LOCUS AF465484 8374 bp mRNA linear HUM 14-AUG-2002
DEFINITION Homo sapiens jejunum L-type calcium channel alpha1C subunit mRNA,
complete cds.
ACCESSION AF465484
VERSION AF465484.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 8374)
AUTHORS Lyford,G.L., Strege,P.R., Shepard,A., Ou,Y., Ermilov,L.,
Miller,S.M., Gibbons,S.J., Rae,J.L., Szurszewski,J.H. and
Farrugia,G.
TITLE alpha(1C) (Ca(V)1.2) L-type calcium channel mediates
mechanosensitive calcium regulation
JOURNAL Am. J. Physiol., Cell Physiol. 283 (3), C1001-C1008 (2002)
PUBMED 12176756
REFERENCE 2 (bases 1 to 8374)
AUTHORS Lyford,G.L., Strege,P., Shepard,A., Miller,S., Rae,J.,
Gibbons,S.J., Szurszewski,J. and Farrugia,G.
TITLE Direct Submission
JOURNAL Submitted (03-JAN-2002) Department of Physiology and Biophysics,
Mayo Foundation, 200 First St. SW, Rochester, MN 55905, USA
FEATURES Location/Qualifiers
source 1..8374
/db_xref="H-InvDB:HIT000080310_02"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/tissue_type="jejunal circular smooth muscle"
CDS 266..6682
/note="CaV1.2"
/codon_start=1
/product="jejunum L-type calcium channel alpha1C subunit"
/protein_id="AAM70049.1"
/translation="MVNENTRMYIPEENHQGSNYGSPRPAHANMNANAAAGLAPEHIP
TPGAALSWQAAIDAARQAKLMGSAGNATISTVSSTQRKRQQYGKPKKQGSTTATRPPR
ALLCLTLKNPIRRACISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLE
RVEYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKA
DGANALGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVL
FVIIIYAIIGLELFMGKMHKTCYNQEGIADVPAEDDPSPCALETGHGRQCQNGTVCKP
GWDGPKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWVNDAVGRDWPWIYFVTLIIIG
SFFVLNLVLGVLSGEFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPE
NEDEGMDEEKPRNMSMPTSETESVNTENVAGGDIEGENCGARLAHRISKSKFSRYWRR
WNRFCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASEHYNQPNWLTEVQDTANKALLAL
FTAEMLLKMYSLGLQAYFVSLFNRFDCFVVCGGILETILVETKIMSPLGISVLRCVRL
LRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDEM
QTRRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFPGMLVCIYFIILFICG
NYILLNVFLAIAVDNLADAESLTSAQKEEEEEKERKKLARTASPEKKQELVEKPAVGE
SKEEKIELKSITADGESPPATKINMDDLQPNENEDKSPYPNPETTGEEDEEEPEMPVG
PRPRPLSELHLKEKAVPMPEASAFFIFSSNNRFRLQCHRIVNDTIFTNLILFFILLSS
ISLAAEDPVQHTSFRNHILFYFDIVFTTIFTIEIALKMTAYGAFLHKGSFCRNYFNIL
DLLVVSVSLISFGIQSSAINVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIG
NIVIVTTLLQFMFACIGVQLFKGKLYTCSDSSKQTEAECKGNYITYKDGEVDHPIIQP
RSWENSKFDFDNVLAAMMALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFF
IIYIIIIAFFMMNIFVGFVIVTFQEQGEQEYKNCELDKNQRQCVEYALKARPLRRYIP
KNQHQYKVWYVVNSTYFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNILNMLFTGLF
TVEMILKLIAFKPKHYFCDAWNTFDALIVVGSIVDIAITEVNPAEHTQCSPSMNAEEN
SRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIG
