LOCUS AY244357 6496 bp mRNA linear HUM 07-MAR-2006
DEFINITION Homo sapiens alpha 1 type XXIV collagen precursor, mRNA, complete
cds.
ACCESSION AY244357 AF410793
VERSION AY244357.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 6496)
AUTHORS Koch,M., Laub,F., Zhou,P., Hahn,R.A., Tanaka,S., Burgeson,R.E.,
Gerecke,D.R., Ramirez,F. and Gordon,M.K.
TITLE Collagen XXIV, a vertebrate fibrillar collagen with structural
features of invertebrate collagens: selective expression in
developing cornea and bone
JOURNAL J. Biol. Chem. 278 (44), 43236-43244 (2003)
PUBMED 12874293
REFERENCE 2 (bases 1 to 6496)
AUTHORS Matsuo,N., Tanaka,S., Gordon,M.K., Koch,M., Yoshioka,H. and
Ramirez,F.
TITLE CREB-AP1 protein complexes regulate transcription of the collagen
XXIV gene (Col24a1) in osteoblasts
JOURNAL J. Biol. Chem. 281 (9), 5445-5452 (2006)
PUBMED 16373341
REFERENCE 3 (bases 1 to 6496)
AUTHORS Koch,M., Jin,W. and Burgeson,R.E.
TITLE Alpha 1(XXIV) Collagen, a New Member of the Collagen Subfamily
JOURNAL Unpublished
REFERENCE 4 (bases 1 to 6496)
AUTHORS Koch,M., Jin,W. and Burgeson,R.E.
TITLE Direct Submission
JOURNAL Submitted (14-AUG-2001) CBRC, Mass General Hospital, 13th Street
Bldg 149, Charlestown, MA 02129, USA
REFERENCE 5 (bases 1 to 6496)
AUTHORS Koch,M., Laub,F., Zhou,P., Hahn,R.A., Tanaka,S., Burgeson,R.E.,
Gerecke,D.R., Ramirez,F. and Gordon,M.K.
TITLE Direct Submission
JOURNAL Submitted (25-FEB-2003) Pharmacology and Toxicology, Rutgers, The
State University of New Jersey, 170 Frelinghuysen Road, Piscataway,
NJ 08854, USA
COMMENT On Jul 1, 2003 this sequence version replaced AF410793.1.
FEATURES Location/Qualifiers
source 1..6496
/db_xref="H-InvDB:HIT000251179"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/tissue_type="cartilage"
5'UTR 1..32
CDS 33..5177
/note="COL24A1"
/codon_start=1
/product="alpha 1 type XXIV collagen precursor"
/protein_id="AAP80185.1"
/translation="MHLRAHRTRRGKVSPTAKTKSLLHFIVLCVAGVVVHAQEQGIDI
LHQLGLGGKDVRHSSPVTAVPSASTPLPQGVHLTESGVIFKNDAYIETPFVKILPVNL
GQPFTILTGLQSHRVNNAFLFSIRNKNRLQLGVQLLPKKLVVHIRGKQPAVFNYSVHD
EQWHSFAITIRNQSVSMFVECGKKYFSTETIPEVQTFDSNSVFTLGSMNNNSIHFEGI
VCQLDIIPSAEASADYCRYVKQQCRQADKYQPETSIPCTTLIPTKIPEHSPPPKLFAE
KVLSEDTFTEGKSIPNIIKNDSETVYKRQEHQISRSQLSSLQSGNVSAVDLTNHGIQA
KEMITEEDTQTNFSLSVTTHRISEAKMNTKEKFSSLLNMSDNITQHDDRVTGLSLFKK
MPSILPQIKQDTITNLKKAITANLHTNELMEMQPILNTSLHRVTNEPSVDNHLDLRKE
