LOCUS AF417861 3474 bp mRNA linear HUM 06-DEC-2001
DEFINITION Homo sapiens PH domain protein CED12A (CED12A) mRNA, complete cds.
ACCESSION AF417861
VERSION AF417861.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 3474)
AUTHORS Zhou,Z., Caron,E., Hartwieg,E., Hall,A. and Horvitz,H.R.
TITLE The C. elegans PH domain protein CED-12 regulates cytoskeletal
reorganization via a Rho/Rac GTPase signaling pathway
JOURNAL Dev. Cell 1 (4), 477-489 (2001)
PUBMED 11703939
REFERENCE 2 (bases 1 to 3474)
AUTHORS Zhou,Z. and Horvitz,H.R.
TITLE Direct Submission
JOURNAL Submitted (10-SEP-2001) Biology, Massachusetts Institute of
Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA
FEATURES Location/Qualifiers
source 1..3474
/db_xref="H-InvDB:HIT000079343"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="20"
/tissue_type="testis"
gene 1..3474
/gene="CED12A"
CDS 1..2163
/gene="CED12A"
/note="contains C-terminal proline-rich motif; similar to
Caenorhabditis elegans protein CED-12; Hced-12A; HCED-12A"
/codon_start=1
/product="PH domain protein CED12A"
/protein_id="AAL38512.1"
/translation="MPPPSDIVKVAIEWPGANAQLLEIDQKRPLASIIKEVCDGWSLP
NPEYYTLRYADGPQLYITEQTRSDIKNGTILQLAISPSRAARQLMERTQSSNMETRLD
AMKELAKLSADVTFATEFINMDGIIVLTRLVESGTKLLSHYSEMLAFTLTAFLELMDH
GIVSWDMVSITFIKQIAGYVSQPMVDVSILQRSLAILESMVLNSQSLYQKIAEEITVG
QLISHLQVSNQEIQTYAIALINALFLKAPEDKRQDMANAFAQKHLRSIILNHVIRGNR
PIKTEMAHQLYVLQVLTFNLLEERMMTKMDPNDQAQRDIIFELRRIAFDAESDPSNAP
GSGTEKRKAMYTKDYKMLGFTNHINPAMDFTQTPPGMLALDNMLYLAKVHQDTYIRIV
LENSSREDKHECPFGRSAIELTKMLCEILQVGELPNEGRNDYHPMFFTHDRAFEELFG
ICIQLLNKTWKEMRATAEDFNKVMQVVREQITRALPSKPNSLDQFKSKLRSLSYSEIL
RLRQSERMSQDDFQSPPIVELREKIQPEILELIKQQRLNRLCEGSSFRKIGNRRRQER
FWYCRLALNHKVLHYGDLDDNPQGEVTFESLQEKIPVADIKAIVTGKDCPHMKEKSAL
KQNKEVLELAFSILYDPDETLNFIAPNKYEYCIWIDGLSALLGKDMSSELTKSDLDTL
LSMEMKLRLLDLENIQIPEAPPPIPKEPSSYDFVYHYG"
BASE COUNT 899 a 919 c 839 g 817 t
ORIGIN
1 atgccaccac cgtcagacat tgtcaaagtg gccattgagt ggccaggtgc taacgcccag
61 ctccttgaaa tcgaccagaa acggcccctg gcatccatta tcaaggaagt ttgtgatggg
121 tggtcgttgc caaacccaga gtattatacc ctccgttatg cagatggtcc tcagctgtac
181 atcaccgaac agactcgcag tgacattaag aatgggacaa tcttacaact ggctatctcc
241 ccgtcccggg ctgcacgcca gctgatggag aggacccagt catccaacat ggagacccgg
301 ctggatgcca tgaaggagct ggccaagctc tctgccgacg tgactttcgc tactgagttc
361 atcaacatgg atggcatcat tgtgctgaca aggctcgtgg aaagtggaac caagctcttg
421 tcccactaca gtgagatgct ggcattcacc ctgactgcct tcctagagct catggaccat
481 ggcattgtct cctgggacat ggtttcaatc acctttatta agcagattgc agggtatgtg
541 agccagccca tggtggacgt gtcaatcctt cagaggtccc tggccatcct ggagagcatg
601 gtcttgaaca gccagagtct gtaccagaag atagccgagg aaatcaccgt gggacagctc
661 atctcacacc tccaggtctc caaccaggag attcagacct acgccattgc actgattaat
721 gcactttttc tgaaggctcc tgaggacaaa cgacaggata tggcaaatgc atttgcacag
781 aagcatctcc ggtctataat cctgaatcat gtgatccgag ggaaccgccc catcaaaact
841 gagatggccc atcagctata tgtccttcaa gtcctaacct ttaaccttct ggaagaaagg
901 atgatgacca agatggaccc caatgaccag gctcaaaggg acatcatatt tgaactgagg
