LOCUS AF332469 5431 bp mRNA linear HUM 10-SEP-2001
DEFINITION Homo sapiens putative protein WHSC1L1l (WHSC1L1) mRNA, complete
cds, alternatively spliced.
ACCESSION AF332469
VERSION AF332469.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 5431)
AUTHORS Stec,I., Nagl,S.B., van Ommen,G.J. and den Dunnen,J.T.
TITLE The PWWP domain: a potential protein-protein interaction domain in
nuclear proteins influencing differentiation?
JOURNAL FEBS Lett. 473 (1), 1-5 (2000)
PUBMED 10802047
REFERENCE 2 (bases 1 to 5431)
AUTHORS Stec,I., van Ommen,G.J. and den Dunnen,J.T.
TITLE Whsc1l1, on human chromosome 8p11.2, closely resembles whsc1 and
maps to a duplicated region shared with 4p16.3
JOURNAL Genomics 76 (1-3), 5-8 (2001)
PUBMED 11549311
REFERENCE 3 (bases 1 to 5431)
AUTHORS Stec,I., van Ommen,G.J. and den Dunnen,J.T.
TITLE Direct Submission
JOURNAL Submitted (26-DEC-2000) Human and Clinical Genetics, Leiden
University Medical Center, Wassenaarseweg 72, 2333 Leiden AL,
Netherlands
FEATURES Location/Qualifiers
source 1..5431
/db_xref="H-InvDB:HIT000077732"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="8"
/map="8p11.2"
/note="long transcript"
gene 1..5431
/gene="WHSC1L1"
/note="Wolf-Hirschhorn syndrome candidate 1-like gene 1"
5'UTR <1..518
/gene="WHSC1L1"
CDS 519..4832
/gene="WHSC1L1"
/note="alternatively spliced"
/codon_start=1
/product="putative protein WHSC1L1l"
/protein_id="AAK00355.1"
/translation="MDFSFSFMQGIMGNTIQQPPQLIDSANIRQEDAFDNNSDIAEDG
GQTPYEATLQQGFQYPATTEDLPPLTNGYPSSISVYETQTKYQSYNQYPNGSANGFGA
VRNFSPTDYYHSEIPNTRPHEILEKPSPPQPPPPPSVPQTVIPKKTGSPEIKLKITKT
IQNGRELFESSLCGDLLNEVQASEHTKSKHESRKEKRKKSNKHDSSRSEERKSHKIPK
LEPEEQNRPNERVDTVSEKPREEPVLKEEAPVQPILSSVPTTEVSTGVKFQVGDLVWS
KVGTYPWWPCMVSSDPQLEVHTKINTRGAREYHVQFFSNQPERAWVHEKRVREYKGHK
QYEELLAEATKQASNHSEKQKIRKPRPQRERAQWDIGIAHAEKALKMTREERIEQYTF
IYIDKQPEEALSQAKKSVASKTEVKKTRRPRSVLNTQPEQTNAGEVASSLSSTEIRRH
SQRRHTSAEEEEPPPVKIAWKTAAARKSLPASITMHKGSLDLQKCNMSPVVKIEQVFA
LQNATGDGKFIDQFVYSTKGIGNKTEISVRGQDRLIISTPNQRNEKPTQSVSSPEATS
GSTGSVEKKQQRRSIRTRSESEKSTEVVPKKKIKKEQVETVPQATVKTGLQKGASEIS
DSCKPLKKRSRASTDVEMTSSAYRDTSDSDSRGLSDLQVGFGKQVDSPSATADADVSD
VQSMDSSLSRRGTGMSKKDTVCQICESSGDSLIPCEGECCKHFHLECLGLASLPDSKF
ICMECKTGQHPCFSCKVSGKDVKRCSVGACGKFYHEACVRKFPTAIFESKGFRCPQHC
CSACSMEKDIHKASKGRMMRCLRCPVAYHSGDACIAAGSMLVSSYILICSNHSKRSSN
SSAVNVGFCFVCARGLIVQDHSDPMFSSYAYKSHYLLNESNRAELMKLPMIPSSSASK
KKCEKGGRLLCCESCPASFHPECLSIEMPEGCWNCNDCKAGKKLHYKQIVWVKLGNYR
WWPAEICNPRSVPLNIQGLKHDLGDFPVFFFGSHDYYWVHQGRVFPYVEGDKSFAEGQ
