LOCUS       AF450243                1116 bp    mRNA    linear   HUM 11-FEB-2002
DEFINITION  Homo sapiens clone 2 T cell immunoglobulin mucin-3 (TIM3) mRNA,
            complete cds.
ACCESSION   AF450243
VERSION     AF450243.1
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1116)
  AUTHORS   Monney,L., Sabatos,C.A., Gaglia,J.L., Ryu,A., Waldner,H.,
            Chernova,T., Manning,S., Greenfield,E.A., Coyle,A.J., Sobel,R.A.,
            Freeman,G.J. and Kuchroo,V.K.
  TITLE     Th1-specific cell surface protein Tim-3 regulates macrophage
            activation and severity of an autoimmune disease
  JOURNAL   Nature 415 (6871), 536-541 (2002)
   PUBMED   11823861
REFERENCE   2  (bases 1 to 1116)
  AUTHORS   Monney,L., Sabatos,C., Gaglia,J.L., Ryu,A., Waldner,H.,
            Chernova,T., Greenfield,E.A., Sobel,R.A., Freeman,G.J. and
            Kuchroo,V.K.
  TITLE     Direct Submission
  JOURNAL   Submitted (23-NOV-2001) Adult Oncology, Dana-Farber Cancer
            Institute, 44 Binney St., Boston, MA 02115, USA
FEATURES             Location/Qualifiers
     source          1..1116
                     /db_xref="H-InvDB:HIT000079818"
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /clone="2"
                     /cell_type="T cell"
     gene            1..1116
                     /gene="TIM3"
     CDS             58..963
                     /gene="TIM3"
                     /note="TIM-3"
                     /codon_start=1
                     /product="T cell immunoglobulin mucin-3"
                     /protein_id="AAL65158.1"
                     /translation="MFSHLPFDCVLLLLLLLLTRSSEVEYRAEVGQNAYLPCFYTPAA
                     PGNLVPVCWGKGACPVFECGNVVLRTDERDVNYWTSRYWLNGDFRKGDVSLTIENVTL
                     ADSGIYCCRIQIPGIMNDEKFNLKLVIKPAKVTPAPTRQRDFTAAFPRMLTTRGHGPA
                     ETQTLGSLPDINLTQISTLANELRDSRLANDLRDSGATIRIGIYIGAGICAGLALALI
                     FGALIFKWYSHSKEKIQNLSLISLANLPPSGLANAVAEGIRSEENIYTIEENVYEVEE
                     PNEYYCYVSSRQQPSQPLGCRFAMP"
BASE COUNT          291 a          268 c          271 g          286 t
ORIGIN      
        1 ggagagttaa aactgtgcct aacagaggtg tcctctgact tttcttctgc aagctccatg
       61 ttttcacatc ttccctttga ctgtgtcctg ctgctgctgc tgctactact tacaaggtcc
      121 tcagaagtgg aatacagagc ggaggtcggt cagaatgcct atctgccctg cttctacacc
      181 ccagccgccc cagggaacct cgtgcccgtc tgctggggca aaggagcctg tcctgtgttt
      241 gaatgtggca acgtggtgct caggactgat gaaagggatg tgaattattg gacatccaga
      301 tactggctaa atggggattt ccgcaaagga gatgtgtccc tgaccataga gaatgtgact
      361 ctagcagaca gtgggatcta ctgctgccgg atccaaatcc caggcataat gaatgatgaa
      421 aaatttaacc tgaagttggt catcaaacca gccaaggtca cccctgcacc gactcggcag
      481 agagacttca ctgcagcctt tccaaggatg cttaccacca ggggacatgg cccagcagag
      541 acacagacac tggggagcct ccctgatata aatctaacac aaatatccac attggccaat
      601 gagttacggg actctagatt ggccaatgac ttacgggact ctggagcaac catcagaata
      661 ggcatctaca tcggagcagg gatctgtgct gggctggctc tggctcttat cttcggcgct
      721 ttaattttca aatggtattc tcatagcaaa gagaagatac agaatttaag cctcatctct
      781 ttggccaacc tccctccctc aggattggca aatgcagtag cagagggaat tcgctcagaa
      841 gaaaacatct ataccattga agagaacgta tatgaagtgg aggagcccaa tgagtattat
      901 tgctatgtca gcagcaggca gcaaccctca caacctttgg gttgtcgctt tgcaatgcca
      961 tagatccaac caccttattt ttgagcttgg tgttttgtct ttttcagaaa ctatgagctg
     1021 tgtcacctga ctggttttgg aggttctgtc cactgctatg gagcagagtt ttcccatttt
     1081 cagaagataa tgactcacat gggaattgaa ctggga
//