaa gaggtggtct taaggggatg cttccagggg ggtgagttca
2581 tgcctctcct gtattttcca gcaagtgggg tatgtgtggt ggtttgtttt ttagaggggc
2641 ataataatcc aggattctaa gcatatgctc agctatttta aagaggaaat taaatattat
2701 aaaagaaata gtaaagataa gttatcctca cttaggcaaa agcacaggtc ctttccatat
2761 caagtttagc ctaccagggt tgttttttgt tttaaccctg cttaataatg ttggtgtttt
2821 agaagtagat acaggcactg ctctgaaaac ctggctagcc aaggatattc tcagaatgtt
2881 atcacctgtt tgtcaaagct tgtttaaatt ataaaacact tttaattata tatatgaggc
2941 aaaagaacta agactttttt caaactaaat tagaaaggag tgtcattatt tgactgttaa
3001 accaaaatat ttttggtggg tctttttatg gaagtttaaa gaaaggacat catcatagat
3061 atgatctaac agtatttcta actatatttg atcattaaaa gcctcttgga atttgaagcg
3121 tgacgtgttt ctaatgcccc ttgagaggtg aaaaatacca cataatgatc agtatgctgt
3181 gccagcttca tttggggaga aataactagt agaaagttct gggtgtgagg tgtacagcag
3241 tctaggtggc atagtgatga agaaagggat cagagtctga ctgtcactca gaatcctggg
3301 ctcagttgct tgacaacctt gggaaaattg ttttatcttt gtgcgtctgt ttgctgatct
3361 tcagcgtggg aataataaca gtacctactt gaaaggatca ttgtgcggat taaaagaaat
3421 aatatatgta aagcacttta acacagcacc aggcccacgg aaagtggcta atgttagcta
3481 ctatgaatgg tgccagtgaa gacactgaaa aataagtgat ttcagtaacc ttctggaaag
3541 ctatcagttt caaataatat tttctctgta gtatgagatg aaattaaaag tggatagctt
3601 tcaggaaaga taaagagaac atgcttagaa tgtaagctaa acagattttt tctgttgctc
3661 tttgaaaact atgagccctg gccagcttaa cctggtctga ggtgagacta aacacaaaaa
3721 cagtagataa atctctccct aaaagatgga ttcccccaca tacccatgct actagtttct
3781 ctgtctattc acacatatgt acaaatacat gaacacagcc tgtctgtgct cagacataga
3841 gaagtactac ctgacttgag tcaatgcacc caagaagaaa agcttggagt agagcagaag
3901 ggagggcttg ggactcctgt ctttccagca tgccctgggg tgcagtggtc agccacctga
3961 agagagagcc aatagcatgg ggtttacaag gcaaagatag tcattcattc aacacatatt
4021 catagagctc cttctctgtg ccagacactg ttctggaaga tagctagatg aaaatctttg
4081 cactcacaga gcttacatgc cagtgagtga agatcgatga taaataaagc aaatgcatca
4141 tatgttcaca tttgataagt atatgccaaa aaatgaagcc gggaaggagg acaaggccca
4201 tgggtgggtg ttgaggtttt taaagtgtgg tcaggaaagg ccccactgat aaggtaacat
4261 ttgagcaagt ctgaaaaagg caaggggatc tttggggcta acttcgggat ccctgcactt
4321 tatgtaagaa tgtaaacctg gagtctcatt taagaatgat cagcaatacg tttagaacat
4381 atgaactgaa tgaaatggac attttttctt aatttatgta taaatccata tgattataca
4441 taaagttctg atgcattaat aaaagcagcc aaatagggcc aaagagaaaa ataacaggac
4501 tctgtactgg acctaacttt atcattaatt aggtaatatt ttcctcattt ctttactgct
4561 gccattttcc tcaccagtat tccagagatg gtcatagctc attactctac caccaagaac
4621 ctaaaaggaa ttagaataca gcagaattgg cctcagtgaa gagcttaaaa ttgttctcct
4681 cgtagaactg gactattgat cattaccacg tgacgttggc tctattactt tctgttccca
4741 atgtccttct agtggtttga aaatgttaaa acatccctaa aatctaaatc atataatcag
4801 aattctatag tgtcccactc tatctgtaaa gatcatttgg aagactttag actctattaa
