LOCUS       AF386649                5198 bp    mRNA    linear   HUM 18-JAN-2002
DEFINITION  Homo sapiens bromodomain-containing 4 (BRD4) mRNA, complete cds.
ACCESSION   AF386649
VERSION     AF386649.1
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5198)
  AUTHORS   French,C.A., Miyoshi,I., Aster,J.C., Kubonishi,I., Kroll,T.G., Dal
            Cin,P., Vargas,S.O., Perez-Atayde,A.R. and Fletcher,J.A.
  TITLE     BRD4 bromodomain gene rearrangement in aggressive carcinoma with
            translocation t(15;19)
  JOURNAL   Am. J. Pathol. 159 (6), 1987-1992 (2001)
   PUBMED   11733348
REFERENCE   2  (bases 1 to 5198)
  AUTHORS   French,C.A. and Fletcher,J.A.
  TITLE     Direct Submission
  JOURNAL   Submitted (28-MAY-2001) Pathology, Brigham and Women's Hospital, 75
            Francis St., Boston, MA 02115, USA
FEATURES             Location/Qualifiers
     source          1..5198
                     /db_xref="H-InvDB:HIT000078753"
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.1"
     gene            1..5198
                     /gene="BRD4"
     CDS             223..4311
                     /gene="BRD4"
                     /note="mitotic chromosome-associated protein; HUNKI; MCAP;
                     CAP; similar to murine product encoded by GenBank
                     Accession Number AF273217"
                     /codon_start=1
                     /product="bromodomain-containing 4"
                     /protein_id="AAL26987.1"
                     /translation="MSAESGPGTRLRNLPVMGDGLETSQMSTTQAQAQPQPANAASTN
                     PPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKIIK
                     TPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQK
                     INELPTEETEIMIVQAKGRGRGRKETGTAKPGVSTVPNTTQASTPPQTQTPQPNPPPV
                     QATPHPFPAVTPDLIVQTPVMTVVPPQPLQTPPPVPPQPQPPPAPAPQPVQSHPPIIA
                     ATPQPVKTKKGVKRKADTTTPTTIDPIHEPPSLPPEPKTTKLGQRRESSRPVKPPKKD
                     VPDSQQHPAPEKSSKVSEQLKCCSGILKEMFAKKHAAYAWPFYKPVDVEALGLHDYCD
                     IIKHPMDMSTIKSKLEAREYRDAQEFGADVRLMFSNCYKYNPPDHEVVAMARKLQDVF
                     EMRFAKMPDEPEEPVVAVSSPAVPPPTKVVAPPSSSDSSSDSSSDSDSSTDDSEEERA
                     QRLAELQEQLKAVHEQLAALSQPQQNKPKKKEKDKKEKKKEKHKRKEEVEENKKSKAK
                     EPPPKKTKKNNSSNSNVSKKEPAPMKSKPPPTYESEEEDKCKPMSYEEKRQLSLDINK
                     LPGEKLGRVVHIIQSREPSLKNSNPDEIEIDFETLKPSTLRELERYVTSCLRKKRKPQ
                     AEKVDVIAGSSKMKGFSSSESESSSESSSSDSEDSETEMAPKSKKKGHPGREQKKHHH
                     HHHQQMQQAPAPVPQQPPPPPQQPPPPPPPQQQQQPPPPPPPPSMPQQAAPAMKSSPP
                     PFIATQVPVLEPQLPGSVFDPIGHFTQPILHLPQPELPPHLPQPPEHSTPPHLNQHAV
                     VSPPALHNALPQQPSRPSNRAAALPPKPARPPAVSPALTQTPLLPQPPMAQPPQVLLE
                     DEEPPAPPLTSMQMQLYLQQLQKVQPPTPLLPSVKVQSQPPPPLPPPPHPSVQQQLQQ
                     QPPPPPPPQPQPPPQQQHQPPPRPVHLQPMQFSTHIQQPPPPQGQQPPHPPPGQQPPP
                     PQPAKPQQVIQHHHSPRHHKSDPYSTGHLREAPSPLMIHSPQMSQFQSLTHQSPPQQN
                     VQPKKQELRAASVVQPQPLVVVKEEKIHSPIIRSEPFSPSLRPEPPKHPESIKAPVHL
                     PQRPEMKPVDVGRPVIRPPEQNAPPPGAPDKDKQKQEPKTPVAPKKDLKIKNMGSWAS
                     LVQKHPTTPSSTAKSSSDSFEQFRRAAREKEEREKALKAQAEHAEKEKERLRQERMRS
                     REDEDALEQARRAHEEARRRQEQQQQQRQEQQQQQQQQAAAVAAAATPQAQSSQPQSM
                     LDQQRELARKREQERRRREAMAATIDMNFQSDLLSIFEENLF"
