LOCUS AF430147 8497 bp mRNA linear HUM 29-JUL-2002
DEFINITION Homo sapiens leukemia-associated protein with a CXXC domain (LCX)
mRNA, complete cds.
ACCESSION AF430147
VERSION AF430147.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 8497)
AUTHORS Ono,R., Taki,T., Taketani,T., Taniwaki,M., Kobayashi,H. and
Hayashi,Y.
TITLE LCX, leukemia-associated protein with a CXXC domain, is fused to
MLL in acute myeloid leukemia with trilineage dysplasia having
t(10;11)(q22;q23)
JOURNAL Cancer Res. 62 (14), 4075-4080 (2002)
PUBMED 12124344
REFERENCE 2 (bases 1 to 8497)
AUTHORS Ono,R., Taki,T., Taketani,T., Taniwaki,M., Kobayashi,H. and
Hayashi,Y.
TITLE Direct Submission
JOURNAL Submitted (08-OCT-2001) Department of Pediatrics, Graduate School
of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo
113-8655, Japan
FEATURES Location/Qualifiers
source 1..8497
/db_xref="H-InvDB:HIT000079530"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="10"
/map="10q22"
gene 1..8497
/gene="LCX"
CDS 210..6620
/gene="LCX"
/codon_start=1
/product="leukemia-associated protein with a CXXC domain"
/protein_id="AAM88301.1"
/translation="MSRSRHARPSRLVRKEDVNKKKKNSQLRKTTKGANKNVASVKTL
SPGKLKQLIQERDVKKKTEPKPPVPVRSLLTRAGAARMNLDRTEVLFQNPESLTCNGF
TMALRSTSLSRRLSQPPLVVAKSKKVPLSKGLEKQHDCDYKILPALGVKHSENDSVPM
QDTQVLPDIETLIGVQNPSLLKGKSQETTQFWSQRVEDSKINIPTHSGPAAEILPGPL
EGTRCGEGLFSEETLNDTSGSPKMFAQDTVCAPFPQRATPKVTSQGNPSIQLEELGSR
VESLKLSDSYLDPIKSEHDCYPTSSLNKVIPDLNLRNCLALGGSTSPTSVIKFLLAGS
KQATLGAKPDHQEAFEATANQQEVSDTTSFLGQAFGAIPHQWELPGADPVHGEALGET
PDLPEIPGAIPVQGEVFGTILDQQETLGMSGSVVPDLPVFLPVPPNPIATFNAPSKWP
EPQSTVSYGLAVQGAIQILPLGSGHTPQSSSNSEKNSLPPVMAISNVENEKQVHISFL
PANTQGFPLAPERGLFHASLGIAQLSQAGPSKSDRGSSQVSVTSTVHVVNTTVVTMPV
PMVSTSSSSYTTLLPTLEKKKRKRCGVCEPCQQKTNCGECTYCKNRKNSHQICKKRKC
EELKKKPSVVVPLEVIKENKRPQREKKPKVLKADFDNKPVNGPKSESMDYSRCGHGEE
QKLELNPHTVENVTKNEDSMTGIEVEKWTQNKKSQLTDHVKGDFSANVPEAEKSKNSE
VDKKRTKSPKLFVQTVRNGIKHVHCLPAETNVSFKKFNIEEFGKTLENNSYKFLKDTA
NHKNAMSSVATDMSCDHLKGRSNVLVFQQPGFNCSSIPHSSHSIINHHASIHNEGDQP
KTPENIPSKEPKDGSPVQPSLLSLMKDRRLTLEQVVAIEALTQLSEAPSENSSPSKSE
KDEESEQRTASLLNSCKAILYTVRKDLQDPNLQGEPPKLNHCPSLEKQSSCNTVVFNG
QTTTLSNSHINSATNQASTKSHEYSKVTNSLSLFIPKSNSSKIDTNKSIAQGIITLDN
CSNDLHQLPPRNNEVEYCNQLLDSSKKLDSDDLSCQDATHTQIEEDVATQLTQLASII
KINYIKPEDKKVESTPTSLVTCNVQQKYNQEKGTMQQKPPSSVHNNHGSSLTKQKNPT
QKKTKSTPSRDRRKKKPTVVSYQENDRQKWEKLSYMYGTICDIWIASKFQNFGQFCPH
DFPTVFGKISSSTKIWKPLAQTRSIMQPKTVFPPLTQIKLQRYPESAEEKVKVEPLDS
LSLFHLKTESNGKAFTDKAYNSQVQLTVNANQKAHPLTQPSSPPNQCANVMAGDDQIR
FQQVVKEQLMHQRLPTLPGISHETPLPESALTLRNVNVVCSGGITVVSTKSEEEVCSS
SFGTSEFSTVDSAQKNFNDYAMNFFTNPTKNLVSITKDSELPTCSCLDRVIQKDKGPY
YTHLGAGPSVAAVREIMENRYGQKGNAIRIEIVVYTGKEGKSSHGCPIAKWVLRRSSD
EEKVLCLVRQRTGHHCPTAVMVVLIMVWDGIPLPMADRLYTELTENLKSYNGHPTDRR
