LOCUS AF418105 7187 bp mRNA linear HUM 15-OCT-2002
DEFINITION Homo sapiens ATP-binding cassette transporter family A member 12
mRNA, complete cds.
ACCESSION AF418105
VERSION AF418105.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 7187)
AUTHORS Schaap,F.G., van Wijland,M. and Groen,A.K.
TITLE Cloning of a novel ABC transporter (ABCA12) tentatively involved in
lipid homeostatis
JOURNAL Unpublished
REFERENCE 2 (bases 1 to 7187)
AUTHORS Schaap,F.G., van Wijland,M. and Groen,A.K.
TITLE Direct Submission
JOURNAL Submitted (12-SEP-2001) Experimental Hepatology, Room F0.116,
Academic Medical Centre, Meibergdreef 9, Amsterdam 1105 AZ, The
Netherlands
FEATURES Location/Qualifiers
source 1..7187
/db_xref="H-InvDB:HIT000079345"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/cell_line="HepG2"
5'UTR 1..86
CDS 87..7130
/note="ABCA12"
/codon_start=1
/product="ATP-binding cassette transporter family A member
12"
/protein_id="AAN40735.1"
/translation="MLSFFSQVQEQKAVWQLLSSFPNVFQNDTSLSNLFDVLRKANSV
LLVVQKVYPRFATNEGFRTLQKSVKHLLYTLDSPAQGDSDNITHVWNEDDGQTLSPSS
LAAQLLILENFEDALLNISANSPYIPYLACVRNVTDSLARGSPENLRLLQSTIRFKKS
FLRNGSYEDYFPPVPEVLKSKLSQLRNLTELLCESETFSLIEKSCQLSDMSFGSLCEE
SEFDLQLLEAAELGTEIAASLLYHDNVISKKVRDLLTGDPSKINLNMDQFLEQALQMN
YLENITQLIPIIEAMLHVNNSADASEKPGQLLEMFKNVEELKEDLRRTTGMSNRTIDK
LLAIPIPDNRAEIISQVFWLHSCDTNITTPKLEDAMKEFCNLSLSERSRQSYLIGLTL
LHYLNIYNFTYKVFFPRKDQKPVEKMMELFIRLKEILNQMASGTHPLLDKMRSLKQMH
LPRSVPLTQAMYRSNRMNTPQGSFSTISQALCSQGITTEYLTAMLPSSQRPKGNHTKD
FLTYKLTKEQIASKYGIPINTTPFCFSLYKDIINMPAGPVIWAFLKPMLLGRILYAPY
NPVTKAIMEKSNVTLRQLAELREKSQEWMDKSPLFMNSFHLLNQAIPMLQNTLRNPFV
QVFVKFSVGLDAVELLKQIDELDILRLKLENNIDIIDQLNTLSSLTVNISSCVLYDRI
QAAKTIDEMEREAKRLYKSNELFGSVIFKLPSNRSWHRGYDSGNVFLPPVIKYTIRMS
LKTAQTTRSLRTKIWAPGPHNSPSHNQIYGRAFIYLQDSIERAIIELQTGRNSQEIAV
QVQAIPYPCFMKDNFLTSVSYSLPIVLMVAWVVFIAAFVKKLVYEKDLRLHEYMKMMG
VNSCSHFFAWLIESVGFLLVTIVILIIILKFGNILPKTNGFILFLYFSDYSFSVIAMS
YLISVFFNNTNIAALIGSLIYIIAFFPFIVLVTVENELSYVLKVFMSLLSPTAFSYAS
QYIARYEEQGIGLQWENMYTSPVQDDTTSFGWLCCLILADSFIYFLIAWYVRNVFPGT
YGMAAPWYFPILPSYWKERFGCAEVKPEKSNGLMFTNIMMQNTNPSASPEYMFSSNIE
PEPKDLTVGVALHGVTKIYGSKVAVDNLNLNFYEGHITSLLGPNGAGKTTTISMLTGL
FGASAGTIFVYGKDIKTDLHTVRKNMGVCMQHDVLFSYLTTKEHLLLYGSIKVPHWTK
KQLHEEVKRTLKDTGLYSHRHKRVGTLSGGMKRKLSISIALIGGSRVVILDEPSTGVD
PCSRRSIWDVISKNKTARTIILSTHHLDEAEVLSDRIAFLEQGGLRCCGSPFYLKEAF
GDGYHLTLTKKKSPNLNANAVCDTMAVTAMIQSHLPEAYLKEDIGGELVYVLPPFSTK
