LOCUS AF454492 3671 bp mRNA linear HUM 02-JAN-2003
DEFINITION Homo sapiens clone FB1 laforin (EPM2A) mRNA, complete cds,
alternatively spliced.
ACCESSION AF454492
VERSION AF454492.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 3671)
AUTHORS Ganesh,S. and Yamakawa,K.
TITLE Cloning of differentially spliced transcripts of the EPM2A gene
JOURNAL Unpublished
REFERENCE 2 (bases 1 to 3671)
AUTHORS Ganesh,S. and Yamakawa,K.
TITLE Direct Submission
JOURNAL Submitted (30-NOV-2001) Lab for Neurogenetics, RIKEN Brain Science
Institute, 2-1, Hirosawa, Wako-shi, Saitama 351-0198, Japan
FEATURES Location/Qualifiers
source 1..3671
/db_xref="H-InvDB:HIT000079898"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="6"
/map="6q24"
/clone="FB1"
/tissue_type="brain"
/dev_stage="fetal"
gene 1..3671
/gene="EPM2A"
CDS 956..1537
/gene="EPM2A"
/note="dual-specificity phosphatase; alternatively
spliced"
/codon_start=1
/product="laforin"
/protein_id="AAO15524.1"
/translation="MKHTTDFYFNIAGHQAMHYSRILPNIWLGSCPRQVEHVTIKLKH
ELGITAVMNFQTEWDIVQNSSGCNRYPEPMTPDTMIKLYREEGLAYIWMPTPDMSTEG
RVQMLPQAVCLLHALLEKGHIVYVHCNAGVGRSTAAVCGWLQYVMGWNLRKVQYFLMA
KRPAVYIDEEALARAQEDFFQKFGKVRSSVCSL"
BASE COUNT 1071 a 718 c 814 g 1068 t
ORIGIN
1 taatgctcat gtgtttgaga tgtgagagtg aatgtgtttg agatatgaga atgaattgtg
61 aatgaatgag agtgaatgct catgtgtttg agatgtgaga atgaattgtg cttgcagaaa
121 gccagtaaac agatagttca atgagataag agctgtctta ggagattgta cctttttctg
181 aaagagctgt ggtaaggctg acaggtcaag attgactgac tggctgggcc ttcaccaggt
241 gtgagaagtc ttagtaccat tgttggtccc aggacttctc ttccagtaag ctcattaaaa
301 tgttttattt ttccaacacc atcaccaatt tgagtttcat tatctggaat atcttctaag
361 ttttttgctc tgatgctggc atcctgggca aagtccagat agctcaggcc tgtagtgccg
421 ccagtacata caggagtgag aagcccaaca gtttcaattc cgtgatcttt atggttttaa
481 atggtaaatt gtaatgccac atgaatgtag cgttttatcc tgaattttag ctaagtaaaa
541 cttcagagaa ttaagggaat gatttttttc tcttttttat ttgacagggt ctggctctgt
601 cacccaggct ggagtacagt ggcatgatct tggctcactg cagcctctgc ctcccaggct
661 caagccatcc tcccatgtca accttctgag tagctgaaac cacaggcatg tttcaccatg
721 gccagctaat ttttgtattt tttagtagaa atggggtttc gccatgttgc ccaggcctgt
781 ctcgaactcc tgaagcacaa gtgatccacc tgcctaggtg acccaaagta atgggattac
841 aggcaatgga cctcatcatg accgttgctg tacttacaat gaaaacaact tggtggatgg
901 tgtgtattgt ctcccaatag gacactggat tgaggccact ggacacacca atgaaatgaa
961 gcacacaaca gacttctatt ttaatattgc aggccaccaa gccatgcatt attcaagaat
1021 tctaccaaat atctggctgg gtagctgccc tcgtcaggtg gaacatgtaa ccatcaaact
1081 gaagcatgaa ttggggatta cagctgtaat gaatttccag actgaatggg atattgtaca
1141 gaattcctca ggctgtaacc gctacccaga gcccatgact ccagacacta tgattaaact
1201 atatagggaa gaaggcttgg cctacatctg gatgccaaca ccagatatga gcaccgaagg
1261 ccgagtacag atgctgcccc aggcggtgtg cctgctgcat gcgctgctgg agaagggaca
1321 catcgtgtac gtgcactgca acgctggggt gggccgctcc accgcggctg tctgcggctg