CTLNENRTCTCQGIDPETCGASFSFGCSWSMYFNGCKFGRSPSPRRFRIDPSSPLHEK
NLEDNLQSLATRLAPIYKQYAPVAYQNQVEYENVARECRLGSKEGRPFSGVTACLDFC
AHPHRDIHNMNNGSTVVCTLTREDNRSLGVIPQDEQLHVLPLYKLSDTDEFGSKEGME
AKIKSGAIEVLAPRRKKRTCFTQPVPRSGKKRAAMMTEVLAHKIRAVEKKPIPRIKRK
NNSTTTNNSKPSSLPTLGSNTETVQPEVKSETEPHFILKSSDNTKTYSLMPSAPHPVK
EASPGFSWSPKTASATPAPLKNDATASCGFSERSSTPHCTMPSGRLSGANAAAADGPG
ISQLGEVAPLPTLSAPVMEPLINSEPSTGVTEPLTPHQPNHQPSFLTSPQDLASSPME
EDEQHSEADEPPSDEPLSDDPLSPAEEKLPHIDEYWSDSEHIFLDANIGGVAIAPAHG
SVLIECARRELHATTPVEHPNRNHPTRLSLVFYQHKNLNKPQHGFELNKIKFEAKEAK
NKKMKASEQKDQAANEGPEQSSEVNELNQIPSHKALTLTHDNVVTVSPYALTHVAGPY
NHWV"
misc_feature 6084..6452
/gene="LCX"
/note="Region: zinc-binding CXXC domain"
BASE COUNT 2721 a 1866 c 1690 g 2220 t
ORIGIN
1 ggcgcgagtt ggaaagtttg cccgagggct ggtgcaggct tggagctggg ggccgtgcgc
61 tgccctggga gtgtgacccg gccagcgacc aaaaccttgt gtgactgagc tgaagagcag
121 tgcatccaga ttctcctcag aagtgagact ttccaaagga ccaatgactc tgtttcctgt
181 gccctttcat tttttcctac tctgtagcta tgtctcgatc ccgccatgca aggccttcca
241 gattagtcag gaaggaagat gtaaacaaaa aaaagaaaaa cagccaacta cgaaagacaa
301 ccaagggagc caacaaaaat gtggcatcag tcaagacttt aagccctgga aaattaaagc
361 aattaattca agaaagagat gttaagaaaa aaacagaacc taaaccaccc gtgccagtca
421 gaagccttct gacaagagct ggagcagcac gcatgaattt ggataggact gaggttcttt
481 ttcagaaccc agagtcctta acctgcaatg ggtttacaat ggcgctacga agcacctctc
541 ttagcaggcg actctcccaa cccccactgg tcgtagccaa atccaaaaag gttccacttt
601 ctaagggttt agaaaagcaa catgattgtg attataagat actccctgct ttgggagtaa
661 agcactcaga aaatgattcg gttccaatgc aagacaccca agtccttcct gatatagaga
721 ctctaattgg tgtacaaaat ccctctttac ttaaaggtaa gagccaagag acaactcagt
781 tttggtccca aagagttgag gattccaaga tcaatatccc tacccacagt ggccctgcag
841 ctgagatcct tcctgggcca ctggaaggga cacgctgtgg tgaaggacta ttctctgaag
901 agacattgaa tgataccagt ggttccccaa aaatgtttgc tcaggacaca gtgtgtgctc
961 cttttcccca aagagcaacc cccaaagtta cctctcaagg aaaccccagc attcagttag
1021 aagagttggg ttcacgagta gaatctctta agttatctga ttcttacctg gatcccatta
1081 aaagtgaaca tgattgctac cccacctcca gtcttaataa ggttatacct gacttgaacc
1141 ttagaaactg cttggctctt ggtgggtcta cgtctcctac ctctgtaata aaattcctct
1201 tggcaggctc aaaacaagcg acccttggtg ctaaaccaga tcatcaagag gccttcgaag
1261 ctactgcaaa tcaacaggaa gtttctgata ccacctcttt cctaggacag gcctttggtg
1321 ctatcccaca tcaatgggaa cttcctggtg ctgacccagt tcatggtgag gccctgggtg
1381 agaccccaga tctaccagag attcctggtg ctattccagt ccaaggagag gtctttggta
1441 ctattttaga ccaacaagaa actcttggta tgagtgggag tgttgtccca gacttgcctg
1501 tcttccttcc tgttcctcca aatccaattg ctacctttaa tgctccttcc aaatggcctg
1561 agccccaaag cactgtctca tatggacttg cagtccaggg tgctatacag attttgcctt
1621 tgggctcagg acacactcct caatcatcat caaactcaga gaaaaattca ttacctccag