MQVFGKIALNDTTEINRNNNFQTFPQAVLLLFRCATGEAWQDIMLACMPGKKCAPESE
PSNSTEGETPCGSSFAVFYFISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHL
DEFKRIWAEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVSMNMPLNS
DGTVMFNATLFALVRTALRIKTEGNLEQANEELRAIIKKIWKRTSMKLLDQVVPPAGD
DEVTVGKFYATFLIQEYFRKFKKRKEQGLVGKPSQRNALSLQAGLRTLHDIGPEIRRA
ISGDLTAEEELDKAMKEAVSAASEDDIFRRAGGLFGNHVSYYQSDGRSAFPQTFTTQR
PLHINKAGSSQGDTESPSHEKLVDSTFTPSSYSSTGSNANINNANNTALGRLPRPAGY
PSTVSTVEGHGPPLSPAIRVQEVAWKLSSNRCHSRESQAAMAGQEETSQDETYEVKMN
HDTEACSEPSLLSTEMLSYQDDENRQLTLPEEDKRDIRQSPKRGFLRSASLGRRASFH
LECLKRQKDRGGDISQKTVLPLHLVHHQALAVAGLSPLLQRSHSPASFPRPFATPPAT
PGSRGWPPQPVPTLRLEGVESSEKLNSSFPSIHCGSWAETTPGGGGSSAARRVRPVSL
MVPSQAGAPGRQFHGSASSLVEAVLISEGLGQFAQDPKFIEVTTQELADACDMTIEEM
ESAADNILSGGAPQSPNGALLPFVNCRDAGQDRAGGEEDAGCVRARGRPSEEELQDSR
VYVSSL"
BASE COUNT 1871 a 2362 c 2290 g 1851 t
ORIGIN
1 ggaaggggcc cggatgtact gaggatgcgt tacagtttca ctcgaggagg cagtagtgga
61 aaggagcagt ttttggggtt tgatgccata atgggaatca ggtaatcgtc ggcggggaag
121 aagaaacgct gcagaccacg gcttcctcga atcttgcgcg aaagccgccg gcctcggagg
181 agggattaat ccagacccgc cggggggtgt tttcacattt cttcctcttc gtggctgctc
241 ctcctattaa aaccattttt ggtccatggt caatgagaat acgaggatgt acattccaga
301 ggaaaaccac caaggttcca actatgggag cccacgcccc gcccatgcca acatgaatgc
361 caatgcggca gcggggctgg cccctgagca catccccacc ccgggggctg ccctgtcgtg
421 gcaggcggcc atcgacgcag cccggcaggc taagctgatg ggcagcgctg gcaatgcgac
481 catctccaca gtcagctcca cgcagcggaa gcggcagcaa tatgggaaac ccaagaagca
541 gggcagcacc acggccacac gcccgccccg agccctgctc tgcctgaccc tgaagaaccc
601 catccggagg gcctgcatca gcattgtcga atggaaacca tttgaaataa ttattttact
661 gactattttt gccaattgtg tggccttagc gatctatatt ccctttccag aagatgattc
721 caacgccacc aattccaacc tggaacgagt ggaatatctc tttctcataa tttttacggt
781 ggaagcgttt ttaaaagtaa tcgcctatgg actcctcttt caccccaatg cctacctccg
841 caacggctgg aacctactag attttataat tgtggttgtg gggcttttta gtgcaatttt
901 agaacaagca accaaagcag atggggcaaa cgctctcgga gggaaagggg ccggatttga
961 tgtgaaggcg ctgagggcct tccgcgtgct gcgccccctg cggctggtgt ccggagtccc
1021 aagtctccag gtggtcctga attccatcat caaggccatg gtccccctgc tgcacatcgc
1081 cctgcttgtg ctgtttgtca tcatcatcta cgccatcatc ggcttggagc tcttcatggg
1141 gaagatgcac aagacctgct acaaccagga gggcatagca gatgttccag cagaagatga
1201 cccttcccct tgtgcgctgg aaacgggcca cgggcggcag tgccagaacg gcacggtgtg
1261 caagcccggc tgggatggtc ccaagcacgg catcaccaac tttgacaact ttgccttcgc
1321 catgctcacg gtgttccagt gcatcaccat ggagggctgg acggacgtgc tgtactgggt
1381 caatgatgcc gtaggaaggg actggccctg gatctatttt gttacactaa tcatcatagg
1441 gtcatttttt gtacttaact tggttctcgg tgtgcttagc ggagagtttt ccaaagagag
1501 ggagaaggcc aaggcccggg gagatttcca gaagctgcgg gagaagcagc agctagaaga