1381 gctccagtat gtgatgggct ggaatctgag gaaggtgcag tatttcctca tggccaagag
1441 gccggctgtc tacattgacg aagaggcctt ggcccgggca caagaagatt ttttccagaa
1501 atttgggaag gttcgttctt ctgtgtgtag cctgtagctg gtcagcctgc ttctgccccc
1561 tcctgatttc cctaaggagc ctgggatgat gttggtcaaa tgacctagaa acaaggattc
1621 tacctgaact gaaaggactg tgtgacctcc cccaagccaa ccactttcac ctgggatgac
1681 tttcgattat gctttgtttt ggggctgtat ttttgaaata ctctacaaga aagctgtggc
1741 tcaacacatg agaagaagca cgaagcagtt aggcttgtac atcagacaga agggtaatgc
1801 gtgcagttcc tgctgcctgc aggcagacga ggcctttgct ttacagcact gtatgtgttg
1861 cacgatggat ccgtgacagc actttcctgt tgcactgaaa ctcttggcca tgtagaggaa
1921 aagatatgga gttatgtgga tttcatcact agtatgtgtg ccgtgagctg gtcaagttgc
1981 caaaggagga aataaggtta gaagcctgaa ccgtacaaaa gaagagctca ctatggtcaa
2041 aaagtgatgg ctttcaggac ttgtttttta tcctgcctca cagttgttaa agtctgttcc
2101 aaggcatcac cttccttctc tacccaacaa ccctgtgtaa caactaaagt agaattatct
2161 ctcatttgtt gttgtttttc ctcaaaatta ccaaacaaag caaaaaatac ccttgttttt
2221 tatagttgag atgtcaagaa gttaaattga ggcttaatga gcataggtag cttgtccaag
2281 gtctcatgac cagtcaaggg caagctggag ttaataatct atatttattt gactcagcac
2341 tgttttcatc acaacttgtt ttcccagcat catgtagtgc atttagtttt gtctttctca
2401 gggtatagtc aatatgcctg caggagtttc tatagcgaga catagaatag tattctgatc
2461 agttgccaaa gaatctagga aattagttgt attttgtgca agctaattta aaaacatgat
2521 gggctgtttt aagaccagag tggaaattca tgagaggaac tatactacca aaagagccca
2581 aatgaccaaa tccatggata attgcttcac agccttggcc atcctggctc agctctcaat
2641 ttagtataat atgcagttcc tgtgcctcca gactatgcag ctcatcaccc taggttctac
2701 aggaaataca gagatgaaca actttgcctt caaaaatgtg ctgcctagaa acagacctgc
2761 attcaaccaa ctgtaatgca ggattggacc atgaatgata tgctagaata gaagaaagag
2821 aagtgttttt ttaattgaga gcctctatgt gcaaggtgat atataatcat atccagttta
2881 atcttcacaa tatccaatga agaaggtctc attatctcca tgataaagat ggggaaacta
2941 aggtcagaag ggttaactca actgtctatt gtcacatgat gaataaatag atgaagtgag
3001 atacaaagct gggtttgatt caaagccctt actttcctaa ttaaactatg atgcgtattt
3061 atttttctgc accttccttt cttccacaaa cacatattga tagatgcaag agactcttat
3121 ttagaaggcg tgggggacaa gaaggataca aggtaagttt cagtggagct cagaggacgg
3181 ggagatagaa ctgtggcact taggggagat gacatttgct ttgggcagag gcagctagcc
3241 aggacacatt tccactataa ttttacaaag ttaaatttat aagctagcat taagtaaagt
3301 gaagtccagc tcccttgcta aaaataacta gaggtaataa ttggtattca ggtaactcat
3361 ttacagtcat aatgtgttgt gaaaatttaa tcttaaaaat taaattttta aactatgtgg
3421 gtctgtgaat ttctttaatg tctaagaaat ccagcttcat aatttccatg atacaaagat
3481 cttttttcag gtggattttt acctttgttc cttttgctct gatagacaaa atcagtttag
3541 gactattaaa gaatgttttg gaataaactg tctttttcct caatgaatgg gatgtctaat
3601 gtatttcaaa atcacccaaa acttttggca aataaaagca tttaaaaaga caaaaaaaaa
3661 gaaaaaaaaa a
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