BASE COUNT         1249 a         1796 c         1323 g          830 t
ORIGIN      
        1 attctttgga atactactgc tagaagtctg acttaagacc cagcttatgg gccacatggc
       61 acccagctgc ttctgcagag aaggcaggcc actgatgggt acagcaaagt gtggtgctgc
      121 tggccaagcc aaagacccgt gtaggatgac tgggcctctg ccccttgtgg gtgttgccac
      181 tgtgcttgag tgcctggtga agaatgtgat gggatcacta gcatgtctgc ggagagcggc
      241 cctgggacga gattgagaaa tctgccagta atgggggatg gactagaaac ttcccaaatg
      301 tctacaacac aggcccaggc ccaaccccag ccagccaacg cagccagcac caaccccccg
      361 cccccagaga cctccaaccc taacaagccc aagaggcaga ccaaccaact gcaatacctg
      421 ctcagagtgg tgctcaagac actatggaaa caccagtttg catggccttt ccagcagcct
      481 gtggatgccg tcaagctgaa cctccctgat tactataaga tcattaaaac gcctatggat
      541 atgggaacaa taaagaagcg cttggaaaac aactattact ggaatgctca ggaatgtatc
      601 caggacttca acactatgtt tacaaattgt tacatctaca acaagcctgg agatgacata
      661 gtcttaatgg cagaagctct ggaaaagctc ttcttgcaaa aaataaatga gctacccaca
      721 gaagaaaccg agatcatgat agtccaggca aaaggaagag gacgtgggag gaaagaaaca
      781 gggacagcaa aacctggcgt ttccacggta ccaaacacaa ctcaagcatc gactcctccg
      841 cagacccaga cccctcagcc gaatcctcct cctgtgcagg ccacgcctca ccccttccct
      901 gccgtcaccc cggacctcat cgtccagacc cctgtcatga cagtggtgcc tccccagcca
      961 ctgcagacgc ccccgccagt gcccccccag ccacaacccc cacccgctcc agctccccag
     1021 cccgtacaga gccacccacc catcatcgcg gccaccccac agcctgtgaa gacaaagaag
     1081 ggagtgaaga ggaaagcaga caccaccacc cccaccacca ttgaccccat tcacgagcca
     1141 ccctcgctgc ccccggagcc caagaccacc aagctgggcc agcggcggga gagcagccgg
     1201 cctgtgaaac ctccaaagaa ggacgtgccc gactctcagc agcacccagc accagagaag
     1261 agcagcaagg tctcggagca gctcaagtgc tgcagcggca tcctcaagga gatgtttgcc
     1321 aagaagcacg ccgcctacgc ctggcccttc tacaagcctg tggacgtgga ggcactgggc
     1381 ctacacgact actgtgacat catcaagcac cccatggaca tgagcacaat caagtctaaa
     1441 ctggaggccc gtgagtaccg tgatgctcag gagtttggtg ctgacgtccg attgatgttc
     1501 tccaactgct ataagtacaa ccctcctgac catgaggtgg tggccatggc ccgcaagctc
     1561 caggatgtgt tcgaaatgcg ctttgccaag atgccggacg agcctgagga gccagtggtg
     1621 gccgtgtcct ccccggcagt gccccctccc accaaggttg tggccccgcc ctcatccagc
     1681 gacagcagca gcgatagctc ctcggacagt gacagttcga ctgatgactc tgaggaggag
     1741 cgagcccagc ggctggctga gctccaggag cagctcaaag ccgtgcacga gcagcttgca
     1801 gccctctctc agccccagca gaacaaacca aagaaaaagg agaaagacaa gaaggaaaag
     1861 aaaaaagaaa agcacaaaag aaaagaggaa gtggaagaga ataaaaaaag caaagccaag
     1921 gaacctcctc ctaaaaagac gaagaaaaat aatagcagca acagcaatgt gagcaagaag
     1981 gagccagcgc ccatgaagag caagccccct cccacgtatg agtcggagga agaggacaag
     2041 tgcaagccta tgtcctatga ggagaagcgg cagctcagct tggacatcaa caagctcccc
     2101 ggcgagaagc tgggccgcgt ggtgcacatc atccagtcac gggagccctc cctgaagaat
     2161 tccaaccccg acgagattga aatcgacttt gagaccctga agccgtccac actgcgtgag
     2221 ctggagcgct atgtcacctc ctgtttgcgg aagaaaagga aacctcaagc tgagaaagtt
     2281 gatgtgattg ccggctcctc caagatgaag ggcttctcgt cctcagagtc ggagagctcc
     2341 agtgagtcca gctcctctga cagcgaagac tccgaaacag agatggctcc gaagtcaaaa
     2401 aagaaggggc accccgggag ggagcagaag aagcaccatc atcaccacca tcagcagatg
     2461 cagcaggccc cggctcctgt gccccagcag ccgcccccgc ctccccagca gcccccaccg
     2521 cctccacctc cgcagcagca acagcagccg ccacccccgc ctcccccacc ctccatgccg
