LOCUS AF330044 7320 bp mRNA linear HUM 17-JUN-2002
DEFINITION Homo sapiens KIAA1008 protein mRNA, complete cds.
ACCESSION AF330044
VERSION AF330044.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 7320)
AUTHORS Rozenblum,E., Vahteristo,P., Sandberg,T., Bergthorsson,J.T.,
Syrjackoski,K., Weaver,D., Haraldsson,K., Johannsdottir,H.K.,
Vehmanen,P., Nigam,S., Goldberger,N., Robbins,C., Pak,E., Dutra,A.,
Gillanders,E., Stephan,D.A., Bailey-Wilson,J., Juo,S.-H.H.,
Kainu,T., Arason,A., Barkardottir,R.B., Nevanlinna,H., Borg,A. and
Kallioniemi,O.-P.
TITLE A genomic map of a 6-Mb region at 13q21-q22 implicated in cancer
development: identification and characterization of candidate genes
JOURNAL Hum. Genet. 110 (2), 111-121 (2002)
PUBMED 11935316
REFERENCE 2 (bases 1 to 7320)
AUTHORS Weaver,D., Haraldsson,K., Syrjakoski,K., Bergthorsson,J.,
Sandberg,T., Vahteristo,P., Rozenblum,E. and Kallioniemi,O.
TITLE Direct Submission
JOURNAL Submitted (19-DEC-2000) Cancer Genetics Branch, National Institute
of Human Genome Research, 49 Convent Dr., MSC 4470, Room 4A24,
Bethesda, MD 20892, USA
FEATURES Location/Qualifiers
source 1..7320
/db_xref="H-InvDB:HIT000077641"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="13"
/map="13q22"
/tissue_type="brain; peripheral blood leukocytes"
CDS 37..2913
/note="member of ribonuclease II family; similar to
Schizosaccharomyces pombe DIS3, a component of the
exosome"
/codon_start=1
/product="KIAA1008 protein"
/protein_id="AAL37479.1"
/translation="MLKSKTFLKKTRAGGVMKIVREHYLRDDIGCGAPGCAACGGAHE
GPALEPQPQDPASSVCPQPHYLLPDTNVLLHQIDVLEDPAIRNVIVLQTVLQEVRNRS
APVYKRIRDVTNNQEKHFYTFTNEHHRETYVEQEQGENANDRNDRAIRVAAKWYNEHL
KKMSADNQLQVIFITNDRRNKEKAIEEGIPAFTCEEYVKSLTANPELIDRLACLSEEG
NEIESGKIIFSEHLPLSKLQQGIKSGTYLQGTFRASRENYLEATVWIHGDSEENKEII
LQGLKHLNRAVHEDIVAVELLPKSQWVAPSSVVLHDEGQNEEDVEKEEETERMLKTAV
SEKMLKPTGRVVGIIKRNWRPYCGMLSKSDIKESRRHLFTPADKRIPRIRIETRQAST
LEGRRIIVAIDGWPRNSRYPNGHFVRNLGDVGEKETETEVLLLEHDVPHQPFSQAVLS
FLPKMPWSITEKDMKNREDLRHLCICSVDPPGCTDIDDALHCRELENGNLEVGVHIAD
VSHFIRPGNALDQESARRGTTVYLCEKRIDMVPELLSSNLCSLKCDVDRLAFSCIWEM
NHNAEILKTKFTKSVINSKASLTYAEAQLRIDSANMNDDITTSLRGLNKLAKILKKRR
IEKGALTLSSPEVRFHMDSETHDPIDLQTKELRETNSMVEEFMLLANISVAKKIHEEF
SEHALLRKHPAPPPSNYEILVKAARSRNLEIKTDTAKSLAESLDQAESPTFPYLNTLL
RILATRCMMQAVYFCSGMDNDFHHYGLASPIYTHFTSPIRRYADVIVHRLLAVAIGAD
CTYPELTDKHKLADICKNLNFRHKMAQYAQRASVAFHTQLFFKSKGIVSEEAYILFVR
KNAIVVLIPKYGLEGTVFFEEKDKPNPQLIYDDEIPSLKIEDTVFHVFDKVKVKIMLD
SSNLQHQKIRMSLVEPQIPGISIPTDTSNMDLNGPKKKKMKLGK"
BASE COUNT 2364 a 1358 c 1521 g 2077 t
ORIGIN
1 cgctgctggg gttaggattc tgcgcggcga ggcaagatgc tcaagtccaa gacgttctta
61 aaaaagaccc gggcgggcgg cgtgatgaag atcgtgcgcg agcactacct gcgagacgac
121 atcggctgcg gtgcgcccgg gtgcgcagcg tgtggagggg cgcacgaggg gccggccctg
181 gagccgcagc cccaggaccc ggcgagcagc gtctgcccgc aaccgcacta cttgctgccc