VSGAYLSLLRALDNGMGDLNIGCYGISDTTVEEVFLNLTKESQKNSAMSLEHLTQKKI
GNSNANGISTPDDLSVSSSNFTDRDDKILTRGERLDGFGLLLKKIMAILIKRFHHTRR
NWKGLIAQVILPIVFVTTAMGLGTLRNSSNSYPEIQISPSLYGTSEQTAFYANYHPST
EALVSAMWDFPGIDNMCLNTSDLQCLNKDSLEKWNTSGEPITNFGVCSCSENVQECPK
FNYSPPHRRTYSSQVIYNLTGQRVENYLISTANEFVQKRYGGWSFGLPLTKDLRFDIT
GVPANRTLAKVWYDPEGYHSLPAYLNSLNNFLLRVNMSKYDAARHGIIMYSHPYPGVQ
DQEQATISSLIDILVALSILMGYSVTTASFVTYVVREHQTKAKQLQHISGIGVTCYWV
TNFIYDMVFYLVPVAFSIGIIAIFKLPAFYSENNLGAVSLLLLLFGYATFSWMYLLAG
LFHETGMAFITYVCVNLFFGINSIVSLSVVYFLSKEKPNDPTLELISETLKRIFLIFP
QFCFGYGLIELSQQQSVLDFLKAYGVEYPNETFEMNKLGAMFVALVSQGTMFFSLRLL
INESLIKKLRLFFRKFNSSHVRETIDEDEDVRAERLRVESGAAEFDLVQLYCLTKTYQ
LIHKKIIAVNNISIGIPAGECFGLLGVNGAGKTTIFKMLTGDIIPSSGNILIRNKTGS
LGHVDSHSSLVGYCPQEDALDDLVTVEEHLYFYARVHGIPEKDIKETVHKLLRRLHLM
PFKDRATSMCSYGTKRKLSTALALIGKPSILLLDEPSSGMDPKSKRHLWKIISEEVQN
KCSVILTSHSMEECEALCTRLAIMVNGKFQCIGSLQHIKSRFGRGFTVKVHLKNNKVT
METLTKFMQLHFPKTYLKDQHLSMLEYHVPVTAGGVANIFDLLETNKTALNITNFLVS
QTTLEEVFINFAKDQKSYETADTSSQGSTISVDSQDDQMES"
3'UTR 7131..>7187
BASE COUNT 2128 a 1608 c 1472 g 1979 t
ORIGIN
1 cttctctcca agaactaaac aaacagttct cccagctatc cagtgacccc aacaatcaga
61 agatagtgtt tcaggaaata gtcagaatgc tgtctttctt ctcacaagtg caagagcaga
121 aagctgtgtg gcagcttctg tctagttttc caaatgtgtt tcagaatgac acatcactaa
181 gcaatctatt tgatgttctt cgaaaggcaa acagtgtgct gctggttgtg cagaaggttt
241 atccacgttt tgcaactaac gaaggtttca gaaccctcca gaagtctgtt aaacatctgc
301 tgtacactct ggactcccca gctcaaggtg actccgataa tataacgcat gtgtggaatg
361 aggatgatgg acagacctta tctccaagca gtctggctgc acagctccta attctggaaa
421 actttgaaga tgccctctta aatatatcag caaatagtcc ttatattcct tacttggcat
481 gtgtgagaaa tgtgactgac agtttggcca gaggttcacc agaaaatcta agactcctgc
541 agtccacaat acgatttaaa aaatcttttc ttcgcaatgg ttcctatgaa gattactttc
601 ctccagttcc tgaagtccta aaatcaaaac tgtctcaact tcgaaacttg accgaacttc
661 tttgtgaatc tgaaactttc agtttgatag agaagtcatg ccagctctct gatatgagct
721 ttgggagcct gtgtgaagaa agtgagtttg atctgcaact cctcgaagcg gcagagctgg
781 gcaccgaaat agcagccagc ttactgtacc atgacaatgt catatctaaa aaagtgagag
841 atttgctgac tggagatcca agcaaaatta atttaaatat ggatcagttt ctagaacagg
901 cactgcaaat gaattacttg gaaaatatca ctcagttaat accgatcata gaagccatgc
961 tgcatgtcaa taacagtgca gatgcttctg aaaagccagg tcagttacta gaaatgttta
1021 aaaatgttga agagctgaaa gaagatttaa ggagaacaac aggaatgtcc aacaggacta
1081 ttgacaagtt gctggccatt cccatccctg ataatagagc tgagattatt tctcaggtgt