     2581 cagcaggcag ccccggcgat gaagtcctcg cccccaccct tcattgccac ccaggtgccc
     2641 gtcctggagc cccagctccc aggcagcgtc tttgacccca tcggccactt cacccagccc
     2701 atcctgcacc tgccgcagcc tgagctgccc cctcacctgc cccagccgcc tgagcacagc
     2761 actccacccc atctcaacca gcacgcagtg gtctctcctc cagctttgca caacgcacta
     2821 ccccagcagc catcacggcc cagcaaccga gccgctgccc tgcctcccaa gcccgcccgg
     2881 cccccagccg tgtcaccagc cttgacccaa acacccctgc tcccacagcc ccccatggcc
     2941 caaccccccc aagtgctgct ggaggatgaa gagccacctg ccccacccct cacctccatg
     3001 cagatgcagc tgtacctgca gcagctgcag aaggtgcagc cccctacgcc gctactccct
     3061 tccgtgaagg tgcagtccca gcccccaccc cccctgccgc ccccacccca cccctctgtg
     3121 cagcagcagc tgcagcagca gccgccacca cccccaccac cccagcccca gcctccaccc
     3181 cagcagcagc atcagccccc tccacggccc gtgcacttgc agcccatgca gttttccacc
     3241 cacatccaac agcccccgcc accccagggc cagcagcccc cccatccgcc cccaggccag
     3301 cagccacccc cgccgcagcc tgccaagcct cagcaagtca tccagcacca ccattcaccc
     3361 cggcaccaca agtcggaccc ctactcaacc ggtcacctcc gcgaagcccc ctccccgctt
     3421 atgatacatt ccccccagat gtcacagttc cagagcctga cccaccagtc tccaccccag
     3481 caaaacgtcc agcctaagaa acaggagctg cgtgctgcct ccgtggtcca gccccagccc
     3541 ctcgtggtgg tgaaggagga gaagatccac tcacccatca tccgcagcga gcccttcagc
     3601 ccctcgctgc ggccggagcc ccccaagcac ccggagagca tcaaggcccc cgtccacctg
     3661 ccccagcggc cggaaatgaa gcctgtggat gtcgggaggc ctgtgatccg gcccccagag
     3721 cagaacgcac cgccaccagg ggcccctgac aaggacaaac agaaacagga gccgaagact
     3781 ccagttgcgc ccaaaaagga cctgaaaatc aagaacatgg gctcctgggc cagcctagtg
     3841 cagaagcatc cgaccacccc ctcctccaca gccaagtcat ccagcgacag cttcgagcag
     3901 ttccgccgcg ccgctcggga gaaagaggag cgtgagaagg ccctgaaggc tcaggccgag
     3961 cacgctgaga aggagaagga gcggctgcgg caggagcgca tgaggagccg agaggacgag
     4021 gatgcgctgg agcaggcccg gcgggcccat gaggaggcac gtcggcgcca ggagcagcag
     4081 cagcagcagc gccaggagca acagcagcag cagcaacagc aagcagctgc ggtggctgcc
     4141 gccgccaccc cacaggccca gagctcccag ccccagtcca tgctggacca gcagagggag
     4201 ttggcccgga agcgggagca ggagcgaaga cgccgggaag ccatggcagc taccattgac
     4261 atgaatttcc agagtgatct attgtcaata tttgaagaaa atcttttctg agcgcaccta
     4321 ggtggcttct gactttgatt ttctggcaaa acattgactt tccatagtgt taggggcggt
     4381 ggtggaggtg ggatcagcgg ccaggggatg cctcagggcc tggccctcct gcatgctatg
     4441 cccggggcag gcctgacggg cagctgagga ttgcagagcc tgtctgcctt acggccagtc
     4501 ggacagacgt cccgccaccc accacccctc acaggacgtc cgctcagcac acgccttgtt
     4561 acgagcaagt gccggctgga cccaagccct gcatccccac atgcggggca gaggcccttc
     4621 tctccgccaa atgtctacac agtatacaca ggacatcgtt gctgccgccg tgactggttt
     4681 tctgtcccca agaacgtgac gttcgtgatg tcctgcccgc cgggagtctt tccccacacc
     4741 ccagccatcg ccgcccgctc ccaggaggcc agggcaggcc tgcgtgggct ggaggcgggc
     4801 gaggccggcc caccccctcg ctggcactga ctttgccttg aacagacccc ccgaccctcc
     4861 cccacaagcc tttaattgag agccgctctc tgtaagtgtt tgcttgtgca aaagggaata
     4921 gtgccgtgga ggtgtgtgtg tccatggcat ccggagcgag gcgactgtcc tgcgtgggta
     4981 gccctcggcc ggggagtgag gccaccaacc aaagtcagtt ccttcccacc tgtgtttctg
     5041 tttcgttttt ttttttcttt tttttctata tatatttttt gttgaattct attttatttt
     5101 taattctctc ttctcctcca gacacaatgg cactgcttat ctccgaaatg gtgtgatcgt
     5161 ctcctcattg agcagcggct gccaccgcgc tgtgggta
//