LOCUS AF375884 5249 bp mRNA linear HUM 23-OCT-2001
DEFINITION Homo sapiens protein o-fucosyltransferase (POFUT1) mRNA, complete
cds.
ACCESSION AF375884
VERSION AF375884.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 5249)
AUTHORS Wang,Y., Shao,L., Shi,S., Harris,R.J., Spellman,M.W., Stanley,P.
and Haltiwanger,R.S.
TITLE Modification of epidermal growth factor-like repeats with O-fucose.
Molecular cloning and expression of a novel GDP-fucose protein
O-fucosyltransferase
JOURNAL J. Biol. Chem. 276 (43), 40338-40345 (2001)
PUBMED 11524432
REFERENCE 2 (bases 1 to 5249)
AUTHORS Shi,S., Stanley,P., Wang,Y., Shao,L., Harris,R.J., Spellman,M.W.
and Haltiwanger,R.S.
TITLE Direct Submission
JOURNAL Submitted (02-MAY-2001) Cell Biology, Albert Einstein College of
Medicine, 1300 Morris Park Ave., New York, NY 10461, USA
FEATURES Location/Qualifiers
source 1..5249
/db_xref="H-InvDB:HIT000078579"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="20"
/map="between PLAGL2 and KIF3B"
/tissue_type="heart"
gene 1..5249
/gene="POFUT1"
CDS 50..1216
/gene="POFUT1"
/function="catalyzes transfer of fucose from GDP-fucose to
serine or threonine on epidermal growth factor-like
repeats"
/note="O-FucT-1; glycosyltransferase"
/codon_start=1
/product="protein o-fucosyltransferase"
/protein_id="AAL09576.1"
/translation="MGAAAWARPLSVSFLLLLLPLPGMPAGSWDPAGYLLYCPCMGRF
GNQADHFLGSLAFAKLLNRTLAVPPWIEYQHHKPPFTNLHVSYQKYFKLEPLQAYHRV
ISLEDFMEKLAPTHWPPEKRVAYCFEVAAQRSPDKKTCPMKEGNPFGPFWDQFHVSFN
KSELFTGISFSASYREQWSQRFSPKEHPVLALPGAPAQFPVLEEHRPLQKYMVWSDEM
VKTGEAQIHAHLVRPYVGIHLRIGSDWKNACAMLKDGTAGSHFMASPQCVGYSRSTAA
PLTMTMCLPDLKEIQRAVKLWVRSLDAQSVYVATDSESYVPELQQLFKGKVKVVSLKP
EVAQVDLYILGQADHFIGNCVSSFTAFVKRERDLQGRPSSFFGMDRPPKLRDEF"
BASE COUNT 1285 a 1275 c 1335 g 1354 t
ORIGIN
1 cttccctccc cgactgtgcg ccgcggctgg ctcgggttcc cgggccgaca tgggcgccgc
61 cgcgtgggca cggccgctga gcgtgtcttt cctgctgctg cttctgccgc tcccggggat
121 gcccgcgggc tcctgggacc cggccggtta cctgctctac tgcccctgca tggggcgctt
181 tgggaaccag gccgatcact tcttgggctc tctggcattt gcaaagctgc taaaccgtac
241 cttggctgtc cctccttgga ttgagtacca gcatcacaag cctcctttca ccaacctcca
301 tgtgtcctac cagaagtact tcaagctgga gcccctccag gcttaccatc gggtcatcag
361 cttggaggat ttcatggaga agctggcacc cacccactgg ccccctgaga agcgggtggc
421 atactgcttt gaggtggcag cccagcgaag cccagataag aagacgtgcc ccatgaagga
481 aggaaacccc tttggcccat tctgggatca gtttcatgtg agtttcaaca agtcggagct
541 ttttacaggc atttccttca gtgcttccta cagagaacaa tggagccaga gattttctcc
601 aaaggaacat ccggtgcttg ccctgccagg agccccagcc cagttccccg tcctagagga
661 acacaggcca ctacagaagt acatggtatg gtcagacgaa atggtgaaga cgggagaggc
721 ccagattcat gcccaccttg tccggcccta tgtgggcatt catctgcgca ttggctctga