1141 tctggctgca ttcctgtgat actaatatca ccactcccaa actagaagat gcaatgaaag
1201 aattctgcaa cctgtctctt tcagagagat cccggcagtc ttacctcatc ggactcaccc
1261 ttctgcacta cttaaacatt tacaacttca catacaaggt gtttttcccg aggaaagatc
1321 aaaagccagt agaaaagatg atggagctct tcataagact aaaagagatt ctcaatcaga
1381 tggcttctgg cacacatccg ctgctagaca aaatgagatc cctgaagcaa atgcatctgc
1441 ccagaagtgt tccattaaca caggcaatgt acagaagcaa ccgaatgaac acaccacaag
1501 gatcatttag caccatctcc caagcattat gttctcaagg aattaccact gaatatttaa
1561 ctgccatgct gccctcttcc cagaggccaa aaggcaacca caccaaggat tttttgactt
1621 ataaattaac taaagagcaa attgcttcaa aatatggaat tcccataaat accacaccat
1681 tttgcttctc cctttataaa gacatcatta acatgcccgc tggacctgtg atttgggctt
1741 tcttgaaacc tatgttgttg ggaagaattt tgtatgcacc atataaccca gtcacaaagg
1801 caataatgga aaagtccaat gtaactctga gacagctggc ggaattaaga gaaaaatctc
1861 aagagtggat ggataagtcg ccacttttca tgaattcctt ccatctgtta aaccaggcaa
1921 ttccaatgct ccagaatact ctaaggaacc cttttgtgca agtttttgta aagttctccg
1981 tgggactcga tgctgttgaa ctattgaaac agatagatga actcgatatt ctaagactga
2041 aattagagaa caacattgac atcatcgatc agcttaacac actatcttcc ctgacagtaa
2101 atatttcctc ttgtgtatta tatgaccgta ttcaggcagc aaaaaccata gatgaaatgg
2161 agagagaggc taaaaggctc tacaaaagca acgaactctt tggaagtgtt atttttaagc
2221 ttccttctaa cagaagctgg cacagaggct atgactctgg aaatgtcttt cttcctcctg
2281 tcataaaata taccatccgg atgagtctca agaccgcaca gaccacaaga agcctaagaa
2341 ccaagatttg ggctccaggg ccacacaatt ctccatcaca caaccagatc tatggcaggg
2401 cttttattta tttacaggat agtattgaaa gagcaatcat tgaattgcaa actggaagga
2461 actcccagga aatagcagtc caggttcaag caattcctta tccctgcttc atgaaagaca
2521 acttcctaac cagtgtctct tattctcttc caattgtgct tatggttgcc tgggttgtat
2581 ttatagctgc ctttgtaaaa aagcttgtct atgagaaaga cctccggctt catgagtaca
2641 tgaagatgat gggtgtgaac tcctgcagcc atttctttgc ctggcttata gagagtgttg
2701 gatttttact ggttaccatc gtgatcctca tcattatact caagtttggc aatattcttc
2761 ctaaaacaaa tgggttcatt ttgttcctgt atttttcgga ctacagcttc tcggttattg
2821 ccatgagcta tcttatcagt gtcttcttca acaacaccaa cattgcagct ctgatcggaa
2881 gcctcatcta catcattgcc ttctttccat ttattgttct ggttacagtg gagaatgagt
2941 tgagctatgt attgaaagtg ttcatgagcc tgctgtcccc aacagcattc agctatgcaa
3001 gccaatacat tgcacgatac gaagaacagg gcattggtct tcagtgggaa aatatgtaca
3061 cctccccggt tcaggatgac accacctcat ttggctggct gtgctgtcta atcctagctg
3121 actctttcat ttatttcctt attgcttggt atgtcaggaa tgtcttccca gggacatacg
