LOCUS AF418270 3070 bp mRNA linear HUM 05-NOV-2003
DEFINITION Homo sapiens connector enhancer of KSR2B mRNA, complete cds.
ACCESSION AF418270
VERSION AF418270.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 3070)
AUTHORS Lanigan,T.M., Liu,A., Huang,Y.Z., Mei,L., Margolis,B. and Guan,K.L.
TITLE Human homologue of Drosophila CNK interacts with Ras effector
proteins Raf and Rlf
JOURNAL FASEB J. 17 (14), 2048-2060 (2003)
PUBMED 14597674
REFERENCE 2 (bases 1 to 3070)
AUTHORS Lanigan,T.M. and Guan,K.L.
TITLE Direct Submission
JOURNAL Submitted (07-SEP-2001) Biological Chemistry, Univ of Michigan,
1301 Catherine St., Ann Arbor, MI 48109, USA
FEATURES Location/Qualifiers
source 1..3070
/db_xref="H-InvDB:HIT000079349"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
CDS 37..2733
/note="CNK2B; membrane protein"
/codon_start=1
/product="connector enhancer of KSR2B"
/protein_id="AAL60503.1"
/translation="MALIMEPVSKWSPSQVVDWMKGLDDCLQQYIKNFEREKISGDQL
LRITHQELEDLGVSRIGHQELILEAVDLLCALNYGLETENLKTLSHKLNASAKNLQNF
ITGRRRSGHYDGRTSRKLPNDFLTSVVDLIGAAKSLLAWLDRSPFAAVTDYSVTRNNV
IQLCLELTTIVQQDCTVYETENKILHVCKTLSGVCDHIISLSSDPLVSQSAHLEVIQL
ANIKPSEGLGMYIKSTYDGLHVITGTTENSPADRCKKIHAGDEVIQVNHQTVVGWQLK
NLVNALREDPSGVILTLKKRPQSMLTSAPALLKNMRWKPLALQPLIPRSPTSSVATPS
STISTPTKRDSSALQDLYIPPPPAEPYIPRDEKGNLPCEDLRGHMVGKPVHKGSESPN
SFLDQEYRKRFNIVEEDTVLYCYEYEKGRSSSQGRRESTPTYGKLRPISMPVEYNWVG
DYEDPNKMKRDSRRENSLLRYMSNEKIAQEEYMFQRNSKKDTGKKSKKKGDKSNSPTH
YSLLPSLQMDALRQDIMGTPVPETTLYHTFQQSSLQHKSKKKNKGPIAGKSKRRISCK
DLGRGDCEGWLWKKKDAKSYFSQKWKKYWFVLKDASLYWYINEEDEKAEGFISLPEFK
IDRASECRKKYAFKACHPKIKSFYFAAEHLDDMNRWLNRINMLTAGYAERERIKQEQD
YWSESDKEEADTPSTPKQDSPPPPYDTYPRPPSMSCASPYVEAKHSRLSSTETSQSQS
SHEEFRQEVTGSSAVSPIRKTASQRRSWQDLIETPLTSSGLHYLQTLPLEDSVFSDSA
AISPEHRRQSTLPTQKCHLQDHYGPYPLAESERMQVLNGNGGKPRSFTLPRDSGFNHC
CLNAPVSACDPQDDVQPPEVEEEEEEEEEEGEAAGENIGEKS"
misc_feature 58..255
/note="Region: SAM; sterile alpha motif"
misc_feature 67..249
/note="Region: SAM; sterile alpha motif"
misc_feature 700..927
/note="Region: PDZ domain"
misc_feature 700..918
/note="Region: PDZ domain"
misc_feature 1753..2037
/note="Region: PH; Pleckstrin homology domain"
misc_feature 1789..2049
/note="Region: PH; Pleckstrin homology domain"
BASE COUNT 971 a 659 c 733 g 707 t
ORIGIN
1 gagctctgcg ctctgcacgg aaccgacccc gtacccatgg ctctgataat ggaaccggtg
61 agcaaatggt ctccgagtca agtagtggac tggatgaaag gtcttgatga ctgtttgcag
121 cagtatatta agaactttga gagggagaag atcagtgggg accagctgct gcgcattaca
181 catcaggagc tagaagatct gggggtcagc cgcattggcc atcaggaact gatcttggaa
241 gcagttgacc ttctgtgtgc attgaattat ggcttggaaa cagaaaatct aaaaaccctt
301 tctcacaagt tgaatgcatc tgccaaaaat ctgcagaatt ttataacagg aaggagaagg
361 agtggccatt atgatgggag gaccagccga aaattgccaa acgactttct gacctcagtt
421 gtggatctga ttggagcagc caagagtctg cttgcctggt tggacaggtc accatttgct
481 gctgtgacag actattcagt tacaagaaat aatgtcatac aactctgcct ggagttaaca
541 acaattgtgc aacaggattg tactgtatat gaaacagaga ataaaattct tcacgtgtgt
