LOCUS       AF358666                3672 bp    mRNA    linear   HUM 11-JAN-2002
DEFINITION  Homo sapiens a disintegrin-like and metalloprotease with
            thrombospondin type 1 motif 14 precursor (ADAMTS14) mRNA, complete
            cds.
ACCESSION   AF358666
VERSION     AF358666.1
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3672)
  AUTHORS   Bolz,H., Ramirez,A., von Brederlow,B. and Kubisch,C.
  TITLE     Characterization of ADAMTS14, a novel member of the ADAMTS
            metalloproteinase family
  JOURNAL   Biochim. Biophys. Acta 1522 (3), 221-225 (2001)
   PUBMED   11779638
REFERENCE   2  (bases 1 to 3672)
  AUTHORS   Bolz,H., Ramirez,A., von Brederlow,B., Gal,A. and Kubisch,C.
  TITLE     Direct Submission
  JOURNAL   Submitted (09-MAR-2001) Institute of Human Genetics,
            Universitaetskrankenhaus Hamburg-Eppendorf, Butenfeld 42, Hamburg
            22529, Germany
FEATURES             Location/Qualifiers
     source          1..3672
                     /db_xref="H-InvDB:HIT000078323"
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q2"
     gene            1..3672
                     /gene="ADAMTS14"
     CDS             1..3672
                     /gene="ADAMTS14"
                     /note="extracellular protease; low level expression in the
                     brain, lungs and liver in adults; MDC
                     (metalloprotease/disintegrin/cysteine)-rich"
                     /codon_start=1
                     /product="a disintegrin-like and metalloprotease with
                     thrombospondin type 1 motif 14 precursor"
                     /protein_id="AAL40229.1"
                     /translation="MAPLRALLSYLLPLHCALCAAAGSRTPELHLSGKLSDYGVTVPC
                     STDFRGRFLSHVVSGPAAASAGSMVVDTPPTLPRHSSHLRVARSPLHPGGTLWPGRVG
                     RHSLYFNVTVFGKELHLRLRPNRRLVVPGSSVEWQEDFRELFRQPLRQECVYTGGVTG
                     MPGAAVAISNCDGLAGLIRTDSTDFFIEPLERGQQEKEASGRTHVVYRREAVQQEWAE
                     PDGDLHNEAFGLGDLPNLLGLVGDQLGDTERKRRHAKPGSYSIEVLLVVDDSVVRFHG
                     KEHVQNYVLTLMNIVDEIYHDESLGVHINIALVRLIMVGYRQSLSLIERGNPSRSLEQ
                     VCRWAHSQQRQDPSHAEHHDHVVFLTRQDFGPSGYAPVTGMCHPLRSCALNHEDGFSS
                     AFVIAHETGHVLGMEHDGQGNGCADETSLGSVMAPLVQAAFHRFHWSRCSKLELSRYL
                     PSYDCLLDDPFDPAWPQPPELPGINYSMDEQCRFDFGSGYQTCLAFRTFEPCKQLWCS
                     HPDNPYFCKTKKGPPLDGTECAPGKWCFKGHCIWKSPEQTYGQDGGWSSWTKFGSCSR
                     SCGGGVRSRSRSCNNPSPAYGGRPCLGPMFEYQVCNSEECPGTYEDFRAQQCAKRNSY
                     YVHQNAKHSWVPYEPDDDAQKCELICQSADTGDVVFMNQVVHDGTRCSYRDPYSVCAR
                     GECVPVGCDKEVGSMKADDKCGVCGGDNSHCRTVKGTLGKASKQAGALKLVQIPAGAR
                     HIQIEALEKSPHRIVVKNQVTGSFILNPKGKEATSRTFTAMGLEWEDAVEDAKESLKT
                     SGPLPEAIAILALPPTEGGPRSSLAYKYVIHEDLLPLIGSNNVLLEEMDTYEWALKSW
                     APCSKACGGGIQFTKYGCRRRRDHHMVQRHLCDHKKRPKPIRRRCNQHPCSQPVWVTE
                     EWGACSRSCGKLGVQTRGIQCLLPLSNGTHKVMPAKACAGDRPEARRPCLRVPCPAQW