3181 gtatggcagc tccctggtat tttccaattc ttccttccta ttggaaggag cgatttgggt
3241 gtgcagaggt gaagcctgag aagagcaatg gcctcatgtt tactaacatc atgatgcaga
3301 acaccaaccc atctgccagt cctgaataca tgttttcctc taacatcgag cctgaaccta
3361 aagatctcac agtcggggtt gccctgcatg gggtcacaaa gatctatggc tcaaaagttg
3421 ctgttgataa cctcaatctg aacttttatg aagggcatat tacttcattg ctggggccca
3481 atggagctgg gaaaactact accatttcca tgttaactgg gctgtttggg gcctcagcag
3541 gcaccatttt tgtatatgga aaagatatca aaacagacct acacacggta cggaagaaca
3601 tgggagtctg tatgcagcac gacgtcttgt tcagttacct cactactaag gagcaccttc
3661 tcctatatgg ttccatcaaa gttcctcact ggactaaaaa gcagctccac gaggaagtaa
3721 aaaggacttt aaaagatact ggactatata gccatcgtca taagagagtt ggaacactgt
3781 caggaggcat gaagaggaag ttatctatat ccatagctct cattggtgga tcaagggtag
3841 taattttgga tgaaccatct actggagttg acccatgttc tcgccgaagt atatgggatg
3901 ttatatccaa gaacaaaact gccagaacaa tcattctgtc aacgcaccac ttggacgagg
3961 ctgaagtgct gagtgaccgc atcgccttcc tggagcaggg tgggcttagg tgctgtgggt
4021 ccccatttta cctcaaggaa gcctttggcg atgggtatca cctcacgctt accaagaaga
4081 agagtccaaa tttaaatgca aatgcagtat gtgacaccat ggccgtgaca gcaatgatcc
4141 aatcacatct ccccgaagcc tacctcaagg aggatattgg gggagagctt gtttatgtac
4201 ttcctccatt cagcaccaaa gtctcagggg cctacctgtc actcctacgg gcactcgaca
4261 atggcatggg tgacctcaac atcgggtgct acggcatttc agataccacc gtggaggagg
4321 tctttctgaa cttgaccaaa gagtcacaaa aaaatagtgc tatgagtctt gagcacttaa
4381 cacaaaagaa aattgggaat tccaatgcca atggcatctc aactcctgac gatttatctg
4441 tgagcagcag caatttcaca gacagagatg acaaaatcct gacaagagga gagaggctgg
4501 atggctttgg actgttgctg aagaagatca tggctatact catcaagagg ttccaccaca
4561 cccgcaggaa ctggaaaggt ctcattgctc aggttatcct ccccatcgtc tttgttacca
4621 ctgccatggg ccttggcaca ctgagaaatt ccagcaacag ttatccagag attcagatct
4681 ccccctctct ttatggtacc tccgaacaga cagccttcta tgctaattat cacccgagca
4741 cggaagcact tgtctcagca atgtgggact tccctggaat tgacaacatg tgtctgaaca
4801 ccagtgatct acagtgttta aacaaagaca gtctggaaaa atggaacacc agtggagaac
4861 ccatcactaa ttttggtgtt tgctcctgct cagaaaatgt ccaggaatgt cctaaattta
4921 actattcccc accgcacaga agaacttact catcccaggt aatttataac ctcactgggc
4981 aacgagtgga aaattatctt atatcaactg caaatgagtt tgtccaaaaa agatatggag
5041 gttggagttt tgggctgcct ttgacaaaag accttcgttt tgatataaca ggagtccctg
5101 ccaatagaac acttgccaag gtatggtatg atccagaagg ctatcactcc cttccagctt