1561 ggatctcaaa ggctacctgg attggatcac tcaggccgaa gacatcgatc ctgagaatga
1621 ggacgaaggc atggatgagg agaagccccg aaacatgagc atgcccacca gtgagaccga
1681 gtccgtcaac accgaaaacg tggctggagg tgacatcgag ggagaaaact gcggggccag
1741 gctggcccac cggatctcca agtcaaagtt cagccgctac tggcgccggt ggaatcggtt
1801 ctgcagaagg aagtgccgcg ccgcagtcaa gtctaatgtc ttctactggc tggtgatttt
1861 cctggtgttc ctcaacacgc tcaccattgc ctctgagcac tacaaccagc ccaactggct
1921 cacagaagtc caagacacgg caaacaaggc cctgctggcc ctgttcacgg cagagatgct
1981 cctgaagatg tacagcctgg gcctgcaggc ctacttcgtg tccctcttca accgctttga
2041 ctgcttcgtc gtgtgtggcg gcatcctgga gaccatcctg gtggagacca agatcatgtc
2101 cccactgggc atctccgtgc tcagatgcgt ccggctgctg aggattttca agatcacgag
2161 gtactggaac tccttgagca acctggtggc atccttgctg aactctgtgc gctccatcgc
2221 ctccctgctc cttctcctct tcctcttcat catcatcttc tccctcctgg ggatgcagct
2281 ctttggagga aagttcaact ttgatgagat gcagacccgg aggagcacat tcgataactt
2341 cccccagtcc ctcctcactg tgtttcagat cctgaccggg gaggactgga attcggtgat
2401 gtatgatggg atcatggctt atggcggccc ctcttttcca gggatgttag tctgtattta
2461 cttcatcatc ctcttcatct gtggaaacta tatcctactg aatgtgttct tggccattgc
2521 tgtggacaac ctggctgatg ctgagagcct cacatctgcc caaaaggagg aggaagagga
2581 gaaggagaga aagaagctgg ccaggactgc cagcccagag aagaaacaag agttggtgga
2641 gaagccggca gtgggggaat ccaaggagga gaagattgag ctgaaatcca tcacggctga
2701 cggagagtct ccacccgcca ccaagatcaa catggatgac ctccagccca atgaaaatga
2761 ggataagagc ccctacccca acccagaaac tacaggagaa gaggatgagg aggagccaga
2821 gatgcctgtc ggccctcgcc cacgaccact ctctgagctt caccttaagg aaaaggcagt
2881 gcccatgcca gaagccagcg cgtttttcat cttcagctct aacaacaggt ttcgcctcca
2941 gtgccaccgc attgtcaatg acacgatctt caccaacctg atcctcttct tcattctgct
3001 cagcagcatt tccctggctg ctgaggaccc ggtccagcac acctccttca ggaaccatat
3061 tctgttttat tttgatattg tttttaccac cattttcacc attgaaattg ctctgaagat
3121 gactgcttat ggggctttct tgcacaaggg ttctttctgc cggaactact tcaacatcct
3181 ggacctgctg gtggtcagcg tgtccctcat ctcctttggc atccagtcca gtgcaatcaa
3241 tgtcgtgaag atcttgcgag tcctgcgagt actcaggccc ctgagggcca tcaacagggc
3301 caaggggcta aagcatgtgg ttcagtgtgt gtttgtcgcc atccggacca tcgggaacat
3361 cgtgattgtc accaccctgc tgcagttcat gtttgcctgc atcggggtcc agctcttcaa
3421 gggaaagctg tacacctgtt cagacagttc caagcagaca gaggcggaat gcaagggcaa
3481 ctacatcacg tacaaagacg gggaggttga ccaccccatc atccaacccc gcagctggga
3541 gaacagcaag tttgactttg acaatgttct ggcagccatg atggccctct tcaccgtctc
3601 caccttcgaa gggtggccag agctgctgta ccgctccatc gactcccaca cggaagacaa
3661 gggccccatc tacaactacc gtgtggagat ctccatcttc ttcatcatct acatcatcat
3721 catcgccttc ttcatgatga acatcttcgt gggcttcgtc atcgtcacct ttcaggagca
3781 gggggagcag gagtacaaga actgtgagct ggacaagaac cagcgacagt gcgtggaata
