LOCUS AF327656 3410 bp mRNA linear HUM 31-JAN-2001
DEFINITION Homo sapiens phosphoinositide-3-kinase gamma catalytic subunit
(PI3CG) mRNA, complete cds.
ACCESSION AF327656
VERSION AF327656.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 3410)
AUTHORS Stoyanov,B., Volinia,S., Hanck,T., Rubio,I., Loubtchenkov,M.,
Malek,D., Stoyanova,S., Vanhaesebroeck,B., Dhand,R., Nurnberg,B.,
Gierschik,P., Seedorf,K., Hsuan,J.J., Waterfield,M.D. and
Wetzker,R.
TITLE Cloning and characterization of a G protein-activated human
phosphoinositide-3 kinase
JOURNAL Science 269 (5224), 690-693 (1995)
PUBMED 7624799
REFERENCE 2 (bases 1 to 3410)
AUTHORS Michalke,M., Schaefer,M., Stoyanov,B., Wetzker,R. and Nuernberg,B.
TITLE Regulation of a G-protein-activated phosphoinositide-3-kinase
JOURNAL Unpublished
REFERENCE 3 (bases 1 to 3410)
AUTHORS Michalke,M., Schaefer,M., Stoyanov,B., Wetzker,R. and Nuernberg,B.
TITLE Direct Submission
JOURNAL Submitted (11-DEC-2000) Department of Pharmacology, Freie
Universitaet Berlin, Thielallee 67-73, Berlin 14195, Germany
FEATURES Location/Qualifiers
source 1..3410
/db_xref="H-InvDB:HIT000077550"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="7"
/map="7q22.2"
gene 1..3410
/gene="PI3CG"
CDS 1..3309
/gene="PI3CG"
/EC_number="2.7.1.137"
/note="PI-3-kinase-gamma; p110 gamma"
/codon_start=1
/product="phosphoinositide-3-kinase gamma catalytic
subunit"
/protein_id="AAG61115.1"
/translation="MELENYKQPVVLREDNCRRRRRMKPRSAAASLSSMELIPIEFVL
PTSQRKCKSPETALLHVAGHGNVEQMKAQVWLRALETSVAADFYHRLGPHHFLLLYQK
KGQWYEIYDKYQVVQTLDCLRYWKATHRSPGQIHLVQRHPPSEESQAFQRQLTALIGY
DVTDVSNVHDDELEFTRRGLVTPRMAEVASRDPKLYAMHPWVTSKPLPEYLWKKIANN
CIFIVIHRSTTSQTIKVSPDDTPGAILQSFFTKMAKKKSLMDIPESQSEQDFVLRVCG
RDEYLVGETPIKNFQWVRHCLKNGEEIHVVLDTPPDPALDEVRKEEWPLVDDCTGVTG
YHEQLTIHGKDHESVFTVSLWDCDRKFRVKIRGIDIPVLPRNTDLTVFVEANIQHGQQ
VLCQRRTSPKPFTEEVLWNVWLEFSIKIKDLPKGALLNLQIYCGKAPALSSKASAESP
SSESKGKVRLLYYVNLLLIDHRFLLRRGEYVLHMWQISGKGEDQGSFNADKLTSATNP
DKENSMSISILLDNYCHPIALPKHQPTPDPEGDRVRAEMPNQLRKQLEAIIATDPLNP
LTAEDKELLWHFRYESLKHPKAYPKLFSSVKWGQQEIVAKTYQLLARREVWDQSALDV
GLTMQLLDCNFSDENVRAIAVQKLESLEDDDVLHYLLQLVQAVKFEPYHDSALARFLL
KRGLRNKRIGHFLFWFLRSEIAQSRHYQQRFAVILEAYLRGCGTAMLHDFTQQVQVIE
MLQKVTLDIKSLSAEKYDVSSQVISQLKQKLENLQNSQLPESFRVPYDPGLKAGALAI
EKCKVMASKKKPLWLEFKCADPTALSNETIGIIFKHGDDLRQDMLILQILRIMESIWE
TESLDLCLLPYGCISTGDKIGMIEIVKDATTIAKIQQSTVGNTGAFKDEVLNHWLKEK
SPTEEKFQAAVERFVYSCAGYCVATFVLGIGDRHNDNIMITETGNLFHIDFGHILGNY
KSFLGINKERVPFVLTPDFLFVMGTSGKKTSPHFQKFQDICVKAYLALRHHTNLLIIL
FSMMLMTGMPQLTSKEDIEYIRDALTVGKNEEDAKKYFLDQIEVCRDKGWTVQFNWFL
HLVLGIKQGEKHSA"
BASE COUNT 950 a 861 c 849 g 750 t
ORIGIN
1 atggagctgg agaactataa acagcccgtg gtgctgagag aggacaactg ccgaaggcgc
61 cggaggatga agccgcgcag tgctgcggcc agcctgtcct ccatggagct catccccatc
121 gagttcgtgc tgcccaccag ccagcgcaaa tgcaagagcc ccgaaacggc gctgctgcac
181 gtggccggcc acggcaacgt ggagcagatg aaggcccagg tgtggctgcg agcgctggag
241 accagcgtgg cggcggactt ctaccaccgg ctgggaccgc atcacttcct cctgctctat
301 cagaagaagg ggcagtggta cgagatctac gacaagtacc aggtggtgca gactctggac
361 tgcctgcgct actggaaggc cacgcaccgg agcccgggcc agatccacct ggtgcagcgg
421 cacccgccct ccgaggagtc ccaagccttc cagcggcagc tcacggcgct gattggctat
481 gacgtcactg acgtcagcaa cgtgcacgac gatgagctgg agttcacgcg ccgtggcttg
541 gtgaccccgc gcatggcgga ggtggccagc cgcgacccca agctctacgc catgcacccg
