LOCUS AF445802 1383 bp mRNA linear HUM 20-APR-2002
DEFINITION Homo sapiens interleukin-1 receptor associated kinase 4 (IRAK4)
mRNA, complete cds.
ACCESSION AF445802
VERSION AF445802.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 1383)
AUTHORS Li,S., Strelow,A., Fontana,E.J. and Wesche,H.
TITLE IRAK-4: a novel member of the IRAK family with the properties of an
IRAK-kinase
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 99 (8), 5567-5572 (2002)
PUBMED 11960013
REFERENCE 2 (bases 1 to 1383)
AUTHORS Suzuki,N., Suzuki,S., Duncan,G.S., Millar,D.G., Wada,T.,
Mirtsos,C., Takada,H., Wakeham,A., Itie,A., Li,S., Penninger,J.M.,
Wesche,H., Ohashi,P.S., Mak,T.W. and Yeh,W.C.
TITLE Severe impairment of interleukin-1 and Toll-like receptor
signalling in mice lacking IRAK-4
JOURNAL Nature 416 (6882), 750-756 (2002)
PUBMED 11923871
REFERENCE 3 (bases 1 to 1383)
AUTHORS Li,S., Strelow,A., Fontana,E.J. and Wesche,H.
TITLE Direct Submission
JOURNAL Submitted (08-NOV-2001) Biology I, Tularik Inc., 2 Corporate Drive,
South San Francisco, CA 94080, USA
FEATURES Location/Qualifiers
source 1..1383
/db_xref="H-InvDB:HIT000079774"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
gene 1..1383
/gene="IRAK4"
CDS 1..1383
/gene="IRAK4"
/note="protein kinase"
/codon_start=1
/product="interleukin-1 receptor associated kinase 4"
/protein_id="AAM15772.1"
/translation="MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSG
DDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTAGDLVDLLIQNEFFAPASLLLP
DAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEV
SDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAM
VDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSC
LDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLAR
ASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHRE
PQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKV
QQLLQEMTAS"
BASE COUNT 463 a 244 c 283 g 393 t
ORIGIN
1 atgaacaaac ccataacacc atcaacatat gtgcgctgcc tcaatgttgg actaattagg
61 aagctgtcag attttattga tcctcaagaa ggatggaaga agttagctgt agctattaaa
121 aaaccatctg gtgatgatag atacaatcag tttcacataa ggagatttga agcattactt
181 caaactggaa aaagtcccac ttctgaatta ctgtttgact ggggcaccac aaattgcaca
241 gctggtgatc ttgtggatct tttgatccaa aatgaatttt ttgctcctgc gagtcttttg
301 ctcccagatg ctgttcccaa aactgctaat acactacctt ctaaagaagc tataacagtt
361 cagcaaaaac agatgccttt ctgtgacaaa gacaggacat tgatgacacc tgtgcagaat
421 cttgaacaaa gctatatgcc acctgactcc tcaagtccag aaaataaaag tttagaagtt
481 agtgatacac gttttcacag tttttcattt tatgaattga agaatgtcac aaataacttt
541 gatgaacgac ccatttctgt tggtggtaat aaaatgggag agggaggatt tggagttgta
601 tataaaggct acgtaaataa cacaactgtg gcagtgaaga agcttgcagc aatggttgac
661 attactactg aagaactgaa acagcagttt gatcaagaaa taaaagtaat ggcaaagtgt
721 caacatgaaa acttagtaga actacttggt ttctcaagtg atggagatga cctctgctta
781 gtatatgttt acatgcctaa tggttcattg ctagacagac tctcttgctt ggatggtact
841 ccaccacttt cttggcacat gagatgcaag attgctcagg gtgcagctaa tggcatcaat
901 tttctacatg aaaatcatca tattcataga gatattaaaa gtgcaaatat cttactggat
961 gaagctttta ctgctaaaat atctgacttt ggccttgcac gggcttctga gaagtttgcc
1021 cagacagtca tgactagcag aattgtggga acaacagctt atatggcacc agaagctttg
1081 cgtggagaaa taacacccaa atctgatatt tacagctttg gtgtggtttt actagaaata
1141 ataactggac ttccagctgt ggatgaacac cgtgaacctc agttattgct agatattaaa
1201 gaagaaattg aagatgaaga aaagacaatt gaagattata ttgataaaaa gatgaatgat
1261 gctgattcca cttcagttga agctatgtac tctgttgcta gtcaatgtct gcatgaaaag
1321 aaaaataaga gaccagacat taagaaggtt caacagctgc tgcaagagat gacagcttct
1381 taa
//