LOCUS AF358666 3672 bp mRNA linear HUM 11-JAN-2002 DEFINITION Homo sapiens a disintegrin-like and metalloprotease with thrombospondin type 1 motif 14 precursor (ADAMTS14) mRNA, complete cds. ACCESSION AF358666 VERSION AF358666.1 KEYWORDS . SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 3672) AUTHORS Bolz,H., Ramirez,A., von Brederlow,B. and Kubisch,C. TITLE Characterization of ADAMTS14, a novel member of the ADAMTS metalloproteinase family JOURNAL Biochim. Biophys. Acta 1522 (3), 221-225 (2001) PUBMED 11779638 REFERENCE 2 (bases 1 to 3672) AUTHORS Bolz,H., Ramirez,A., von Brederlow,B., Gal,A. and Kubisch,C. TITLE Direct Submission JOURNAL Submitted (09-MAR-2001) Institute of Human Genetics, Universitaetskrankenhaus Hamburg-Eppendorf, Butenfeld 42, Hamburg 22529, Germany FEATURES Location/Qualifiers source 1..3672 /db_xref="H-InvDB:HIT000078323" /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" /chromosome="10" /map="10q2" gene 1..3672 /gene="ADAMTS14" CDS 1..3672 /gene="ADAMTS14" /note="extracellular protease; low level expression in the brain, lungs and liver in adults; MDC (metalloprotease/disintegrin/cysteine)-rich" /codon_start=1 /product="a disintegrin-like and metalloprotease with thrombospondin type 1 motif 14 precursor" /protein_id="AAL40229.1" /translation="MAPLRALLSYLLPLHCALCAAAGSRTPELHLSGKLSDYGVTVPC STDFRGRFLSHVVSGPAAASAGSMVVDTPPTLPRHSSHLRVARSPLHPGGTLWPGRVG RHSLYFNVTVFGKELHLRLRPNRRLVVPGSSVEWQEDFRELFRQPLRQECVYTGGVTG MPGAAVAISNCDGLAGLIRTDSTDFFIEPLERGQQEKEASGRTHVVYRREAVQQEWAE PDGDLHNEAFGLGDLPNLLGLVGDQLGDTERKRRHAKPGSYSIEVLLVVDDSVVRFHG KEHVQNYVLTLMNIVDEIYHDESLGVHINIALVRLIMVGYRQSLSLIERGNPSRSLEQ VCRWAHSQQRQDPSHAEHHDHVVFLTRQDFGPSGYAPVTGMCHPLRSCALNHEDGFSS AFVIAHETGHVLGMEHDGQGNGCADETSLGSVMAPLVQAAFHRFHWSRCSKLELSRYL PSYDCLLDDPFDPAWPQPPELPGINYSMDEQCRFDFGSGYQTCLAFRTFEPCKQLWCS HPDNPYFCKTKKGPPLDGTECAPGKWCFKGHCIWKSPEQTYGQDGGWSSWTKFGSCSR SCGGGVRSRSRSCNNPSPAYGGRPCLGPMFEYQVCNSEECPGTYEDFRAQQCAKRNSY YVHQNAKHSWVPYEPDDDAQKCELICQSADTGDVVFMNQVVHDGTRCSYRDPYSVCAR GECVPVGCDKEVGSMKADDKCGVCGGDNSHCRTVKGTLGKASKQAGALKLVQIPAGAR HIQIEALEKSPHRIVVKNQVTGSFILNPKGKEATSRTFTAMGLEWEDAVEDAKESLKT SGPLPEAIAILALPPTEGGPRSSLAYKYVIHEDLLPLIGSNNVLLEEMDTYEWALKSW APCSKACGGGIQFTKYGCRRRRDHHMVQRHLCDHKKRPKPIRRRCNQHPCSQPVWVTE EWGACSRSCGKLGVQTRGIQCLLPLSNGTHKVMPAKACAGDRPEARRPCLRVPCPAQW RLGAWSQCSATCGEGIQQRQVVCRTNANSLGHCEGDRPDTVQVCSLPACGGNHQNSTV RADVWELGTPEGQWVPQSEPLHPINKISSTEPCTGDRSVFCQMEVLDRYCSIPGYHRL CCVSCIKKASGPNPGPDPGPTSLPPFSTPGSPLPGPQDPADAAEPPGKPTGSEDHQHG