LOCUS AF478446 1489 bp mRNA linear HUM 17-JUN-2002
DEFINITION Homo sapiens farnesoid-X-receptor beta splice variant 2 (NR1H4)
mRNA, complete cds; alternatively spliced.
ACCESSION AF478446
VERSION AF478446.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 1489)
AUTHORS Huber,R.M., Murphy,K., Miao,B., Link,J.R., Cunningham,M.R.,
Rupar,M.J., Gunyuzlu,P.L., Haws,T.F. Jr., Kassam,A., Powell,F.,
Hollis,G.F., Young,P.R., Mukherjee,R. and Burn,T.C.
TITLE Generation of multiple farnesoid-X-receptor isoforms through the
use of alternative promoters
JOURNAL Gene 290 (1-2), 35-43 (2002)
PUBMED 12062799
REFERENCE 2 (bases 1 to 1489)
AUTHORS Huber,R.M., Murphy,K., Mukherjee,R. and Burn,T.C.
TITLE Direct Submission
JOURNAL Submitted (30-JAN-2002) Metabolic Diseases, Bristol-Myers Squibb,
Experimental Station E400/3468, Wilmington, DE 19880, USA
FEATURES Location/Qualifiers
source 1..1489
/db_xref="H-InvDB:HIT000080413"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
gene 1..1489
/gene="NR1H4"
CDS 29..1489
/gene="NR1H4"
/note="nuclear receptor subfamily 1, group H, member 4;
alternatively spliced"
/codon_start=1
/product="farnesoid-X-receptor beta splice variant 2"
/protein_id="AAM53551.1"
/translation="MVMQFQGLENPIQISPHCSCTPSGFFMEMMSMKPAKGVLTEQVA
GPLGQNLEVEPYSQYSNVQFPQVQPQISSSSYYSNLGFYPQQPEEWYSPGIYELRRMP
AETLYQGETEVAEMPVTKKPRMGASAGRIKGDELCVVCGDRASGYHYNALTCEGCKGF
FRRSITKNAVYKCKNGGNCVMDMYMRRKCQECRLRKCKEMGMLAECMYTGLLTEIQCK
SKRLRKNVKQHADQTVNEDSEGRDLRQVTSTTKSCREKTELTPDQQTLLHFIMDSYNK
QRMPQEITNKILKEEFSAEENFLILTEMATNHVQVLVEFTKKLPGFQTLDHEDQIALL
KGSAVEAMFLRSAEIFNKKLPSGHSDLLEERIRNSGISDEYITPMFSFYKSIGELKMT
QEEYALLTAIVILSPDRQYIKDREAVEKLQEPLLDVLQKLCKIHQPENPQHFACLLGR
LTELRTFNHHHAEMLMSWRVNDHKFTPLLCEIWDVQ"
BASE COUNT 471 a 287 c 355 g 376 t
ORIGIN
1 attttcagtg gctgtgaata agctaagaat ggtaatgcag tttcaggggt tagaaaatcc
61 aattcaaatt agtcctcact gcagctgtac gccgtcagga tttttcatgg aaatgatgag
121 tatgaagccc gcgaaaggtg ttttaacaga acaagtggca ggtcctctgg gacagaacct
181 ggaagtggaa ccatactcgc aatacagcaa tgttcagttt ccccaagttc aaccacagat
241 ttcctcgtca tcctattatt ccaacctggg tttctacccc cagcagcctg aagagtggta
301 ctctcctgga atatatgaac tcaggcgtat gccagctgag actctctacc agggagaaac
361 tgaggtagca gagatgcctg taacaaagaa gccccgcatg ggcgcgtcag cagggaggat
421 caaaggggat gagctgtgtg ttgtttgtgg agacagagcc tctggatacc actataatgc
481 actgacctgt gaggggtgta aaggtttctt caggagaagc attaccaaaa acgctgtgta
541 caagtgtaaa aacgggggca actgtgtgat ggatatgtac atgcgaagaa agtgtcaaga
601 gtgtcgacta aggaaatgca aagagatggg aatgttggct gaatgtatgt atacaggctt
661 gttaactgaa attcagtgta aatctaagcg actgagaaaa aatgtgaagc agcatgcaga
721 tcagaccgtg aatgaagaca gtgaaggtcg tgacttgcga caagtgacct cgacaacaaa
781 gtcatgcagg gagaaaactg aactcacccc agatcaacag actcttctac attttattat
841 ggattcatat aacaaacaga ggatgcctca ggaaataaca aataaaattt taaaagaaga
901 attcagtgca gaagaaaatt ttctcatttt gacggaaatg gcaaccaatc atgtacaggt
961 tcttgtagaa ttcacaaaaa agctaccagg atttcagact ttggaccatg aagaccagat
1021 tgctttgctg aaagggtctg cggttgaagc tatgttcctt cgttcagctg agattttcaa
1081 taagaaactt ccgtctgggc attctgacct attggaagaa agaattcgaa atagtggtat
1141 ctctgatgaa tatataacac ctatgtttag tttttataaa agtattgggg aactgaaaat
1201 gactcaagag gagtatgctc tgcttacagc aattgttatc ctgtctccag atagacaata
1261 cataaaggat agagaggcag tagagaagct tcaggagcca cttcttgatg tgctacaaaa
1321 gttgtgtaag attcaccagc ctgaaaatcc tcaacacttt gcctgtctcc tgggtcgcct
1381 gactgaatta cggacattca atcatcacca cgctgagatg ctgatgtcat ggagagtaaa
1441 cgaccacaag tttaccccac ttctctgtga aatctgggac gtgcagtga
//