1681 taatggctat aagcaatgta gaaaatgaga agcaggttca tataagcttc ctgccagcta
1741 acactcaggg gttcccatta gcccctgaga gaggactctt ccatgcttca ctgggtatag
1801 cccaactctc tcaggctggt cctagcaaat cagacagagg gagctcccag gtcagtgtaa
1861 ccagcacagt tcatgttgtc aacaccacag tggtgactat gccagtgcca atggtcagta
1921 cctcctcttc ttcctatacc actttgctac cgactttgga aaagaagaaa agaaagcgat
1981 gtggggtctg tgaaccctgc cagcagaaga ccaactgtgg tgaatgcact tactgcaaga
2041 acagaaagaa cagccatcag atctgtaaga aaagaaaatg tgaggagctg aaaaagaaac
2101 catctgttgt tgtgcctctg gaggttataa aggaaaacaa gaggccccag agggaaaaga
2161 agcccaaagt tttaaaggca gattttgaca acaaaccagt aaatggcccc aagtcagaat
2221 ccatggacta cagtagatgt ggtcatgggg aagaacaaaa attggaattg aacccacata
2281 ctgttgaaaa tgtaactaaa aatgaagaca gcatgacagg catcgaggtg gagaagtgga
2341 cacaaaacaa gaaatcacag ttaactgatc acgtgaaagg agattttagt gctaatgtcc
2401 cagaagctga aaaatcgaaa aactctgaag ttgacaagaa acgaaccaaa tctccaaaat
2461 tgtttgtaca aaccgtaaga aatggcatta aacatgtaca ctgtttacca gctgaaacaa
2521 atgtttcatt taaaaaattc aatattgaag aattcggcaa gacattggaa aacaattctt
2581 ataaattcct aaaagacact gcaaaccata aaaacgctat gagctctgtt gctactgata
2641 tgagttgtga tcatctcaag gggagaagta acgttttagt attccagcag cctggcttta
2701 actgcagttc cattccacat tcttcacact ccatcataaa tcatcatgct agtatacaca
2761 atgaaggtga tcaaccaaaa actcctgaga atataccaag taaagaacca aaagatggat
2821 ctcccgttca accaagtctc ttatcgttaa tgaaagatag gagattaaca ttggagcaag
2881 tggtagccat agaggccctg actcaactct cagaagcccc atcagagaat tcctccccat
2941 caaagtcaga gaaggatgag gaatcagagc agagaacagc cagtttgctt aatagctgca
3001 aagctatcct ctacactgta agaaaagacc tccaagaccc aaacttacag ggagagccac
3061 caaaacttaa tcactgtcca tctttggaaa aacaaagttc atgcaacacg gtggttttca
3121 atgggcaaac tactaccctt tccaactcac atatcaactc agctactaac caagcatcca
3181 caaagtcaca tgaatattca aaagtcacaa attcattatc tctttttata ccaaaatcaa
3241 attcatccaa gattgacacc aataaaagta ttgctcaagg gataattact cttgacaatt
3301 gttccaatga tttgcatcag ttgccaccaa gaaataatga agtggagtat tgcaaccagt
3361 tactggacag cagcaaaaaa ttggactcag atgatctatc atgtcaggat gcaacccata
3421 cccaaattga ggaagatgtt gcaacacagt tgacacaact tgcttcgata attaagatca
3481 attatataaa accagaggac aaaaaagttg aaagtacacc aacaagcctt gtcacatgta
3541 atgtacagca aaaatacaat caggagaagg gcacaatgca acagaaacca ccttcaagtg
3601 tacacaataa tcatggttca tcattaacaa aacaaaagaa cccaacccag aaaaagacaa
3661 aatccacccc atcaagagat cggcggaaaa agaagcccac agttgtaagt tatcaagaaa
3721 atgatcggca gaagtgggaa aagttgtcct atatgtatgg cacaatatgc gacatttgga
3781 tagcatcgaa atttcaaaat tttgggcaat tttgtccaca tgattttcct actgtatttg
3841 ggaaaatttc ttcctcgacc aaaatatgga aaccactggc tcaaacgagg tccattatgc
3901 aacccaaaac agtatttcca ccactcactc agataaaatt acagagatat cctgaatcag
