LOCUS AF332558 1840 bp mRNA linear HUM 11-APR-2001
DEFINITION Homo sapiens PUMA/JFY1 protein mRNA, complete cds.
ACCESSION AF332558
VERSION AF332558.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 1840)
AUTHORS Yu,J., Zhang,L., Hwang,P.M., Kinzler,K.W. and Vogelstein,B.
TITLE PUMA Induces the Rapid Apoptosis of Colorectal Cancer Cells
JOURNAL Mol. Cell 7 (3), 673-682 (2001)
PUBMED 11463391
REFERENCE 2 (bases 1 to 1840)
AUTHORS Yu,J., Zhang,L., Hwang,P.M., Kinzler,K.W. and Vogelstein,B.
TITLE Direct Submission
JOURNAL Submitted (28-DEC-2000) Oncology, The Johns Hopkins Oncology
Center, 1650 Orleans Street, Baltimore, MD 21231, USA
FEATURES Location/Qualifiers
source 1..1840
/db_xref="H-InvDB:HIT000077737"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="19"
/map="19q"
CDS 282..863
/note="p53-induced BH3-only protein; interacts with Bcl2
and Bcl-XL; promotes apoptosis; similar to protein found
in GenBank accession numnber U82987"
/codon_start=1
/product="PUMA/JFY1 protein"
/protein_id="AAK31316.1"
/translation="MARARQEGSSPEPVEGLARDGPRPFPLGRLVPSAVSCGLCEPGL
AAAPAAPTLLPAAYLCAPTAPPAVTAALGGSRWPGGPRSRPRGPRPDGPQPSLSLAEQ
HLESPVPSAPGALAGGPTQAAPGVRGEEEQWAREIGAQLRRMADDLNAQYERRRQEEQ
QRHRPSPWRVLYNLIMGLLPLPRGHRAPEMEPN"
BASE COUNT 283 a 650 c 634 g 273 t
ORIGIN
1 gcggcgcgag ccacatgcga gcgggcgcct ggcggcggcg gcggcggcac cagcgatccc
61 agcagcggcc acgacgcgga cgcgcctgcg gcccggggag cagcagcagc cacagccaca
121 gcagccgcca ctgcagttag agcggcagca gcagcgacag ccacagcagc agccgccgcg
181 gagagcggcg ctcggcgggc gcgccctcct gaaggaagcc gcccgccccc caccgccgcc
241 ccctccggcg tgttcatgcc cccggggccc cagggagcgc catggcccgc gcacgccagg
301 agggcagctc cccggagccc gtagagggcc tggcccgcga cggcccgcgc cccttcccgc
361 tcggccgcct ggtgccctcg gcagtgtcct gcggcctctg cgagcccggc ctggctgccg
421 cccccgccgc ccccaccctg ctgcccgctg cctacctctg cgcccccacc gccccacccg
481 ccgtcaccgc cgccctgggg ggttcccgct ggcctggggg tccccgcagc cggccccgag
541 gcccgcgccc ggacggtcct cagccctcgc tctcgctggc ggagcagcac ctggagtcgc
601 ccgtgcccag cgccccgggg gctctggcgg gcggtcccac ccaggcggcc ccgggagtcc
661 gcggggagga ggaacagtgg gcccgggaga tcggggccca gctgcggcgg atggcggacg
721 acctcaacgc acagtacgag cggcggagac aagaggagca gcagcggcac cgcccctcac
781 cctggagggt cctgtacaat ctcatcatgg gactcctgcc cttacccagg ggccacagag
841 cccccgagat ggagcccaat taggtgcctg cacccgcccg gtggacgtca gggactcggg
901 gggcaggccc ctcccacctc ctgacaccct ggccagcgcg ggggactttc tctgcaccat
961 gtagcatact ggactcccag ccctgcctgt cccgggggcg ggccggggca gccactccag
1021 ccccagccca gcctggggtg cactgacgga gatgcggact cctgggtccc tggccaagaa
1081 gccaggagag ggacggctga tggactcagc atcggaaggt ggcggtgacc gagggggtgg
1141 ggactgagcc gcccgcctct gccgcccacc accatctcag gaaaggctgt tgtgctggtg
1201 cccgttccag ctgcaggggt gacactgggg gggggggggc tctcctctcg gtgctccttc
1261 actctgggcc tggcctcagg cccctggtgc ttccccccct cctcctggga gggggcccgt
1321 gaagagcaaa tgagccaaac gtgaccacta gcctcctgga gccagagagt ggggctcgtt
1381 tgccggttgc tccagcccgg cgcccagcca tcttccctga gccagccggc gggtggtggg
1441 catgcctgcc tcaccttcat cagggggtgg ccaggagggg cccagactgt gaatcctgtg
1501 ctctgcccgt gaccgccccc cgccccatca atcccattgc ataggtttag agagagcgac
1561 gtgtgaccac tggcattcat ttggggggtg ggagattttg gctgaagccg ccccagcctt
1621 agtccccagg gccaagcgct ggggggaaga cggggagtca gggagggggg gaaatctcgg
1681 aagagggagg agtctgggag tggggaggga tggcccagcc tgtaagatac tgtatatgcg
1741 ctgctgtaga taccggaatg aattttctgt acatgtttgg ttaatttttt ttgtacatga
1801 tttttgtatg tttccttttc aataaaatca gattggaaca
//