781 ctggaagaac gcctgtgcca tgctgaagga cgggactgca ggctcgcact tcatggcctc
841 tccgcagtgt gtgggctaca gccgcagcac agcggccccc ctcacgatga ctatgtgcct
901 gcctgacctg aaggagatcc agagggctgt gaagctctgg gtgaggtcgc tggatgccca
961 gtcggtctac gttgctactg attccgagag ttatgtgcct gagctccaac agctcttcaa
1021 agggaaggtg aaggtggtga gcctgaagcc tgaggtggcc caggtcgacc tgtacatcct
1081 cggccaagcc gaccacttta ttggcaactg tgtctcctcc ttcactgcct ttgtgaagcg
1141 ggagcgggac ctccagggga ggccgtcttc tttcttcggc atggacaggc cccctaagct
1201 gcgggacgag ttctgattct ggccggagca ccagaccctc tgatcctgga gggaccagag
1261 tctgagctgg tccttccagc caggcctggc agccagaggt gctccgggat tgcaaactcc
1321 tcttctcacc tgccaaagat ggagaagagt gccagggacc cctcaaggag ggagacgctc
1381 catatcccag ggcataggac ttgcaggttc ctaggagcag gagcatctcc catcgcacgt
1441 gctttctgct cttctgggaa tttctcacac tggcaaagca gtccagcctc cgtcttctgg
1501 tccactctgc tctgagcagc ctgggatgct gaactcttca gagagatttt tttatagaga
1561 gatttctata attttgatac aaggtcatga ctatcctaga actctctgtg gtttttgaaa
1621 atcattgaat tctattaatg taggtaccta aagtgacctt aactgaatgt ggatgaggct
1681 ggggctggtg tgggtctttt ggctgctttt caaggtgtcc cccaatgtgg ccctcaagag
1741 ccatccccac tgcctggcca gagccattgt tgtcccctac ttcctaggcc atttctgggg
1801 cttgggggat gaatgctgtc ctgtgctgta aacactatgc aaatggaagt tatcggttgt
1861 ggtgctgtgc agcgctctgt gggcgactaa gtgccactca cgcagcatgt tcctggcaag
1921 gagcacatac catcaagcca cactatcatg gtattgttct cacagtcttt tggtggttga
1981 tggccactgc aaacctggca ccatcagatc tcttctgatc tcttgcccca gtggggcctg
2041 gttggtagaa tgttggcatt cggttgatat ccaaagcctg ttctcccagc cgtcctcctg
2101 cagctggagc cttcaggccg tattctcacg agggaacgtt tgccaaggct ctgacctcac
2161 agaagatgcc cagggcccag aagccatcag aattatcagt ggagaagcac cttttgactc
2221 ttcccttcca atgtaatctc tgccaacacc atgaggctta aggtgctcta agtcatgagt
2281 gttttggtct caaatgctgc agttttaata atctgtgact cctgagagcc catggttttt
2341 tgaccttgtg gttctaaaat tccttgtctg acccctgtag atcttttcct tgccatgtca
2401 cctcccttgg cctttgatcc tggaaaggtg gcagagcctc cactgagcca ggcccagagc
2461 tccttgcagt gccttcttcc ttgtttacct gtgggaggaa acactttttt tgtcaggggc
2521 agcctggttc agagctcaga ggtcacactg tatcaaagat ctcaaacagc aaagtcagca
2581 tttgctgtat agagctgcca cccaactcta agcaggagaa actgtacaga aagggctttg
2641 ctatttttcc cttttgggaa aacaatgaag tgttttaagt cctgggtgga ctgagagatg
2701 gtttgcctgt ccagacttgc tctcaagcct catccagaga aggagctgca gatgagggag
2761 cccgtacact ccctgccacc actaggttgt aagcctgtag ctggctggct gatttcattt
2821 tggaattcat ttgccatcca cagccttaca ctaggcacac actttagagt ctggggctcc
2881 agtggggccc gcctaatttt ttttcccccc aagacagggc cttgctctgt ctcccaggct
2941 ggagtgcagt ggcatgatca tggcttactg cagccttgat ctcccaggct caagcgatcc