601 tgggtgacgt ccaagcccct cccggagtac ctgtggaaga agattgccaa caactgcatc
661 ttcatcgtca ttcaccgcag caccaccagc cagaccatta aggtctcacc cgacgacacc
721 cccggcgcca tcctgcagag cttcttcacc aagatggcca agaagaaatc tctgatggat
781 attcccgaaa gccaaagcga acaggatttt gtgctgcgcg tctgtggccg ggatgagtac
841 ctggtgggcg aaacgcccat caaaaacttc cagtgggtga ggcactgcct caagaacgga
901 gaagagattc acgtggtact ggacacgcct ccagacccgg ccctagacga ggtgaggaag
961 gaagagtggc cgctggtgga cgactgcacg ggagtcaccg gctaccatga gcagcttacc
1021 atccacggca aggaccacga gagtgtgttc accgtgtccc tgtgggactg cgaccgcaag
1081 ttcagggtca agatcagagg cattgatatc cccgtcctgc ctcggaacac cgacctcaca
1141 gtttttgtag aggcaaacat ccagcatggg caacaagtcc tttgccaaag gagaaccagc
1201 cccaaaccct tcacagagga ggtgctgtgg aatgtgtggc ttgagttcag tatcaaaatc
1261 aaagacttgc ccaaaggggc tctactgaac ctccagatct actgcggtaa agctccagca
1321 ctgtccagca aggcctctgc agagtccccc agttctgagt ccaagggcaa agttcggctt
1381 ctctattatg tgaacctgct gctgatagac caccgtttcc tcctgcgccg tggagaatac
1441 gtcctccaca tgtggcagat atctgggaag ggagaagacc aaggaagctt caatgctgac
1501 aaactcacgt ctgcaactaa cccagacaag gagaactcaa tgtccatctc cattcttctg
1561 gacaattact gccacccgat agccctgcct aagcatcagc ccacccctga cccggaaggg
1621 gaccgggttc gagcagaaat gcccaaccag cttcgcaagc aattggaggc gatcatagcc
1681 actgatccac ttaaccctct cacagcagag gacaaagaat tgctctggca ttttagatac
1741 gaaagcctta agcacccaaa agcatatcct aagctattta gttcagtgaa atggggacag
1801 caagaaattg tggccaaaac ataccaattg ttggccagaa gggaagtctg ggatcaaagt
1861 gctttggatg ttgggttaac aatgcagctc ctggactgca acttctcaga tgaaaatgta
1921 agagccattg cagttcagaa actggagagc ttggaggacg atgatgttct gcattacctt
1981 ctacaattgg tccaggctgt gaaatttgaa ccataccatg atagcgccct tgccagattt
2041 ctgctgaagc gtggtttaag aaacaaaaga attggtcact ttttgttttg gttcttgaga
2101 agtgagatag cccagtccag acactatcag cagaggttcg ctgtgattct ggaagcctat
2161 ctgaggggct gtggcacagc catgctgcac gactttaccc aacaagtcca agtaatcgag
2221 atgttacaaa aagtcaccct tgatattaaa tcgctctctg ctgaaaagta tgacgtcagt
2281 tcccaagtta tttcacaact taaacaaaag cttgaaaacc tgcagaattc tcaactcccc
2341 gaaagcttta gagttccata tgatcctgga ctgaaagcag gagcgctggc aattgaaaaa
2401 tgtaaagtaa tggcctccaa gaaaaaacca ctatggcttg agtttaaatg tgccgatcct
2461 acagccctat caaatgaaac aattggaatt atctttaaac atggtgatga tctgcgccaa
2521 gacatgctta ttttacagat tctacgaatc atggagtcta tttgggagac tgaatctttg
2581 gatctatgcc tcctgccata tggttgcatt tcaactggtg acaaaatagg aatgatcgag
2641 attgtgaaag acgccacgac aattgccaaa attcagcaaa gcacagtggg caacacggga
2701 gcatttaaag atgaagtcct gaatcactgg ctcaaagaaa aatcccctac tgaagaaaag
2761 tttcaggcag cagtggagag atttgtttat tcctgtgcag gctactgtgt ggcaaccttt
2821 gttcttggaa taggcgacag acacaatgac aatattatga tcaccgagac aggaaaccta
2881 tttcatattg acttcgggca cattcttggg aattacaaaa gtttcctggg cattaataaa
2941 gagagagtgc catttgtgct aacccctgac ttcctctttg tgatgggaac ttctggaaag
3001 aagacaagcc cacacttcca gaaatttcag gacatctgtg ttaaggctta tctagccctt
3061 cgtcatcaca caaacctact gatcatcctg ttctccatga tgctgatgac aggaatgccc
3121 cagttaacaa gcaaagaaga cattgaatat atccgggatg ccctcacagt ggggaaaaat
3181 gaggaggatg ctaaaaagta ttttcttgat cagatcgaag tttgcagaga caaaggatgg
3241 actgtgcagt ttaattggtt tctacatctt gttcttggca tcaaacaagg agagaaacat
3301 tcagcctaat actttaggct agaatcaaaa acaagttagt gttctatggt ttaaattagc
3361 atagcaatca tcgaacttgg atttcaaatg caatagacat tgtgaaagct
//