RATQLPGALDTSSPGTQHPFAPETPIPGASWSISPTTPGGLPWGWTQTPTPVPEDKGQ PGEDLRHPGTSLPAASPVT" sig_peptide 1..66 /gene="ADAMTS14" misc_feature 67..774 /gene="ADAMTS14" /note="Region: prodomain" misc_feature >754..756 /gene="ADAMTS14" /note="putative furin cleavage site" misc_feature 775..1380 /gene="ADAMTS14" /note="Region: metalloprotease domain" misc_feature 1654..1824 /gene="ADAMTS14" /note="Region: 1st thrombospondin motif" misc_feature 1825..2136 /gene="ADAMTS14" /note="Region: cysteine-rich domain" misc_feature 2539..3072 /gene="ADAMTS14" /note="Region: 2nd to 4th thrombospondin motifs" BASE COUNT 726 a 1162 c 1142 g 642 t ORIGIN 1 atggctccac tccgcgcgct gctgtcctac ctgctgcctt tgcactgtgc gctctgcgcc 61 gccgcgggca gccggacccc agagctgcac ctctctggaa agctcagtga ctatggtgtg 121 acagtgccct gcagcacaga ctttcgggga cgcttcctct cccacgtggt gtctggccca 181 gcagcagcct ctgcagggag catggtagtg gacacgccac ccacactacc acgacactcc 241 agtcacctcc gggtggctcg cagccctctg cacccaggag ggaccctgtg gcctggcagg 301 gtggggcgcc actccctcta cttcaatgtc actgttttcg ggaaggaact gcacttgcgc 361 ctgcggccca atcggaggtt ggtagtgcca ggatcctcag tggagtggca ggaggatttt 421 cgggagctgt tccggcagcc cttacggcag gagtgtgtgt acactggagg tgtcactgga 481 atgcctgggg cagctgttgc catcagcaac tgtgacggat tggcgggcct catccgcaca 541 gacagcaccg acttcttcat tgagcctctg gagcggggcc agcaggagaa ggaggccagc 601 gggaggacac atgtggtgta ccgccgggag gccgtccagc aggagtgggc agaacctgac 661 ggggacctgc acaatgaagc ctttggcctg ggagaccttc ccaacctgct gggcctggtg 721 ggggaccagc tgggcgacac agagcggaag cggcggcatg ccaagccagg cagctacagc 781 atcgaggtgc tgctggtggt ggacgactcg gtggttcgct tccatggcaa ggagcatgtg 841 cagaactatg tcctcaccct catgaatatc gtagatgaga tttaccacga tgagtccctg 901 ggggttcata taaatattgc cctcgtccgc ttgatcatgg ttggctaccg acagtccctg 961 agcctgatcg agcgcgggaa cccctcacgc agcctggagc aggtgtgtcg ctgggcacac 1021 tcccagcagc gccaggaccc cagccacgct gagcaccatg accacgttgt gttcctcacc 1081 cggcaggact ttgggccctc agggtatgca cccgtcactg gcatgtgtca ccccctgagg 1141 agctgtgccc tcaaccatga ggatggcttc tcctcagcct tcgtgatagc tcatgagacc 1201 ggccacgtgc tcggcatgga gcatgacggt caggggaatg gctgtgcaga tgagaccagc 1261 ctgggcagcg tcatggcgcc cctggtgcag gctgccttcc accgcttcca ttggtcccgc 1321 tgcagcaagc tggagctcag ccgctacctc ccctcctacg actgcctcct cgatgacccc 1381 tttgatcctg cctggcccca gcccccagag ctgcctggga tcaactactc aatggatgag 1441 cagtgccgct ttgactttgg cagtggctac cagacctgct tggcattcag gacctttgag 1501 ccctgcaagc agctgtggtg cagccatcct gacaacccgt acttctgcaa gaccaagaag 1561 gggcccccgc tggatgggac