961 aggattgcat ttgacgcaga gtctgatcct agcaatgccc ctgggagtgg gaccgaaaaa
1021 cgcaaagcca tgtacacaaa ggactacaaa atgctgggat ttaccaacca catcaatcca
1081 gccatggact ttacccagac tcctcctgga atgctggcct tggacaacat gctgtacttg
1141 gctaaagtcc accaggacac ctacatccgg attgtcttgg agaacagtag ccgggaagac
1201 aaacatgaat gcccctttgg ccgcagtgcc attgagctca ccaaaatgct ctgtgaaatc
1261 ctgcaggttg gggaactacc aaatgaagga cgcaatgact accacccgat gttctttacc
1321 catgaccgag cctttgaaga gctctttgga atctgcatcc agctgttgaa caagacctgg
1381 aaggagatga gggcaacagc agaggacttc aacaaggtta tgcaagtcgt ccgagagcaa
1441 atcactcgag ctttgccctc caaacccaac tctttggatc agttcaagag caaattgcgt
1501 agcctgagtt actctgagat tctacgactg cgccagtctg agaggatgag tcaggatgac
1561 ttccagtccc cgccaattgt ggagctgagg gagaagatcc agcccgagat ccttgagctg
1621 atcaagcagc agcgcctgaa ccggctctgt gagggcagca gcttccgaaa gattgggaac
1681 cgccgaaggc aagaacggtt ctggtactgc cggttggcac tgaaccacaa ggtccttcac
1741 tatggtgact tggatgacaa cccacaaggg gaggtgacat ttgaatccct gcaggagaaa
1801 attcctgttg cagacattaa ggccattgtc actgggaaag attgtcccca catgaaagag
1861 aaaagtgctc tgaaacagaa caaggaggtg ttggaattgg ccttctccat cctgtatgac
1921 cctgatgaga ccttaaactt catcgcacct aataaatatg agtactgcat ctggattgat
1981 ggcctcagtg cccttctggg gaaggacatg tccagtgagc tgaccaagag tgacctggac
2041 accctgctga gcatggagat gaagctgcgg ctcctggacc tggagaacat ccagattccc
2101 gaagccccac cccccatccc caaggagccc agcagctatg actttgtcta tcactatggc
2161 tgagcctgga gccagaaacg acggtaccca ggagaaggga ttttgggccc aggagaaaca
2221 cttacattct ggtgccttgt cttttgcttg tacagaatct gtagtgattt tggtggccag
2281 taaatgccag ccatttctca aacccacctc ggaccaccca gagtttcctc ttggtccctg
2341 tctactaaga gtcatgaagg cagggtgctc tgcccactcc atcaccatga agcctgggat
2401 tgggccacga ggaacaaaca gcagatgccc ttgccttcca gtccaagaaa ctgcttcttg
2461 aaatggattt aacaacagcc actcaccttt tcctcctgag cctgctctct gatcagctgg
2521 atccccacgt gagcaacagc tggcccagga aaggctgcct gcagaggaca ggtgtgttgg
2581 gcgtgttgag agccttgaag tgactacctg tatcttagat ctgagtacaa gcctgaggct
2641 tttgcttttg tcttttttga tgagggctca ctccagcttc atatggtgcc aagacgttgc
2701 tgcttctgag gttggctcta acatctctgg tctttagagc caccagatct ctctggccca
2761 tacagatatc agagcagacg gaaatttctc cctgcaagcg ctcagtctca tcccagcaag
2821 tcaaagacct cctggccaag tcctgccctc ttaagtctcc aggaacgctg cagggaaaac
2881 ccagctgagg cctgggccta gactgtggtg aggtcactag attctactgc tcttccccca
2941 cattaatacc ttttccttcc tcagagagaa atctccccta acctgaattg cagccccctc
3001 cagtttgctt tcctttggcc ttccagaccc caggaagttg gccttccctt cctagtgcta
3061 tggtttctgc cattggccat gatttcaggg agctggctga ggccggctga ggccacacct
3121 gtgccagtgg ggcttccctg gtgctgcagc acttgtaaac cacacacaca gcctctctcc
3181 ctggacatac gttagcacat tggcattcag tattggtggc ctggcatggt aggtactacc
3241 caatgaagag tgtactatat attttcatta ctataggcca tacttataca gacgtgtata
3301 tatatttata taagatctac ctatcttagg atggaacctt ggggaaaaat aaaattgagg
3361 ggaagtaaaa agtatgtaac acttccagtt gtgagccaag attgtaacca gagagcagcc
3421 aggagcttcc tgtcagtaac catgttttca ataaatactc tttcatgtac aaac
//