LOCUS AF438313 1797 bp mRNA linear HUM 12-MAR-2002
DEFINITION Homo sapiens Ras-induced senescence 1 (RIS1) mRNA, complete cds.
ACCESSION AF438313
VERSION AF438313.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 1797)
AUTHORS Barradas,M., Gonos,E.S., Zebedee,Z., Kolettas,E., Petropoulou,C.,
Delgado,M.D., Leon,J., Hara,E. and Serrano,M.
TITLE Identification of a candidate tumor-suppressor gene specifically
activated during Ras-induced senescence
JOURNAL Exp. Cell Res. 273 (2), 127-137 (2002)
PUBMED 11822868
REFERENCE 2 (bases 1 to 1797)
AUTHORS Barradas,M. and Serrano,M.
TITLE Direct Submission
JOURNAL Submitted (22-OCT-2001) Dept. of Immunology and Oncology, National
Center of Biotechnology, Campus de Cantoblanco, Madrid E-28049,
Spain
FEATURES Location/Qualifiers
source 1..1797
/db_xref="H-InvDB:HIT000079663"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="3"
/map="3p21.3"
gene 1..1797
/gene="RIS1"
misc_feature 190..219
/gene="RIS1"
/note="small ORF in the 5'UTR"
CDS 236..1138
/gene="RIS1"
/note="candidate tumor suppressor protein"
/codon_start=1
/product="Ras-induced senescence 1"
/protein_id="AAL30845.1"
/translation="MLPLLAALLAAACPLPPVRGGAADAPGLLGVPSNASVNASSADE
PIAPRLLASAAPGPPERPGPEETAAAAAPCNISVQRQMLSSLLVRWGRPRGFQCDLLL
FSTNAHGRAFFAAAFHRVGPPLLIEHLGLAAGGAQQDLRLCVGCGWVRGRRTGRLRPA
AAPSAAAATAGAPTALPAYPAAEPPGPLWLQGEPLHFCCLDFSLEELQGEPGWRLNRK
PIESTLVACFMTLVIVVWSVAALIWPVPIIAGFLPNGMEQRRTTASTTAATPAAVPAG
TTAAAAAAAAAAAAAAVTSGVATK"
BASE COUNT 263 a 645 c 552 g 337 t
ORIGIN
1 ccggcgccgg gggcggcggg gaaccccaaa cgcaaccggg tctggaggga tccccgcgcc
61 gagccagccg ccgtcaccgc ctccgcgccg cccctgcggg cttggcaggc gcccggcgcg
121 cccgcactgc gcccggccgc cggctcccgc ggtcccaccg tgagctcgcc ggcccgtcgc
181 ccgctcgcca tgcaaccgcc gccggcctcg cgcgcgtagg cgcccgccgc aggccatgct
241 gcccctgctc gccgcgctcc tggccgccgc ctgcccgctg ccgcccgtcc gcggcggggc
301 cgcggacgcg cccggcctcc tcggggtgcc ctccaatgct tcagtcaacg cgtcctccgc
361 ggacgagccc atcgccccgc ggctgctggc ctcggcggcc cccgggcccc ccgagcgccc
421 gggcccggag gagacggcgg cggcagcggc gccgtgcaac atcagcgtgc agcggcagat
481 gctgagctcg ctgctcgtgc gctggggccg cccgcggggc ttccagtgcg acctactgct
541 cttctccacc aacgcgcacg gccgcgcttt cttcgccgcc gccttccacc gcgtcgggcc
601 gccgctgctc atcgagcacc tggggctggc ggcgggcggc gcgcagcagg acctgcgcct
661 ctgcgtgggc tgcggctggg tgcgcggtcg ccgcactggc cgcctccggc ccgccgccgc
721 ccccagcgcc gccgccgcca ccgccggggc gcccaccgcg ctgccagcct accccgcggc
781 cgagccgccc gggccgctgt ggctgcaggg cgagccgctg catttctgct gcctagactt
841 cagcctggag gagctgcagg gcgagccggg ctggcggctg aaccgtaagc ccattgagtc
901 cacgctggtg gcctgcttca tgaccctggt catcgtggtg tggagcgtgg ccgccctcat
961 ctggccggtg cccatcatcg ccggcttcct gcccaacggc atggaacagc gccggaccac
1021 cgccagcacc accgcagcca cccccgccgc agtgcccgca gggaccaccg cagccgccgc
1081 cgccgccgcc gctgccgccg ccgccgcggc cgtcacttcg ggggtggcga ccaagtgacc
1141 cgctccgctc ctccctgtgt ccgtcctgtg tccgcgcgcg cgggtgcctt tcccgccggg
1201 gactcggccg gtgtgcttcg tgctgtagtt atcgttagtt cctcttcccg agatggggcc
1261 gccgagagac cccagcgcct ttgaaaagca aggtttgtgc tgcgcttcca gttccgaaaa
1321 gcagatgttt aagcccttgg actgagggtg ggatcgcagc tccgaagacg gagaggaggg
1381 aaatggggcc ctttcccctc tattgcatcc ccctgcccga ctccttcccc gcacccacgt
1441 gccctagatt catggcagaa aatgaccaaa tcctgtgtat ttgttttata tatttaataa
1501 ctgttttaaa tgaaagtttt agtaaaaaaa atacaaaaca aaaagattaa attgctattg
1561 ctgtagtaag agaagctctt tgtatctgaa catagttgta tttgaaattt gtggtttttt
1621 aatttattta aaattggggg gagggcatgg gaaggattta acaccgatat attgttaccg
1681 ctgaaaatga actttatgaa ccttttccaa gttgatctat ccagtgacgt ggcctggtgg
1741 gcgtttcttc ttgtacttat gtggtttttt ggcttttaat acagacattt tcctcca
//