LOCUS AF438203 1953 bp mRNA linear HUM 12-DEC-2001
DEFINITION Homo sapiens small conductance calcium-activated potassium channel
mRNA, complete cds; alternatively spliced.
ACCESSION AF438203
VERSION AF438203.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 1953)
AUTHORS Tomita,H., Shakkottai,V., Wulff,H., Sun,G., Potkin,S.G.,
Bunney,W.E., Chandy,G.K. and Gargus,J.J.
TITLE Splice variants of small conductance calcium-activated potassium
channel gene, KCNN3/ SKCa3 cause dominant-negative supression of
SKCa currents
JOURNAL Am. J. Hum. Genet. 69S, 569 (2001)
REFERENCE 2 (bases 1 to 1953)
AUTHORS Tomita,H., Shakkottai,V. and Gargus,J.J.
TITLE Direct Submission
JOURNAL Submitted (22-OCT-2001) Psychiatry & Biophysics, UC Irvine, 288
Irvine Hall, Irvine, CA 92697-4561, USA
FEATURES Location/Qualifiers
source 1..1953
/db_xref="H-InvDB:HIT000079662"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="1"
/map="1q21"
/cell_type="germinal center B cells"
exon 1..146
/note="alternate exon"
/number=1C
CDS 129..1409
/note="KCNN3/SKCa3/SK3; subfamily N member 3; transcript
variant 1C"
/codon_start=1
/product="small conductance calcium-activated potassium
channel"
/protein_id="AAL40801.1"
/translation="MERPIKDSMFSLALKCLISLSTIILLGLIIAYHTREVQLFVIDN
GADDWRIAMTYERILYISLEMLVCAIHPIPGEYKFFWTARLAFSYTPSRAEADVDIIL
SIPMFLRLYLIARVMLLHSKLFTDASSRSIGALNKINFNTRFVMKTLMTICPGTVLLV
FSISLWIIAAWTVRVCERYHDQQDVTSNFLGAMWLISITFLSIGYGDMVPHTYCGKGV
CLLTGIMGAGCTALVVAVVARKLELTKAEKHVHNFMMDTQLTKRIKNAAANVLRETWL
IYKHTKLLKKIDHAKVRKHQRKFLQAIHQLRSVKMEQRKLSDQANTLVDLSKMQNVMY
DLITELNDRSEDLEKQIGSLESKLEHLTASFNSLPLLIADTLRQQQQQLLSAIIEARG
VSVAVGTTHTPISDSPIGVSSTSFPTPYTSSSSC"
BASE COUNT 479 a 552 c 493 g 429 t
ORIGIN
1 gaaagtcagc ttaaaggaca ctccttacag ggactgagct ggcacctact ccttagagct
61 tgctgatacc aggcctgcca cgcgacatct gcaaggacag ttgtttggtg ttttgcttca
121 ggttatagat ggagagacct ataaaggact ccatgttttc gttggccctg aaatgcctta
181 tcagtctgtc caccatcatc cttttgggct tgatcatcgc ctaccacaca cgtgaagtcc
241 agctcttcgt gatcgacaac ggcgcggatg actggcggat agccatgacc tacgagcgca
301 tcctgtacat cagcctggag atgctggtgt gcgccatcca ccccattcct ggcgagtaca
361 agttcttctg gacggcacgc ctggccttct cctacacacc ctcccgggcg gaggccgatg
421 tggacatcat cctgtctatc cccatgttcc tgcgcctgta cctgatcgcc cgagtcatgc
481 tgctgcacag caagctcttc accgatgcct cgtcccgcag catcggggcc ctcaacaaga
541 tcaacttcaa cacccgcttt gtcatgaaga cgctcatgac catctgccct ggcactgtgc
601 tgctcgtgtt cagcatctct ctgtggatca ttgctgcctg gaccgtccgt gtctgtgaaa
661 ggtaccatga ccagcaggac gtaactagta actttctggg tgccatgtgg ctcatctcca
721 tcacattcct ttccattggt tatggggaca tggtgcccca cacatactgt gggaaaggtg
781 tctgtctcct cactggcatc atgggtgcag gctgcactgc ccttgtggtg gccgtggtgg
841 cccgaaagct ggaactcacc aaagcggaga agcacgttca taacttcatg atggacactc
901 agctcaccaa gcggatcaag aatgctgcag ccaatgtcct tcgggaaaca tggttaatct
961 ataaacacac aaagctgcta aagaagattg accatgccaa agtgaggaaa caccagagga
1021 agttcctcca agctatccac cagttgagga gcgtcaagat ggaacagagg aagctgagtg
1081 accaagccaa cactctggtg gacctttcca agatgcagaa tgtcatgtat gacttaatca
1141 cagaactcaa tgaccggagc gaagacctgg agaagcagat tggcagcctg gagtcgaagc
1201 tggagcatct caccgccagc ttcaactccc tgccgctgct catcgccgac accctgcgcc
1261 agcagcagca gcagctcctg tctgccatca tcgaggcccg gggtgtcagc gtggcagtgg
1321 gcaccaccca caccccaatc tccgatagcc ccattggggt cagctccacc tccttcccga
1381 ccccgtacac aagttcaagc agttgctaaa taaatctccc cactccagaa gcattaccca
1441 taggtcttaa gatgcaaatc aactctctcc tggtcgcttt gccatcaaga aacattcaga
1501 ccagggaacg gaaagaagag agaccgagct aattaactaa ctcatgttca ttcagcgtgc
1561 ttggtccgac atgccttgaa accagaaatc taatctctgt ttaggtgcct ctacttggga
1621 gcgggaagag gagatgacag gaagcgacgc ctctggcagg gcccttgctg cagagttggt
1681 ggagaacaga aatccacgct caatctcagg tcttcacgcg gggggtgggg gtcagatgca
1741 ctgaagtagc caacagcgaa accagtccag aagaggggtc cgctgggagg gagggttgtg
1801 tcaggcttgg gggatgggct cttcgccatg ggggtctttg aacacacctc tctcctttcc
1861 ttttgtctac ggaagcctct gggtgacaaa agtaaaagag agctgcccac aacttgccaa
1921 aacagatata ctcgaatcag actgaaaaaa aaa
//