GEFYPDATYPIENSYETELYDYYYYEDLNTMLEMEYLRGPKGDTGPPGPPGPAGIPGP
SGKRGPRGIPGPHGNPGLPGLPGPKGPKGDPGFSPGQSVPGEKGDQGLSGLMGPPGMQ
GDKGLKGHPGLPGLPGEQGIPGFAGNIGSPGYPGRQGLAGPEGNPGPKGAQGFIGSPG
EAGQLGPEGERGIPGIRGKKGFKGRQGFPGDFGDRGPAGLDGSPGLVGGTGPPGFPGL
RGSVGPVGPIGPAGIPGPMGLSGNKGLPGIKGDKGEQGTAGELGEPGYSGDKGAVGLP
GPPGMRGKSGPSGQTGDPGLQGPSGPPGPEGFPGDIGIPGQNGPEGPKGLLGNRGPPG
PPGLKGTQGEEGPIGAFGELGPRGKPGQKGYAGEPGPEGLKGEVGDQGNIGKIGETGP
VGLPGEVGMTGSIGEKGERGSPGPLGPQGEKGVMGYPGPPGVPGPIGPLGLPGHVGAR
GPPGSQGPKGQRGSRGPDGLLGEQGIQGAKGEKGDQGKRGPHGLIGKTGNPGERGFQG
KPGLQGLPGSTGDRGLPGEPGLRGLQGDVGPPGEMGMEGPPGTEGESGLQGEPGAKGD
VGTAGSVGGTGEPGLRGEPGAPGEEGLQGKDGLKGVPGGRGLPGEDGEKGEMGLPGII
GPLGRSGQTGLPGPEGIVGIPGQRGRPGKKGDKGQIGPTGEVGSRGPPGKIGKSGPKG
ARGTRGAVGHLGLMGPDGEPGIPGYRGHQGQPGPSGLPGPKGEKGYPGEDSTVLGPPG
PRGEPGPVGDQGERGEPGAEGYKGHVGVPGLRGATGQQGPPGEPGDQGEQGLKGERGS
EGNKGKKGAPGPSGKPGIPGLQGLLGPKGIQGYHGADGISGNPGKIGPPGKQGLPGIR
GGPGRTGLAGAPGPPGVKGSSGLPGSPGIQGPKGEQGLPGQPGIQGKRGHRGAQGDQG
PCGDPGLKGQPGEYGVQGLTGFQGFPGPKGPEGDAGIVGISGPKGPIGHRGNTGPLGR
EGIIGPTGRTGPRGEKGFRGETGPQGPRGQPGPPGPPGAPGPRKQMDINAAIQALIES
NTALQMESYQNTEVTLIDHSEEIFKTLNYLSNLLHSIKNPLGTRDNPARICKDLLNCE
QKVSDGKYWIDPNLGCPSDAIEVFCNFSAGGQTCLPPVSVTKLEFGVGKVQMNFLHLL
SSEATHIITIHCLNTPRWTSTQTSGPGLPIGFKGWNGQIFKVNTLLEPKVLSDDCKIQ
DGSWHKATFLFHTQEPNQLPVIEVQKLPHLKTERKYYIDSSSVCFL"
sig_peptide 33..146
misc_feature 147..1676
/note="Region: N propeptide"
misc_feature 1497..1658
/note="Region: minor triple helix"
misc_feature 1677..4469
/note="Region: major triple helix"
misc_feature 3621..3632
/note="Region: STLV imperfection in major triple helix"
misc_feature 4470..5174
/note="Region: C propeptide"
misc_feature 3621..3632
/note="STLV imperfection in major triple helix"
3'UTR 5178..6496
BASE COUNT 2008 a 1273 c 1607 g 1608 t
ORIGIN
1 tgttttccgt tagcgctttg ctgcacggac aaatgcattt aagagcccac agaacaaggc
61 gtggaaaagt ctcccccacg gcaaaaacga aatcacttct tcattttatt gtactatgtg
121 tggctggggt ggttgttcat gcacaagaac aaggcataga tattcttcat caactaggcc
181 ttggaggcaa agacgtaaga cactcatcac cagtgactgc tgtaccatca gcatctacac
241 cgttacctca gggggtccat ttaacagaat caggagtcat ttttaaaaat gatgcttata
301 tcgagacacc tttcgtgaaa attttaccag tcaacttggg gcagccgttt acaatattaa
361 ctgggttaca gtcacatcgg gtgaacaatg catttctctt cagcattaga aataaaaata
421 gactgcaatt aggagtacaa ttactaccta aaaaattagt agtacacatt agaggaaagc
481 agcctgcagt tttcaactac agtgttcatg atgagcaatg gcactcattt gccattacta