241 gacactaatg tgttactgca ccagattgat gttcttgagg accctgccat caggaatgta
301 attgtgctac aaacagttct tcaagaagtg agaaatcgca gtgcccccgt atataaacgc
361 atccgagatg tgactaataa ccaagagaag catttctata ctttcactaa tgagcaccat
421 agagaaacct atgtagaaca agaacaggga gaaaatgcta atgacaggaa tgatagagcg
481 attcgagtag cagcaaaatg gtacaatgaa catttgaaaa aaatgtcagc agacaaccag
541 ctgcaagtta tcttcataac aaatgacagg agaaacaaag agaaagccat agaagaagga
601 ataccagctt tcacttgtga agaatatgta aagagcctaa ctgctaaccc cgaactcata
661 gatcgtcttg cttgtttgtc tgaagaaggg aatgaaatag aaagtggaaa aataatattt
721 tcagagcatc ttcccttaag taagctacag caaggcataa aatctggtac ataccttcaa
781 ggaacattta gagctagcag ggaaaattac ttggaagcta cagtatggat tcatggcgac
841 agtgaagaaa ataaagagat aatcttacag ggacttaaac atttaaacag agctgttcac
901 gaagatattg tggctgtgga gcttctcccc aagagtcagt gggtagcacc atcttctgtg
961 gttttacatg atgaaggtca aaatgaagaa gatgtggaga aagaagaaga gacagaacga
1021 atgcttaaga ctgctgtaag cgagaaaatg ttgaagccta caggtagagt tgtaggaata
1081 ataaaaagga attggagacc atattgtggc atgctttcca agtctgacat taaggagtca
1141 agaagacatc tctttacacc tgctgataag agaatccctc gaattcgcat agaaaccaga
1201 caggcttcca cattagaagg acggagaatt attgttgcta ttgatggttg gcccagaaat
1261 tccagatatc caaatggaca ctttgtgaga aatttaggtg atgttggaga gaaagagact
1321 gaaacagaag ttttgttact tgaacacgat gttccccatc agcctttttc acaggctgtt
1381 cttagttttc tgccaaagat gccctggagc attactgaaa aggacatgaa aaaccgagaa
1441 gacctgaggc atctgtgtat ttgtagtgta gacccaccag gatgtactga tatagacgat
1501 gctctacatt gtcgagaact cgaaaatgga aatttggagg ttggtgttca tattgctgat
1561 gtgagccatt ttattaggcc aggaaatgcc ttggatcaag aatcagccag aagaggaaca
1621 actgtgtatc tttgtgaaaa gaggattgac atggttccag agttgcttag ctctaacttg
1681 tgttccttaa aatgtgacgt ggacaggctg gcattttcat gtatttggga aatgaatcac
1741 aatgctgaaa tcttaaaaac gaagtttacc aaaagtgtta ttaattcaaa ggcatctctg
1801 acatatgctg aagctcagtt gagaattgat tcagcaaaca tgaatgatga tattaccact
1861 agtctccgtg gactgaataa actagccaaa attctgaaga aaagaaggat tgaaaaaggg
1921 gctttgactc tatcctctcc tgaagttcga ttccacatgg acagtgaaac tcacgatcct
1981 atagatctgc agaccaagga acttagggaa acaaattcca tggttgaaga atttatgtta
2041 cttgccaata tttctgttgc aaaaaaaatt catgaggaat tttctgaaca tgctctgctt
2101 cgaaaacatc ctgctccacc tccatcaaat tatgaaattc ttgttaaggc agccaggtca
2161 aggaatttgg aaattaagac tgatacagcc aagtctttgg ctgagtcttt ggatcaggcc
2221 gaatctccta cttttccata tctaaacact ctgttgagaa tattagccac tcgctgtatg
2281 atgcaagctg tgtacttctg ttctggaatg gataatgatt ttcatcacta tggcttagcg
2341 tctccaatat acacacattt tacttcaccc attagaagat acgcagatgt cattgttcat
2401 cggcttttgg ctgtggctat tggggctgac tgtacttatc cagagttgac agacaaacac
2461 aagcttgcag atatatgtaa aaatctaaat ttccggcaca aaatggctca atatgcccaa
2521 cgtgcatcag tggcttttca tacccagtta ttcttcaaaa gcaaaggaat agtaagtgaa