601 aaaactcttt ctggagtctg tgaccacatc atatccctgt cgtcagatcc tctggtttca
661 cagtctgctc acctggaagt gattcaactg gcaaacatta aaccaagcga agggctgggt
721 atgtatatta aatctacata tgatggcctc catgtaatta ctggaaccac agaaaattca
781 cctgcagatc ggtgcaagaa aatccatgct ggcgatgaag tgattcaagt taatcatcag
841 actgtggtgg ggtggcagtt gaaaaatttg gtgaatgcac tacgagagga cccgagtggt
901 gttatcttaa ctttgaaaaa gcgacctcag agcatgctta cctcagcacc agctttactg
961 aaaaatatga gatggaagcc ccttgctctg cagcctctta tacctagaag tcccacaagc
1021 agcgttgcca cgccttccag caccatcagt acacccacca aaagagacag ttctgccctc
1081 caggatctct acattccccc tcctcctgca gaaccatata ttcccaggga tgaaaaagga
1141 aaccttcctt gtgaagacct cagaggacat atggtgggca agccagtgca taagggatct
1201 gaatcaccaa attcatttct ggatcaggaa tatcgaaaga gatttaatat tgtcgaagaa
1261 gatactgtct tatattgcta tgaatatgaa aaaggaagat caagtagtca aggaagacga
1321 gaaagcaccc caacttatgg caagctacga cctatatcta tgccagtgga atataattgg
1381 gtgggggact atgaagatcc aaataagatg aagagagata gtagaagaga aaactctcta
1441 cttcggtata tgagcaatga aaagattgct caagaagaat acatgtttca gagaaacagc
1501 aaaaaggaca cagggaagaa gtcaaaaaag aagggtgata agagtaatag cccaactcac
1561 tattcattgc tacctagttt acaaatggat gcactgagac aagacatcat gggcactcct
1621 gtgccagaga ccacactata ccatacattt cagcagtcct cactgcagca caaatcaaag
1681 aagaaaaaca aaggtcctat agcaggcaag agcaaaagac gaatttcttg caaagatctt
1741 ggccgtggtg actgtgaggg ctggctttgg aaaaagaaag atgcgaagag ttacttttca
1801 cagaaatgga aaaaatattg gtttgtccta aaggatgcat ccctttattg gtatattaat
1861 gaggaggatg aaaaagcaga aggattcatt agcctgcctg aatttaaaat tgatagagcc
1921 agtgaatgcc gcaaaaaata tgcattcaaa gcctgtcatc ctaaaatcaa aagcttttat
1981 tttgctgctg aacatcttga tgatatgaac aggtggctta acagaattaa tatgctgact
2041 gcaggatatg cagaaagaga gaggattaag caggaacaag attactggag tgagagtgac
2101 aaggaagaag cagatactcc atcaacacca aaacaagata gccctccacc cccatatgat
2161 acatacccac gacctccctc gatgagttgc gccagtcctt atgtggaagc aaaacatagc
2221 cgactttcct ccacggagac ttctcagtct cagtcttctc atgaggagtt tcgccaggaa
2281 gtaactggga gcagtgcagt gtctcccatt cgcaagacag ccagtcagcg ccgctcctgg
2341 caggatttaa ttgagacgcc actgacaagt tcaggcttac actatcttca gactctgccc
2401 ctggaggatt ctgtcttctc tgactccgcg gccatctccc cagagcacag gcggcagtct
2461 accctgccaa ctcagaaatg ccacctgcag gatcactatg ggccataccc cttagctgag
2521 agtgagagga tgcaagtgct aaatggaaat gggggcaagc ctcgaagttt tactctgcct
2581 cgagatagcg ggttcaacca ttgctgtctg aatgctccag ttagtgcctg tgacccacag
2641 gatgacgtgc aacccccaga ggtggaggaa gaggaggagg aggaggagga ggaaggggag
2701 gcagcagggg aaaacatagg agaaaaaagc taatacactg cgagagttgg tagaacctct
2761 ccatgccaaa tcggatccac ttctgttggc actcaaccca ttggactcac agattgataa
2821 gctaatgttt agagaattta gatcggagag agtcggtacg gcgcagactc aacatcaacc
2881 tcttgcaagc aactaaaatg gcctcgtcct tgctgtttat aacagaaaac agacttgtaa
2941 aaagcttaga tcatcaagtg ttttggattg ggggcctccc aaagggatat aagaggggca
3001 ggccactctt aagaagaatg cgagctttct acattgggac tagcataaga tcaaagccaa
3061 tcaagatgga
//