                     RLGAWSQCSATCGEGIQQRQVVCRTNANSLGHCEGDRPDTVQVCSLPACGGNHQNSTV
                     RADVWELGTPEGQWVPQSEPLHPINKISSTEPCTGDRSVFCQMEVLDRYCSIPGYHRL
                     CCVSCIKKASGPNPGPDPGPTSLPPFSTPGSPLPGPQDPADAAEPPGKPTGSEDHQHG
                     RATQLPGALDTSSPGTQHPFAPETPIPGASWSISPTTPGGLPWGWTQTPTPVPEDKGQ
                     PGEDLRHPGTSLPAASPVT"
     sig_peptide     1..66
                     /gene="ADAMTS14"
     misc_feature    67..774
                     /gene="ADAMTS14"
                     /note="Region: prodomain"
     misc_feature    >754..756
                     /gene="ADAMTS14"
                     /note="putative furin cleavage site"
     misc_feature    775..1380
                     /gene="ADAMTS14"
                     /note="Region: metalloprotease domain"
     misc_feature    1654..1824
                     /gene="ADAMTS14"
                     /note="Region: 1st thrombospondin motif"
     misc_feature    1825..2136
                     /gene="ADAMTS14"
                     /note="Region: cysteine-rich domain"
     misc_feature    2539..3072
                     /gene="ADAMTS14"
                     /note="Region: 2nd to 4th thrombospondin motifs"
BASE COUNT          726 a         1162 c         1142 g          642 t
ORIGIN      
        1 atggctccac tccgcgcgct gctgtcctac ctgctgcctt tgcactgtgc gctctgcgcc
       61 gccgcgggca gccggacccc agagctgcac ctctctggaa agctcagtga ctatggtgtg
      121 acagtgccct gcagcacaga ctttcgggga cgcttcctct cccacgtggt gtctggccca
      181 gcagcagcct ctgcagggag catggtagtg gacacgccac ccacactacc acgacactcc
      241 agtcacctcc gggtggctcg cagccctctg cacccaggag ggaccctgtg gcctggcagg
      301 gtggggcgcc actccctcta cttcaatgtc actgttttcg ggaaggaact gcacttgcgc
      361 ctgcggccca atcggaggtt ggtagtgcca ggatcctcag tggagtggca ggaggatttt
      421 cgggagctgt tccggcagcc cttacggcag gagtgtgtgt acactggagg tgtcactgga
      481 atgcctgggg cagctgttgc catcagcaac tgtgacggat tggcgggcct catccgcaca
      541 gacagcaccg acttcttcat tgagcctctg gagcggggcc agcaggagaa ggaggccagc
      601 gggaggacac atgtggtgta ccgccgggag gccgtccagc aggagtgggc agaacctgac
      661 ggggacctgc acaatgaagc ctttggcctg ggagaccttc ccaacctgct gggcctggtg
      721 ggggaccagc tgggcgacac agagcggaag cggcggcatg ccaagccagg cagctacagc
      781 atcgaggtgc tgctggtggt ggacgactcg gtggttcgct tccatggcaa ggagcatgtg
      841 cagaactatg tcctcaccct catgaatatc gtagatgaga tttaccacga tgagtccctg
      901 ggggttcata taaatattgc cctcgtccgc ttgatcatgg ttggctaccg acagtccctg
      961 agcctgatcg agcgcgggaa cccctcacgc agcctggagc aggtgtgtcg ctgggcacac
     1021 tcccagcagc gccaggaccc cagccacgct gagcaccatg accacgttgt gttcctcacc
     1081 cggcaggact ttgggccctc agggtatgca cccgtcactg gcatgtgtca ccccctgagg
     1141 agctgtgccc tcaaccatga ggatggcttc tcctcagcct tcgtgatagc tcatgagacc
     1201 ggccacgtgc tcggcatgga gcatgacggt caggggaatg gctgtgcaga tgagaccagc
     1261 ctgggcagcg tcatggcgcc cctggtgcag gctgccttcc accgcttcca ttggtcccgc