2581 gaagcctata ttttatttgt aagaaagaat gccattgtgg tattaattcc aaagtatggt
2641 ttagaaggga cagtcttttt tgaagaaaag gacaaaccaa acccacagct tatttatgat
2701 gatgagatac cctcacttaa aatagaagat acagtgttcc atgtatttga taaagttaaa
2761 gtgaaaatca tgttagactc atctaatctt caacatcaga agatccgaat gtccctggta
2821 gaaccacaga taccaggaat aagcattcct actgatactt caaacatgga ccttaatgga
2881 ccaaagaaaa agaagatgaa gcttggaaaa tagctatatt caacaaaaat cttcaaagac
2941 tggtttcttt tttaaaagaa aaaacttgaa agaacacttc taagcctaag tgtgtgatac
3001 agtttgttac ttttaagtac attttaataa tttcagacat ctgcattttt attgaacagt
3061 tgactgtatc tgacccatca tactactata cttctgggtt gaacagaatt atttatgcag
3121 aataattcaa ttgaatatcc atcacttaaa tacagtgaca ggacagcaac ttcagggatc
3181 tgtaaagatc atttaaatgg agtgctcatc tcattgagga gcagattaat tttgcgtaag
3241 tactttgatt atttaatatt tgtaagaaaa aactttcatt ttcctacaga ggaaaataga
3301 acaattttag aagcaaggaa caatctcttt tctaagtctt ggaagctgtc agtgttgagg
3361 atgtaatctc ctttgccatc tttaattcac ctaacttaca ctaggtgttc tcttactgtc
3421 tttaaaagct tcctgtattt tattagtggt ccttgaaaaa ctgtgaatgt ttgggaattg
3481 gtagaaaggc aaaaagtagg atattttgac ctgactggaa agatggttgt gtttttattg
3541 ccaggtaata agtgtgatca ttgttgaact tcagctccag tgtctctcca gaataagaca
3601 ttggcattca aatgtctata tcttgttact tacaaaataa aaaacagata attagtggct
3661 tttaaattgt agttatatca gtgtatatac acgaggggaa ctgtataaag acatactaaa
3721 gggaacagat taaaataagt attattaata aaatttggtg tgccagactg actacttccc
3781 ttgctaatca cagagattag taatgattaa attaatatct tcaggaatat tttgggatag
3841 ggttgcctta aaacatttta cttggcttat tcaatttcta aagcacttac gttgtgccag
3901 gttccactca agtaaactat ctctgccttc aaggagcttg cagtatagtg agaaaagcct
3961 gccaagtaaa tcagcaggta tactaaatag gtagtcattt aggcactcaa taaatgttga
4021 ctaatttttc cagtttccta ttactgagga aaacctccat acactgaggc agaaacttgt
4081 gtcagttgga ggaaaataga cttgagtagt ctttggtcca ggtaaaatgg gtcagtagac
4141 actgaaacag tagagtagga gtcaaaaagc cttttctgtg aagtgctaga acattttaga
4201 ctttgttggc tatggtctgt attgcaacta tagtacacaa ctctgccgtt gatagtgtgt
4261 aaggagccat atacaatatg taaacaaatc aacatgactg tgtttcaaca aggcctgatt
4321 tgttaagttt catatatagt catatgtcac ttaatgacag ggatatgttc tgagacatgt
4381 cacttggcaa tttcatcatt gtgtgaaaat catgatgtag ttacacaaac ctagatggta
4441 taccctatgg tatcctatat gggatagcct attgctccta acctacaaac ctgtatggca
4501 tattactgta ctgattactg taggcagttg taacacagtg ctaagtattt gtgtatctaa
4561 acatatctaa acatagaaaa ggtacagtaa aaatatatat atagatatat ataagatata
4621 aaatggtaca cctatttagg acatttacca tgaacaagtt ggcaggactg gaagctggct
4681 ctgggtgagt cagtaagtgg ttagtgaatg tgaaggccat gatattactg tgcactactg
4741 tagactttta taaacactat atacttaggc tacataaagt aatttcacta tgatgttacc
4801 atggctgtgt ccgcaggcaa taggaatttt tcagctccat tgtaatctta cgggatcatc
4861 atcgtatatt tggccattgt tgaccaaaag ttatgcagca catcattata attttgatgt
4921 gtcacaaaac attactcatt tgatttcccc cacccccgcc aaccatttaa aaaagtttgc
