LOCUS AH011131 7887 bp DNA linear HUM 10-JUN-2016
DEFINITION Homo sapiens chromosome 8 topoisomerase I gene, complete cds;
nuclear gene for mitochondrial product.
ACCESSION AH011131 AF349018 AF349019 AF349020 AF349021 AF349022 AF349023
AF349024 AF349025 AF349026 AF349027 AF349028 AF349029 AF349030
AF349031
VERSION AH011131.2
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 7887)
AUTHORS Zhang,H., Barcelo,J.M., Lee,B., Kohlhagen,G., Zimonjic,D.B.,
Popescu,N.C. and Pommier,Y.
TITLE Human mitochondrial topoisomerase I
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 98 (19), 10608-10613 (2001)
PUBMED 11526219
REFERENCE 2 (bases 1 to 7887)
AUTHORS Zhang,H. and Pommier,Y.
TITLE Direct Submission
JOURNAL Submitted (14-FEB-2001) Laboratory of Molecular Pharmacology, NCI,
National Institutes of Health, Bldg. 37, Rm. 4E28, Bethesda, MD
20892-4255, USA
COMMENT On or before Jun 10, 2016 this sequence version replaced
AF349018.1, AF349019.1, AF349020.1, AF349021.1, AF349022.1,
AF349023.1, AF349024.1, AF349025.1, AF349026.1, AF349027.1,
AF349028.1, AF349029.1, AF349030.1, AF349031.1, AH011131.1.
FEATURES Location/Qualifiers
source 1..7887
/organism="Homo sapiens"
/mol_type="genomic DNA"
/db_xref="taxon:9606"
/chromosome="8"
/map="8q24.3"
mRNA join(722..862,4514..4629,5139..5260,5361..5483,5584..5771,
5872..6016,6117..6260,6361..6546,6647..6715,6816..6930,
7031..7158,7259..7353,7454..7603,7704..7887)
/product="topoisomerase I"
exon 722..862
/number=1
CDS join(741..862,4514..4629,5139..5260,5361..5483,5584..5771,
5872..6016,6117..6260,6361..6546,6647..6715,6816..6930,
7031..7158,7259..7353,7454..7603,7704..7806)
/codon_start=1
/product="topoisomerase I"
/protein_id="AAL10791.1"
/translation="MRVVRLLRLRAALTLLGEVPRRPASRGVPGSRRTQKGSGARWEK
EKHEDGVKWRQLEHKGPYFAPPYEPLPDGVRFFYEGRPVRLSVAAEEVATFYGRMLDH
EYTTKEVFRKNFFNDWRKEMAVEEREVIKSLDKCDFTEIHRYFVDKAAARKVLSREEK
QKLKEEAEKLQQEFGYCILDGHQEKIGNFKIEPPGLFRGRGDHPKMGMLKRRITPEDV
VINCSRDSKIPEPPAGHQWKEVRSDNTVTWLAAWTESVQNSIKYIMLNPCSKLKGETA
WQKFETARRLRGFVDEIRSQYRADWKSREMKTRQRAVALYFIDKLALRAGNEKEDGEA
ADTVGCCSLRVEHVQLHPEADGCQHVVEFDFLGKDCIRYYNRVPVEKPVYKNLQLFME
NKDPRDDLFDRLTTTSLNKHLQELMDGLTAKVFRTYNASITLQEQLRALTRAEDSIAA
KILSYNRANRVVAILCNHQRATPSTFEKSMQNLQTKIQAKKEQVAEARAELRRARAEH
KAQGDGKSRSVLEKKRRLLEKLQEQLAQLSVQATDKEENKQVALGTSKLNYLDPRISI
AWCKRFRVPVEKIYSKTQRERFAWALAMAGEDFEF"
gap 1964..2063
/estimated_length=unknown
exon 4514..4629
/number=2
gap 5039..5138
/estimated_length=unknown
exon 5139..5260
/number=3
gap 5261..5360
/estimated_length=unknown
exon 5361..5483
/number=4
gap 5484..5583
/estimated_length=unknown
exon 5584..5771
/number=5
gap 5772..5871
/estimated_length=unknown
exon 5872..6016
/number=6
gap 6017..6116
/estimated_length=unknown
exon 6117..6260
/number=7
gap 6261..6360
/estimated_length=unknown
exon 6361..6546
/number=8
gap 6547..6646
/estimated_length=unknown
exon 6647..6715
/number=9
gap 6716..6815
/estimated_length=unknown
exon 6816..6930
/number=10
gap 6931..7030
/estimated_length=unknown
exon 7031..7158
/number=11
gap 7159..7258
/estimated_length=unknown
exon 7259..7353
/number=12
gap 7354..7453
/estimated_length=unknown
exon 7454..7603
/number=13
