LOCUS AF366402 1178 bp mRNA linear HUM 13-MAY-2001
DEFINITION Homo sapiens TRIP-Br1 mRNA, complete cds.
ACCESSION AF366402
VERSION AF366402.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 1178)
AUTHORS Hsu,S.I., Yang,C.M., Sim,K.G., Hentschel,D.M., O'Leary,E. and
Bonventre,J.V.
TITLE TRIP-Br: a novel family of PHD zinc finger- and
bromodomain-interacting proteins that regulate the transcriptional
activity of E2F-1/DP-1
JOURNAL EMBO J. 20 (9), 2273-2285 (2001)
PUBMED 11331592
REFERENCE 2 (bases 1 to 1178)
AUTHORS Hsu,S.I. and Bonventre,J.V.
TITLE Direct Submission
JOURNAL Submitted (29-MAR-2001) Dept. of Medicine, National University
Hospital, 5 Lower Kent Ridge Road 119074, Singapore
FEATURES Location/Qualifiers
source 1..1178
/db_xref="H-InvDB:HIT000078438"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="19"
/map="19q13"
CDS 112..822
/function="acts at E2F-responsive promoters to integrate
signals provided by PHD- and/or bromodomain-containing
transcription factors"
/function="a CDK4-binding protein that renders the
activity of cyclin D/CDK4 resistant to the inhibitory
effects of p16(INK4a)"
/note="hTRIP-Br1; transcriptional regulator interacting
with the PHD-bromodomain; hTRIP-Br1(SEI-1)"
/codon_start=1
/product="TRIP-Br1"
/protein_id="AAK52831.1"
/translation="MLSKGLKRKREEEEEKEPLAVDSWWLDPGHAAVAQAPPAVASSS
LFDLSVLKLHHSLQQSEPDLRHLVLVVNTLRRIQASMAPAAALPPVPSPPAAPSVADN
LLASSDAALSASMASLLEDLSHIEGLSQAPQPLADEGPPGRSIGGAAPSLGALDLLGP
ATGCLLDDGLEGLFEDIDTSMYDNELWAPASEGLKPGPEDGPGKEEAPELDEAELDYL
MDVLVGTQALERPPGPGR"
BASE COUNT 245 a 343 c 365 g 225 t
ORIGIN
1 cgcgacccag gcgagtttcc ggaggcagcc aacaagcgat gctgccgccg ccgtttcctg
61 attggttgtg ggtggctacc tcttcgttct gattggccgc tagtgagcaa gatgctgagc
121 aagggtctga agcggaaacg ggaggaggag gaggagaagg aacctctggc agtcgactcc
181 tggtggctag atcctggcca cgcagcggtg gcacaggcac ccccggccgt ggcctctagc
241 tccctctttg acctctcagt gctcaagctc caccacagcc tgcagcagag tgagccggac
301 ctgcggcacc tggtgctggt cgtgaacact ctgcggcgca tccaggcgtc catggcaccc
361 gcggctgccc tgccacctgt gcctagccca cctgcagccc ccagtgtggc tgacaactta
421 ctggcaagct cggacgctgc cctttcagcc tccatggcca gcctcctgga ggacctcagc
481 cacattgagg gcctgagtca ggctccccaa cccttggcag acgaggggcc accaggccgt
541 agcatcgggg gagcagcgcc cagcctgggt gccttggacc tgctgggccc agccactggc
601 tgtctactgg acgatgggct tgagggcctg tttgaggata ttgacacctc tatgtatgac
661 aatgaacttt gggcaccagc ctctgagggc ctcaaaccag gccctgagga tgggccgggc
721 aaggaggaag ctccggagct ggacgaggcc gaattggact acctcatgga tgtgctggtg
781 ggcacacagg cactggagcg accgccgggg ccagggcgct gagccctcgt gctggaatgg
841 ttgtctggta tctgaactga gcctgctggc tggaccaact gtcctcgaaa agacacagct
901 ggcttcccta gtacagagaa cagggcttgg gccactttgg agagacagaa tctagtcctg
961 ggcaacttca catccgtcct cctgtctcag ggctggcagg ggggagcctg gaattacccc
1021 ctagtgatgg aatgacaggg tctggtgggg actgaattcc ctggccctgg ggtcatagct
1081 tgggctgttc cttctctgat acgggaagag accccaatca gatttttcaa attaaagcca
1141 gtcctgggaa atctcaaaaa aaaaaaaaaa aaaaaaaa
//