LOCUS AF333955 1779 bp DNA linear HUM 05-JUL-2001
DEFINITION Homo sapiens small proline-rich protein 2E (SPRR2E) gene, complete
cds.
ACCESSION AF333955
VERSION AF333955.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 1779)
AUTHORS Cabral,A., Voskamp,P., Cleton-Jansen,A.M., South,A., Nizetic,D. and
Backendorf,C.
TITLE Structural organization and regulation of the small proline-rich
family of cornified envelope precursors suggest a role in adaptive
barrier function
JOURNAL J. Biol. Chem. 276 (22), 19231-19237 (2001)
PUBMED 11279051
REFERENCE 2 (bases 1 to 1779)
AUTHORS Cabral,A. and Backendorf,C.
TITLE Direct Submission
JOURNAL Submitted (08-JAN-2001) Molecular Genetics, University Leiden,
Einsteinweg 55, Leiden 2333 CC, Netherlands
FEATURES Location/Qualifiers
source 1..1779
/organism="Homo sapiens"
/mol_type="genomic DNA"
/db_xref="taxon:9606"
/chromosome="1"
/map="1q21"
gene 296..1779
/gene="SPRR2E"
misc_feature 296..303
/gene="SPRR2E"
/note="octamer site"
misc_feature 344..347
/gene="SPRR2E"
/note="ets binding site"
misc_feature 350..353
/gene="SPRR2E"
/note="ets binding site"
misc_feature 357..364
/gene="SPRR2E"
/note="KLF binding site"
regulatory 376..381
/regulatory_class="TATA_box"
/gene="SPRR2E"
mRNA join(408..447,1161..1779)
/gene="SPRR2E"
/product="small proline-rich protein 2E"
exon 408..447
/gene="SPRR2E"
/number=1
exon 1161..1779
/gene="SPRR2E"
/number=2
CDS 1180..1398
/gene="SPRR2E"
/note="SPRR2E; cornified envelope precursor"
/codon_start=1
/product="small proline-rich protein 2E"
/protein_id="AAK70942.1"
/translation="MSYQQQQCKQPCQPPPVCPTPKCPEPCPPPKCPEPCPPPKCPQP
CPPQQCQQKCPPVTPSPPCQPKCPPKSK"
BASE COUNT 475 a 402 c 404 g 498 t
ORIGIN
1 aaagtagagg tggagatggg ttcatgtaca aacaatatgg cattcagcta aagtggatca
61 gggcaggaag ttttatgatt cagggaatgt gtaagacagg aagcattcat tgcccccaat
121 caagaaagag agcccttgac caccagttag agaatccccc aagtccctct ttgctgtcac
181 tgaaactgag atctaaggca gggcctcagt gagtcagggc acttaatcca gtggaaagat
241 cccagaacag gatatttccc agtttgagaa tccctgtcat gccagttatg gatagatttg
301 cattttagtt gggacattgc tgggccagcc cagttttggg tagttccact tcctgctggg
361 tggggtagca ggccctataa agaggttctc tgctctacaa ctcctaaact cctggtactt
421 gagcactgat ctgctttgga gaacctggtg agtctgcttc cttgagttcc tctgttcttt
481 gtgccctgaa gtgttgaatt taacctgaat ccagcaagtt tggtggatcc aaacctgtga
541 tcataggttt gatggtactt agttgatgga actacaggat tagattacat gatacagtgt
601 tttacacaga tttttaaaaa atgtacaatt atatgtccat atggacagag aagttaatag
661 gaaagttttg gtttgaagaa agggatgaag tatttttctc ttttccatat tttcctggta
721 tccttttcaa aggtttgtgt cttagcaggt gtgagagcca gtacttcttc ctgaacagcc
781 cttgctctgt gcccaagtca acccactggt gctttacaac agataatgat gataggaata
841 gcttgtgaga ttgcccagga ggtctgaact tgtgactgcc tttcctgaag atgtcatttt
901 catggaataa catgcttgct tctttattat agagatgttt tctttggaaa aattgtatga
961 ggaaaggcag gaattcctag ggctgatgaa acaacttgct aaagtggaaa ggagaagaca
1021 ggaagtcatg aaaagagagc taagagttta aataaatttt tggagattgg agaaataata
1081 tgccatggta ttacataagc tttggcttct ctctctggag gagtccattc ctgtgaacac
1141 tgtcatatca tttctttcag attctgagac tccagcagga tgtcttatca acagcagcag
1201 tgcaagcagc cctgccagcc acctcctgtg tgccccacgc caaagtgccc agagccatgt
1261 ccacccccga agtgccctga gccctgccca ccaccaaagt gtccacagcc ctgcccacct
1321 cagcagtgcc agcaaaaatg tcctcctgtg acaccttccc caccctgcca gccaaagtgt
1381 ccacccaaga gcaagtaaca gcttcagaat tcatcaggag catgaaagga taaggataat
1441 tggctcacct tgttccacag cttcacctgc atcttctcat caaagcctac catggataca
1501 cagttagctt ctttcctctt agccagtgat ctgcccatga tgatccctga tagcaaaagg
1561 tttcctttct gaggctgcca tattgccact gtccaggtgg agactgagaa aggaagtcct
1621 cagcagtgtc agttcccaga gctttggaag aaggaccagc agctctgtcc ctgggaacca
1681 tcaaaaaatg ctgttgatgt tttctgtgtc tgtctgtcac ctgggcatgg gcttctaaca
1741 cctgtgcaat tgtcactttt ctttcactcc ctgaataaa
//