3961 cagaggaaaa ggtgaaggtt gaaccattgg attcactcag cttatttcat cttaaaacgg
4021 aatccaacgg gaaggcattc actgataaag cttataattc tcaggtacag ttaacggtga
4081 atgccaatca gaaagcccat cctttgaccc agccctcctc tccacctaac cagtgtgcta
4141 acgtgatggc aggcgatgac caaatacggt ttcagcaggt tgttaaggag caactcatgc
4201 atcagagact gccaacattg cctggtatct ctcatgaaac acccttaccg gagtcagcac
4261 taactctcag gaatgtaaat gtagtgtgtt caggtggaat tacagtggtt tctaccaaaa
4321 gtgaagagga agtctgttca tccagttttg gaacatcaga attttccaca gtggacagtg
4381 cacagaaaaa ttttaatgat tatgccatga acttctttac taaccctaca aaaaacctag
4441 tgtctataac taaagattct gaactgccca cctgcagctg tcttgatcga gttatacaaa
4501 aagacaaagg cccatattat acacaccttg gggcaggacc aagtgttgct gctgtcaggg
4561 aaatcatgga gaataggtat ggtcaaaaag gaaacgcaat aaggatagaa atagtagtgt
4621 acaccggtaa agaagggaaa agctctcatg ggtgtccaat tgctaagtgg gttttaagaa
4681 gaagcagtga tgaagaaaaa gttctttgtt tggtccggca gcgtacaggc caccactgtc
4741 caactgctgt gatggtggtg ctcatcatgg tgtgggatgg catccctctt ccaatggccg
4801 accggctata cacagagctc acagagaatc taaagtcata caatgggcac cctaccgaca
4861 gaagatgcac cctcaatgaa aatcgtacct gtacatgtca aggaattgat ccagagactt
4921 gtggagcttc attctctttt ggctgttcat ggagtatgta ctttaatggc tgtaagtttg
4981 gtagaagccc aagccccaga agatttagaa ttgatccaag ctctccctta catgaaaaaa
5041 accttgaaga taacttacag agtttggcta cacgattagc tccaatttat aagcagtatg
5101 ctccagtagc ttaccaaaat caggtggaat atgaaaatgt tgcccgagaa tgtcggcttg
5161 gcagcaagga aggtcgtccc ttctctgggg tcactgcttg cctggacttc tgtgctcatc
5221 cccacaggga cattcacaac atgaataatg gaagcactgt ggtttgtacc ttaactcgag
5281 aagataaccg ctctttgggt gttattcctc aagatgagca gctccatgtg ctacctcttt
5341 ataagctttc agacacagat gagtttggct ccaaggaagg aatggaagcc aagatcaaat
5401 ctggggccat cgaggtcctg gcaccccgcc gcaaaaaaag aacgtgtttc actcagcctg
5461 ttccccgttc tggaaagaag agggctgcga tgatgacaga ggttcttgca cataagataa
5521 gggcagtgga aaagaaacct attccccgaa tcaagcggaa gaataactca acaacaacaa
5581 acaacagtaa gccttcgtca ctgccaacct tagggagtaa cactgagacc gtgcaacctg
5641 aagtaaaaag tgaaaccgaa ccccatttta tcttaaaaag ttcagacaac actaaaactt
5701 attcgctgat gccatccgct cctcacccag tgaaagaggc atctccaggc ttctcctggt
5761 ccccgaagac tgcttcagcc acaccagctc cactgaagaa tgacgcaaca gcctcatgcg
5821 ggttttcaga aagaagcagc actccccact gtacgatgcc ttcgggaaga ctcagtggtg
5881 ccaatgcagc tgctgctgat ggccctggca tttcacagct tggcgaagtg gctcctctcc
5941 ccaccctgtc tgctcctgtg atggagcccc tcattaattc tgagccttcc actggtgtga
6001 ctgagccgct aacgcctcat cagccaaacc accagccctc cttcctcacc tctcctcaag
6061 accttgcctc ttctccaatg gaagaagatg agcagcattc tgaagcagat gagcctccat
6121 cagacgaacc cctatctgat gaccccctgt cacctgctga ggagaaattg ccccacattg
6181 atgagtattg gtcagacagt gagcacatct ttttggatgc aaatattggt ggggtggcca