541 ttagaaacca aagtgtctca atgtttgttg agtgtggaaa gaaatatttt agcacagaga
601 ctattccaga agttcagacc tttgattcta atagtgtgtt tactttagga agtatgaata
661 ataattctat ccattttgaa ggaatagtat gtcagttaga tattattcct tctgcagaag
721 catctgcaga ctactgcaga tatgtgaaac agcagtgtcg ccaagcagac aaataccaac
781 ctgaaacaag cattccttgt acaactctca taccaacaaa gataccggaa cactctcccc
841 cgcccaaact atttgctgaa aaagtactgt cagaggatac atttactgaa ggcaaaagca
901 ttccaaatat cataaaaaat gattctgaaa ccgtgtataa aagacaagaa caccagatat
961 caagatctca gttatcttct cttcagtcag gaaatgtctc tgctgtggat ctcacaaacc
1021 atgggattca ggccaaagaa atgatcactg aggaagatac tcagacaaat ttcagcctgt
1081 cagtgaccac tcatcgcatc agtgaggcaa aaatgaatac caaagagaaa tttagttctc
1141 tcctaaacat gtctgacaat atcacacaac atgatgatag agtaactggt ctgtcactgt
1201 ttaagaagat gccatctatt cttccacaaa ttaaacaaga tacaattact aatctcaaga
1261 aggctatcac agcaaatcta cacactaacg aactcatgga aatgcaacca attttaaaca
1321 caagcttgca tagagtgaca aatgagccat ctgtggataa tcaccttgat ctaaggaaag
1381 aaggtgaatt ttatcctgat gctacttatc ccatcgaaaa tagctatgaa actgagcttt
1441 atgattatta ttattatgag gatctaaata caatgcttga aatggagtat ctgagagggc
1501 caaaaggaga cactggacct cccggtccac ctggtccagc aggtatccca ggtccgtcag
1561 ggaagagagg tccacggggc ataccagggc cacatggaaa tcctggttta cctggattac
1621 ctggtccaaa gggccccaaa ggagatccag gattttcccc aggtcaatct gttcctggag
1681 aaaagggtga tcaaggcctt tctggattaa tgggcccccc tggtatgcaa ggtgataagg
1741 gtctcaaagg acatcctgga ctcccaggac ttccaggtga acaaggaatt ccaggatttg
1801 ctggtaatat tggttcaccc ggttaccctg gcaggcaggg tttagctgga ccagaaggta
1861 atccaggtcc taaaggtgca caaggtttta ttggctctcc tggagaagcg ggacaactgg
1921 gacctgaagg agaacggggc attcctggga tccgtggaaa gaagggtttt aaggggagac
1981 agggttttcc aggtgacttt ggagacagag gccctgctgg tcttgatggc agtcctggac
2041 ttgtaggtgg cactggtcct ccggggtttc ctgggcttag aggcagtgtt ggccctgtgg
2101 gaccaattgg acctgctgga attcctggcc caatgggcct ttcagggaat aaaggactac
2161 ctggaatcaa aggtgataag ggtgaacaag gcacagcagg agagctagga gaacccgggt
2221 attctggaga caagggtgct gttggtttac caggaccacc agggatgaga ggaaagtcag
2281 ggccttcagg ccaaacaggt gacccaggac tccaaggacc atctggccct ccaggaccag
2341 agggttttcc aggagatatt gggattcctg gacaaaacgg ccctgaagga ccaaagggac
2401 tccttggaaa tagaggacct cctggacctc ctggtctcaa aggaactcag ggagaagaag
2461 gaccaattgg agcctttggg gaactggggc caagaggaaa accaggtcaa aaggggtatg