tgagtgtgca cccggcaagt ggtgcttcaa aggtcactgc 1621 atctggaagt cgccggagca gacatatggc caggatggag gctggagctc ctggaccaag 1681 tttgggtcat gttcgcggtc atgtgggggc ggggtgcgat cccgcagccg gagctgcaac 1741 aacccctccc cagcctatgg aggccgcccg tgcttagggc ccatgttcga gtaccaggtc 1801 tgcaacagcg aggagtgccc tgggacctac gaggacttcc gggcccagca gtgtgccaag 1861 cgcaactcgt actatgtgca ccagaatgcc aagcacagct gggtgcccta cgagcctgac 1921 gatgacgccc agaagtgtga gctgatctgc cagtcggcgg acacggggga cgtggtgttc 1981 atgaaccagg tggttcacga tgggacacgc tgcagctacc gggacccata cagcgtctgt 2041 gcgcgtggcg agtgtgtgcc tgtcggctgt gacaaggagg tggggtccat gaaggcggat 2101 gacaagtgtg gagtctgcgg gggtgacaac tcccactgca ggactgtgaa ggggacgctg 2161 ggcaaggcct ccaagcaggc aggagctctc aagctggtgc agatcccagc aggtgccagg 2221 cacatccaga ttgaggcact ggagaagtcc ccccaccgca ttgtggtgaa gaaccaggtc 2281 accggcagct tcatcctcaa ccccaagggc aaggaagcca caagccggac cttcaccgcc 2341 atgggcctgg agtgggagga tgcggtggag gatgccaagg aaagcctcaa gaccagcggg 2401 cccctgcctg aagccattgc catcctggct ctccccccaa ctgagggtgg cccccgcagc 2461 agcctggcct acaagtacgt catccatgag gacctgctgc cccttatcgg gagcaacaat 2521 gtgctcctgg aggagatgga cacctatgag tgggcgctca agagctgggc cccctgcagc 2581 aaggcctgtg gaggagggat ccagttcacc aaatacggct gccggcgcag acgagaccac 2641 cacatggtgc agcgacacct gtgtgaccac aagaagaggc ccaagcccat ccgccggcgc 2701 tgcaaccagc acccgtgctc tcagcctgtg tgggtgacgg aggagtgggg tgcctgcagc 2761 cggagctgtg ggaagctggg ggtgcagaca cgggggatac agtgcctgct gcccctctcc 2821 aatggaaccc acaaggtcat gccggccaaa gcctgtgccg gggaccggcc tgaggcccga 2881 cggccctgtc tccgagtgcc ctgcccagcc cagtggaggc tgggagcctg gtcccagtgc 2941 tctgccacct gtggagaggg catccagcag cggcaggtgg tgtgcaggac caacgccaac 3001 agcctcgggc attgcgaggg ggataggcca gacactgtcc aggtctgcag cctgcctgcc 3061 tgtggaggaa atcaccagaa ctccacggtg agggccgatg tctgggaact tgggacgcca 3121 gaggggcagt gggtgccaca atctgaaccc ctacatccca ttaacaagat atcatcaacg 3181 gagccctgca cgggagacag gtctgtcttc tgccagatgg aagtgctcga tcgctactgc 3241 tccattcccg gctaccaccg gctctgctgt gtgtcctgca tcaagaaggc ctcgggcccc 3301 aaccctggcc cagaccctgg cccaacctca ctgcccccct tctccactcc tggaagcccc 3361 ttaccaggac cccaggaccc tgcagatgct gcagagcctc ctggaaagcc aacgggatca 3421 gaggaccatc agcatggccg agccacacag ctcccaggag ctctggatac aagctcccca 3481 gggacccagc atccctttgc ccctgagaca ccaatccctg gagcatcctg gagcatctcc 3541 cctaccaccc ccggggggct gccttggggc tggactcaga cacctacgcc agtccctgag 3601 gacaaagggc aacctggaga agacctgaga catcccggca ccagcctccc tgctgcctcc 3661 ccggtgacat ga //