4981 cggctaggtg cggtggctca tgcctgtaat cctagcattt tgggaggacg aggcgggtgg
5041 atcactcgat gtcaggagtt tgagaccagc ctggccaaca tggtaaaacg ccgtctctac
5101 taaaaataca aaaacttagc tgggtgtaac ggcggatgcc tgtaatccca gctacttggg
5161 aggctgaggc aggagaatcg cttgaacctg ggaggcggaa gttgcagtga gccgagattg
5221 caccactgca gttcagcctg gatgatgaga gtgagactcc atcgcaaaaa aaaaaaaaaa
5281 aaaaagaaaa gaaaattagc caggtgtggt ggcaagtgcc tttaatccca cctcaggagg
5341 ctgaggcagg agaatcgctt gaacctggga ggcagaggtt gcagtgagcc aagatcgcgc
5401 cactgcactc cagcctgggt gacagaacaa gactgtctca aaaaaaaaaa aaaagaagaa
5461 aaactgccta caggccatag ttaacctgca atagagaaga aagggaagta gggcagtgca
5521 tgactggcct taggtttttt ctttccaagt ttattttctt gtgcttcagc tactagaaag
5581 gtttaattca gggataagtc ccaattgagt agttcaagat gatcagagac tttgctattt
5641 tcccctaagt tctattccat aatctaaaat gttctgtttc tagtgccagt tcttatgcta
5701 agcaggttac gtggaatata tcacttaact caaaaagccc tgttaagcca ggactgttat
5761 ctccatttaa cagatgagaa aatggaggtt tatggtctgt tctcacactg ctacgaagaa
5821 ataccccaaa ctgggtaatt attataaagg aaagaggttt aatggactca gttccgcatt
5881 gctggtgagg cctcaggaca cttatacaat catggcagaa aaaggagaag caggcacctt
5941 tttcacaggg cggcaggatg aaaatgactg ccagcagtgg aaatgccaga cgcttataaa
6001 accttcagat ctcatgagac cggctcacta tcacaggaac agcatggagg aaaccgcccc
6061 catgatccag ttacctccac ctggtcccac ccttgacacg tggggattgc tacaattcaa
6121 ggttagattt gggtgaggac acagagccat accatatcag cccagatcaa gtagtgacag
6181 agtagggatt tgaatacagg ttatagtcac tattgtgtta tttcttgact tttgtactat
6241 taaaaaactg tagccagtga ggcttctacc cttagtaccc agaactcctt ttaggtatag
6301 caattgtttt taggtaaatt tatattgagt ttaacacctg tgtgattaaa gacaactttc
6361 caatgtagta tctgtagcca tgtcccctaa tggctattag tgttcatggt tagtgtgttg
6421 aagatgagcc aggtacataa cgcggcacat tttctgcagg tcagcagtaa ggtttcaagg
6481 tacagttatg gaggaaagaa gaaaatgaca cattgataac acaggtcttt attccctttt
6541 gaatgagaca gtttttaaaa gttgatttat aaatacaaaa atacattctc caaagatagt
6601 atttccaaac tgttatatac ccatctactc ccaacatgga tataagtttt ttaaaaaaat
6661 agttgtatat aacatacata tctgccccag tgttacttca caggcctatg ccctacggga
6721 actccactct cccagcccca ctttttctct tggttctccc acattcttat tctcccacat
6781 ccctacccac gtttgagctg gaaaggatgt ccctacccta ggcatgaggt atattttatt
6841 ctgggcacca cacatttgcc ccatagataa caatacacgt gatgatgtca ctagtactac
6901 ctttctagta tttacatact taaaagtagt aactagaaca gttatcactg gaactaagaa
6961 ttttccccac agaggtgaac aggaccaagg aactaaaatt tcaggaaacc tgtttaattt
7021 cttttgtatc tttgaaaagt tagttttata tctaagattt cttcacatag gttataattc
7081 atctgtatgt tcaagctttt atgtaaaaat atatagtgcc ttcagtttta acatagtttc
7141 acatgttctc agaactgcta aattcagtgc taccagtaag gcttaataag tagttcattg
7201 accctgtaag ataggagcac tcagctctgt cacaatttgt tgttaaacac atcactcaat
7261 gtaagtataa aaatatttat tgataaaaaa taaacttata attcagcaaa aaaaaaaaaa
//