TSINKTFKKALEEAAKRFQELKAQRESKEALEIEKNSRKPPPYKHIKANKVIGKVQIQ
VADLSEIPRCNCKPADENPCGLESECLNRMLQYECHPQVCPAGDRCQNQCFTKRLYPD
AEIIKTERRGWGLRTKRSIKKGEFVNEYVGELIDEEECRLRIKRAHENSVTNFYMLTV
TKDRIIDAGPKGNYSRFMNHSCNPNCETQKWTVNGDVRVGLFALCDIPAGMELTFNYN
LDCLGNGRTECHCGADNCSGFLGVRPKSACASTNEEKAKNAKLKQKRRKIKTEPKQMH
EDYCFQCGDGGELVMCDKKDCPKAYHLLCLNLTQPPYGKWECPWHQCDECSSAAVSFC
EFCPHSFCKDHEKGALVPSALEGRLCCSEHDPMAPVSPEYWSKIKCKWESQDHGEEVK
E"
misc_feature 1308..1490
/gene="WHSC1L1"
/note="Region: PWWP domain; Pfam PF00855"
misc_feature 2607..2732
/gene="WHSC1L1"
/note="Region: PHD type zinc finger motif"
misc_feature 2751..2903
/gene="WHSC1L1"
/note="Region: PHD type zinc finger motif"
misc_feature 3090..3353
/gene="WHSC1L1"
/note="Region: PHD type zinc finger motif"
misc_feature 3378..3557
/gene="WHSC1L1"
/note="Region: PWWP domain; Pfam PF00855"
misc_feature 3963..4283
/gene="WHSC1L1"
/note="Region: SET domain"
misc_feature 4467..4610
/gene="WHSC1L1"
/note="Region: PHD type zinc finger motif"
3'UTR 4833..>5431
/gene="WHSC1L1"
BASE COUNT 1642 a 1187 c 1323 g 1279 t
ORIGIN
1 gggggctttg tgcgcggcgg cggcgggaga ggcggcggcg gcggccagca cggaggcgga
61 ggccgagggg gctgtgcaca ggtcgccgcg gagaggcgtg cgaattccga gccgagcgcc
121 gaggaccgtg ctacccaggc cgggctgcca gccgcaggct cctctctggc agcagcggcg
181 gcgcggcgac ccccgtccct cggcctcccc ttcccatccc acctcccgag ccttcctctt
241 cccgcagcac gcccggcccg gcccggccgt ggccctcctc agtgccggcc gccatggcag
301 aggcgtccgg cgcggggaaa atctagcccg gggatttcat gcggcctagc tcggttccgc
361 ctcctcctcg cgcggcccca gcggctgccc gcaccccagc cccactccgg gcctccgtgt
421 ctctcctgtg atcgcactga cacggccggg gggttagaat ggaacaaact gaaggcccga
481 tgagagaaag ggaaagttaa ggatgctgga gcagaacaat ggatttctct ttctctttca
541 tgcaagggat catgggaaac acaattcagc aaccacctca actcattgac tccgccaaca
601 tccgtcagga ggatgccttt gataacaaca gtgacattgc tgaagatggt ggccagacac
661 catatgaagc tactttgcag caaggctttc agtacccagc tacaacagaa gatcttcctc
721 cactcacaaa tgggtatcca tcatcaatca gtgtgtatga aactcaaacc aaataccagt
781 catataatca gtatcctaat gggtcagcca atggctttgg tgcagttaga aactttagcc
841 ccactgacta ttatcattca gaaattccaa acacaagacc acatgaaatt ctggaaaaac
901 cttcccctcc acagccacca cctcctcctt cggtaccaca aactgtgatt ccaaagaaga
961 ctggctcacc tgaaattaaa ctaaaaataa ccaaaactat ccagaatggc agggaattgt
1021 ttgagtcttc cctttgtgga gaccttttaa atgaagtaca ggcaagtgag cacacgaaat
1081 caaagcatga aagcagaaaa gaaaagagga aaaaaagcaa caagcatgac tcatcaagat
1141 ctgaagagcg caagtcacac aaaatcccca aattagaacc agaggaacaa aatagaccaa
1201 atgagagggt tgacactgta tcagaaaaac caagggaaga accagtacta aaagaggaag