3841 cgccctcaag gcccggcccc tgcggaggta catccccaag aaccagcacc agtacaaagt
3901 gtggtacgtg gtcaactcca cctacttcga gtacctgatg ttcgtcctca tcctgctcaa
3961 caccatctgc ctggccatgc agcactacgg ccagagctgc ctgttcaaaa tcgccatgaa
4021 catcctcaac atgctcttca ctggcctctt caccgtggag atgatcctga agctcattgc
4081 cttcaaaccc aagcactatt tctgtgatgc atggaataca tttgacgcct tgattgttgt
4141 gggtagcatt gttgatatag caatcaccga ggtaaaccca gctgaacata cccaatgctc
4201 tccctctatg aacgcagagg aaaactcccg catctccatc accttcttcc gcctgttccg
4261 ggtcatgcgt ctggtgaagc tgctgagccg tggggagggc atccggacgc tgctgtggac
4321 cttcatcaag tccttccagg ccctgcccta tgtggccctc ctgatcgtga tgctgttctt
4381 catctacgcg gtgatcggga tgcaggtgtt tgggaaaatt gccctgaatg ataccacaga
4441 gatcaaccgg aacaacaact ttcagacctt cccccaggcc gtgctgctcc tcttcaggtg
4501 tgccaccggg gaggcctggc aggacatcat gctggcctgc atgccaggca agaagtgtgc
4561 cccagagtcc gagcccagca acagcacgga gggtgaaaca ccctgtggta gcagctttgc
4621 tgtcttctac ttcatcagct tctacatgct ctgtgccttc ctgatcatca acctctttgt
4681 agctgtcatc atggacaact ttgactacct gacaagggac tggtccatcc ttggtcccca
4741 ccacctggat gagtttaaaa gaatctgggc agagtatgac cctgaagcca agggtcgtat
4801 caaacacctg gatgtggtga ccctcctccg gcggattcag ccgccactag gttttgggaa
4861 gctgtgccct caccgcgtgg cttgcaaacg cctggtctcc atgaacatgc ctctgaacag
4921 cgacgggaca gtcatgttca atgccaccct gtttgccctg gtcaggacgg ccctgaggat
4981 caaaacagaa gggaacctag aacaagccaa tgaggagctg cgggcgatca tcaagaagat
5041 ctggaagcgg accagcatga agctgctgga ccaggtggtg ccccctgcag gtgatgatga
5101 ggtcaccgtt ggcaagttct acgccacgtt cctgatccag gagtacttcc ggaagttcaa
5161 gaagcgcaaa gagcagggcc ttgtgggcaa gccctcccag aggaacgcgc tgtctctgca
5221 ggctggcttg cgcacactgc atgacatcgg gcctgagatc cgacgggcca tctctggaga
5281 tctcaccgct gaggaggagc tggacaaggc catgaaggag gctgtgtccg ctgcttctga
5341 agatgacatc ttcaggaggg ccggtggcct gttcggcaac cacgtcagct actaccaaag
5401 cgacggccgg agcgccttcc cccagacctt caccactcag cgcccgctgc acatcaacaa
5461 ggcgggcagc agccagggcg acactgagtc gccatcccac gagaagctgg tggactccac
5521 cttcaccccg agcagctact cgtccaccgg ctccaacgcc aacatcaaca acgccaacaa
5581 caccgccctg ggtcgcctcc ctcgccccgc cggctacccc agcacagtca gcactgtgga
5641 gggccacggg ccccccttgt cccctgccat ccgggtgcag gaggtggcgt ggaagctcag
5701 ctccaacagg tgccactccc gggagagcca ggcagccatg gcgggtcagg aggagacgtc
5761 tcaggatgag acctatgaag tgaagatgaa ccatgacacg gaggcctgca gtgagcccag
5821 cctgctctcc acagagatgc tctcctacca ggatgacgaa aatcggcaac tgacgctccc
5881 agaggaggac aagagggaca tccggcaatc tccgaagagg ggtttcctcc gctctgcctc
5941 actaggtcga agggcctcct tccacctgga atgtctgaag cgacagaagg accgaggggg
6001 agacatctct cagaagacag tcctgccctt gcatctggtt catcatcagg cattggcagt
6061 ggcaggcctg agccccctcc tccagagaag ccattcccct gcctcattcc ctaggccttt