5161 acctcaacag cctgaataat ttccttctgc gagttaacat gtcaaaatac gatgctgccc
5221 gacatggcat catcatgtat agccatcctt atccaggagt gcaagaccaa gaacaagcca
5281 caatcagcag tttaatcgat attttagtgg cactgtctat cttgatgggc tactctgtca
5341 ccaccgccag ctttgtcacc tatgttgtaa gggaacatca aaccaaagcc aaacagttgc
5401 agcacatttc aggcattggc gtgacatgct actgggtaac aaacttcatt tatgacatgg
5461 ttttctactt ggtgcctgta gcgttttcaa ttggtatcat tgcgattttc aaattacctg
5521 cattctacag tgaaaacaac ctaggcgctg tatctctcct acttctcctg tttgggtatg
5581 caacattttc ctggatgtac ttgctggctg ggctcttcca tgaaacagga atggccttca
5641 tcacttatgt ctgtgtcaac ttgttttttg gcattaattc cattgtttcc ctgtcagtgg
5701 tatactttct ttccaaggaa aagcctaatg atccgacttt agaacttatt tctgaaaccc
5761 tcaagcgcat tttcctgatt ttcccacaat tctgttttgg ctacggtttg attgaacttt
5821 ctcaacaaca gtcggtccta gacttcttaa aagcatatgg agtggaatac ccaaatgaaa
5881 cctttgagat gaataaacta ggtgcaatgt ttgtggcttt ggtttctcag ggcaccatgt
5941 ttttttcctt gcgactctta atcaacgaat ccctgataaa gaaactcagg cttttcttca
6001 gaaaatttaa ttcttcacat gtaagggaga caatagatga ggatgaagat gtgcgggctg
6061 agagattaag agttgagagt ggtgcagctg aatttgactt ggtccaactt tattgtctca
6121 caaagaccta ccaacttatc cacaaaaaga ttatagctgt aaacaacatc agcattggga
6181 tacctgctgg agagtgtttt gggcttcttg gagtgaatgg agcaggaaag accactatat
6241 tcaagatgct gacaggagac atcattcctt caagtggaaa cattctgatc agaaataaga
6301 ccggatctct gggtcacgtt gattctcaca gctcattagt tggctactgt cctcaggaag
6361 atgccttaga tgacctggta actgtggaag aacatttgta tttctatgcc agggtacatg
6421 gaattccaga aaaggatatt aaagaaactg ttcataaact ccttaggaga cttcacctga
6481 tgcccttcaa ggacagagct acctctatgt gcagttatgg cacaaaaaga aaattatcca
6541 ctgcactggc cttgataggg aaaccttcca ttctactgct ggatgagccg agctctggca
6601 tggatccgaa gtcgaaacgg cacctctgga agatcatttc agaagaagta cagaacaaat
6661 gttccgtcat cctcacatct cacagcatgg aagaatgtga agctctctgt accaggttgg
6721 ccattatggt gaatggaaag tttcaatgta ttggatcttt gcagcacata aagagcaggt
6781 ttggacgagg atttactgtc aaagttcact tgaagaataa caaagtgacc atggagaccc
6841 tcacaaagtt catgcagctg cactttccaa aaacatactt aaaagatcag cacctcagca
6901 tgctagagta tcatgtacca gtcacagcag gaggagtcgc aaacattttt gatctgctgg
6961 aaaccaacaa gactgcttta aatattacaa atttcttagt gagtcagacc actctggaag
7021 aggttttcat caactttgcc aaagaccaga agtcctatga aactgctgat accagcagcc
7081 aaggttccac tataagtgtt gactcacaag atgaccagat ggagtcttaa cacttccagc
7141 aaactcaatc tcagcatgtg accaatggct tcattttgaa gaaaagc
//