     1321 tgcagcaagc tggagctcag ccgctacctc ccctcctacg actgcctcct cgatgacccc
     1381 tttgatcctg cctggcccca gcccccagag ctgcctggga tcaactactc aatggatgag
     1441 cagtgccgct ttgactttgg cagtggctac cagacctgct tggcattcag gacctttgag
     1501 ccctgcaagc agctgtggtg cagccatcct gacaacccgt acttctgcaa gaccaagaag
     1561 gggcccccgc tggatgggac tgagtgtgca cccggcaagt ggtgcttcaa aggtcactgc
     1621 atctggaagt cgccggagca gacatatggc caggatggag gctggagctc ctggaccaag
     1681 tttgggtcat gttcgcggtc atgtgggggc ggggtgcgat cccgcagccg gagctgcaac
     1741 aacccctccc cagcctatgg aggccgcccg tgcttagggc ccatgttcga gtaccaggtc
     1801 tgcaacagcg aggagtgccc tgggacctac gaggacttcc gggcccagca gtgtgccaag
     1861 cgcaactcgt actatgtgca ccagaatgcc aagcacagct gggtgcccta cgagcctgac
     1921 gatgacgccc agaagtgtga gctgatctgc cagtcggcgg acacggggga cgtggtgttc
     1981 atgaaccagg tggttcacga tgggacacgc tgcagctacc gggacccata cagcgtctgt
     2041 gcgcgtggcg agtgtgtgcc tgtcggctgt gacaaggagg tggggtccat gaaggcggat
     2101 gacaagtgtg gagtctgcgg gggtgacaac tcccactgca ggactgtgaa ggggacgctg
     2161 ggcaaggcct ccaagcaggc aggagctctc aagctggtgc agatcccagc aggtgccagg
     2221 cacatccaga ttgaggcact ggagaagtcc ccccaccgca ttgtggtgaa gaaccaggtc
     2281 accggcagct tcatcctcaa ccccaagggc aaggaagcca caagccggac cttcaccgcc
     2341 atgggcctgg agtgggagga tgcggtggag gatgccaagg aaagcctcaa gaccagcggg
     2401 cccctgcctg aagccattgc catcctggct ctccccccaa ctgagggtgg cccccgcagc
     2461 agcctggcct acaagtacgt catccatgag gacctgctgc cccttatcgg gagcaacaat
     2521 gtgctcctgg aggagatgga cacctatgag tgggcgctca agagctgggc cccctgcagc
     2581 aaggcctgtg gaggagggat ccagttcacc aaatacggct gccggcgcag acgagaccac
     2641 cacatggtgc agcgacacct gtgtgaccac aagaagaggc ccaagcccat ccgccggcgc
     2701 tgcaaccagc acccgtgctc tcagcctgtg tgggtgacgg aggagtgggg tgcctgcagc
     2761 cggagctgtg ggaagctggg ggtgcagaca cgggggatac agtgcctgct gcccctctcc
     2821 aatggaaccc acaaggtcat gccggccaaa gcctgtgccg gggaccggcc tgaggcccga
     2881 cggccctgtc tccgagtgcc ctgcccagcc cagtggaggc tgggagcctg gtcccagtgc
     2941 tctgccacct gtggagaggg catccagcag cggcaggtgg tgtgcaggac caacgccaac
     3001 agcctcgggc attgcgaggg ggataggcca gacactgtcc aggtctgcag cctgcctgcc
     3061 tgtggaggaa atcaccagaa ctccacggtg agggccgatg tctgggaact tgggacgcca
     3121 gaggggcagt gggtgccaca atctgaaccc ctacatccca ttaacaagat atcatcaacg
     3181 gagccctgca cgggagacag gtctgtcttc tgccagatgg aagtgctcga tcgctactgc
     3241 tccattcccg gctaccaccg gctctgctgt gtgtcctgca tcaagaaggc ctcgggcccc
     3301 aaccctggcc cagaccctgg cccaacctca ctgcccccct tctccactcc tggaagcccc
     3361 ttaccaggac cccaggaccc tgcagatgct gcagagcctc ctggaaagcc aacgggatca
     3421 gaggaccatc agcatggccg agccacacag ctcccaggag ctctggatac aagctcccca
     3481 gggacccagc atccctttgc ccctgagaca ccaatccctg gagcatcctg gagcatctcc
     3541 cctaccaccc ccggggggct gccttggggc tggactcaga cacctacgcc agtccctgag
     3601 gacaaagggc aacctggaga agacctgaga catcccggca ccagcctccc tgctgcctcc
     3661 ccggtgacat ga
//