gap 7604..7703
/estimated_length=unknown
exon 7704..7887
/number=14
BASE COUNT 1251 a 1870 c 2029 g 1417 t
ORIGIN
1 gatctagagg ttttgcccct tggccatgct ccccagtgaa gacactgggg ttaaaccctg
61 gtcagggtca gcagtcacgc tggggactga gcgcaggaag gaggctccag ctgtgcctgg
121 tctctggtct ccttgggagt gagaggctgg ttggcaggga tgatttcgca ggacttcctg
181 tgacctttgt ccagaggcac cacctctgag gggctgctgt gggctggaca gcaggtgctt
241 ctgccggttt ctgcgtcctg gaagtgctgc tgtttgtagg ggatgaggta gggggccatc
301 tgagcctgtg aggtcccttc tccagagcag cagagcgtgt acttaggaag gacctgctag
361 gtgcccctgc cctcagaggc tctgggagag agctgtgtgc aagccctggg caggagttca
421 ctggcctggt cgtgtgacct gtggggcatc ctgacagcca gccctgtgct gcagaggtca
481 gtgggactgg gtttggatct gggtccccgc ccagcgtgaa ggggcgctgg accacgaagg
541 cagggaaacc agggggaggc cggcaggaca gtcagtggtc ctgctgccgc agccccgtgc
601 aggcttagac cgcccagcct tgggatgagc gccgctgggg gcggaggccg cgctcggggg
661 cggggctggc cgctgggggc ggggcggggc tggccgctgg ggcggggccc agcttgtcgc
721 cctttcccgg aggctggcag atgcgcgtgg tgcggctgct gcggctccgg gcggctctga
781 cgctgctcgg ggaggtcccc cgccgcccgg cctcccgggg tgtcccgggc tcgcgcagga
841 cgcagaaggg cagtggagcc aggtaaggtg tcccagtgag caggcggcga gggccctgag
901 caccgggctt gggtaggtcc agaaagggga gtggcaggcc tcgtgggacg gccttgccct
961 gcttccggtt ttcccaaaag tcgggccagg agagcatgcg tgccgcggtg tgaccggccc
1021 gcctcctgcc cggggtgtac aggccccccc atgacgtcgc ccttgcttcc ccaggcacca
1081 ccccaccaac cctatttggg gaaatctccc ctcttttttt ccgcttgtgg tttcatcatt
1141 tgtgtagctg tgcctgggcc tcaacactgt agggtttggt taggtacttt ataaaaagct
1201 tatgttgctg tgcatggtct tctgagaccc gctctttcct ggagtcggtt cccgggttgt
1261 ctccaggacc gattctgcat ggcggcgggc gctcactgtc atatctacat caccaggcac
1321 aagccgcatg gatccagtgg ccctggtggc cgttggtggt cccaggcgct ttcctggagg
1381 acatgtgaga agccctgccg gcgcatactg ggcctggggt agccgcatgg ggatgggtct
1441 ctgcgcatga aatgctggag tttccgaaga gctggagagt tgacagcctc actggtgcgt
1501 gggagatcct gcaggagttc ccgccaggtc tcgcggttta tcatcattca cttagtgctt
1561 ccagcgtggc atgtctctgt gacctggtgg tgcgctatca gcatacccat tcacagctga
1621 gggcctgcac agctgcctaa ggccatgctg cagaaatgtc ctgtctgcct gcaggagctt
1681 gggacccaaa gagagcccca gatggggcag ggtgtcttgg gaggagggag ttctggcctg
1741 cgcttggagc tggggctggc tgtgggccct gcattgaggc acatctctcc gagggtgcac
1801 aggcaggtag gtgctttcca aaaagtgctg ctgagctgca gtcgcccagg tggacaggtg
1861 ggtttggaac aaggtctctg gctttgaaag ccagcttgtg tctgatggtg gtgcttggtg
1921 ccctggtctc tgcaggggtg aaagaatgtc actacaatgt gcannnnnnn nnnnnnnnnn
1981 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
2041 nnnnnnnnnn nnnnnnnnnn nnnggctcat agnatttcga gtncagagag tgttcaaaat
2101 ntntactcat ancagggaca gnggttgaca aggtctctgc ttgaaancag ctgtgtctat
2161 ggtggtgttg gtgccttggt ctnngcaggg gaaaanaagt cactncaatg tgcagccctc
2221 agttgggctt gagcgcacac ccagtgggca gccttgcctg gccgctggcc ggcaggttgt
2281 ttcacctcag tgtcttcatc tgtgaaatga gactggtgat gtgactaccc tagaggcttt
2341 gtgaaggact tggcagtcag ggtcactgtc agttctttat ttttattttt attattatta
2401 tttgagacaa aatcttgccc tgtcacccag gctggagtgc agtggtgcaa tttcaactca
2461 ctgcaacctc gtgcctcctg ggttcaagtg attctcctgc ttcagcctcc ttgagtagct
2521 gggattacag gcacccgcca ccacgcctag ttaatttttg tatttttagt agagacgggg
