LOCUS AF336127 3138 bp mRNA linear HUM 01-MAY-2001
DEFINITION Homo sapiens bicarbonate transporter-related protein BTR1 mRNA,
complete cds.
ACCESSION AF336127
VERSION AF336127.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 3138)
AUTHORS Parker,M.D., Ourmozdi,E.P. and Tanner,M.J.
TITLE Human BTR1, a new bicarbonate transporter superfamily member and
human AE4 from kidney
JOURNAL Biochem. Biophys. Res. Commun. 282 (5), 1103-1109 (2001)
PUBMED 11302728
REFERENCE 2 (bases 1 to 3138)
AUTHORS Ourmozdi,E.P., Parker,M.D. and Tanner,M.J.A.
TITLE Direct Submission
JOURNAL Submitted (12-JAN-2001) Biochemistry, University of Bristol,
University Walk, Bristol BS8 1TD, UK
FEATURES Location/Qualifiers
source 1..3138
/db_xref="H-InvDB:HIT000077827"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="20"
/map="20p13"
/tissue_type="kidney; trachea; thyroid; salivary glands;
esophagus; testis; brain; neck; ovary; lung squamous cell
tumor"
misc_feature <1..2
/note="cap site"
CDS 49..2724
/note="similar to dJ79416.2 protein encoded by GenBank
Accession Number AL109976"
/codon_start=1
/product="bicarbonate transporter-related protein BTR1"
/protein_id="AAK16734.1"
/translation="MSQVGGRGDRCTQEVQGLVHGAGDLSASLAENSPTMSQNGYFED
SSYYKCDTDDTFEAREEILGDEAFDTANSSIVSGESIRFFVNVNLEMQATNTENEATS
GGCVLLHTSRKYLKLKNFKEEIRAHRDLDGFLAQASIVLNETATSLDNVLRTMLRRFA
RDPDNNEPNCNLDLLMAMLFTDAGAPMRGKVHLLSDTIQGVTATVTGVRYQQSWLCII
CTMKALQKRHVCISRLVRPQNWGENSCEVRFVILVLAPPKMKSTKTAMEVARTFATMF
SDIAFRQKLLETRTEEEFKEALVHQRQLLTMVSHGPVAPRTKERSTVSLPAHRHPEPP
KCKDFVPFGKGIREDIARRFPLYPLDFTDGIIGKNKAVGKYITTTLFLYFACLLPTIA
FGSLNDENTDGAIDVQKTIAGQSIGGLLYALFSGQPLVILLTTAPLALYIQVIRVICD
DYDLDFNSFYAWTGLWNSFFLALYAFFNLSLVMSLFKRSTEEIIALFISITFVLDAVK
GTVKIFWKYYYGHYLDDYHTKRTSSLVSLSGLGASLNASLHTALNASFLASPTELPSA
THSGQATAVLSLLIMLGTLWLGYTLYQFKKSPYLHPCVREILSDCALPIAVLAFSLIS
SHGFREIEMSKFRYNPSESPFAMAQIQSLSLRAVSGAMGLGFLLSMLFFIEQNLVAAL
VNAPENRLVKGTAYHWDLLLLAIINTGLSLFGLPWIHAAYPHSPLHVRALALVEERVE
NGHIYDTIVNVKETRLTSLGASVLVGLSLLLLPVPLQWIPKPVLYGLFLYIALTSLDG
NQLVQRVALLLKEQTAYPPTHYIRRVPQRKIHYFTGLQVLQLLLLCAFGMSSLPYMKM
IFPLIMIAMIPIRYILLPRIIEAKYLDVMDAEHRP"
regulatory 57..64
/regulatory_class="promoter"
/note="downstream promoter element"
variation 1272
/experiment="experimental evidence, no additional details
recorded"
/note="Q408H variant"
/replace="t"
variation 1275
/experiment="experimental evidence, no additional details
recorded"
/note="K409N variant"
/replace="c"
variation 1496
/experiment="experimental evidence, no additional details
recorded"
/note="M483T variant"
/replace="c"
misc_feature 1681..1689
/note="putative; glycosylation site"
misc_feature 1705..1713
/note="putative; glycosylation site"
variation 2170
/experiment="experimental evidence, no additional details
recorded"
/note="T708A variant"
/replace="g"
regulatory 3061..3066
/regulatory_class="polyA_signal_sequence"
regulatory 3068..3073
/regulatory_class="polyA_signal_sequence"
misc_feature 3078..3084
/note="poly_A downstream element"
BASE COUNT 656 a 975 c 838 g 669 t
ORIGIN
1 ctttctccct agggtggcgt gggttgcatc cctcggaaga gcgaaggaat gagccaggtc
61 ggggggcggg gagacaggtg cacacaggag gtccagggct tggtccatgg ggctggtgac
121 ctttctgctt cccttgcaga aaactctccc accatgtcgc agaatggata cttcgaggat
181 tcaagctact acaagtgtga cacagatgac accttcgaag cccgagagga gatcctgggg
241 gatgaggcct tcgacactgc caactcctcc atcgtgtctg gcgagagtat ccgttttttt