4861 ttttaaaagg aatatttatt agccatatgc agaatttcta atgatgatat tgtacagctt
4921 ctaattcact tttcagatca gtgtttgaaa tggcaattat cagtgttgga tttagttcca
4981 actacttgat ttacaaaaat gtacatttag aggttaaaag aaacagtgag aaatgtaaac
5041 attcaaaatg ataattgaat ctctcagttg tgggaataat tatcagagac atgcaactga
5101 aaatgtctca cctttcatct ttttttctta attcataaag ttatcttgta gaatttgatg
5161 agaccctccc tagtcattct caactggggc ggtgctgtca ccgaatggtg tttgagagtg
5221 ttggggctag ggcacatttt tggttgtcac agcaactggg gtggcatttg ctgcccagtg
5281 ccaggaatag taacattatg aatgccaggg acagtgtgct cagtaaagtc ttccatccaa
5341 aaggggcagg gcacggtggc tcacgcctgt aatcccagca ctttgggagg ccaaggtggg
5401 cggatcacct gatgtcaggg gttcgagacc agcctggcca acatggtgaa accctgttgc
5461 tactaaaaat acaaaaattg gctgggtgtg gtgtcacatg ccagtaaccc cagctactag
5521 ggaggctgag gcaggagaat cacttgaacc cgggaggcag aggttgcagt gagctgagat
5581 tgcaccacta cactccagcc tggatgacag agtgagactt catctcaaaa aaaaaaaaaa
5641 acaaaaaaaa acaacccggt agcattgtcc cttccccact gacaaactta tcaaatccag
5701 aagctttaga gtttcgtctc taattatttt tctcctgaac aaaattaccc aagtcaaaac
5761 aaaatgtatt tttagaatta cggcagcata cgacctgaat tttgtgagtt tcgtggcttt
5821 atcttaaatc accatttccc taaaaatggt ttctttctcc ttagaaatgc tggtggcaac
5881 ttgatgaaac agccaaatgc accagggcag gtcactttcc cattacactg attccacaat
5941 taaaaaaaaa aaagaaaaaa aactcattga gatagctaca gttctatagg ttaatttaaa
6001 gcctcctttt tctactcatt tttgaaagca aaattacatt ttactatttt acataaccag
6061 tgaaaagacg ttgaaagcct acagctcact gtttttggtg ctctggaaat gttgagggtg
6121 ggtttttaac cagtgatttt taacgtgcag tgaatttgtt agacttttaa acaccagcta
6181 aggtagtcaa acttgatccc cattaaaaat caaggaatta ggggtcgggg gagggtttag
6241 gagtgatcca gaatgacctc ccagaattac tgtgcgtaca actttatttt tcagagtttt
6301 cattggaatg gtaagagttt tatgaaagac agttttaaaa cttattctga gttaaatatt
6361 aatactttaa aaaattattg tactagactt attgcagcct tttgaaagta gcagagtttc
6421 atcataccac atatataaca gagcataaat tttctataat caggcacctt ttgctgcttt
6481 tgagtaagac tgttttcctg tttaagtgtt aagcatcgcc agacataaaa atctattctc
6541 tcctctcgat tgtagcatag cctgacagct ctagatacag catttctatg atgaaaaatg
6601 agtatccatc aggaaatcta gaagactagc cgtgttttct cagactccac ctttgtttgc
6661 actctgttgc ctgtgaggag ctttctggca tgtgattatt tacttcaaaa ctagagttcc
6721 aagcacctac attaattatt ttatattgtg tgcagaatag tatatctttt aatgtcagat
6781 atgatacact gcacatattg cttttgcact cttaaaattt ttgtactaaa taatagaaaa
6841 tatttatatt ctttgagtgt gagctttgaa tagatggcat tatcacttta ttgttttttt
6901 aacaaaaact ttttctcaat tattctattg caatgttatt ctgagcaagt cctatgccaa
6961 atatcttgta taatgtttgt atggaagatt aaattttact cttgtgtggt aagactattt
7021 cagttactga ttttatagtt ggaatttgat attccagcac aaagtccaca gtgtattcag
7081 aaatccaagt tggtgtcata catttcattt tgatgtgaac ttttctttgc tttcctttgt
7141 tctaagactc cattttgcaa taaacgtttt gacagtaaaa aaaaaaaaaa aaaaa
//