2581 gttttgccat gttggccagg cgggtctcga actcctggcc tcaagtgatc cgcccgcctc
2641 ggcctcccaa agtgctggta ttacaggcgt gagtcaccgc gcctggctcc tatcagttag
2701 ttccgagata cacgtggttt cccattttct cacacccgac atgatccatc ttcccttatt
2761 ctctaagaag gcgttgtcta ggtttgcatc cttcagggca cttagtggtg cagcctccta
2821 ccagccccac cctagacatg ctgtatcagg gctggtgggc tctcttgaac tcctaaaacc
2881 tgtaagaaag gtgaggctgg tctcacctga cgtggaaaag ctttgcagag tcagcagaac
2941 ccccctctcc ccgagtctcc ctccagactc cagctgcctg cagcatctgc cagctagttt
3001 ttttgtactt tcgccatgtt ggccaggctg gccttgagct cctgagcctg cctcagcctc
3061 ccaaagtgct gggatcacag gcgtgagcca ccacgcccgg ctccaccctg gaaggttctt
3121 gagcccgtta acttctccct actttatcag ctccgtctct acgtcttcta accttgccca
3181 ttccctcctc tgcagaaaca gccagaaagg ccctttcaga aatgtctgtt gcacatgctt
3241 tcccctctca gacccttcag agacttcctg ttgctctgag gacactcatc ccagccgacc
3301 aggcccacca ggcccccaac agcactacct ggctggggtc acgtgcaggt ctcctggctc
3361 tggcaggtgg gggtgtgatc tggaaccttc tgtccttgtg cgtctggggg aggctcagaa
3421 ggtgtgccca tctcactctc ccccatcctg atggtgctcc caccctctcg ccaaagcctc
3481 tcccactgag gcctttgcac tggccatcct gggtgctgga cttgctcttc ccgcagccct
3541 gctgaccgag cctgcccact gcctgccagc cacgccccat ctcgctcctc ttctcccagg
3601 cccatctcag aatctaggtt cagttgagcc cttcgtatgg gttttggtga tctgcatccg
3661 caggacccag cgcagtgctg gttcagggca ggcttgggct tgcctcaatg gatagatgat
3721 gactggcctg gagagttagg atgggctgta gccgccacgc tggctgtgtc cccccacccc
3781 ctccaacacc cccccaatct ccagagctgg gcttgccaga agggggcgcc ctggggaggg
3841 ggaccttggc agggagccct gtggagcctc attgtgttag tgccttacaa aaggagccct
3901 tccctgaaaa cccctgaggc ttctggcttc agggcctccc ctccctgccc cgcctcctcc
3961 accccgccct gcctcttcca cccttccacc ctgcccgatc ctctgtgggc ggcggtcctg
4021 cgccctgctg tggtgcctct ccactggctg cactgctgga cccccttcca cccagctcct
4081 cggaggcagg gctctctcat aagcagccag gtcctttatt tagcaaatga aatggtccca
4141 tggagaggtt cccgaagatt ctagaccggc tctgaaggga cccatctggg gagaggccct
4201 agagcctggg agaggcacgt tgcctttccc acttagctgg gcttgccctt tcccgcttag
4261 ctgggtttgg tgggatccgt gactcagcag cacacgggcc tctgcaggtg gggggcatgg
4321 gcgggtacac gggcatgggg tctgaggtca ggtagggttg cctccctctg caggccttgt
4381 tttcctcccc cgtgaggtgg aggccacact gctcacctgc taggagccac agggaggagc
4441 cactgtggga gcggggaaga ggctcatgca gggcctggcc caggagagtg acacgtcctg
4501 tctccgtctt taggtgggag aaggagaagc acgaagacgg ggtgaagtgg agacagctgg
4561 agcacaaggg cccgtacttc gcacccccat acgagcccct tcccgacgga gtgcgtttct
4621 tctatgaagg taaggatgca gggagcggct cctccccagc ctgcgcttgg ttccctgggc
4681 gtgggctccc agtgggcatc tggctcgctc cctcagcccc cctgcaggct tctggctatg
4741 agcgctctgt gccctcttct tgcaggtgat gcgtgggggc tgctgaccaa ctgacccatg
4801 ctcagagggt ggcagttcgg gggctcccgt ccctgccttt cctgntgagc ctgcactgnc
4861 tgtgcctgtt gtgtccagga ccctctgggc aaagcggacc ccccctccct ccccccgcac
4921 cactgngttc cctgtgngtt ctgagtatac acagnacgta cactgcgtgt acacacatgg
4981 atnacaaaaa cggtcacttn accccagctt gtnattctca acnagaaccc gagccccgnn
5041 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
5101 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnga aggcctgtga gattgagcgt
5161 ggcagcggag gaggtcgcca ctttttatgg gaggatgtta gatcatgaat acacaacaaa