6241 tcgcacctgc tcacggctcg gttttgattg agtgtgcccg gcgagagctg cacgctacca
6301 ctcctgttga gcaccccaac cgtaatcatc caacccgcct ctcccttgtc ttttaccagc
6361 acaaaaacct aaataagccc caacatggtt ttgaactaaa caagattaag tttgaggcta
6421 aagaagctaa gaataagaaa atgaaggcct cagagcaaaa agaccaggca gctaatgaag
6481 gtccagaaca gtcctctgaa gtaaatgaat tgaaccaaat tccttctcat aaagcattaa
6541 cattaaccca tgacaatgtt gtcaccgtgt ccccttatgc tctcacacac gttgcggggc
6601 cctataacca ttgggtctga aggcttttct ccccctctta atgcctttgc tagtgcagtg
6661 tattttttca aggtgctgtt aaaagaaagt catgttgtcg tttactatct tcatctcacc
6721 catttcaagt ctgaggtaaa aaaataataa tgataacaaa acggggtggg tattcttaac
6781 tgtgactata ttttgacaat tggtagaagg tgcacatttt aagcaaaaat aaaagtttta
6841 tagttttaaa tacataaaga aatgtttcag ttaggcatta accttgatag aatcactcag
6901 tttggtgctt taaattaagt ctgtttacta tgaaacaaga gtcattttta gaggatttta
6961 acaggttcat gttctatgat gtaaaatcaa gacacacagt gttaactcta cacagcttct
7021 ggtgcttaac cacatccaca cagttaaaaa taagctgaat tattatttca tggtgccatt
7081 gttccaacat cttccaatca ttgctagaaa attggcatat tcctttgaaa taaacttatg
7141 aaatgttttc tctcttaaaa tatttctcct gtgtaaaata aatcattgtt gttagtaatg
7201 gttggaggct gttcataaat tgtaaatata tattttaaaa gcactttcta tttttaaaag
7261 taacttgaaa taatatagta taagaatcct attgtctatt gtttgtgcat atttgcatac
7321 aagagaaatc atttatcctt gctgtgtaga gttccatctt gttaactgca gtatgtattc
7381 taatcatgta tatggtttgt gttcttttac tgtgtcctct cacattcaag tattagcaac
7441 ttgcagtata taaaatagtt agataatgag aagttgttaa ttatctctaa aattggaatt
7501 aggaagcata tcaccaatat tgattaacat tctctttgga actaggtaag agtggtctct
7561 tcttattgaa caacctcaat ttagtttcat cccacctttc tcagtataat ccatgagagg
7621 tgtttccaaa aggagatgag ggaacaggat aggtttcaga agagtcaaat gcttctaatg
7681 tctcaaggtg ataaaataca aaaactaagt agacagatat ttgtactgaa gtctgataca
7741 gaattaaaaa aaaaaaaatc ttgttgaaat attttgaaaa caaattccct actatcatca
7801 catgcctccc caaccccaag tcaaaaacaa gaggaatggt actacaaaca tggctttgtc
7861 cattaagagc taattcattt gtttatctta gcatactaga tttgggaaaa tgataactca
7921 tcttttctga taattgccta tgttctaggt aacaggaaaa caggcattaa gtttatttta
7981 gtcttcccat tttcttccta ttactttatt gactcatttt attgcaaaac aaaaaggatt
8041 acccaaacaa catgtttcga acaaggagaa ttttcaatga aatacttgat tctgttaaaa
8101 tgcagaggtg ctataacatt caaagtgtca gattccttgg gagtatggaa aacctaatgg
8161 tgcttctccc ttggaaatgc cataggaagc ccacaaccgc taacacttac aattttggtg
8221 caaaagcaaa cagttccagc aggctctcta aagaaaaact cattgtaact tattaaaata
8281 atatctggtg caaagtatct gttttgagct tttgactaat ccaagtaaag gaatatgaag
8341 ggattgtaaa aaacaaaatg tccattgata gaccatcgtg tacaagtaga tttctgcttg
8401 ttgaatatgt aaaatagggt aattcattga cttgttttag tattttgtgt gccttagatt
8461 tccgttttaa gacatgtata tttttgtgag cctaagg
//