2521 caggtgaacc aggaccagaa ggcttaaagg gagaagtagg agatcaagga aatattggaa
2581 aaattggtga aacaggacct gttggcttac ctggagaagt tgggatgact ggaagcattg
2641 gcgaaaaggg agaacgtgga agtccaggcc cactaggtcc ccagggagaa aaaggtgtta
2701 tgggatatcc aggtcctcct ggggttccag gacctatcgg tccattggga ttacctggtc
2761 atgtgggggc aagaggacca cctgggagtc aaggtcctaa aggacaaaga ggatcaagag
2821 gaccagatgg tctcttaggg gaacaaggta tacaaggtgc caagggtgaa aaaggagatc
2881 aaggaaaaag agggcctcat ggtcttattg gtaagactgg aaaccctgga gaaagaggat
2941 ttcaagggaa accaggttta cagggattgc ctggaagtac aggtgacaga ggacttccag
3001 gagagccagg actgcgagga ctgcaaggtg atgttggacc tcctggagaa atgggcatgg
3061 agggacctcc aggcactgag ggagagtctg gtctgcaagg tgaaccaggt gcaaagggag
3121 atgttggaac tgctggcagt gttggaggaa ctggggaacc aggtttacgg ggtgaaccag
3181 gagctcctgg agaagaaggt ctccagggaa aagatgggtt aaagggagta ccaggaggaa
3241 ggggacttcc tggagaggat ggagaaaaag gagagatggg cttaccagga attataggac
3301 ccttgggtag atcaggccaa acaggccttc cgggacctga aggaattgtg ggaattccag
3361 ggcaaagagg tcgtccagga aaaaagggtg ataaaggaca aataggaccc acaggagaag
3421 ttggaagcag aggtcctcct ggaaaaattg ggaaaagtgg tcctaagggt gccagaggaa
3481 ctagaggtgc tgtgggacat ttaggattga tgggacctga tggagaacca ggaattccag
3541 ggtacagggg ccatcagggc caaccaggac cctctggatt gccaggacct aaaggagaaa
3601 agggctaccc aggagaagat agcacagtcc taggaccacc tgggcctcga ggtgaaccag
3661 gtccagtggg ggaccaagga gagagaggag agcctggagc agagggatat aagggccatg
3721 tgggtgtacc aggactaaga ggtgccactg gacaacaagg acccccaggc gaaccaggtg
3781 accagggtga acaaggacta aaaggagaga gaggatctga aggtaataag gggaaaaaag
3841 gagctcctgg tccttctggg aaacctggga ttcctggact tcaaggccta cttgggccaa
3901 aaggcataca aggataccat ggagcagatg gcatttcagg aaaccctgga aaaattgggc
3961 caccaggaaa acagggactt cctggcatca gaggcggccc aggaagaaca ggtcttgctg
4021 gggctccagg tcctccagga gtaaagggtt catcaggctt gccaggaagc ccaggaattc
4081 aaggcccaaa gggtgaacaa gggctacctg gtcaacctgg aattcaaggt aaaagaggtc
4141 accgaggagc acaaggtgat caaggaccat gtggagaccc tggcctgaaa gggcagcctg
4201 gagaatatgg tgttcaaggt ttgacaggtt tccaaggatt cccaggccct aaaggtcctg
4261 aaggggatgc tggcattgtt gggatatcag gtcctaaagg tcctattgga cacagaggaa
4321 acactggtcc ccttggcaga gaaggtataa taggcccaac aggtagaact ggacccagag
4381 gtgaaaaggg ctttagaggt gaaactggtc ctcaaggacc aagaggtcaa ccagggcctc
4441 caggtccacc tggagcacca ggcccaagaa agcaaatgga tatcaatgct gctattcaag