5221 ggaggttttc cggaagaact tcttcaatga ctggcgaaag nnnnnnnnnn nnnnnnnnnn
5281 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
5341 nnnnnnnnnn nnnnnnnnnn gaaatggcgg tggaagagag ggaagtcatc aagagcctgg
5401 acaagtgtga cttcacggag atccacagat actttgtgga caaggccgca gcccggaaag
5461 tcctgagcag ggaggagaag cagnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
5521 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
5581 nnnaagctaa aagaagaggc agaaaaactt cagcaagagt tcggctactg tattttagat
5641 ggtcaccaag aaaaaatagg caacttcaag attgagccgc ctggcttgtt ccgtggccgt
5701 ggcgaccatc ccaagatggg gatgctgaag agaaggatca cgccagagga tgtggttatc
5761 aactgcagca gnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
5821 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nggactcgaa
5881 gatccccgag ccgccggcgg ggcaccagtg gaaggaggtg cgctccgata acaccgtcac
5941 gtggctggca gcttggaccg agagcgttca gaactccatc aagtacatca tgctgaaccc
6001 ttgctcgaag ctgaagnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
6061 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnngggg
6121 agacagcttg gcagaagttt gaaacagctc gacgcctgcg gggatttgtg gacgagatcc
6181 gctcccagta ccgggctgac tggaagtctc gggaaatgaa gacgagacag cgggcggtgg
6241 ccctgtattt catcgataag nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
6301 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
6361 ctggcactga gagcaggaaa tgagaaggag gacggtgagg cggccgacac cgtgggctgc
6421 tgttccctcc gcgtggagca cgtccagctg cacccggagg ccgatggctg ccaacacgtg
6481 gtggaatttg acttcctggg gaaggactgc atccgctact acaacagagt gccggtggag
6541 aagccgnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
6601 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnngtgt acaagaactt
6661 acagctcttt atggagaaca aggacccccg ggacgacctc ttcgacaggc tgaccnnnnn
6721 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
6781 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnacgac cagcctgaac aagcacctcc
6841 aggagctgat ggacgggctg acggccaagg tgttccggac ctacaacgcc tccatcactc
6901 tgcaggagca gctgcgggcc ctgacgcgcg nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
6961 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
7021 nnnnnnnnnn ccgaggacag catagcagct aagatcttat cctacaaccg agccaaccga
7081 gtcgtggcca ttctctgcaa ccatcagcga gcaaccccca gtacgttcga gaagtcgatg
7141 cagaatctcc agacgaagnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
7201 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnat
7261 ccaggcaaag aaggagcagg tggctgaggc cagggcagag ctgaggaggg cgagggctga
7321 gcacaaagcc caaggggatg gcaagtccag gagnnnnnnn nnnnnnnnnn nnnnnnnnnn
7381 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
7441 nnnnnnnnnn nnntgtcctg gagaagaaga ggcggctcct ggagaagctg caggagcagc
7501 tggcgcagct gagtgtgcag gccacggaca aggaggagaa caagcaggtg gccctgggca
7561 cgtccaagct caactacctg gaccccagga tcagcattgc ctgnnnnnnn nnnnnnnnnn
7621 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
7681 nnnnnnnnnn nnnnnnnnnn nnngtgcaag cggttcaggg tgccagtgga gaagatctac
7741 agcaaaacac agcgggagag gttcgcctgg gctctcgcca tggcaggaga agactttgaa
7801 ttctaacgac gagccgtgtt gaaacttctt ttgtatgtgt gtgtgttttt ttcactatta
7861 aagcagtact ggggaatttt gtacaat
//