3001 ttctgcctca gcctctctgg tagctgagac tgcatgccca gctccaaatc accttgattc
3061 atatcagcag taataatcac ttgtgttctg aaagaaaggg caccagaagt tctagcaaaa
3121 ttcagttgtg ttctgtgagc tagcactttt tcctctgacc caattttctt acctataaaa
3181 tggtgataaa aaccgacagg ttgttcaaag gcccagatca gctaaagcat gtatataaga
3241 gcacgttgta aacttgaaag agacaaaggc acaaatgtgg ctgttgatta atttgactgc
3301 ttctcgttgc tcgtcacctc catgccaggc actgtgcttg ctaattgctt tatgggggca
3361 ttctcttatt tattccccag ccctgggaaa taggagctgt cattatcctt ctctttctgc
3421 acaaggaaaa attaatgccc tgagaattgt cataattttc ccaaggctgc ccagctggtg
3481 gtgttaagcc agaatttgac ctcccagagc cagtttccat tagctgccat gctctgctgc
3541 ctctaattca cagaatgcac tttctaccct gtgtgccatg gagacctcct atggaaaaat
3601 gatcagccac cttaccttct actgggtacc tgctgtgagt ctgcctatgc cagaaggatt
3661 aaggagggga ggttacccaa gaaacaaagc ctacatgccg cttacagccc ccgttggatg
3721 gttgctcagt acaacagtct tgcattcagc aggtgtttgt tcatcaccta ctatgtgtca
3781 ggctctatgc taggtactgg ggatacagga gagaatcaag cgtaaagtct ttgttctcaa
3841 ggaatttgca ttctagaaag tagaagatgt aataaatgta ctgtgggaca tgttaataag
3901 tgctataaag aaatataaag ggtttgggag caaaaagagg gagtggatct attttagatg
3961 agcccaggta agacctctct gaagagctgt catgaaggag ggagggagca cattcctggc
4021 agagaaaaca gcacgtgcaa aggccccgag actggagtgt gttcctgaag agcagccagg
4081 aggccagcat ggctggagag gcaggcatag gcagggaacc gagcagcagg tcagagcagg
4141 cgagctgaca ttctgcagcc tggacggcca tggcaggaag cttttagttg gagagataca
4201 ggaagcctcc tagggttctg agcagaagag gggcatgagc tgattcacat tctgaaggac
4261 ctctctagct ggccagtgct gaggaggttg gagagagaaa gggtgaaagc agagagacca
4321 gtgcagggct gttaacaggg ttgcaggcga gagactgggg tgctgggctc ccctagacta
4381 ggactccagt gccctcctct cccaagagac aaaggccatt gcattgaagg aggtgggaaa
4441 tgattagatt ctgaacatat gtaattattt ttcagtcttt ttcaaagata caaatattta
4501 catagtttta atcatgtaat atatacaatt taatgtccta gtgttttact taatagtgta
4561 tcatgttttc cctgttggta tgtagcctgg ataaatgctc ttaattataa aaaattctgt
4621 cgaggagtgt tccatagttt attgttttcc tattatgaga atttaggcca agtgtggtgg
4681 ctcatgcctg taatcccagc actttgcgag gccgaggtgg gcagatcact tgaggtgagg
4741 agttcaagac cagcctggcc aacatggtga attatctcta ctaaaaatac aaaaaaataa
4801 taataatagc caggcgtggt ggcacatgcc tgtattccca gctgcttggg aggctgaggc
4861 aggagaatgg cttgaacctg ggaggtggag gttgcagtga gccgagatgg tgccactgca
4921 ttccagcctg ggcaacagag cgagactcca tctcaaaaaa aaggagactt catgtgcccc
4981 caatttttca ctattgttat ttgaaaaaat atttttattt gtaagagttt ttctttattt
5041 aaaatgttca ttaataaagt tgttggacgg gaagcaaaaa aaaaaagttg tttaagataa
5101 attcccagaa gtgaatttgt tagatcaaac acttaaaact ttttgttatg gaagaattca
5161 aatataaata aaaaattgtg agtaataaaa tgaactcaca gtttcaacaa tggcccacaa
5221 aaaaaaaaaa aaaaaaaaaa aaaaaaaaa
//