4501 ccttgattga atcaaatact gccctacaga tggagagcta ccagaatact gaagtgactt
4561 taattgacca cagtgaagag atattcaaaa ccctgaacta ccttagcaat ttattgcaca
4621 gcatcaagaa tcctcttggc acacgagata acccagcacg aatctgcaaa gatttactta
4681 actgtgaaca aaaagtatca gatggaaaat actggattga cccaaatctt ggctgtcctt
4741 cagatgccat tgaggttttc tgcaatttca gtgctggtgg ccagacatgc ttacctcctg
4801 tttctgtaac aaagttggag tttggagttg ggaaagtcca gatgaacttc cttcatttac
4861 tgagttcgga agccacccat atcatcacca ttcactgtct aaacacccca aggtggacaa
4921 gcacacaaac aagtggccca ggattgccta ttggtttcaa gggatggaat ggccagattt
4981 ttaaagtaaa cactctactt gaacctaaag tgctttcaga tgactgcaag attcaagatg
5041 gcagctggca taaggcaaca tttctttttc acacccagga acctaatcaa cttccagtga
5101 ttgaagtaca aaaacttcct catctcaaaa ctgaacgaaa gtattacatt gacagcagtt
5161 ctgtatgctt tctgtaaagt ctctgaatta gttccgaatt caggctgttg gccaggtaat
5221 tgctgcagag ggagaaataa gacagacaga tacagtcatt atgaaatgca tgtaataaag
5281 cattggctaa atcttaaaga atctcaggaa gaacagactt cctcctaaga aggagaaaag
5341 gcatttttaa aggactatga ttgataaagt atttaattct tttaaaaatt atattcatct
5401 cagctttctt agagaattcc ctagaactaa aaatttataa atatggaatt cttcagggta
5461 tcttatattt ttgactgagt gcgtagtacc cattagacag ctggagatgc agagcactat
5521 ggagcaatac tggctaatgc ttccagatgt gcactgcttc tgtctaaaaa ttacaagcca
5581 cagtctaata tgtcttattt tccaaaacac taagctgtat tcaggtcccc gatgggcata
5641 tacatcttag ccggtgatac actacctctt acgtgttgcc tctttgtgtt gcttggtgct
5701 ctttcgaaaa caaggtgctt atggctttca tagactattt cctttttcat ctttgtcatt
5761 ctttaaaagt gtatgtactg gttacatcaa gatatgtttt ggttgttagt acttatttta
5821 atttgtttgg tcacacactt aataacacgt gaaactattt atgtgaagtc cttgttttat
5881 tttaaaattc tctttgtgta tttggaatca aagccagcac attgtaacct gtgcttgtac
5941 gcaaaagaat tagatttctt tgtttttgtt ttatttttta aattgttgta aaaattatta
6001 taggccagct acatctagta gtaggtttgg ggtacagatt gggggttgtg ccatactgtt
6061 tttaaagttc atgatcatct ggaatgatac ttagtgtata tatattttgt aaagttttaa
6121 ttcagcaaat tttttgaaat tgctgctgtt ttaaattata aaacctttat atttctgctt
6181 tgtagaaatt atatgttttg tagtattcat tgattttctt tcactgtact taaatttagt
6241 gttagtactt taaaattttt aatttaccag tctttaaagc aacatccaga aaaaaaaagt
6301 cttttcccat ttaaaatagg ctcagccagt tcaatgtctc cttgttatca gagaaatgtt
6361 agttcaatac tgaaagaaaa atattatacc tcttggtatc tagaaaagct tgttcatcca
6421 ttataaatat atctttagcc acagcaaacc acacttaacc tatctataat aaaaatgtgc
6481 tttaaataaa aaaaaa
//