6121 tgccacccca ccagccacac ctggcagccg aggctggccc ccacagcccg tccccaccct
6181 gcggcttgag ggggtcgagt ccagtgagaa actcaacagc agcttcccat ccatccactg
6241 cggctcctgg gctgagacca cccccggtgg cgggggcagc agcgccgccc ggagagtccg
6301 gcccgtctcc ctcatggtgc ccagccaggc tggggcccca gggaggcagt tccacggcag
6361 tgccagcagc ctggtggaag cggtcttgat ttcagaagga ctggggcagt ttgctcaaga
6421 tcccaagttc atcgaggtca ccacccagga gctggccgac gcctgcgaca tgaccataga
6481 ggagatggag agcgcggccg acaacatcct cagcgggggc gccccacaga gccccaatgg
6541 cgccctctta ccctttgtga actgcaggga cgcggggcag gaccgagccg ggggcgaaga
6601 ggacgcgggc tgtgtgcgcg cgcggggtcg accgagtgag gaggagctcc aggacagcag
6661 ggtctacgtc agcagcctgt agtgggcgct gccagatgcg ggcttttttt tatttgtttc
6721 aatgttccta atgggttcgt ttcagaagtg cctcactgtt ctcgtgacct ggagttaacc
6781 ggaacagcgt cttcattcat ttctgttggg accagacgcg gagcctgggt gcgcgagccg
6841 ccctccggga ggaaggcgcc cggctgcgtc tgcagaggcg gggagaggag gcggcgaggg
6901 tcccggggcg cgaggaaggc gcctgccctc tcccagctcg caggccccgg gcccggccgc
6961 gcctctgcgg ggagagcacc ccggcttccc gcgcgccctc accaaaagga ccctacagca
7021 aacgggtgtc tttcgactct gcttgtagaa accatttgca catattctgt acgagcctcg
7081 ctgtctccct agagccaggg ccctgcggat ttggagaagg gagcggggca ggacttccag
7141 gaggacccca acccggcccg gagagggagg aggaggcctc caggggcgcg gagctctggg
7201 gatgggcgtc gggccggcag tggtgcggct cactccgtcc ctgcccacct gcgacgggat
7261 cccccgaccg gcacgggcca cgccgagctc ccggccagcc gccggcccgc aggcagcgcg
7321 agggaggagc tgcgccgccg ggaaggggcc gccggctccg cccaaccagg tggtgctgag
7381 cttccgctga gcgctctttt gttttgtggt ttgacacttt tcttgacagc atgttgcagt
7441 ttcttttcgg ttttggtttt ttttaaatgt tttattttgc tttcccagcg ggaggggagg
7501 aagaagagtg tttacaaagt cctgtagccc cctcaccttt ctgttttcac ttttgccaat
7561 gtacatcggg tttggttttc ttgtattatt taaacggttg tggtttcctt tttccacgga
7621 ggttcaatag aagccgctgc aggagagttt taccaaccat tgtgtatgcc caataatttg
7681 ttatcatttc cttaggtagt aacctatttt tgttctggtt tggttcggtt atctaatgga
7741 aaggtaactg gcaatgcact tgatgtggtc ttgcacatgt gggtgataga gttgggttcc
7801 tttttatgct gggtgtacag gtgggtttgg gagagaggag catgcgcgag agagtctccg
7861 agtgtgtgcg acgcgtgtgt gtgtggtggg ttgtctgtgt gcatatgtcc tgcccgtgta
7921 tatgcaccca caccatgtgc ccgtgcacac cagtgactac gcagtccccc ctttctggtt
7981 tagctgtggg aagatctgaa tctggggccg tttgaaagca aaaacaaacc actgtctctg
8041 cttctgaaac gggaatcagt aactctttgc attttctgtc ccacaagata tgcaaaaaca
8101 atgcaataat attcatttaa aaatacaatt gtgagttgtg ttggcattaa aactgtattt
8161 taaaaaaaga cagaaattta agggaaaaac acaagaaggc attttgcttc aatatattcc
8221 gtgtaatgtt ttattgcatt gataatgttt ctgttgaaga aaccgttata cttgaattca
8281 ggtcagtttc agtatttttc aaatattttt ttaaaactga attgcaattg tgccaagcga
8341 atataatgaa ttgaactaaa aaaaaaaaaa aaaa
//