1261 ccccagttca gccaatacta tcttctgttc caacaacgga agtgtccact ggtgttaagt
1321 ttcaggttgg cgatcttgtg tggtccaagg tgggaaccta tccttggtgg ccttgtatgg
1381 tttcaagtga tccccagctt gaggttcata ctaaaattaa cacaagaggt gcccgagaat
1441 atcatgtcca gttttttagc aaccagccag agagggcgtg ggttcatgaa aaacgggtac
1501 gagagtataa aggtcataaa cagtatgaag aattactggc tgaggcaacc aaacaagcca
1561 gcaatcactc tgagaaacaa aagattcgga aaccccgacc tcagagagaa cgtgctcagt
1621 gggatattgg cattgcccat gcagagaaag cattgaaaat gactcgagaa gaaagaatag
1681 aacagtatac ttttatttac attgataaac agcctgaaga ggctttatcc caagcaaaaa
1741 agagtgttgc ctccaaaacc gaagttaaaa aaacccgacg accaagatct gtgctgaata
1801 ctcagccaga acagaccaat gcaggggagg tggcctcctc actctcaagt actgaaattc
1861 ggagacatag ccagaggcgg cacacaagtg cggaagagga agagccaccg cctgttaaaa
1921 tagcctggaa aactgcggca gcaaggaaat ccttaccagc ttccattacg atgcacaaag
1981 ggagcctgga tttgcagaag tgtaacatgt ctccagttgt gaaaattgaa caagtgtttg
2041 ctcttcagaa tgctacaggg gatgggaaat ttatcgatca atttgtttat tcaacaaagg
2101 gaattggtaa caaaacagaa ataagtgtca gggggcaaga caggcttata atttctacac
2161 caaaccagag aaatgaaaag ccaacgcaga gtgtatcatc tcctgaagca acatctggtt
2221 ctacaggctc agtagaaaag aagcaacaga gaagatcaat tagaactcgt tctgaatcag
2281 agaaatccac tgaggttgtg ccaaagaaga agatcaaaaa ggagcaggtt gaaacagttc
2341 ctcaggctac agtgaagact ggattacaga aaggtgccag cgagatttca gattcctgta
2401 aacctctaaa gaaaaggagt cgcgcctcaa ctgatgtaga aatgactagt tcagcataca
2461 gagacacatc tgactccgat tctagaggac tgagtgacct gcaggtaggc tttggaaagc
2521 aagtagatag cccttcagct actgcagatg cagacgtttc tgatgtgcag tccatggatt
2581 caagtttgtc gagaagaggc actggaatga gtaagaagga cactgtatgt cagatttgtg
2641 aaagctctgg tgactctctg attccttgtg agggagagtg ctgcaaacac tttcacctgg
2701 agtgcctggg attggcatca cttcctgata gcaagttcat ctgcatggaa tgtaaaactg
2761 ggcagcaccc atgtttttcg tgtaaagtgt ctggtaaaga tgtgaagcgt tgttctgttg
2821 gtgcttgtgg gaaattttat catgaagcct gtgtccgcaa attccccact gccatctttg
2881 aatcaaaagg attccgctgt cctcagcact gctgctctgc ctgctctatg gagaaagata
2941 tccacaaagc aagtaaaggc cgcatgatga gatgtttaag atgtccagtt gcctatcact
3001 ctggagatgc ttgcattgcg gccggaagca tgttagtatc ctcctacatt ctcatctgta
3061 gtaatcattc caaacggagc agtaattctt ctgctgtaaa tgtaggcttt tgtttcgttt
3121 gtgccagagg gctgatagtt caggaccatt cagaccccat gttcagttca tatgcctata
3181 agtcccacta cctactgaat gaatcaaatc gtgctgagtt gatgaaatta cctatgattc
3241 cttcttcgtc agcttccaaa aagaaatgtg agaaaggtgg aagattgctc tgctgtgaat
3301 cgtgcccagc ttccttccac ccggaatgcc taagcataga aatgccagaa ggctgctgga