301 gtcaatgtca accttgagat gcaggccacc aacactgaga atgaagcgac ttccggtggc
361 tgtgtgctcc tgcacacctc ccgaaagtac ctgaagttaa agaacttcaa ggaagagatc
421 cgtgcgcacc gcgacctaga tggcttcctg gcgcaggcca gcatcgtcct gaacgagacg
481 gccacctccc tggataacgt gctgcggacc atgcttcgcc gcttcgccag ggaccctgac
541 aacaatgagc ccaactgcaa cctggacctg ctcatggcca tgctcttcac cgatgccggg
601 gcacccatgc ggggtaaagt ccacctgctg tcagatacca tccaaggggt caccgccaca
661 gtgacagggg tgcggtacca gcagtcgtgg ctctgcatca tctgtaccat gaaggcccta
721 cagaagcggc acgtgtgcat cagccgcctg gttcgcccac agaactgggg ggagaattcc
781 tgtgaggttc ggttcgtcat cctggtgctg gccccaccca agatgaaaag cactaagact
841 gcgatggagg tggcgcgcac gtttgccacc atgttctcgg atatcgcctt ccgccagaag
901 ctcctggaga cccgcacaga ggaggaattc aaggaggcct tggtgcatca gagacagctg
961 ctcaccatgg tgagccacgg tccagtggcg ccgagaacga aggaacgcag cacagtctcc
1021 ctccctgccc acagacaccc agagccccca aagtgcaagg actttgtccc ttttgggaag
1081 ggcatccggg aggacatcgc acgcaggttc cccttgtacc ccttggactt cactgatggc
1141 attattggga aaaacaaggc tgtgggcaaa tacatcacca ccaccctgtt cctctacttc
1201 gcctgcctcc tgcccaccat cgctttcggg tctctcaatg acgagaacac agacggggcc
1261 atcgacgtgc agaagaccat agccgggcag agcatcgggg gcctgctcta cgcgctcttc
1321 tctgggcagc cattggtgat tctgctgacc accgcgcccc tggcgctcta catccaggtg
1381 attcgtgtca tctgtgatga ctatgacctg gacttcaact ccttctacgc atggacgggc
1441 ctgtggaata gtttcttcct tgcgctttat gcctttttca acctcagcct ggtcatgagt
1501 ctcttcaaga ggtcgacgga ggagatcatc gccctcttca tttccatcac gtttgtgctg
1561 gatgccgtca agggcacggt taaaatcttc tggaagtact actatgggca ttacttggac
1621 gactatcaca caaaaaggac ttcatccctt gtcagcctgt caggcctcgg cgccagcctc
1681 aacgccagcc tccacactgc cctcaacgcc agcttcctcg ccagccccac ggagctgccc
1741 tcggccacac actcaggcca ggcgaccgcc gtgctcagcc tcctcatcat gctgggcacg
1801 ctctggctgg gctacaccct ctaccaattc aagaagagcc cctacctgca cccctgcgtg
1861 cgagagatcc tgtccgactg cgccctgccc atcgcggtgc tcgccttctc cctcatcagc
1921 tcccatggct tccgggaaat cgagatgagc aagttccgct acaaccccag cgagagcccc
1981 tttgcgatgg cgcagatcca gtcgctgtcc ctgagggccg tcagcggtgc catgggcctc
2041 ggcttcctgc tgtccatgct cttcttcatc gagcagaact tggtggccgc cttggtgaat
2101 gcaccggaga acaggctggt gaagggcact gcctaccact gggacctcct gctcctcgcc
2161 atcatcaaca cagggctgtc tctgtttggg ctgccttgga tccatgccgc ctacccccac
2221 tccccgctgc acgtgcgagc cctggcctta gtggaggagc gtgtggagaa cggacacatc
2281 tatgacacga ttgtgaacgt gaaggagacg cggctgacct cgctgggcgc cagcgtcctg
2341 gtgggcctgt ccctgttgct gctgccggtc ccgcttcagt ggatccccaa gcccgtgctc
2401 tatggcctct tcctctacat cgcgctcacc tccctcgatg gcaaccagct cgtccagcgc
2461 gtggccctgc tgctcaagga gcagactgcg taccccccga cacactacat ccggagggtg
2521 ccccagagga agatccacta cttcacgggc ctgcaggtgc ttcagctgct gctgctgtgt
2581 gccttcggca tgagctccct gccctacatg aagatgatct ttcccctcat catgatcgcc
2641 atgatcccca tccgctatat cctgctgccc cgaatcattg aagccaagta cttggatgtc
2701 atggacgctg agcacaggcc ttgactggca gaccctgccc acgccccatt cgccagccct
2761 ccacgtcctc ccaggctggc tctggagctg tgaggggagg tgtaggtgtg tgggtgactg
2821 ctctgtgctg cgccttctca tggctgactc aggcctgggg catctgggca ttgtaggggt
2881 gcagtggtat gtgcccaccc ctctcccatt atcctttagc tttaggccaa gagcgttgct
2941 cagggcagct tctgcccagg gtgggtggga ctgagcagga tggattttct tttgataaaa
3001 gagtcgatgc ctgaaagaga aaccatttcc ttgattgtgt aaggaacttg ctggacgcac
3061 attaaagaat aaagctcctg tttctaggct cctaaaaaaa aaaaaaaaaa aaaaaaaaaa
3121 aaaaaaaaaa aaaaaaaa
//