3361 attgtaatga ctgtaaagct ggcaagaaac tacattacaa gcagattgtt tgggtcaaat
3421 tgggaaatta cagatggtgg ccagcagaga tctgcaaccc caggtctgtg ccactgaaca
3481 tccagggcct taaacatgac ttgggggact tccctgtatt cttctttggt tctcatgact
3541 actactgggt acaccagggc agagtgttcc cttatgttga aggagacaaa agctttgctg
3601 aagggcagac tagtattaac aagaccttca aaaaggcact ggaagaagct gcaaaacgtt
3661 tccaggaatt gaaagcacaa agagaaagta aagaagccct agagattgaa aaaaactcaa
3721 gaaaaccccc tccctacaaa cacatcaaag ctaacaaagt aataggaaag gtgcagatcc
3781 aggttgctga cctgtcagag attccccgct gtaactgcaa gccagctgat gaaaaccctt
3841 gtggcttgga atcggagtgc ctgaacagaa tgttgcagta tgaatgccac ccgcaggtgt
3901 gcccagctgg agatcgttgt cagaaccagt gctttacaaa gagactatac cctgatgcag
3961 agatcatcaa aacggagcgg agaggctggg gcctcaggac caaaaggagc attaagaagg
4021 gtgaatttgt aaatgaatac gtcggtgaat taattgatga agaagaatgc agattgcgaa
4081 tcaagcgagc ccacgagaac agtgtaacta atttttatat gttaactgtt accaaggacc
4141 gtataattga tgccggccca aaaggaaatt attctcgctt catgaaccac agttgtaatc
4201 ccaactgtga aacacaaaag tggacagtga atggagatgt tcgagtggga ctatttgctc
4261 tctgtgatat tcctgcaggg atggagttaa catttaatta taacctagat tgtctgggca
4321 acggcagaac ggagtgccac tgtggagcag ataactgcag tggttttcta ggagtgcggc
4381 caaagtcggc atgtgcgtca acaaatgaag agaaggcaaa aaatgctaag ttaaaacaga
4441 agagacgaaa gatcaaaaca gaaccaaagc agatgcatga agattactgt tttcaatgtg
4501 gagatggtgg agagctggtc atgtgtgaca aaaaagactg tcccaaagca taccacctcc
4561 tatgccttaa cctgactcag ccaccatatg gaaagtggga gtgtccgtgg catcagtgcg
4621 atgagtgcag cagtgcagct gtttccttct gtgaattctg tccacattca ttttgtaaag
4681 atcatgaaaa gggggccctg gttccctctg cactggaagg ccgcctctgc tgctcggaac
4741 atgaccccat ggctcctgtg tcaccagaat actggagcaa gataaaatgt aaatgggaat
4801 cacaagatca tggagaagaa gtaaaagaat aaatgtgtgg tgtcccctcc tttctattta
4861 agtgaaaaaa gcaaatagat catgcattta aaaagaagag actgctacag tgcatacagc
4921 ctttgccatc ggaactgcct tattaaagca aaaatgggaa accagttcat gcaggcagaa
4981 gcagttggtg gtgtctggtt tttgtttgat ttggttggtt tgggattctt ttgtggaggg
5041 ttaaattccc ttggtctttt cttgcctttt attgtgcttc agtgccattg cagcttgaaa
5101 aagaaatgtt tttgctgtta aaataagaac aaagagaaaa gtaagttttg ttaatgagat
5161 aaatttaaag tctaagatgt gttccttggt tgtataaagc aaaagtagcc atcattcctt
5221 tatttatttt catttttagg aatttcaaga agtgtagttc aatagtctaa tcaagtgtgt
5281 gtgtgtttta agtaggaatc tgagaaagcc ctctaggaaa gggtatgata agctttatat
5341 acctctttac tgagcagtag gtaggctcac ttctctttcc cttcaaaatg cttttcatag
5401 gcttagagaa gggctctatg gaagtattaa a
//